Article
Neurosciences
Hamideh Esmailpour, Rajani Raman, Rufin Vogels
Summary: This study found that both the inferior temporal (IT) neurons and the ventrolateral prefrontal cortex (VLPFC) are sensitive to the statistical regularities in visual sequences. The results suggested that both IT and VLPFC have similar response patterns to the deviants in the image sequences, supporting the predictive coding theories.
Article
Neurosciences
Marinka M. G. Koenis, Pavlos K. Papasavas, Ronald J. Janssen, Darren S. Tishler, Godfrey D. Pearlson
Summary: This study found substantial variability in the percent total weight loss following bariatric surgery, with functional brain imaging showing more variance in post-surgical weight loss than psychological or metabolic information. The neuronal responses during anticipatory cues and receipt of drops of milkshake differed between individuals with severe obesity and healthy-weight controls, with changes in brain response related to a composite health index. Despite no correlation with post-surgical weight loss in the entire surgical group, participants who underwent Roux-en-Y gastric bypass (RYGB) showed predictive power in several regions and contrasts.
Article
Multidisciplinary Sciences
Nima Khalighinejad, Neil Garrett, Luke Priestley, Patricia Lockwood, Matthew F. S. Rushworth
Summary: The study reveals the core feature of voluntary behavior in deciding to act rather than refrain from acting, involving the formation of willingness to act and the coordination of brain regions. Willingness to act is influenced by rewards and other contextual features, regulated by the Habenula and anterior insula. Additionally, the network transmits information through multiple layers to make decisions.
NATURE COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
X. Yang, X. Liu, Y. Zeng, R. Wu, W. Zhao, F. Xin, S. Yao, K. M. Kendrick, R. P. Ebstein, B. Becker
Summary: The study found that primary rewards decrease in hedonic value with repeated receipt, while secondary rewards increase in hedonic value and preference. This suggests that secondary reinforcers, such as money, can acquire enhanced incentive motivation with repeated receipt.
BRAIN STRUCTURE & FUNCTION
(2021)
Review
Physiology
Yael Prilutski, Yoav Livneh
Summary: Physiological needs such as thirst and hunger drive powerful motivations. Research in humans and animal models suggests that the insular cortex plays a role in regulating these needs and associated behaviors. This article reviews mechanistic models of insular cortex involvement and proposes a framework for testing these models in both healthy and pathological conditions.
Article
Psychology, Multidisciplinary
Alexander W. Albury, Roberta Bianco, Benjamin P. Gold, Virginia B. Penhune
Summary: Predictability plays a crucial role in musical pleasure, as it induces pleasure through tension and surprise. However, musical predictions are influenced by prior knowledge and immediate context. Similarly, musical pleasure varies depending on the individual and context. This study investigates how perceptions of a melody are influenced by comparisons to other music pieces heard in the same context.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko Ito
Summary: The study aimed to investigate the role of the mPFC and NAc in cue-elicited adaptive responding, finding that the mPFC plays a crucial role in regulating nonreinforced cue responding.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Guilhem Marion, Giovanni M. Di Liberto, Shihab A. Shamma
Summary: Musical imagery involves hearing music in the mind without physical action or external stimulation. Studies have shown overlapping but distinctive neural responses between imagined music and actual listening, with melodic expectations playing a similar role in both scenarios. Neural signals from imagery can accurately predict responses, similar to listening tasks, indicating the impact of imagined music on the brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Marion Ponserre, Federica Fermani, Louise Gaitanos, Ruediger Klein
Summary: In order to successfully forage in a rewarding and threatening environment, animals rely on familiar structures of the environment to signal the availability of food. This study found that two major subpopulations of neurons in the central amygdala, CeA(Sst) and CeA(PKC delta) neurons, can assign motivational properties to environmental cues. The activity of CeA(PKC delta) neurons is required for learning contextual food cues.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Iris Ka-Yi Chat, Erin E. Dunning, Corinne P. Bart, Ann L. Carroll, Mora M. Grehl, Katherine S. F. Damme, Lyn Y. Abramson, Robin Nusslock, Lauren B. Alloy
Summary: This study found that individuals with high trait reward sensitivity and individuals with moderate trait reward sensitivity exhibit different neural reward anticipation responses following reward-relevant life events, which has implications for understanding psychopathology.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Behavioral Sciences
Matthew S. McGregor, Ryan T. LaLumiere
Summary: The role of the insular cortex (IC) in risky decision making and drug-seeking behaviors is not always consistent across procedures and may differ between its subregions. Evidence suggests that IC activity is broadly important for selection of appropriate behaviors based on learned action-outcome contingencies and that associated risk is sufficient, but not necessary, to recruit the anterior IC in reward seeking without involving the posterior IC.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jana Tegelbeckers, Daria B. Porter, Joel L. Voss, Geoffrey Schoenbaum, Thorsten Kahnt
Summary: This study used neuroimaging and brain stimulation to investigate how the brain integrates outcome predictions to guide behavior. The lateral orbitofrontal cortex was found to play a crucial role in integrating outcome predictions and disrupting its network activity impaired individuals' ability to leverage predictions from multiple cues.
Article
Biology
Federica Lucantonio, Eunyoung Kim, Zhixiao Su, Anna J. Chang, Bilal A. Bari, Jeremiah Y. Cohen
Summary: Predictions about future rewards or punishments are influenced by prior experiences, with exposure to aversive stimuli leading to hyperactivity in medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT), resulting in a negative behavioral bias towards motivationally relevant cues. Mimicking this hyperactive response recapitulates the bias induced by aversive stimuli, while inactivating these neurons prevents the development of the negative bias, highlighting the critical role of the mPFC -> PVT circuit in predicting motivationally-relevant outcomes based on prior experience.
Article
Neurosciences
A-Hyun Jung, Camille Tessitore King, Ginger D. Blonde, Michael King, Camilla Griggs, Koji Hashimoto, Alan C. Spector, Lindsey A. Schier
Summary: This study reveals new roles for the posterior gustatory and anterior visceral insular cortices in multisensory integrative function, particularly in regulating consummatory responses to food tastes.
Article
Biology
David S. Jacobs, Madeleine C. Allen, Junchol Park, Bita Moghaddam
Summary: This study developed a novel model for anxiety during motivated behavior and found that neuronal activity in the ventral tegmental area (VTA) and dorsomedial prefrontal cortex (dmPFC) represents the relationship between action and punishment risk. Additionally, the study suggests that diazepam may have anxiolytic properties.
Article
Biology
Matthew P. H. Gardner, Geoffrey Schoenbaum, Samuel J. Gershman
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Jingfeng Zhou, Matthew P. H. Gardner, Thomas A. Stalnaker, Seth J. Ramus, Andrew M. Wikenheiser, Yael Niv, Geoffrey Schoenbaum
Article
Biochemistry & Molecular Biology
Jingfeng Zhou, Marlian Montesinos-Cartagena, Andrew M. Wikenheiser, Matthew P. H. Gardner, Yael Niv, Geoffrey Schoenbaum
Article
Biochemistry & Molecular Biology
Matthew P. H. Gardner, Jessica C. Conroy, Davied C. Sanchez, Jingfeng Zhou, Geoffrey Schoenbaum
Article
Neurosciences
Etienne J. P. Maes, Melissa J. Sharpe, Alexandra A. Usypchuk, Megan Lozzi, Chun Yun Chang, Matthew P. H. Gardner, Geoffrey Schoenbaum, Mihaela D. Iordanova
NATURE NEUROSCIENCE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Matthew P. H. Gardner, Geoffrey Schoenbaum
Article
Neurosciences
Matthew P. H. Gardner, Davied Sanchez, Jessica C. Conroy, Andrew M. Wikenheiser, Jingfeng Zhou, Geoffrey Schoenbaum
Article
Biology
Evan E. Hart, Melissa J. Sharpe, Matthew P. H. Gardner, Geoffrey Schoenbaum
Article
Multidisciplinary Sciences
Jingfeng Zhou, Chunying Jia, Marlian Montesinos-Cartagena, Matthew P. H. Gardner, Wenhui Zong, Geoffrey Schoenbaum
Summary: Neural elements in the brain can generalize common structures learned in different situations to speed up learning new problems. The orbitofrontal cortex can form and utilize schemas during learning to support complex cognitive operations.
Article
Neurosciences
Melissa J. Sharpe, Hannah M. Batchelor, Lauren E. Mueller, Matthew P. H. Gardner, Geoffrey Schoenbaum
Summary: The study shows that prior reward-learning experience can influence the learning process, opening up neural boundaries and even changing the way neural circuits are recruited. The impact of prior experience on learning is crucial.
NATURE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Jingfeng Zhou, Wenhui Zong, Chunying Jia, Matthew P. H. Gardner, Geoffrey Schoenbaum
Summary: This study used a nonspatial, continuous, alternating odor-sequence task to investigate the encoding of retrospective and prospective aspects in the orbitofrontal cortex (OFC) of rats. The results showed a proximal prospective code for sequence information and a distal perspective code for positional information in the OFC. This predictive code in the rat OFC was closely associated with their ability to predict future outcomes.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Andrew M. Wikenheiser, Matthew P. H. Gardner, Lauren E. Mueller, Geoffrey Schoenbaum
Summary: Research indicates that OFC neurons exhibit spatial firing fields in a manner similar to hippocampus when engaged in a free-foraging task, with different representations observed between flavored and unflavored conditions resembling hippocampal remapping.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Kaue Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan, Geoffrey Schoenbaum
Summary: Research suggests that the lateral orbitofrontal cortex (lOFC) may play a role in behavior not only by simulating outcomes, but also by supporting map creation. Inactivation of lOFC principal neurons disrupted subsequent inference and led to generalized devaluation, indicating a selective role of the lOFC in defining the specificity of associations in cognitive maps.
NATURE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Matthew P. H. Gardner, Geoffrey Schoenbaum
Summary: The theories on the function of the orbitofrontal cortex (OFC) have advanced significantly, with a general consensus that OFC is crucial for predicting future events. However, different theories propose varying answers regarding the exact role of OFC, with some failures possibly hinting at a more nuanced and unique role for OFC.
BEHAVIORAL NEUROSCIENCE
(2021)
Meeting Abstract
Behavioral Sciences
Matthew P. Gardner, Jessica C. Conroy, Davied Sanchez, Geoffrey Schoenbaum