Article
Biochemistry & Molecular Biology
Berenice Le Dieu-Lugon, Nicolas Dupre, Celine Derambure, Francois Janin, Bruno J. Gonzalez, Stephane Marret, Arnaud Arabo, Philippe Leroux
Summary: MgSO4 is widely used in preventing neurological disabilities in preterm infants, mainly by suppressing synaptogenesis and axonal development to reduce inflammation and innate immune responses. Additionally, MgSO4 affects neural development by inhibiting RNA polymerase II transcription and regulating mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
L. E. Duran-Carabali, J. L. Da Silva, A. C. M. Colucci, C. A. Netto, L. S. De Fraga
Summary: Sex steroid hormones, such as progesterone and 17 beta estradiol, have been shown to have positive effects on reducing brain damage in neonatal hypoxia-ischemia. This systematic review and meta-analysis confirmed their efficacy in reducing cerebral infarction size, cell death, neuroinflammatory responses, and astrocyte reactivity, while only showing a small effect on cognitive function. However, further research is needed to examine neurological function during hypoxia-ischemia recovery and to standardize methodological aspects to avoid spurious findings.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Article
Chemistry, Medicinal
Tingting Li, Jiangbing Li, Tong Li, Yijing Zhao, Hongfei Ke, Shuanglian Wang, Dexiang Liu, Zhen Wang
Summary: The study found that L-Cysteine treatment prevented acute brain damage and long-term memory impairment in neonatal mice exposed to hypoxia-ischemia. This protective effect was associated with the phosphorylation of Akt and PTEN. The neuroprotective effects of L-Cysteine were attenuated when the PI3K inhibitor, LY294002, was used.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon
Summary: In this study, divergently modified peptide analogs derived from EPO showed potent neuroprotective effects against oxidative stress without inducing cell proliferation. One of the peptides, ML1-h3, exhibited unique binding potency to EPOR and inhibited neuronal death and brain injury under hypoxic stress.
Article
Biochemistry & Molecular Biology
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stephane Sizonenko
Summary: Combining early oral administration of lactoferrin with whole body hypothermia can enhance neuroprotection in neonatal hypoxic-ischemic encephalopathy, preventing lactate accumulation, reducing inflammation, and mitigating brain damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Tyler C. Hillman, Ryan Idnani, Christopher G. Wilson
Summary: Understanding hypoxia/hyperoxia exposure requires precise control of gas concentrations. Current commercial chambers are expensive and limited in functionality. We developed a low-cost and customizable chamber controlled by open-source software, allowing for reproducible data acquisition and analysis for different exposure protocols.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lalita Subedi, Bhakta Prasad Gaire
Summary: The search for novel therapeutic agents for cerebral ischemia/stroke has led to a focus on neuroprotective phytochemicals with anti-inflammatory properties as potential drug candidates. Studies have shown that these compounds reduce brain inflammation by decreasing proinflammatory microglia and macrophages while promoting anti-inflammatory responses, leading to improved outcomes in animal stroke models.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biology
Sarah Kolnik, Thomas R. Wood
Summary: Vitamin E has potential as a neuroprotectant in newborn infants with brain injury, but its effectiveness in clinical settings is still uncertain. Recent studies have shown that fat emulsions containing higher levels of Vitamin E can improve outcomes in neonatal co-morbidities, leading to a reconsideration of Vitamin E administration as a potential therapeutic modality. This review discusses the structure, mechanism(s) of action, evidence in animal models, and association with health outcomes in neonates, highlighting the need for further research and assessment of safety profiles before large clinical trials.
Article
Environmental Sciences
Peng Su, Diya Wang, Zipeng Cao, Jingyuan Chen, Jianbin Zhang
Summary: Lead exposure induces neuroinflammation, with NLRP3 playing a role in regulating neurotoxicity. Minocycline can mitigate neurotoxicity and inhibit neuroinflammation, while blocking NLRP3 can attenuate neural alterations induced by lead.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Julie A. Wixey, Kah Meng Lee, Stephanie M. Miller, Kate Goasdoue, Paul B. Colditz, S. Tracey Bjorkman, Kirat K. Chand
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Gastroenterology & Hepatology
Peter J. Lewindon, Mora Puertolas-Lopez, Louise E. Ramm, Charlton Noble, Tamara N. Pereira, Julie A. Wixey, Gunter F. Hartel, Diego A. Calvopina, Daniel H. Leung, Grant A. Ramm
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Developmental Biology
Kate Goasdoue, Kirat Kishore Chand, Stephanie Melita Miller, Kah Meng Lee, Paul Bernard Colditz, Julie Anne Wixey, Stella Tracey Bjorkman
DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Nursing
C. J. Andrews, D. Ellwood, P. F. Middleton, C. S. E. Homer, H. E. Reinebrant, N. Donnolley, F. M. Boyle, A. Gordon, M. Nicholl, J. Morris, G. Gardener, M. Davies-Tuck, E. M. Wallace, V. J. Flenady
Review
Public, Environmental & Occupational Health
Susannah Hopkins Leisher, Arin A. Balalian, Hanna Reinebrant, Stephanie Shiau, Vicki Flenady, Louise Kuhn, Stephen S. Morse
Summary: Studies have not provided enough evidence to determine whether there is a higher risk of foetal death in Zika-affected pregnancies, but suggest that the quality of reporting on foetal deaths needs improvement.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Review
Pediatrics
Elliot J. Teo, Lara E. Jones, Julie A. Wixey, Roslyn N. Boyd, Paul B. Colditz, S. Tracey Bjorkman
Summary: This study found that combined HTH-MSC therapy improves astrocyte optical density, but there is insufficient preclinical data to confirm its superiority over HTH alone. Further research is needed to establish the efficacy of HTH and MSCs on neuropathology and neurobehavior measures. Improved reporting standards using checklists such as SYRCLE or ARRIVE tools could enhance the quality of preclinical data in this area.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Clinical Neurology
Bobbi Fleiss, Deidre M. Murray, S. Tracey Bjorkman, Julie A. Wixey
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Kirat K. Chand, Stephanie M. Miller, Gary J. Cowin, Lipsa Mohanty, Jany Pienaar, Paul B. Colditz, Stella Tracey Bjorkman, Julie A. Wixey
Summary: Inflammation plays a key role in the progression of brain impairment in FGR newborns, and ibuprofen may reduce NVU disruption and brain impairment in FGR piglets. Ibuprofen treatment decreases pro-inflammatory response, enhances astrocyte interaction with blood vessels, and restores NVU integrity, improving the FGR brain microenvironment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell & Tissue Engineering
Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey
Summary: The study found that a dose of combined MSC-ECFC on the first day of life for FGR newborn piglets improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation, and improved adverse neuronal and white matter changes in the FGR newborn piglet brain. These effects were not observed with MSCs alone, indicating that cECFC treatment may act as a neuroprotectant for the FGR brain.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Developmental Biology
Kirat K. K. Chand, Kerstin Pannek, Paul B. B. Colditz, Julie A. A. Wixey
Summary: Fetal growth restriction (FGR) is associated with long-term neurodevelopmental disabilities, but the mechanisms are still unknown and there are no current therapies to protect the FGR newborn brain. Piglets, which naturally develop FGR, serve as an ideal animal model to study how perinatal insults affect brain structure and function without the need for surgical or chemical intervention. Findings from FGR piglet studies may provide critical information to develop neuroprotective interventions for newborn babies.
DEVELOPMENTAL NEUROSCIENCE
(2022)
Review
Pediatrics
Nathan J. Stevenson, Melissa M. Lai, Hava E. Starkman, Paul B. Colditz, Julie A. Wixey
Summary: This review explores the potential of electroencephalography (EEG) as a tool for assessing brain development in fetuses with growth restriction (FGR) or born small for gestational age (SGA). Findings suggest that FGR/SGA is associated with measurable changes in EEG immediately after birth and into childhood. Early manifestations in EEG include changes in spectral power, symmetry/synchrony, sleep-wake cycling, and continuity of EEG amplitude, while later manifestations include changes in spectral power, sleep architecture, and EEG amplitude. FGR/SGA infants also show poorer neurodevelopmental outcomes compared to those appropriate for gestational age (AGA). EEG has the potential to identify FGR/SGA infants and assess the functional correlates of neurological damage.
PEDIATRIC RESEARCH
(2022)
Review
Cell & Tissue Engineering
Kirat Chand, Rachel Nano, Julie Wixey, Jatin Patel
Summary: This review discusses the potential application of stem cell therapy for FGR newborns. FGR newborns suffer from chronic inflammation and vascular disruption, and stem cell therapy may serve as an effective intervention for treating their neurological impairments and long-term disabilities.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Developmental Biology
Hannah Musco, Kate Beecher, Kirat K. Chand, Paul B. Colditz, Julie A. Wixey
Summary: Fetal growth restriction (FGR) and small for gestational age (SGA) infants have increased risk of mortality and morbidity. Blood biomarkers may be a promising tool for early detection of brain injury risk in FGR and SGA neonates.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Cell Biology
Hanna E. Reinebrant, Julie A. Wixey, Kathryn M. Buller
NEURAL REGENERATION RESEARCH
(2020)