期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 201, 期 2, 页码 438-443出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2011.08.014
关键词
Cross-frequency coupling; Parkinson's disease; Phase-amplitude coupling; Oscillations; Local field potentials; Synchronization
资金
- ERANET-Neuron Grant PhysiolDBS [Neuron-48-013]
- Scientific and Technological Research Council of Turkey [TUBITAK BiDEB - 2232]
Recent studies have observed the ubiquity of phase-amplitude coupling (PAC) phenomenon in human and animal brain recordings. While various methods were performed to quantify it, a rigorous analytical definition of PAC is lacking. This paper yields an analytical definition and accordingly offers theoretical insights into some of the current methods. A direct PAC estimator based on the given definition is presented and shown theoretically to be superior to some of the previous methods such as general linear model (GLM) estimator. It is also shown that the proposed PAC estimator is equivalent to GLM estimator when a constant term is removed from its formulation. The validity of the derivations is demonstrated with simulated data of varying noise levels and local field potentials recorded from the subthalamic nucleus of a Parkinson's disease patient. (C) 2011 Elsevier B.V. All rights reserved.
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