Article
Engineering, Biomedical
Jia Hu, Ridwan Fayaz Hossain, Zahra S. Navabi, Alana Tillery, Michael Laroque, Preston D. Donaldson, Sarah L. Swisher, Suhasa B. Kodandaramaiah
Summary: In this study, a flexible graphene ECoG array was successfully fabricated through liquid exfoliation of graphene and stencil-printing technology. This device has good conductivity and can record brain signals from different regions on the cortical surface, providing unique insights into the relationship between brain computations and behavior. The fabrication process used commonly available laboratory equipment and can produce customized graphene ECoG devices within 24 hours, making it highly practical for research purposes.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Giovanni Piantoni, Dora Hermes, Nick Ramsey, Natalia Petridou
Summary: ECoG is used to identify seizure focus and brain functions for surgical resection in epilepsy patients. Understanding the spatial smoothness of BOLD signal is crucial for optimal integration of fMRI and ECoG.
Article
Clinical Neurology
Bryan Howell, Faical Isbaine, Jon T. Willie, Enrico Opri, Robert E. Gross, Coralie De Hemptinne, Philip A. Starr, Cameron C. McIntyre, Svjetlana Miocinovic
Summary: This study evaluated the accuracy of patient-specific estimates of neural pathway activations in the subthalamic region using connectomic modeling of subthalamic DBS. Results showed that good model performance required accurate lead localization, image fusions, and appropriate selection of fiber diameter in the biophysical model. The findings demonstrated that connectomic models of DBS with sufficient anatomical and electrical details can predict recruitment dynamics of white matter, aiding in defining standards for surgical targeting and patient programming applications.
Article
Engineering, Biomedical
Nicholas S. Witham, Christopher F. Reiche, Thomas Odell, Katrina Barth, Chia-Han Chiang, Charles Wang, Agrita Dubey, Katie Wingel, Sasha Devore, Daniel Friedman, Bijan Pesaran, Jonathan Viventi, Florian Solzbacher
Summary: This study provides a mechanical characterization of a novel liquid crystal polymer (LCP) ECoG array prototype and demonstrates that its thinner geometry reduces the force exerted on the cortex. The LCP prototype has a maximal force less than 20% of commercially available ECoG arrays tested, but it is more rigid than traditional silicone material. This suggests that flexible circuit manufacturing techniques and reduced thickness can lower the force applied to the brain.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Ritwik Vatsyayan, Jihwan Lee, Andrew M. Bourhis, Youngbin Tchoe, Daniel R. Cleary, Karen J. Tonsfeldt, Keundong Lee, Rhea Montgomery-Walsh, Angelique C. Paulk, U. Hoi Sang, Sydney S. Cash, Shadi A. Dayeh
Summary: Electrophysiological recording and stimulation are essential for functional mapping and cellular activity monitoring in the human brain. This review summarizes the latest advances in electrode array systems for these purposes. The study investigates various electrode materials and scaling effects on signal-to-noise ratio and safety, and discusses the circuit components influencing electrode performance. Additionally, recent progress in connectorization and packaging of high-channel count electrode arrays and wireless neuronal monitoring systems is presented.
Article
Oncology
Diana Cristina Ghinda, Ben Lambert, Junfeng Lu, Ning Jiang, Eve Tsai, Adam Sachs, Jin-Song Wu, Georg Northoff
Summary: The study demonstrated distinct power law exponent features in the tumoral tissue for the first time, potentially providing a novel electrophysiological marker in the future. The significant features observed in the peritumoral tissue of gliomas indicate the area where both the onset of epileptiform activity and the tumor infiltration occur.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anita Monteverdi, Danila Di Domenico, Egidio D'Angelo, Lisa Mapelli
Summary: In this study, the frequency dependence and spatial anisotropy of cerebellar activation were investigated using a high-throughput high-density multielectrode array. The results showed that mossy fiber inputs reached the Purkinje cell layer even at low frequencies, but the efficiency of transmission increased at higher frequencies. These findings provide important insights into the computational properties and pathological alterations of the cerebellar cortex.
Editorial Material
Clinical Neurology
David King-Stephens
Summary: This study investigated the predictive value of pre-and post-MRLiTT epileptiform discharges (EDs) on intraoperative electrocorticography (iECoG) in seizure outcomes for patients with mesial temporal lobe epilepsy (mTLE). The results showed that responders had a significant reduction in ED frequency compared to pre-MRLiTT iECoG. Clinical characteristics and factors such as duration of epilepsy and ablation volume were not significantly associated with responder status. This study suggests that intraoperative reduction in EDs during MRLiTT may serve as a potential biomarker for satisfactory ablation.
Article
Neurosciences
Joanna Daria Dolzycka, Jan Nikadon, Patrick Peter Weis, Cornelia Herbert, Magdalena Formanowicz
Summary: When examining the processing of words from different grammatical classes, using EEG combined with the pseudoword paradigm can provide deeper insight into the neuro- and psycholinguistic dimensions of grammar. In this study, an EEG experiment followed by a behavioral lexical decision task (LDT) revealed different neural and behavioral reactions to verbs and nouns, contributing to the ongoing discussion on the functional processing of words.
BRAIN AND COGNITION
(2023)
Article
Materials Science, Multidisciplinary
Ayano Imai, Shunta Takahashi, Sho Furubayashi, Yosuke Mizuno, Masaki Sonoda, Tomoyuki Miyazaki, Eizo Miyashita, Toshinori Fujie
Summary: A flexible thin-film electrode, fabricated using printed electronics, is capable of long-term monitoring and electrical stimulation of the cerebral cortex without causing severe inflammatory reactions. This electrode, with 35 channels, successfully visualized epileptiform activity in a drug-induced epilepsy rat model, showing potential for the management of intractable epilepsy.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Neurosciences
Coralie de Hemptinne, Witney Chen, Caroline A. Racine, Andreea L. Seritan, Andrew M. Miller, Maria S. Yaroshinsky, Sarah S. Wang, Roee Gilron, Simon Little, Ian Bledsoe, Marta San Luciano, Maya Katz, Edward F. Chang, Heather E. Dawes, Jill L. Ostrem, Philip A. Starr
Summary: The study found that beta spectral power in the prefrontal cortex of PD patients correlates with symptoms of depression and anxiety, providing a physiological basis for these non-motor features. This may be useful in the development of neurostimulation paradigms for anxiety and depression in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Mansoureh Fahimi Hnazaee, Maxime Verwoert, Zachary Freudenburg, Sandra M. A. van der Salm, Erik J. Aarnoutse, Sacha Leinders, Marc M. Van Hulle, Nick F. Ramsey, Mariska J. Vansteensel
Summary: This study investigates whether non-invasive scalp electroencephalography (EEG) can predict the performance of brain-computer interfaces (BCIs) based on electrocorticography (ECoG). By analyzing the experimental results of participants with locked-in syndrome (LIS) and healthy participants, it was found that EEG can detect the characteristics observed in ECoG signals. These findings provide new insights for predicting the performance of ECoG-BCIs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Florian Fallegger, Alix Trouillet, Stephanie P. Lacour
Summary: Electrocorticography (ECoG) arrays are used to diagnose or treat neurological impairments and diseases. They have applications in delineating epileptic regions and recording brain activity for brain-computer interfaces. However, current electrode grids are not ideal for high-resolution brain recordings and long-term integration.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Neurosciences
Bryan M. Krause, Declan Campbell, Christopher K. Kovach, Rashmi N. Mueller, Hiroto Kawasaki, Kirill Nourski, Matthew Banks
Summary: Theories of consciousness suggest that brain mechanisms underlying transitions into and out of unconsciousness are conserved no matter the context or precipitating conditions. We compared signatures of these mechanisms using intracranial electroencephalography in neurosurgical patients during propofol anesthesia and overnight sleep and found strikingly similar reorganization of human cortical networks. This network reorganization constitutes a neural signature of states of reduced consciousness that is common to anesthesia and sleep.
Article
Audiology & Speech-Language Pathology
Melissa A. Papesh, Alyssa A. Stefl, Frederick J. Gallun, Curtis J. Billings
Summary: The study aimed to investigate auditory performance and cognitive responses in blast-exposed Veterans, revealing that they reported more auditory difficulties but did not necessarily perform worse in behavioral tests. The use of complex stimuli and challenging signal contrasts did not improve the detection ability of these differences.
Article
Neurosciences
Brian H. Scott, Paul A. Leccese, Kadharbatcha S. Saleem, Yukiko Kikuchi, Matthew P. Mullarkey, Makoto Fukushima, Mortimer Mishkin, Richard C. Saunders
Review
Neurosciences
Makoto Fukushima, Zenas C. Chao, Naotaka Fujii
CURRENT OPINION IN NEUROBIOLOGY
(2015)
Article
Behavioral Sciences
Makoto Fukushima, Peter L. Rauske, Daniel Margoliash
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2015)
Correction
Biochemical Research Methods
Makoto Fukushima, Richard C. Saunders, Matthew Mullarkey, Alexandra M. Doyle, Mortimer Mishkin, Naotaka Fujii
JOURNAL OF NEUROSCIENCE METHODS
(2015)
Article
Multidisciplinary Sciences
Makoto Fukushima, Daniel Margoliash
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Makoto Fukushima, Alex M. Doyle, Matthew P. Mullarkey, Mortimer Mishkin, Bruno B. Averbeck
ROYAL SOCIETY OPEN SCIENCE
(2015)
Article
Neurosciences
Brian H. Scott, Kadharbatcha S. Saleem, Yukiko Kikuchi, Makoto Fukushima, Mortimer Mishkin, Richard C. Saunders
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Neurosciences
Makoto Fukushima, Richard C. Saunders, David A. Leopold, Mortimer Mishkin, Bruno B. Averbeck
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Makoto Fukushima, Richard C. Saunders, David A. Leopold, Mortimer Mishkin, Bruno B. Averbeck
Proceedings Paper
Engineering, Biomedical
Makoto Fukushima, Richard C. Saunders, Naotaka Fujii, Bruno B. Averbeck, Mortimer Mishkin
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2014)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)