期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 212, 期 1, 页码 87-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2012.09.025
关键词
Alzheimer's disease; Myo-inositol; Magnetic resonance spectroscopy; Chemical exchange saturation transfer imaging; Glial cells proliferation
资金
- National Center for Research Resources
- National Institute of Biomedical Imaging and Bioengineering of the National Institute of Health [P41-EMB015893]
Myo-inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer's disease (AD) pathology. mins exhibits a concentration dependent chemical-exchange-saturation-transfer (CEST) effect (MICEST) between its hydroxyl groups and bulk water protons. Using the endogenous MICEST technique brain mins concentration and glial cells proliferation can be mapped at high spatial resolution. The high resolution mapping of mins was performed using MICEST technique on similar to 20 months old APP-PS1 transgenic mouse model of AD as well as on age matched wild type (WT) control (n=5). The APP-PS1 mice show similar to 50% higher MICEST contrast than WT control with concomitant increase in mIns concentration as measured through proton spectroscopy. Immunostaining against glial-fibric-acidic protein also depicts proliferative glial cells in larger extent in APP-PS1 than WT mice, which correspond to the higher mins concentration. Potential significance of MICEST in early detection of AD pathology is discussed in detail. Published by Elsevier B.V.
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