Article
Oncology
Pavithra Viswanath, Georgios Batsios, Vinay Ayyappan, Celine Taglang, Anne Marie Gillespie, Peder E. Z. Larson, H. Artee Luchman, Joseph F. Costello, Russell O. Pieper, Sabrina M. Ronen
Summary: This study investigated the connection between TERT expression and metabolism in LGOGs, revealing that TERT regulates glucose metabolism through the PPP pathway. The use of hyperpolarized glucose allowed for noninvasive assessment of TERT expression and response to TERT inhibition.
Article
Endocrinology & Metabolism
Theresia Ziegs, Johanna Dorst, Loreen Ruhm, Nikolai Avdievitch, Anke Henning
Summary: For the first time, labeling effects after oral intake of [1-13C]glucose are observed in the human brain with pure 1H detection at 9.4 T. This study demonstrates that the combination of oral administration of [1-13C]Glc with pure 1H MRS acquisition is a simple and suitable technique to measure metabolic rates in the brain.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Marta Cacciatore, Eleonora Agata Grasso, Roberta Tripodi, Francesco Chiarelli
Summary: Glucose is crucial for proper brain functioning and its alterations can lead to developmental issues. Changes in glucose homeostasis can affect brain structure and cognition, such as intelligence deficits and learning abnormalities. Glycemic control is important in preventing diabetic ketoacidosis and protecting brain development in children. Neuroimaging techniques provide insights into the mechanisms underlying brain changes due to dysglycemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa
Summary: This study found that lysine lactylation in brain cells is regulated by neural excitation and social stress, with parallel changes in lactate levels. These stimuli increase lysine lactylation, resulting in increased expression of the neuronal activity marker c-Fos, as well as decreased social behavior and increased anxiety-like behavior in the stress model.
Review
Biochemistry & Molecular Biology
Ayhan Gursan, Jeanine J. Prompers
Summary: The liver is crucial for glucose homeostasis and MRI and MRS techniques provide unique insights into liver glucose metabolism in both healthy individuals and those with metabolic diseases such as diabetes.
Article
Neurosciences
Malik Galijasevic, Ruth Steiger, Milovan Regodic, Michaela Waibel, Patrick Julian David Sommer, Astrid Ellen Grams, Nicolas Singewald, Elke Ruth Gizewski
Summary: This study investigated changes in brain energy metabolism during focused attention meditation (FAM) using phosphorous magnetic resonance spectroscopy (P-31-MRS). Results showed higher energetic state in temporal areas and basal ganglia during FAM, while down-regulation in ATP turnover was observed in frontal and occipital areas.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Editorial Material
Biology
Polytimi Frangou, William T. Clarke
Summary: By combining methods that monitor blood oxygenation and biochemicals, researchers have discovered how the brain processes both perceived and unperceived stimuli.
Review
Nutrition & Dietetics
Alessia Quarta, Daniela Iannucci, Miriana Guarino, Annalisa Blasetti, Francesco Chiarelli
Summary: Hypoglycemia is a metabolic condition that occurs due to defects in the metabolic systems or hormone control involved in the transition from the fed to the fasting state. In children, it is considered an emergency as it can lead to brain injury, permanent neurological damage, and even death. Diagnosis involves laboratory investigations during a hypoglycemic event, as well as biochemical tests between episodes, dynamic endocrine tests, and molecular genetics.
Article
Clinical Neurology
Xiongfei Xie, Yan Shi, Lin Ma, Wenqin Yang, Juncai Pu, Yiqing Shen, Yiyun Liu, Hanping Zhang, Fajin Lv, Liangbo Hu
Summary: Through large-scale magnetic resonance spectroscopy studies, changes in neurometabolite levels in patients with depression were explored. Consistent alterations were found in the levels of total choline and the tCho/N-acetyl aspartate ratio, which were higher, and in the levels of NAA, glutamate and glutamine, and gamma-aminobutyric acid, which were lower. Specific brain regions also showed altered neurometabolite levels, such as lower glutamate levels in the prefrontal cortex and lower GABA concentrations in the occipital cortex. These findings contribute to our understanding of neurometabolic changes in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Annette Thierauf-Emberger, Dominik Schuldis, Michael Dacko, Thomas Lange
Summary: This study used magnetic resonance spectroscopy to investigate the kinetics of ethanol concentration in the human brain after oral consumption. The results showed a good correlation between plasma and brain ethanol concentrations, indicating rapid equilibrium between blood and brain. The ethanol concentrations in the brain were substantially lower than in the plasma, suggesting only 63% visibility of ethanol in brain tissue. There were significant inter-individual differences in brain ethanol concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Justine Deborne, Noel Pinaud, Yannick Cremillieux
Summary: The study evaluated the potential of a miniaturized implantable NMR coil to acquire proton NMR spectra in sub-microliter regions of interest and to obtain metabolic information. Results showed that the designed implantable microcoil is suitable for in vivo MRS and can be used for probing the metabolism in localized and very small regions of interest in a tumor.
Review
Medicine, General & Internal
Ramona Woitek, Kevin M. Brindle
Summary: One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Magnetic resonance imaging of hyperpolarized C-13-labeled pyruvate can be a versatile tool for evaluating tumor metabolism. If the technical complexity and costs associated with hyperpolarization can be reduced, hyperpolarized C-13-MRI has the potential to become widely available for large-scale clinical trials.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hideto Kuribayashi, Yuta Urushibata, Hirohiko Imai, Sinyeob Ahn, Ravi Teja Seethamraju, Tadashi Isa, Tomohisa Okada
Summary: The present study aims to quantify cerebral glucose by detecting the H1-alpha-glucose peak at 5.23 ppm in 1H magnetic resonance spectroscopy at 7 T. The results show that the precision of fitting the H1-alpha-glucose peak can be improved by removing the residual water peak. Compared to the short echo time stimulated echo acquisition mode, the semi-localized by adiabatic selective refocusing (semi-LASER) method is superior in terms of the signal-to-noise ratio of the H1-alpha-glucose peak.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cell Biology
Elizabeth J. Fear, Frida H. Torkelsen, Elisa Zamboni, Kuan-Ju Chen, Martin Scott, Glenn Jeffery, Heidi Baseler, Aneurin J. Kennerley
Summary: This study quantifies the effects of 670 nm PBM treatment on the brains of healthy aging humans for the first time using 31P magnetisation transfer magnetic resonance spectroscopy (MT-MRS). The study finds a significant increase in the rate of ATP synthase flux in the brain after PBM in a cohort of older adults. This provides initial evidence of PBM therapeutic efficacy for improving mitochondrial function and restoring ATP flux with age.
Article
Cell Biology
Qishan Chen, Hu Li, He Tian, Sin Man Lam, Yili Liao, Ziyin Zhang, Manyuan Dong, Shaoru Chen, Yuxiao Yao, Jiemiao Meng, Yong Meng, Lemin Zheng, Zhuo-Xian Meng, Weiping Han, Guanghou Shui, Dahai Zhu, Suneng Fu
Summary: In this study, C13 fluxomics was used to monitor the metabolism of dietary glucose carbon in various tissues and brain compartments over a 4-day period. With the help of elementary metabolite unit (EMU) modeling, the rates of reactions related to central carbon metabolism were determined. The results show that lactate oxidation occurs at a similar pace as the tricarboxylic acid cycle (TCA), suggesting lactate as the primary fuel. The study also expands the EMU framework to track metabolite flows across tissues and elucidates the metabolic cross talk between organs.
Article
Endocrinology & Metabolism
Evita C. Wiegers, Hanne M. Rooijackers, Cees J. Tack, Bart W. J. Philips, Arend Heerschap, Marinette van der Graaf, Bastiaan E. de Galan
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Endocrinology & Metabolism
Marleen Olde Bekkink, Mats Koeneman, Bastiaan E. de Galan, Sebastian J. Bredie
Review
Endocrinology & Metabolism
Stephanie A. Amiel, Brian M. Frier, Simon R. Heller, Rory J. McCrimmon, Kamlesh Khunti, Pablo Aschner, Belinda Childs, Philip E. Cryer, Linda Gonder-Frederick, Elizabeth R. Seaquist, Bastiaan E. de Galan, Timothy Jones, Sophia Zoungas, Lawrence A. Leiter, Yingying Luo, Ulrik Pedersen-Bjergaard
LANCET DIABETES & ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Evita C. Wiegers, Hanne M. Rooijackers, Jack J. A. van Asten, Cees J. Tack, Arend Heerschap, Bastiaan E. de Galan, Marinette van der Graaf
Article
Endocrinology & Metabolism
Lian A. van Meijel, Femmie de Vegt, Evertine J. Abbink, Femke Rutters, Miranda T. Schram, Melanie M. van der Klauw, Bruce H. R. Wolffenbuttel, Sarah Siegelaar, J. Hans DeVries, Eric J. G. Sijbrands, Behiye Ozcan, Harold W. de Valk, Bianca Silvius, Nicolaas Schaper, Coen D. A. Stehouwer, Petra J. M. Elders, Cornelis J. Tack, Bastiaan E. de Galan
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Review
Endocrinology & Metabolism
Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Alison Scope, Louise Preston, Simon Heller, Bastiaan E. de Galan, Frans Pouwer, Christel Hendrieckx
Summary: This study summarizes recent qualitative evidence on the impact of hypoglycaemia on the quality of life of family members of adults with type 1 or type 2 diabetes. The findings suggest that family members experience a severe negative impact of hypoglycaemia on different aspects of their lives, including daily living, sleep, relationships, and emotional well-being. The study concludes that the unmet needs of family members regarding hypoglycaemia require further attention in research and clinical practice.
Article
Multidisciplinary Sciences
William P. T. M. van Doorn, Yuri D. Foreman, Nicolaas C. Schaper, Hans H. C. M. Savelberg, Annemarie Koster, Carla J. H. van der Kallen, Anke Wesselius, Miranda T. Schram, Ronald M. A. Henry, Pieter C. Dagnelie, Bastiaan E. de Galan, Otto Bekers, Coen D. A. Stehouwer, Steven J. R. Meex, Martijn C. G. J. Brouwers
Summary: Machine learning-based models showed promising results in accurately and safely predicting glucose values at 15- and 60-minute intervals based on CGM data, with the incorporation of accelerometer data only slightly improving prediction. The study demonstrated the potential of machine learning models for optimizing closed-loop insulin delivery systems.
Review
Endocrinology & Metabolism
Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Hannah Chatwin, Alison Scope, Anna Cantrell, Simon Heller, Bastiaan E. de Galan, Christel Hendrieckx, Frans Pouwer
Summary: This systematic review summarizes and evaluates the evidence regarding the impact of hypoglycemia in children and adolescents with type 1 diabetes on parental quality of life. The review found that greater frequency and severity of hypoglycemia was associated with greater parental fear, emotional distress, and family burden.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Therese W. Fabricius, Giesje Nefs, Roy P. C. Kessels, Frans Pouwer, Steven Teerenstra, Cees J. Tack, Melanie M. Broadley, Peter L. Kristensen, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: This study suggests that IHSG level 2 hypoglycemia impairs cognitive function regardless of diabetes status, type of diabetes, or hypoglycemia awareness.
Article
Endocrinology & Metabolism
Theodorus J. P. Jansen, Maarten Brom, Marti Boss, Mijke Buitinga, Cees J. Tack, Lian A. van Meijel, Bastiaan E. de Galan, Martin Gotthardt
Summary: This study investigated the role of beta cell mass in glucose control and hypoglycemic burden in individuals with type 1 diabetes. The results showed that individuals with low glucose variability had higher beta cell mass compared to those with high glucose variability.
Article
Clinical Neurology
Bernice J. A. Gulpers, Frans R. J. Verhey, Simone J. P. M. Eussen, Miranda T. Schram, Bastiaan E. de Galan, Martin P. J. van Boxtel, Coen D. A. Stehouwer, S. Kohler
Summary: This study investigates the relationship between individual anxiety disorders, generalized anxiety symptoms, and multiple cognitive domains. The results show that agoraphobia is associated with worse scores on all cognitive domains and higher odds of cognitive impairment. High scores on the Generalized Anxiety Disorder 7-item scale (GAD-7) are associated with worse scores on processing speed and higher odds of cognitive impairment. Panic disorder is significantly associated with worse scores on memory tasks. These associations are stronger in younger participants and in those with type 2 diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Endocrinology & Metabolism
Sarah E. Siegelaar, Bastiaan E. de Galan
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pediatrics
Loes A. van Gemert, Bastiaan E. de Galan, Ron A. Wevers, Rob ter Heine, Michel A. Willemsen
Summary: This review summarizes the potential benefits of lactate as an alternative energy source for the brain and explores the therapeutic use of lactate infusion in adults and children. The results show that sodium lactate infusion is safe and beneficial, potentially providing therapeutic effects for conditions such as traumatic brain injury.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
M. Koeneman, M. Olde Bekkink, S. J. Bredie, B. E. de Galan
DIABETES TECHNOLOGY & THERAPEUTICS
(2019)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
