Article
Neurosciences
Xiaoqiang Mo, Mengxue Liu, Jihong Gong, Ying Mei, Huidan Chen, Huajun Mo, Xiaofei Yang, Jun Li
Summary: Zinc is essential for normal brain development and physiology, and it regulates synapse formation and transmission. PTPRM gene is identified as a key gene involved in zinc-regulated synapse formation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Susann Michanski, Timo Henneck, Mohona Mukhopadhyay, Anna M. Steyer, Paola Aguei Gonzalez, Katharina Grewe, Peter Ilgen, Mehmet Gueltas, Eugenio F. Fornasiero, Stefan Jakobs, Wiebke Moebius, Christian Vogl, Tina Pangrsic, Silvio O. Rizzoli, Carolin Wichmann
Summary: In mammals, the sensory hair cells of the vestibular labyrinth encode spatial orientation through synaptic activity. However, the mechanism and morphological changes underlying vestibular deficits associated with aging are not well understood. We used electron microscopy, confocal and super-resolution light microscopy, and metabolic imaging to study the ultrastructure of ribbon-type active zones in murine utricles. Our findings suggest that aging leads to dramatic structural alterations in vestibular hair cells' ribbon-type active zones.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Tina Ghelani, Carolina Montenegro-Venegas, Anna Fejtova, Thomas Dresbach
Summary: Bassoon acts as a core scaffold protein in the presynaptic active zone, with its N-terminus oriented towards the trans-Golgi network membrane and its C-terminus facing away from the trans-Golgi network. This topographic arrangement at the Golgi-apparatus is essential for the assembly of active zone precursor structures and provides insights into the biogenesis of active zones.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
W. Dylan Hale, Thomas C. Suedhof, Richard L. Huganir
Summary: In multicellular organisms, cell-adhesion molecules play a crucial role in connecting cells into tissues and mediating intercellular signaling. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. However, the identification of novel SAMs from bacterial proteins, Barnoligin and Starexin, has offered a new way to manipulate and study synaptic connections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Sarra Djemil, Claire R. Ressel, Mai Abdel-Ghani, Amanda K. Schneeweis, Daniel T. S. Pak
Summary: The study utilized an optimized primary septal-hippocampal co-culture system to generate developmentally mature cholinergic synapses, which mimicked the molecular composition and physiological properties of in vivo counterparts. This co-culture system will facilitate research on the formation, plasticity, and dysfunction of central mammalian cholinergic synapses.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Shreya H. Dhume, Steven A. Connor, Fergil Mills, Parisa Karimi Tari, Sarah H. M. Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T. Roppongi, Hiroshi Kawabe, Shernaz X. Bamji, Yu Tian Wang, Nils Brose, Michael F. Jackson, Ann Marie Craig, Tabrez J. Siddiqui, Katalin Toth
Summary: LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses in hippocampal circuits, and play a role in long-term potentiation and enduring fear memory, contributing to fine-tuning of hippocampal circuit connectivity and plasticity.
Article
Developmental Biology
Chunzhu Song, Shannon N. Leahy, Emma M. Rushton, Kendal Broadie
Summary: The study reveals that FMRP and Staufen act together at the Drosophila neuromuscular junction to regulate GluRIIA levels and synaptic bouton development by co-regulating postsynaptic Coracle expression. Additionally, they impact neurotransmission strength. This suggests a FMRP-Staufen-Coracle-GluRIIA-pMad pathway in synapse development.
Article
Biochemistry & Molecular Biology
Rahul S. Guda, Katherine E. Odegaard, Chengxi Tan, Victoria L. Schaal, Sowmya Yelamanchili, Gurudutt Pendyala
Summary: This study investigated the impact of oxycodone on mixed neuroglial cultures, revealing its disruption of key pathways associated with synaptic function, particularly those related to GDP binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow, Ross Vlahos
Summary: The study revealed that smoking can impair pulmonary and neurocognitive functions, leading to memory deficits and microglial activation. While smoking cessation can reduce lung inflammation, its effectiveness in improving memory deficits and microglial activation remains uncertain. Antioxidant therapy may help prevent smoking-induced memory impairment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Chanchanok Chaichim, Tamara Tomanic, Holly Stefen, Esmeralda Paric, Lucy Gamaroff, Alexandra K. Suchowerska, Peter W. Gunning, Yazi D. Ke, Thomas Fath, John Power
Summary: The study found that, despite being enriched in dendritic spines, overexpression of Tpm3.1 does not significantly alter the morphology or function of dendritic spines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-ya Kubo, Kagaku Azuma
Summary: The deletion of Wnt10a leads to decreased neurogenesis, impaired synaptic function, and neuroinflammation in the hippocampus, ultimately resulting in hippocampal neurodegeneration and memory deficits.
Article
Neurosciences
David M. Steffen, Sarah L. Ferri, Charles G. Marcucci, Kelsey L. Blocklinger, Michael J. Molumby, Ted Abel, Joshua A. Weiner
Summary: Cell adhesion molecules play a key role in neural circuit formation, with gamma-protocadherins negatively regulating neuroligins to limit synapse density. Loss of gamma-Pcdhs results in increased inhibitory synapse density and abnormal behavior phenotypes.
MOLECULAR NEUROBIOLOGY
(2021)
Editorial Material
Cell Biology
Bassem A. Hassan, P. Robin Hiesinger
Summary: A recent study on Drosophila revealed two different mechanisms of autophagy in regulating synapse formation in two different types of neurons during brain development. In photoreceptor neurons, autophagosome formation in synaptogenic filopodia destabilizes presumptive synaptic contacts to prevent incorrect synaptic partnerships. In dorsal cluster neurons, autophagy is suppressed to maintain stable synapses during axonal branching. These findings suggest that different neuron types may require either activation or suppression of synaptic autophagy to ensure proper synapse formation and brain connectivity during the same developmental period.
Article
Neurosciences
Zhendong Feng, Lopamudra Saha, Clio Dritsa, Qi Wan, Oleg O. O. Glebov
Summary: The function of the central nervous system is strongly influenced by temperature. This study reveals that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in synaptic strengthening and weakening respectively. Hypothermia also remodels inhibitory postsynaptic scaffold, leading to enlarged sparse synapses enriched with GABAA receptors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Peng
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic agents and can be found in the environment. Prenatal exposure to acetaminophen (PAcE) can cause damage to the developing hippocampus, but the underlying molecular mechanisms are unclear. This study shows an increased risk of adverse neurodevelopmental outcomes in offspring following exposure to acetaminophen during pregnancy in mice. Different doses, timings, and duration of exposure to acetaminophen during pregnancy were associated with dose-dependent changes in the offspring's hippocampus.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qoua L. Her, Diane L. Seger, Mary G. Amato, Patrick E. Beeler, Olivia Dalleur, Sarah P. Slight, Patricia C. Dykes, David W. Bates
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2016)
Article
Ecology
Helena M. B. Seth-Smith, Nancy Dourala, Alexander Fehr, Weihong Qi, Pantelis Katharios, Maja Ruetten, Jose M. Mateos, Lisbeth Nufer, Roseline Weilenmann, Urs Ziegler, Nicholas R. Thomson, Ralph Schlapbach, Lloyd Vaughan
Article
Computer Science, Information Systems
Qoua L. Her, Mary G. Amato, Diane L. Seger, Patrick E. Beeler, Sarah P. Slight, Olivia Dalleur, Patricia C. Dykes, James F. Gilmore, John Fanikos, Julie M. Fiskio, David W. Bates
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2016)
Article
Urology & Nephrology
C. D. Schuh, D. Haenni, E. Craigie, U. Ziegler, B. Weber, O. Devuyst, Andrew M. Hall
KIDNEY INTERNATIONAL
(2016)
Article
Biotechnology & Applied Microbiology
Inge K. Herrmann, Beatrice Beck-Schimmer, Christoph M. Schumacher, Sabrina Gschwind, Andres Kaech, Urs Ziegler, Pierre-Alain Clavien, Detlef Guenther, Wendelin J. Stark, Rolf Graf, Andrea A. Schlegel
Article
Genetics & Heredity
Irene Ojeda Naharros, Matthias Gesemann, Jose M. Mateos, Gery Barmettler, Austin Forbes, Urs Ziegler, Stephan C. F. Neuhauss, Ruxandra Bachmann-Gagescu
Article
Multidisciplinary Sciences
Jose M. Mateos, Gery Barmettler, Jana Doehner, Irene Ojeda Naharros, Bruno Guhl, Stephan C. F. Neuhauss, Andres Kaech, Ruxandra Bachmann-Gagescu, Urs Ziegler
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Multidisciplinary Sciences
Jose Maria Mateos, Bruno Guhl, Jana Doehner, Gery Barmettler, Andres Kaech, Urs Ziegler
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Jose Maria Mateos, Gery Barmettler, Jana Doehner, Andres Kaech, Urs Ziegler
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Nicolo Dubacher, Justyna Muenger, Maria C. Gorosabel, Jessica Crabb, Agnieszka A. Ksiazek, Sylvan M. Caspar, Erik N. T. P. Bakker, Ed van Bavel, Urs Ziegler, Thierry Carrel, Beat Steinmann, Steffen Zeisberger, Janine Meienberg, Gabor Matyas
CARDIOVASCULAR RESEARCH
(2020)
Article
Biochemical Research Methods
Fabian F. Voigt, Daniel Kirschenbaum, Evgenia Platonova, Stephane Pages, Robert A. A. Campbell, Rahel Kastli, Martina Schaettin, Ladan Egolf, Alexander van der Bourg, Philipp Bethge, Karen Haenraets, Noemie Frezel, Thomas Topilko, Paola Perin, Daniel Hillier, Sven Hildebrand, Anna Schueth, Alard Roebroeck, Botond Roska, Esther T. Stoeckli, Roberto Pizzala, Nicolas Renier, Hanns Ulrich Zeilhofer, Theofanis Karayannis, Urs Ziegler, Laura Batti, Anthony Holtmaat, Christian Luscher, Adriano Aguzzi, Fritjof Helmchen
Article
Multidisciplinary Sciences
Esther M. Gottwald, Claus D. Schuh, Patrick Drucker, Dominik Haenni, Adam Pearson, Susan Ghazi, Milica Bugarski, Marcello Polesel, Michael Duss, Ehud M. Landau, Andres Kaech, Urs Ziegler, Anne K. M. Lundby, Carsten Lundby, Petra S. Dittrich, Andrew M. Hall
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Bianca Striednig, Ulrike Lanner, Selina Niggli, Ana Katic, Simone Vormittag, Sabrina Brulisauer, Ramon Hochstrasser, Andres Kaech, Amanda Welin, Antje Flieger, Urs Ziegler, Alexander Schmidt, Hubert Hilbi, Nicolas Personnic
Summary: Legionella pneumophila, the causative agent of Legionnaires' disease, replicates in a distinct compartment within amoebae and macrophages. The pathogen switches between replicative, non-virulent and non-replicating, virulent/transmissive phases. Individual motile and virulent L. pneumophila cells emerge in the cluster of non-growing bacteria within the Legionella-containing vacuole at late stages of infection, with distinct proteomes and phenotypic heterogeneity. The emergence and spreading of a subpopulation of transmissive L. pneumophila at the LCV periphery at the end of an infection cycle are regulated by the Legionella quorum sensing system.
Article
Orthopedics
Jose Maria Mateos, Gad Singer, Andres Kaech, Urs Ziegler, Karim Eid
Summary: This study investigates the deposits in calcific tendinitis and finds that these deposits are not amorphous, but composed of highly crystalline structures. Fragmentation of these structures and subsequent release may initiate a strong inflammatory reaction commonly seen in patients with calcifying tendinitis.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bernhard Steiner, Anna Leoni Swart, Amanda Welin, Stephen Weber, Nicolas Personnic, Andres Kaech, Christophe Freyre, Urs Ziegler, Robin W. Klemm, Hubert Hilbi
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)