期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 215, 期 1, 页码 139-155出版社
ELSEVIER
DOI: 10.1016/j.jneumeth.2013.02.020
关键词
Closed-loop; Local field potentials; Turtle cortex; Software; Detection of oscillations; Real-time system; Open source code freely available
资金
- Max Planck Society
- European Research Council under the European Union [n. 322705]
- European Research Council (ERC) [322705] Funding Source: European Research Council (ERC)
Brain activity often consists of interactions between internal or on-going and external or sensory activity streams, resulting in complex, distributed patterns of neural activity. Investigation of such interactions could benefit from closed-loop experimental protocols in which one stream can be controlled depending on the state of the other. We describe here methods to present rapid and precisely timed visual stimuli to awake animals, conditional on features of the animal's on-going brain state; those features are the presence, power and phase of oscillations in local field potentials (LFP). The system can process up to 64 channels in real time. We quantified its performance using simulations, synthetic data and animal experiments (chronic recordings in the dorsal cortex of awake turtles). The delay from detection of an oscillation to the onset of a visual stimulus on an LCD screen was 47.5 ms and visual-stimulus onset could be locked to the phase of ongoing oscillations at any frequency <= 40 Hz. Our software's architecture is flexible, allowing on-the-fly modifications by experimenters and the addition of new closed-loop control and analysis components through plugins. The source code of our system StimOMatic is available freely as open-source. (C) 2013 Elsevier B.V. All rights reserved.
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