期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 171, 期 1, 页码 48-52出版社
ELSEVIER
DOI: 10.1016/j.jneumeth.2008.02.003
关键词
anxiety; mouse strains; open-field; elevated plus-maze; emergence test
The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests. (c) 2008 Elsevier B.V. All rights reserved.
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