Article
Clinical Neurology
Marta Montero-Crespo, Marta Dominguez-Alvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorca
Summary: Alzheimer's disease is a common form of dementia characterized by cognitive impairment, with extracellular protein deposits and abnormal protein accumulation in neurons. Synaptic alterations were found in different stages of the disease, with more severe changes observed in late-stage cases.
Article
Clinical Neurology
Marta Montero-Crespo, Marta Dominguez-Alvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorca
Summary: Alzheimer's disease is a common form of dementia characterized by persistent and progressive impairment of cognitive functions. Early-stage cases show normal synaptic morphology, but late-stage cases experience decreased synaptic density and morphological alterations.
Article
Cell Biology
Bingxuan Han, Shuang Cui, Feng-Yu Liu, You Wan, Yan Shi, Ming Yi
Summary: The study found that inhibiting the activity of pyramidal neurons in the ventral hippocampal CA1 area increases water intake in rats. The results suggest that the hippocampus plays an important role in regulating drinking behavior, but the specific mechanisms need further investigation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Abhilash Sawant, Briana N. Ebbinghaus, Adam Bleckert, Clare Gamlin, Wan-Qing Yu, David Berson, Uwe Rudolph, Raunak Sinha, Mrinalini Hoon
Summary: This study used a combination of techniques to determine the composition and organization of inhibitory synapses in a well-characterized RGC type in the mouse retina. The researchers found the presence of mixed GABA-glycine receptor synapses, as well as the sequence of postsynaptic assembly for these synapses. These findings reveal the characteristics of an additional motif of inhibition in the mammalian retina.
Review
Neurosciences
Micael Carrier, Kira Dolhan, Bianca Caroline Bobotis, Michele Desjardins, Marie-eve Tremblay
Summary: This review focuses on the alterations in structural and functional connectivity between neurons, glial cells, and blood vessels, and their correlation with psychiatric disorders such as schizophrenia, major depressive disorder, and disorder of consciousness.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Shadab Batool, Basma Akhter, Jawwad Zaidi, Frank Visser, Gavin Petrie, Matthew Hill, Naweed I. Syed
Summary: The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders. Previous research found that the tumor suppressor gene MEN1 regulates the expression and targeting of alpha 7 nAChRs. Knockdown of alpha 7 nAChRs initially upregulated and then downregulated menin expression, which could be rescued by exogenous expression of menin in hippocampal neurons, suggesting an important interplay between MEN1 gene and alpha 7 nAChRs in regulating hippocampal-dependent learning and memory.
Article
Neurosciences
Adeel A. Memon, Micah E. Bagley, Rose B. Creed, Amy W. Amara, Matthew S. Goldberg, Lori L. McMahon
Summary: This study found no differences in basal synaptic transmission at CA3-CA1 excitatory synapses in 4-to 5-month old PINK1 knockout rats, suggesting that loss of PINK1 protein does not cause a general dysfunction of excitatory transmission throughout the brain at this young adult age when excitatory transmission is abnormal in the striatum.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Tal Sharf, Tjitse van der Molen, Stella M. K. Glasauer, Elmer Guzman, Alessio P. Buccino, Gabriel Luna, Zhuowei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan, Kenneth R. Tovar, Linda R. Petzold, Andreas Hierlemann, Paul K. Hansma, Kenneth S. Kosik
Summary: Brain organoids can replicate the cellular organization found in the developing human brain, and by utilizing microelectronics, functional circuits can be assembled to mirror the complexity of brain networks. This study explores the physiology of neuronal circuits within brain organoids and how they can be influenced by external stimuli. The results suggest that brain organoids have the potential to be used in studying neuropsychiatric diseases, drug action, and the effects of external stimuli on neuronal networks.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Gao-Jing Xu, Qun Zhang, Si-Yue Li, Yi-Tong Zhu, Ke-Wei Yu, Chuan-Jie Wang, Hong-Yu Xie, Yi Wu
Summary: There is currently no specific treatment for cognitive recovery after stroke. Dysfunction of the actin cytoskeleton is linked to cognitive decline after stroke, and regulation of ROCK proteins is important for its reorganization. Fasudil, combined with environmental enrichment, shows promise in improving memory dysfunction post-stroke by inhibiting the hippocampal ROCK/cofilin pathway and promoting neuronal survival in the CA1 region.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Rebecca A. Mount, Mohamed Athif, Margaret O'Connor, Amith Saligrama, Hua-an Tseng, Sudiksha Sridhar, Chengqian Zhou, Emma Bortz, Erynne San Antonio, Mark A. Kramer, Heng-Ye Man, Xue Han
Summary: Mutations in autism spectrum disorder (ASD) risk genes disrupt neural network dynamics that lead to abnormal behavior. Using calcium imaging, researchers found that the neural network in an ASD model is oversynchronized and fails to desynchronize during behavior.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Akihiro Takamiya, Taishiro Kishimoto, Jinichi Hirano, Shiro Nishikata, Kyosuke Sawada, Shunya Kurokawa, Bun Yamagata, Toshiaki Kikuchi, Masaru Mimura
Summary: The study found that improvement in depressive symptoms after ECT was positively associated with changes in the right hippocampus-ventromedial prefrontal cortex connectivity and negatively associated with the right hippocampus-superior frontal gyrus connectivity. In addition, data-driven multivoxel pattern analysis identified additional clusters such as the thalamus, sensorimotor cortex, and precuneus that were associated with clinical improvement following ECT.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Rasha H. Mehder, Brian M. Bennett, R. David Andrew
Summary: This study investigated the relationship between oxidative damage in the dorsal hippocampal CA1 region and progressive cognitive impairment in a mouse model of Alzheimer's disease. Results showed that increased oxidative damage preceded synaptic trimming and may be associated with alterations in neuronal structure leading to cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biology
Vivek Verma, Ruchika Kumari, Muniyandi Singaravel
Summary: This study compares the changes in hippocampal neurons between diurnal and nocturnal species. The results suggest that prolonged constant light may have adverse effects on the neuronal complexity of both diurnal and nocturnal animals, while constant darkness mainly affects diurnal animals.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Wilhelm Braun, Raoul-Martin Memmesheimer
Summary: Hippocampal sharp wave/ripple oscillations are important for memory consolidation, but the mechanisms underlying their generation are not fully understood. Recent experiments indicate that in addition to inhibitory cells, the activity of excitatory pyramidal cells is required for generating this pattern.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Thomas Bouillet, Manuel Ciba, Caroline Lourenco Alves, Francisco Aparecido Rodrigues, Christiane Thielemann, Morvane Colin, Luc Buee, Sophie Halliez
Summary: This study investigated the physiological role of Tau through brain network remodeling using hippocampal-entorhinal slice co-cultures. The results showed that Tau ablation had anti-synchrony effects on the networks, with differential effects at the sub-network scale. These findings suggest that Tau plays multifaceted roles in the remodeling of complex brain-derived neural networks.
JOURNAL OF NEURAL ENGINEERING
(2022)
Letter
Respiratory System
Nina Rol, Chris Happe, Jeroen A. M. Belien, Frances S. de Man, Nico Westerhof, Anton Vonk-Noordegraaf, Katrien Grunberg, Harm J. Bogaard
EUROPEAN RESPIRATORY JOURNAL
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
Guus De Waard, Maurits Hollander, Elisa Meinster, Jeroen Belien, Hans Niessen, Niels van Royen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Article
Neurosciences
Floris G. Wouterlood, Angela Engel, Mariah Daal, Gertjan Houwen, Aileen Meinderts, Tomas Jorda Siquier, Jeroen A. M. Belien, Yvette C. van Dongen, Jorgen Scheel-Krueger, Anne-Marie Thierry, Henk J. Groenewegen, Jean-Michel Deniau
JOURNAL OF NEUROSCIENCE RESEARCH
(2018)
Article
Cell & Tissue Engineering
Linde Woudstra, Elisa Meinster, Laura Van Haren, Amber M. Kay, Marit Koopman, Jeroen A. M. Belien, Martine C. Morrison, Albert C. Van Rossum, Marco N. Helder, Lynda J. M. Juffermans, Hans W. M. Niessen, Paul A. J. Krijnen
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Woudstra, E. Meinster, L. van Haren, M. Koopman, J. A. M. Belien, M. C. Morrison, A. C. van Rossum, M. N. Helder, L. J. M. Juffermans, H. W. M. Niessen, P. A. J. Krijnen
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Floris G. Wouterlood, Sanne van Oort, Lucian Bloemhard, Nico A. Flierman, Jorik Spijkerman, Christopher I. Wright, Jeroen A. M. Belien, Hendrik J. Groenewegen
JOURNAL OF CHEMICAL NEUROANATOMY
(2018)
Article
Clinical Neurology
R. P. Gorter, J. Stephenson, E. Nutma, J. Anink, J. C. de Jonge, W. Baron, M. -C. Jahreiss, J. A. M. Belien, J. M. van Noort, C. Mijnsbergen, E. Aronica, S. Amor
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2019)
Article
Gastroenterology & Hepatology
Sjoerd H. den Uil, Evert van den Broek, Veerle M. H. Coupe, Thomas T. Vellinga, Pien M. Delis-van Diemen, Herman Bril, Eric J. Th. Belt, Onno Kranenburg, Hein B. A. C. Stockmann, Jeroen A. M. Belien, Gerrit A. Meijer, Remond J. A. Fijneman
BMC GASTROENTEROLOGY
(2019)
Article
Hematology
Guus A. de Waard, Maurits R. Hollander, Danique Ruiter, Thomas ten Bokkel Huinink, Romain Meer, Nina W. van der Hoeven, Elisa Meinster, Jeroen A. M. Belien, Hans W. Niessen, Niels van Royen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Oncology
Niels Verburg, Floris P. Barthel, Kevin J. Anderson, Kevin C. Johnson, Thomas Koopman, Maqsood M. Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Frederik Barkhof, Petra J. W. Pouwels, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, Jeroen A. M. Belien, Ronald Boellaard, Michael D. Taylor, Sunit Das, Joseph F. Costello, William Peter Vandertop, Pieter Wesseling, Philip C. de Witt Hamer, Roel G. W. Verhaak
Summary: This study investigated intratumoral heterogeneity in diffuse gliomas using DNA methylation profiling, demonstrating the infiltrative nature of the tumors and the variability in tumor purity contributing to epigenetic spatial heterogeneity. The results suggest that DNA methylation subtypes in diffuse gliomas are relatively consistent, but some heterogeneity exists.
Article
Multidisciplinary Sciences
K. Joeri van der Velde, Gurnoor Singh, Rajaram Kaliyaperumal, Xiaofeng Liao, Sander de Ridder, Susanne Rebers, Hindrik H. D. Kerstens, Fernanda de Andrade, Jeroen van Reeuwijk, Fini E. De Gruyter, Saskia Hiltemann, Maarten Ligtvoet, Marjan M. Weiss, Hanneke W. M. van Deutekom, Anne M. L. Jansen, Andrew P. Stubbs, Lisenka E. L. M. Vissers, Jeroen F. J. Laros, Esther van Enckevort, Daphne Stemkens, Peter A. C. t Hoen, Jeroen A. M. Belien, Marielle E. van Gijn, Morris A. Swertz
Summary: FAIR Genomes aims to facilitate the reuse of genomic data by developing metadata standards and providing templates for data entry and programmatic interfaces. It addresses the challenge of storing and sharing genomic data by offering a semantic schema for data descriptions. With FAIR Genomes, rare disease diagnosis and personalized medicine research can be enhanced.
Article
Obstetrics & Gynecology
Hein S. Zelisse, Mignon van Gent, Sander de Ridder, Maaike A. van der Aa, Anne M. van Altena, Joost Bart, Jeroen A. M. Belien, Ingrid A. Boere, Steven L. Bosch, Annegien Broeks, Johan Bulten, Margriet Collee, Floris H. Groenendijk, Hugo Horlings, Maurice P. H. M. Jansen, G. N. Jonges, Loes Kooreman, Cornelis D. de Kroon, Sandrina Lambrechts, Christianne Lok, Jurgen M. Piek, Anna K. L. Reyners, Eva-Maria Roes, Michiel Simons, Gba Wisman, Refika Yigit, Ronald Zweemers, Constantijne H. Mom, Marc J. van de Vijver, Frederike Dijk
Summary: The Archipelago of Ovarian Cancer Research (AOCR) is a Dutch nationwide interdisciplinary infrastructure and biobank that aims to improve fundamental and translational research on ovarian cancer. It collects and stores biomaterials for future genetic research and encourages researchers to contribute their own data and materials. The ultimate goal is to enhance diagnostics, treatment, and survival rates for ovarian cancer patients.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Kasper Joeri van der Velde, Gurnoor Singh, XiaoFeng Liao, Rajaram Kaliyaperumal, Daphne Stemkens, Esther van Enckevort, Susanne Rebers, Katy Wolstencroft, Sander de Ridder, Terry Vrijenhoek, Fernanda de Andrade, Anna Niehues, Hindrik H. D. Kerstens, Annika Jacobsen, Bart de Koning, Jeroen van Reeuwijk, Kim Elsink, Christine Staiger, Joris van Montfrans, Erik van Iperen, Nine Knoers, Stefan Willems, Wendy van Zelst-Stams, Helger Ijntema, Edwin Cuppen, Lieneke Steeghs, Salome Scholtens, Leon Mei, Patrick Kemmeren, Marco Roos, Cor Oosterwijk, Marjan Weiss, Andrew Stubbs, Peter A. C. tHoen, Jeroen Laros, Jeroen A. M. Belien, Marielle E. van Gijn, Morris A. Swertz
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
T. Rigter, J. A. M. Belien, G. M. W. R. de Wert, C. Ploem, E. M. Bunnik, A. L. Bredenoord, M. C. Cornel
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Gastroenterology & Hepatology
Jasper L. A. Vleugels, Sanne M. van Neerven, Monique E. van Leerdam, Linda K. Wanders, Meike de Wit, Beatriz Carvalho, Pien M. Delis-van Diemen, Frank G. J. Kallenberg, Louis Vermeulen, Jeroen A. Belien, James E. East, Gerrit A. Meijer, Evelien Dekker
ENDOSCOPY INTERNATIONAL OPEN
(2019)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)