期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 177, 期 2, 页码 434-439出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2008.11.002
关键词
Trace conditioning; Eyeblink; Somatosensory; Barrel cortex; PMBSF; Vibrissae
资金
- NIA NIH HHS [R37 AG008796-20, R01 AG017139, R37 AG008796] Funding Source: Medline
The somatosensory whisker pathway has been a useful system for increasing our understanding of experience-induced plasticity. However, precisely timed whisker activation in the awake freely moving mouse has been very difficult. This manuscript describes a method for construction of a whisker stimulator that can be attached to a freely moving mouse. The stimulator was used to activate the whiskers in a time-sensitive forebrain-dependent task, trace eyeblink conditioning. After repeatedly pairing whisker stimulation with delivery of a mild periorbital shock following a stimulus-free trace interval, trace-conditioned mice were able to learn the association. This study demonstrates the potential for using the whisker stimulator in time-sensitive behavioral tasks, such as trace eyeblink conditioning, thus enhancing our ability to examine experience-induced neuronal plasticity in the somatosensory whisker pathway in awake behaving rodents. Published by Elsevier B.V.
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