Article
Neurosciences
J. Wickham, M. Ledri, M. Andersson, M. Kokaia
Summary: During epileptic seizures, parvalbumin-interneurons and principal cells play different roles in triggering epileptiform discharges. This study investigated the seizure-triggering ability of parvalbumin-interneurons and principal cells without the use of external convulsive agents. The results showed that selective synchronized activation of principal neurons, but not parvalbumin-interneurons, can trigger epileptiform discharges, suggesting a region-specific role of these cells in ictogenesis.
Article
Neurosciences
Jared T. Shapiro, Emily A. R. Gosselin, Nicole M. Michaud, Nathan A. Crowder
Summary: The study found that by increasing Pvalb+ input to pyramidal cells, their latency was significantly increased and their receptive field size decreased, confirming the proposed role of Pvalb+ interneurons in sculpting pyramidal tuning by controlling cortical gain.
NEUROSCIENCE LETTERS
(2022)
Review
Geriatrics & Gerontology
Caesar M. Hernandez, Abigail R. Hernandez, Jessica M. Hoffman, Peter H. King, Lori L. McMahon, Thomas W. Buford, Christy Carter, Jennifer L. Bizon, Sara N. Burke
Summary: The article discusses the history of neuroscience research on the neurobiology of aging and introduces gerontologists to the methodological approaches used by neuroscientists. The goal is to enhance collaboration between neuroscientists and gerontologists in order to strengthen the field of cognitive aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Neurosciences
Carlo N. G. Giachello, Iain Hunter, Tom Pettini, Bramwell Coulson, Athene Knufer, Sebastian Cachero, Michael Winding, Aref Arzan Zarin, Hiroshi Kohsaka, Yuen Ngan Fan, Akinao Nose, Matthias Landgraf, Richard A. Baines
Summary: The Drosophila connectome project aims to map the synaptic connectivity of the fly neural networks in order to better understand their development and function. Although impressive progress has been made in reconstructing specific synapses using electron microscopy data, the data are still underutilized. This study combines patch-clamp recordings with optogenetic stimulation to test the proposed synaptic connectivity in fruit fly larvae and highlights the need for functional validation and appropriate genetic tools in connectome projects.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Tohar S. Yarden, Adi Mizrahi, Israel Nelken
Summary: This study investigated the role of inhibition in auditory cortex in stimulus-specific adaptation (SSA). Using two-photon targeted cell-attached recordings and optogenetic manipulations, the researchers found that parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing interneurons showed early-onset SSA. Surprisingly, inhibiting PV neurons enhanced responses to deviant stimuli more than to standard stimuli, while inhibiting VIP neurons decreased responses to standard stimuli but not to deviant stimuli.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Cassandra L. Retzlaff, Patrick E. Rothwell
Summary: This study is the first to examine the physiological properties of neuropeptide Y interneurons in the nucleus accumbens and shows that activation of mu opioid receptors inhibits the activity of low-threshold spiking interneurons and reduces GABA release onto medium spiny neurons.
Review
Physiology
M. Caroline Muellenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani, Claudia Richter, Philipp Sasse, Tania Zaglia, Leonardo Sacconi, Godfrey L. Smith
Summary: Optical techniques have rapidly advanced the field of cellular electrophysiology, allowing for in-depth analysis of cardiac dynamics and opening new possibilities for clinical applications with the recent advent of optogenetics.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Eduard Masvidal-Codina, Trevor M. Smith, Daman Rathore, Yunan Gao, Xavi Illa, Elisabet Prats-Alfonso, Elena Del Corro, Andrea Bonaccini Calia, Gemma Rius, Inigo Martin-Fernandez, Christoph Guger, Patrick Reitner, Rosa Villa, Jose A. Garrido, Anton Guimera-Brunet, Rob C. Wykes
Summary: The study successfully induced CSD in awake mice using graphene micro-transistor arrays, allowing high-density electrophysiological mapping of the CSD waveform.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Saeyeong Jeon, Youjin Lee, Daeho Ryu, Yoon Kyung Cho, Yena Lee, Sang Beom Jun, Chang-Hyeon Ji
Summary: Optogenetics has become crucial in neuroscience research due to its cell-type-specific neuromodulation feature. Technological advances in light delivery devices have allowed for the combination of optogenetics and electrophysiology, as demonstrated by a novel optrode array design for optical modulation and electrophysiological recording. In vivo experiments with transgenic mice expressing channelrhodopsin have confirmed the effectiveness of optical activation and neural recording.
Article
Neurosciences
Olga A. Sergeeva, Karolina Mazur, David Reiner-Link, Kiril Lutsenko, Helmut L. Haas, Mercedes Alfonso-Prieto, Holger Stark
Summary: Researchers have found that Nα-oleoylhistamine (OLHA) can modulate the activity of histaminergic (HA) neurons in mice. OLHA has different effects on HA neuron firing depending on its concentration. The excitatory and rise in intracellular calcium caused by OLHA are influenced by specific receptors and inhibitors, possibly related to fatty acid metabolism and the PKA pathway. PPAR-alpha and H3 receptors play important roles in this process.
Article
Neurosciences
Julien Catanese, Dieter Jaeger
Summary: The study demonstrates the importance of thalamic ramping activity in controlling impulsive actions, with inhibitory nigral inputs able to modulate this activity and affect the level of motor impulsivity.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Louisa E. Linders, Laura F. Supiot, Wenjie Du, Roberto D'Angelo, Roger A. H. Adan, Danai Riga, Frank J. Meye
Summary: The combination of brain slice patch clamp electrophysiology with optogenetic stimulation has proven to be a powerful approach for analyzing neural circuits and synaptic plasticity. This review discusses the rationale, current applications, and caveats of this combination, as well as methods for assessing synaptic connections and measuring synaptic strength and function. The review also highlights advances in studying synaptic modulation using pharmacological approaches and dual color optogenetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zexu Lin, Dmitry Kireev, Ning Liu, Shubham Gupta, Jessica LaPiano, Sofian N. N. Obaid, Zhiyuan Chen, Deji Akinwande, Igor R. R. Efimov
Summary: Heart rhythm disorders, known as arrhythmias, are a significant cause of illness and mortality. This study reports the first use of a graphene biointerface for cardiac electrophysiology, demonstrating its potential for in vivo and in vitro applications. The graphene arrays show effective electrochemical properties and have shown positive results in arrhythmia treatment.
ADVANCED MATERIALS
(2023)
Article
Neurosciences
Dimitrios Firfilionis, Frances Hutchings, Reza Tamadoni, Darren Walsh, Mark Turnbull, Enrique Escobedo-Cousin, Richard G. Bailey, Johannes Gausden, Aaliyah Patel, Dorian Haci, Yan Liu, Fiona E. N. LeBeau, Andrew Trevelyan, Timothy G. Constandinou, Anthony O'Neill, Marcus Kaiser, Patrick Degenaar, Andrew Jackson
Summary: Neuromodulation is an established treatment for neurological conditions, but improving the specificity of stimulation is necessary. Optogenetics offers promising research potential for optical stimulation of specific cell types. An open-source system is being developed for closed-loop optogenetic neuromodulation, allowing for flexibility and expansion in various neuroscientific applications.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Jose A. Fernandez-Leon, Douglas S. Engelke, Guillermo Aquino-Miranda, Alexandria Goodson, Maria N. Rasheed, Fabricio H. Do Monte
Summary: The study demonstrates that neurons in the prelimbic cortex play a crucial role in regulating memory-based risky decision-making by modulating threat-avoidance vs. reward-approach behaviors. Individual variability in behavioral responses during conflict may be linked to the activity levels of glutamatergic neurons in the prelimbic cortex.
Article
Anatomy & Morphology
Fumito Naganuma, Sathyajit S. Bandaru, Gianna Absi, Melissa J. Chee, Ramalingam Vetrivelan
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Endocrinology & Metabolism
Omar Al-Massadi, Mar Quinones, Jerome Clasadonte, Rene Hernandez-Bautista, Amparo Romero-Pico, Cintia Folgueira, Donald A. Morgan, Imre Kallo, Violeta Heras, Ana Senra, Samuel C. Funderburk, Michael J. Krashes, Yara Souto, Miguel Fidalgo, Serge Luquet, Melissa J. Chee, Monica Imbernon, Daniel Beiroa, Lucia Garcia-Caballero, Rosalia Gallego, Brian Y. H. Lam, Giles Yeo, Miguel Lopez, Zsolt Liposits, Kamal Rahmouni, Vincent Prevot, Carlos Dieguez, Ruben Nogueiras
Article
Neurosciences
Kenichiro Negishi, Mikayla A. Payant, Kayla S. Schumacker, Gabor Wittmann, Rebecca M. Butler, Ronald M. Lechan, Harry W. M. Steinbusch, Arshad M. Khan, Melissa J. Chee
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Giovanne B. Diniz, Daniella S. Battagello, Marianne O. Klein, Bianca S. M. Bono, Jozelia G. P. Ferreira, Livia C. Motta-Teixeira, Jessica C. G. Duarte, Francoise Presse, Jean-Louis Nahon, Antoine Adamantidis, Melissa J. Chee, Luciane V. Sita, Jackson C. Bittencourt
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Endocrinology & Metabolism
Myriam P. Hoyeck, Rayanna C. Merhi, Hannah L. Blair, C. Duncan Spencer, Mikayla A. Payant, Diana I. Martin Alfonso, Melody Zhang, Geronimo Matteo, Melissa J. Chee, Jennifer E. Bruin
MOLECULAR METABOLISM
(2020)
Article
Nutrition & Dietetics
Melissa J. Chee, Nikita K. Koziel Ly, Hymie Anisman, Kimberly Matheson
Article
Behavioral Sciences
Mikayla A. Payant, Melissa J. Chee
Summary: Fructose consumption is linked to metabolic syndrome and obesity, potentially promoting obesity through various pathways such as overeating, increased visceral fat, hypertension, and insulin resistance. Emerging evidence suggests that dietary fructose can act on multiple brain systems to increase appetite drive, reduce time between meals, and decrease cognitive control, leading to overeating behaviors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Bianca S. Bono, Nikita K. Koziel Ly, Persephone A. Miller, Jesukhogie Williams-Ikhenoba, Yasmina Dumiaty, Melissa J. Chee
Summary: This study used in situ hybridization to label Klb mRNA and captured the distribution and levels of Klb in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. The results showed heterogeneous expression of Klb in the hypothalamus and amygdala, suggesting novel roles for FGF15/19 or FGF21 signaling. These findings are consistent with the reported functions of Klb in metabolism, taste preference, and neuroprotection.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Kaylin G. Earnest, Erin M. McConnell, Eman M. Hassan, Mark Wunderlich, Bahareh Hosseinpour, Bianca S. Bono, Melissa J. Chee, James C. Mulloy, William G. Willmore, Maria C. DeRosa, Edward J. Merino
Summary: A DNA aptamer specific to AML cells was developed using SELEX technology in this study, showing specific binding to AML cells at a concentration of 37.5 nM, while displaying no binding to other cell types.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Neurosciences
Melissa J. Chee
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Endocrinology & Metabolism
Aditi S. Sankhe, Dillon Bordeleau, Diana I. Martin Alfonso, Gabor Wittman, Melissa J. Chee
Summary: Melanin-concentrating hormone (MCH) neurons in the hypothalamus are heterogeneous and can express other neuropeptides and transmitters. MCH neurons can release glutamate to directly innervate downstream neurons, potentially affecting glucose homeostasis, nutrient-sensing, energy balance, and mood disorders. By deleting the expression of vesicular glutamate transporter 2 (Vglut2) specifically in MCH neurons, researchers found that Mch-Vglut2-KO mice displayed anxiety-like behaviors and reduced exploratory activity, suggesting that glutamatergic signaling from MCH neurons, similar to MCH peptide, contributes to anxiety regulation and promotion.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Nikita K. Koziel Ly, Ladan Mohamud, Paul J. Villeneuve, Kimberly Matheson, Hymie Anisman, Melissa J. Chee
Summary: The COVID-19 pandemic has led to increased depression, anxiety, and stress. Physical activity during the pandemic has been found to be related to mental health outcomes, as it serves as a coping strategy to manage stress and promote resilience. This longitudinal study showed that a reduction in leisure-time physical activity was linked to subsequent feelings of depression, and individuals with lower levels of physical activity were more likely to appraise their COVID-19 situation as uncontrollable, which in turn was related to depressive feelings.
Meeting Abstract
Neurosciences
Bianca S. Bono, Melissa J. Chee
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)
Meeting Abstract
Neurosciences
C. Duncan Spencer, Alex J. Hebert, Bianca S. Bono, Melissa J. Chee
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)
Meeting Abstract
Neurosciences
Mikayla A. Payant, Jenny Campbell, Alex J. Hebert, Eleftheria Maratos-Flier, Melissa J. Chee
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)