Article
Biochemical Research Methods
Tobiloba Adejumo, Tae-Hoon Kim, David Le, Taeyoon Son, Guangying Ma, Xincheng Yao
Summary: This study characterizes the reflectance profiles of retinal blood vessels in optical coherence tomography (OCT) and explores the potential of using these features to guide artery-vein classification in OCT angiography (OCTA) of the human retina. The study reveals unique reflectance features of retinal arteries and veins, and demonstrates that the venous lumen intensity is dependent on vessel size.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Computer Science, Interdisciplinary Applications
Xiao Tan, Xinjian Chen, Qingquan Meng, Fei Shi, Dehui Xiang, Zhongyue Chen, Lingjiao Pan, Weifang Zhu
Summary: In this study, a new end-to-end transformer-based network called OCT2Former was proposed to accurately segment retinal vessels in OCTA images. The experimental results demonstrated that the proposed OCT2Former achieved competitive performance on retinal OCTA vessel segmentation tasks.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Optics
Yusi Miao, Jun Song, Myeong Jin Ju
Summary: A fast and practical computational cross-calibration method for multiple spectrometers is described, which constructs a signal correlation matrix and can be used for physical alignment or numerical matching of spectra. The performance is comparable to the previously reported optimization approach.
Article
Medicine, General & Internal
Kyu Jin Han, Hyeong Ju Kim, Je Moon Woo, Jung Kee Min
Summary: Retinal layer thickness and capillary vessel density were investigated in patients with spontaneously resolved CSC, showing a decrease in outer retinal layer thickness and choriocapillaris VD. Outer retinal layer thickness may be an important visual predictor of CSC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Optics
Yusi Miao, Mahsa Siadati, Jun Song, Da Ma, Yifan Jian, Mirza Faisal Beg, Marinko Sarunic, Myeong Jin Ju
Summary: The article presents a coherent buffer averaging technique for megahertz-rate retinal imaging to improve OCTA contrast, demonstrating a 10-fold increase in phase alignment among buffers. This method provides better OCTA contrast than conventional approaches with a faster acquisition time.
Review
Biochemistry & Molecular Biology
Vlad Constantin Donica, Anisia Iuliana Alexa, Irina Andreea Pavel, Ciprian Danielescu, Manuela Andreea Ciapa, Alexandra Lori Donica, Camelia Margareta Bogdanici
Summary: This paper discusses the increasing prevalence of multiple sclerosis among young people in developing countries and introduces the main biomarkers identified through Optical Coherence Tomography Angiography. It investigates the potential role of this technology in studying changes to the central nervous system.
Article
Multidisciplinary Sciences
Bin He, Yuxin Zhang, Lu Zhao, Zhenwen Sun, Xiyuan Hu, Yanrong Kang, Lei Wang, Zhihui Li, Wei Huang, Zhigang Li, Guidong Xing, Feng Hua, Chengming Wang, Ping Xue, Ning Zhang
Summary: In this study, a robotic-OCT technique is developed for non-destructive inspection and data recovery of MSDs. It offers high resolution and automated imaging capability, and can be used for precise laser ablation.
NATURE COMMUNICATIONS
(2023)
Article
Optics
Xiangsen Guo, Guangyuan Ren, Jianbo Tang
Summary: In this study, an autocorrelation analysis-based optical coherence tomography (OCT) method was introduced for accurate measurement of blood flow velocity in the capillary network. The axial blood flow velocity was obtained from the phase change in the decorrelation period of the first-order field autocorrelation function (g1) of the OCT field data. The proposed method showed accurate measurement of axial speed in the range of 0.5-15 mm/s in phantom experiments, and it achieved robust axial velocity measurements with more than five times shorter acquisition time compared to phase-resolved Doppler optical coherence tomography (pr-DOCT) in living animals.
Article
Biochemical Research Methods
Steve Frisken, Trevor Anderson, Armin Segref, Dirk Lorenser, Grant Frisken
Summary: HP-OCT is a parallel spectral domain imaging technology that is well-suited for imaging the anterior segment of the eye. This study demonstrates that sparsely sampled volumes can be registered without active eye tracking to produce motion artifact-free 3D volumes. The anterior volume provides comprehensive 3D biometric information, including lens position, curvature, epithelial thickness, tilt, and axial length. Moreover, by changing a detachable lens, high-resolution anterior volumes and posterior volume images for preoperative assessment of the posterior segment can be captured. Importantly, the retinal volumes have the same Nyquist range as the anterior imaging mode.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Multidisciplinary Sciences
Lionel D. Fiske, Maurice C. G. Aalders, Mitra Almasian, Ton G. van Leeuwen, Aggelos K. Katsaggelos, Oliver Cossairt, Dirk J. Faber
Summary: Optical coherence tomography (OCT) is an optical technique for volumetric visualization of translucent materials, with additional information gained through depth-resolved attenuation analysis. Despite the presence of speckle causing fluctuations in OCT images, depth-resolved attenuation analysis can still provide insight into tissue structure and organization.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Di Yang, Weike Wang, Zhuoqun Yuan, Yanmei Liang
Summary: In this study, a high-resolution multi-functional optical coherence tomography (OCT) was used to obtain detailed intra- and extracranial imaging outcomes of adult zebrafish, including pigmentation distribution, tissue-specific information, cranial vascular imaging, and the monitoring of traumatic brain injury (TBI). Additionally, the channels through the zebrafish cranial suture were observed for the first time, which may have a crucial function in maintaining the patency of the cranial sutures. The results demonstrate that the high-resolution multi-functional OCT system can provide a wealth of novel and interpretable biological information for intra- and extracranial studies of adult zebrafish.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Nicholas Young, Robert Zivadinov, Michael G. Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Dejan Jakimovski
Summary: This study found that people with multiple sclerosis (pwMS) have fewer retinal blood vessels compared to healthy controls (HCs). Over time, pwMS experience a decrease in retinal vessel number while HCs experience an increase. Furthermore, there is a correlation between lower RNFL thickness and fewer retinal vessel number and smaller diameter in pwMS.
Article
Cardiac & Cardiovascular Systems
Zhifeng Qin, Muhua Cao, Xiangwen Xi, Yanwen Zhang, Zhuozhong Wang, Suhong Zhao, Yanan Tian, Qinglu Xu, Huai Yu, Jinwei Tian, Bo Yu
Summary: This study found that cholesterol crystals (CCs) are associated with plaque vulnerability in patients with ST-segment elevated myocardial infarction. CCs are more frequently found in ruptured non-culprit plaques and larger and more superficial CCs are associated with plaque rupture. Factors such as lipid burden, presence of macrophages, and spotty calcification are also related to the presence of CCs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Aldo Vagge, Paolo Corazza, Lorenzo Ferro Desideri, Paola Camicione, Giulia Agosto, Roberta Vagge, Calevo Maria Grazia, Adriano Carnevali, Giuseppe Giannaccare, Massimo Nicolo, Carlo Enrico Traverso
Summary: Patients with NF1 exhibit lower macular RNFL and retinal thickness, along with higher vascular flow area in the SCP. Compared to control subjects, the flow area in the second choroidal layer is also lower in NF1 patients. OCTA is a potentially valuable tool for detecting early ocular abnormalities in NF1.
Article
Biochemical Research Methods
Zhijian Huang, Delang Hen, Zhichao Iang, Shuangyang Hang, Zhenyang Iu, Wufan Hen, Li Qi
Summary: This study proposes a fully automatic framework for 3D airway reconstruction based on endoscopic airway optical coherence tomography (OCT). It includes automatic detection of the airway lumen contour, correction of rotational distortion, and anatomic bending reconstruction. The proposed framework has the potential to improve the efficiency of endoscopic OCT image analysis.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Endocrinology & Metabolism
Baoqiang Li, Ryo Ohtomo, Martin Thunemann, Stephen R. Adams, Jing Yang, Buyin Fu, Mohammad A. Yaseen, Chongzhao Ran, Jonathan R. Polimeni, David A. Boas, Anna Devor, Eng H. Lo, Ken Arai, Sava Sakadzic
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Review
Chemistry, Multidisciplinary
Nick Todd, Cleide Angolano, Christiane Ferran, Anna Devor, David Borsook, Nathan McDannold
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Optics
Xiaojun Cheng, Sanaz Sadegh, Sharvari Zilpelwar, Anna Devor, Lei Tian, David A. Boas
Article
Endocrinology & Metabolism
Ikbal Sencan, Tatiana Esipova, Kivilcim Kilic, Baoqiang Li, Michele Desjardins, Mohammad A. Yaseen, Hui Wang, Jason E. Porter, Sreekanth Kura, Buyin Fu, Timothy W. Secomb, David A. Boas, Sergei A. Vinogradov, Anna Devor, Sava Sakadzic
Summary: This study investigates the laminar profile of stimulus-induced intravascular partial pressure of oxygen (pO2) transients in fully awake mice. The results demonstrate that stimulus-induced changes in intravascular pO2 are consistent across cortical layers and show differences in response between veins and arteries, as well as differences from the response under anesthesia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Dennis van der Meer, Oleksandr Frei, Tobias Kaufmann, Alexey A. Shadrin, Anna Devor, Olav B. Smeland, Wesley K. Thompson, Chun Chieh Fan, Dominic Holland, Lars T. Westlye, Ole A. Andreassen, Anders M. Dale
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Nicholas Rogers, Martin Thunemann, Anna Devor, Vikash Gilja
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Physiology
Kivilcim Kilic, Michele Desjardins, Jianbo Tang, Martin Thunemann, Smrithi Sunil, Sefik Evren Erdener, Dmitry D. Postnov, David A. Boas, Anna Devor
Summary: Chronic cranial windows allow for long-term brain imaging experiments in awake, behaving mice. Different imaging technologies have unique advantages, and combining them can provide measurements of a wide range of parameters needed for comprehensive investigation. Following the surgical techniques for installation of different cranial windows targeted for specific imaging technologies can enhance experimental success and result reproducibility.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Optics
Jianbo Tang, Xiaojun Cheng, Kivilcim Kilic, Anna Devor, Jonghwan Lee, David A. Boas
Summary: In awake mice, optical coherence tomography (OCT) imaging was used to detect localized fast optical signals (FOSs) caused by whisker stimulation. By fitting the OCT intensity signal time course with a response function, activated voxels were identified in the expected brain region for whisker stimulation, providing a new tool for neural activity studies.
Editorial Material
Neurosciences
Anna Devor
Article
Neurosciences
Angelique C. Paulk, Jimmy C. Yang, Daniel R. Cleary, Daniel J. Soper, Milan Halgren, Alexandra R. O'Donnell, Sang Heon Lee, Mehran Ganji, Yun Goo Ro, Hongseok Oh, Lorraine Hossain, Jihwan Lee, Youngbin Tchoe, Nicholas Rogers, Kivilcim Kilic, Sang Baek Ryu, Seung Woo Lee, John Hermiz, Vikash Gilja, Istvan Ulbert, Daniel Fabo, Thomas Thesen, Werner K. Doyle, Orrin Devinsky, Joseph R. Madsen, Donald L. Schomer, Emad N. Eskandar, Jong Woo Lee, Douglas Maus, Anna Devor, Shelley Fried, Pamela S. Jones, Brian Nahed, Sharona Ben-Haim, Sarah K. Bick, Robert Mark Richardson, Ahmed M. Raslan, Dominic A. Siler, Daniel P. Cahill, Ziv M. Williams, G. Rees Cosgrove, Shadi A. Dayeh, Sydney S. Cash
Summary: By utilizing ultra-high-density microelectrode arrays, researchers discovered three distinct classes of cortical activity not locked to ongoing natural brain rhythmic activity, including fast waveforms, slower-paced discrete events, and events found mostly in upper cortical layers. These activities were modulated by various stimuli and manipulation techniques, with small causal co-occurrences among them.
Article
Neurosciences
Francesca Puppo, Sanaz Sadegh, Cleber A. Trujillo, Martin Thunemann, Evan P. Campbell, Matthieu Vandenberghe, Xiwei Shan, Ibrahim A. Akkouh, Evan W. Miller, Brenda L. Bloodgood, Gabriel A. Silva, Anders M. Dale, Gaute T. Einevoll, Srdjan Djurovic, Ole A. Andreassen, Alysson R. Muotri, Anna Devor
Summary: Voltage imaging and all-optical electrophysiology in human induced pluripotent stem cell (hiPSC)-derived neurons offer new opportunities for high-throughput phenotyping of neuronal activity with unique genetic backgrounds. By using a synthetic voltage sensor and genetically encoded optogenetic actuator, this study demonstrates a reliable protocol for measuring spontaneous and evoked activity in hiPSC-derived neurons with distinct genetic backgrounds.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Anna Devor
Editorial Material
Neurosciences
Anna Devor, Darcy S. Peterka, Erin M. Buckley, Rickson C. Mesquita
Editorial Material
Neurosciences
Anna Devor
Review
Engineering, Biomedical
Philipp Machler, Thomas Broggini, Celine Mateo, Martin Thunemann, Natalie Fomin-Thunemann, Patrick R. Doran, Ikbal Sencan, Kivilcim Kilic, Michele Desjardins, Hana Uhlirova, Mohammad A. Yaseen, David A. Boas, Andreas A. Linninger, Massimo Vergassola, Xin Yu, Laura D. Lewis, Jonathan R. Polimeni, Bruce R. Rosen, Sava Sakadzic, Richard B. Buxton, Martin Lauritzen, David Kleinfeld, Anna Devor
Summary: Recent advancements in optical microscopy have opened up new opportunities for studying neurovascular and neurometabolic coupling in behaving animals. Future studies will use these tools to investigate the regulation of cerebral blood flow and metabolism in different brain states, as well as how this regulation changes with brain maturation and aging. This knowledge is crucial for interpreting hemodynamic signals observed with fMRI.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
