Article
Biochemistry & Molecular Biology
Anne Marlene Landau, Steen Jakobsen, Majken Borup Thomsen, Aage Kristian Olsen Alstrup, Dariusz Orlowski, Jan Jacobsen, Gregers Wegener, Arne Mork, Jens Christian Hedemann Sorensen, Doris J. Doudet
Summary: This study combines PET and microdialysis to explore the use of [C-11]yohimbine in assessing changes in synaptic noradrenaline during acute pharmacological challenges. The results suggest that [C-11]yohimbine can be used to evaluate acute variations in synaptic noradrenaline concentrations after pharmacological challenges.
Article
Environmental Sciences
Naseer Maliyakkal, Uzma Saleem, Fareeha Anwar, Muhammad Ajmal Shah, Bashir Ahmad, Filzah Umer, Mohammad Ali Abdullah Almoyad, Della Grace Thomas Parambi, Asmy Appadath Beeran, Lekshmi R. Nath, Lotfi Aleya, Bijo Mathew
Summary: Parkinson's disease is a progressive neurodegenerative disorder affecting primarily the elderly. The compound E7 demonstrated anti-Parkinson activity in a haloperidol-induced animal model of mice, showing improved locomotor activity and motor coordination in the treatment group. Oxidative stress biomarkers and neurotransmitter levels were influenced by E7 treatment, with dose-dependent effects observed. E7 compound exhibited more evident anti-Parkinson activity at 30 mg/kg oral dose in mice.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Geosciences, Multidisciplinary
Erfan Firuzi, Kambod Amini Hosseini, Anooshiravan Ansari, Shayan Tabasian
Summary: This study presents the development of an empirical fatality model based on earthquakes data in Iran since 1962. The model considers uncertainties and uses fuzzy regression and Monte Carlo simulation tools. The study finds that PGA is the best parameter for estimating fatality rate. The model is successfully applied to a case study and can provide initial assessment for death toll after destructive earthquakes, important for rescue and relief activities. The model is used in Iran's rapid loss assessment system and can be employed for seismic risk mitigation planning.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Geosciences, Multidisciplinary
Erfan Firuzi, Kambod Amini Hosseini, Anooshiravan Ansari, Shayan Tabasian
Summary: This study developed an empirical fatality model based on earthquake data in Iran since 1962, showing that PGA parameter provides the best estimation of fatality. The model was validated in the Ahar-Varzaghan 2012 earthquake case and can provide initial assessment of death toll after destructive earthquakes.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Neurosciences
Blanca Perez-Palomar, Amaia M. Erdozain, Ines Erkizia-Santamaria, Jorge E. Ortega, J. Javier Meana
Summary: Infection during pregnancy can lead to abnormal functioning of the prefrontal cortex catecholaminergic system and cognitive impairment in the offspring. Using a poly(I:C)-based model, researchers found that offspring exposed to prenatal infection displayed memory deficits and decreased dopamine concentrations, as well as impaired release of dopamine and noradrenaline. These findings replicate catecholamine phenotypes seen in schizophrenia and provide an opportunity for studying cognitive impairment in this disorder.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dominika Luptakova, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andren
Summary: This study presents a new approach that combines in vivo and in vitro neuropharmacokinetic investigations with mass spectrometry imaging to quantify and visualize the extent of unbound drug transport across the blood-brain barrier, as well as the post-BBB distribution of drugs at regional and subregional levels. The approach allows differentiation of regional and subregional BBB transport characteristics of antipsychotic drugs, providing a new tool for investigating heterogeneity in BBB transport and facilitating interpretation of regional target-site exposure results for molecular psychiatrists.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Samara Vilca, Claes Wahlestedt, Sari Izenwasser, Raul R. Gainetdinov, Marta Pardo
Summary: This study showed that chronic cocaine treatment affected the expression of epigenetic modulators in a sex- and genotype-dependent manner in DAT transgenic rats. Male rats with partial DAT mutation had decreased KDM6B expression, while female rats had increased KDM6B expression. Furthermore, both male and female rats with full DAT knockout showed increased BRD4 expression.
Article
Biology
Lindsay Collins, John Francis, Brett Emanuel, David A. McCormick
Summary: This study investigates the activity of cholinergic and noradrenergic axons in the cortex of awake mice and their correlation with behavioral state. The findings suggest that these neuromodulatory systems play a prominent role in regulating behavioral state-dependent cortical activity and excitability. Furthermore, the study reveals both broad coordination and heterogeneity in the activity of these axons, indicating complex mechanisms underlying their communication.
Article
Materials Science, Multidisciplinary
Sirlene Trugilho Perin Passigatti, Marcia Spelta de Oliveira, Jose Roberto de Oliveira, Raphael Mariano de Souza, Estefano Aparecido Vieira
Summary: In recent decades, the control of non-metallic inclusions in steel has been crucial for the quality and performance of materials. This study compared methodologies for inclusions characterization and analysis, specifically Spark-DAT, ASCAT, and optical microscope systems, to validate their effectiveness in measuring and controlling the amount and size of inclusions during steelmaking.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Infectious Diseases
Johan van Griensven, Ermias Diro, Cedric P. Yansouni
Summary: Using datasets from field diagnostic trials of visceral leishmaniasis, we demonstrate the potential effects of unrecognised biases on test accuracy. We explain why these biases can go unnoticed despite following guidelines, and provide recommendations for avoiding biases in study design, reporting, and location.
LANCET INFECTIOUS DISEASES
(2023)
Article
Neurosciences
Rosaria Formisano, Katarzyna D. Rosikon, Abhyudai Singh, Harbinder S. Dhillon
Summary: The study examined the mechanisms of dopamine release and clearance, finding that DAT-1 acts as a negative feedback modulator in regulating neurotransmitter vesicle fusion. Through experimental results and a mechanistic model, the dynamics of synaptic vesicle fusion were dissected, and the feedback effects of DAT-1 were compared with dopamine auto-receptors. The findings have broader significance as similar dynamics may be utilized by other synaptic modulators across species.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Immunology
Thilo Bartolmaes, Axel Pruss, Beate Mayer
Summary: This study investigated different types of hemolysis in autoimmune hemolytic anemia (AIHA) and found that in addition to the routine C3d-DAT test, indirect tests should be used to determine the proportion of extravascular, intravascular, and eryptotic hemolysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Hoeger, Gert Lubec
Summary: The worldwide increase in cognitive decline calls for the search of pharmacological treatment. Current dopamine transporter (DAT) inhibitors have unwanted side effects due to lack of specificity. A highly specific DAT inhibitor, S-CE-123, was synthesized and tested for its potential to enhance cognitive functions in rats. S-CE-123 showed good bioavailability and improved the performance of aged rats.
Article
Infectious Diseases
Yasmeen Abouelhassan, Andrew J. Fratoni, Ashley K. Shepard, David P. Nicolau, Tomefa E. Asempa
Summary: This study assessed the pharmacokinetics of tebipenem in healthy subjects and patients with diabetic foot infection, and found that tebipenem demonstrated excellent distribution into skin and soft tissue.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Engineering, Environmental
Elliott M. Hamilton, Scott D. Young, Elizabeth H. Bailey, Olivier S. Humphrey, Michael J. Watts
Summary: Microdialysis coupled with high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) allows for continuous sampling and simultaneous detection of Cr-VI in soil solution, offering improved temporal resolution and a significant reduction in analysis time.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sarah Beggiato, Andrea C. Borelli, Maria C. Tomasini, M. Paola Castelli, Nicholas Pintori, Roberto Cacciaglia, Antonella Loche, Luca Ferraro
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Neurosciences
Ilaria Rossetti, Laura Zambusi, Paola Maccioni, Roberta Sau, Luciano Provini, M. Paola Castelli, Krzysztof Gonciarz, Giancarlo Colombo, Stefano Morara
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Psychology, Clinical
Roberto Collu, Maria Scherma, Fabiana Piscitelli, Elisa Giunti, Valentina Satta, Maria P. Castelli, Roberta Verde, Walter Fratta, Tiziana Bisogno, Paola Fadda
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2019)
Article
Pharmacology & Pharmacy
Cristina Miliano, Matteo Marti, Nicholas Pintori, Maria Paola Castelli, Micaela Tirri, Raffaella Arfe, Maria Antonietta De Luca
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Claudia Mugnaini, Antonella Brizzi, Rafaela Mostallino, Maria Paola Castelli, Federico Corelli
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Neurosciences
Liana Fattore, Matteo Marti, Rafaela Mostallino, Maria Paola Castelli
Article
Pharmacology & Pharmacy
Francesca Ferlenghi, Paola Maccioni, Claudia Mugnaini, Antonella Brizzi, Federica Fara, Rafaela Mostallino, M. Paola Castelli, Giancarlo Colombo, Marco Mor, Federica Vacondio, Federico Corelli
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Nicholas Pintori, Maria Paola Castelli, Cristina Miliano, Nicola Simola, Paola Fadda, Liana Fattore, Maria Scherma, Maria Grazia Ennas, Rafaela Mostallino, Giovanna Flore, Marta De Felice, Claudia Sagheddu, Marco Pistis, Gaetano Di Chiara, Maria Antonietta De Luca
Summary: Repeated exposure to JWH-018 induced anxious and aversive behaviors, decreased dopamine neurons in the VTA, and altered dopaminergic transmission. The drug also affected dopamine sensitivity in the NAc shell and core, while causing neuroinflammatory responses in specific brain areas. This study suggests that recurring use of Spice/K2 drugs may have detrimental effects on behavior and dopamine regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Alessandra Porcu, Rafaela Mostallino, Valeria Serra, Miriam Melis, Valeria Sogos, Sarah Beggiato, Luca Ferraro, Fabrizio Manetti, Beatrice Gianibbi, Bernhard Bettler, Federico Corelli, Claudia Mugnaini, M. Paola Castelli
Summary: This study characterized the negative allosteric modulator COR758 for GABA(B) receptors, showing its potential as a therapeutic candidate by inhibiting G protein signaling. COR758 may serve as a scaffold for developing additional NAMs for therapeutic intervention by interacting with an allosteric binding site of GABA(B) receptors.
Article
Biochemistry & Molecular Biology
Valeria Sogos, Paola Caria, Clara Porcedda, Rafaela Mostallino, Franca Piras, Cristina Miliano, Maria Antonietta De Luca, M. Paola Castelli
Summary: Novel psychoactive substances (NPS) are synthetic compounds designed to mimic the effects of scheduled drugs, but limited information is available on their pharmacology and toxicology. This study investigated the toxicity mechanisms of two emerging NPS and fentanyl, with results showing that they induce cell death through different pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Giovanna Flore, Antonio Preti, Mauro Giovanni Carta, Andrea Deledda, Michele Fosci, Antonio Egidio Nardi, Andrea Loviselli, Fernanda Velluzzi
Summary: Only 25% of patients succeed in maintaining the result of weight loss for a long time after a low-calorie diet. This systematic review and meta-analysis find that intensive intervention during the maintenance phase may contribute to greater preservation of weight loss achieved during the previous slimming phase, although the difference from the control group is not statistically significant.
Article
Neurosciences
Giulia Margiani, Maria Paola Castelli, Nicholas Pintori, Roberto Frau, Maria Grazia Ennas, Valeria Orru, Valentina Serra, Edoardo Fiorillo, Paola Fadda, Giovanni Marsicano, Maria Antonietta De Luca
Summary: This study suggests that male mice self-administer the prototypical SCRA JWH-018 during adolescence. The adolescent voluntary consumption of JWH-018 leads to long-lasting behavioral and neurochemical aberrations along with glia-mediated inflammatory responses in adult brains.
PSYCHOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Graziella Tocco, Antonio Laus, Maksims Vanejevs, Anastasija Ture, Rafaela Mostallino, Nicholas Pintori, Maria Antonietta De Luca, M. Paola Castelli, Gaetano Di Chiara
Summary: This study designed and synthesized a series of novel mu-opioid receptor antagonists, and evaluated their activity in vitro and in silico. Compound 9 showed the best antagonist activity and stability.
ARCHIV DER PHARMAZIE
(2023)