Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
Na Suo, Bingqing He, Shihao Cui, Ying Yang, Min Wang, Qianting Yuan, Xin Xie
Summary: GPR149, an orphan G protein-coupled receptor enriched in OPCs, negatively regulates OPC to OL differentiation and myelination, impacting myelin development and remyelination. Deficiency of GPR149 enhances myelin regeneration. Further study suggests that GPR149 may regulate OL differentiation and myelin formation via the MAPK/ERK pathway.
Article
Cell Biology
Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: This study found that LGR4 expression was significantly upregulated in multiple myeloma (MM) tissues and cells. Knockdown of LGR4 inhibited MM cell proliferation, promoted apoptosis and cell cycle arrest in G1, while overexpression showed the opposite effect. Mechanistic studies revealed that LGR4 could interact with TGF-beta 1 and activate the TGF-beta 1/Smad signaling pathway, promoting MM progression. LGR4 may be a potential new target for MM diagnosis and treatment.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Sarah S. McCarthy, Michele Karolak, Leif Oxburgh
Summary: Expansion of interstitial cells in adult kidney is a hallmark of chronic disease, while their proliferation during fetal development is necessary for organ formation. Inactivation of TGF beta/Smad response in mouse interstitial cell lineage leads to overproliferation of interstitial cells regionally in the kidney medulla. Smad4 loss primarily reduces TGF beta signaling in the interstitium, while increasing Wnt/beta-catenin signaling.
Review
Neurosciences
Jacob H. Hines
Summary: Oligodendrocytes are essential for neural function in gnathostomes, with well-established roles in myelination, but recent studies have shown their involvement in other aspects of central nervous system development, function, and maintenance. Advances in understanding myelin plasticity have revealed experience-dependent adaptations as a form of neural plasticity. The evolutionary origins and specializations of oligodendrocytes remain mysteries, prompting questions about when and for what functions the cell type emerged, and the genetic changes responsible for their evolutionary innovations.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Natalia Dolgova, Zelan Wei, Brandon Spink, Le Gui, Qinyun Hua, Davin Truong, Zhen Zhang, Yanbo Zhang
Summary: This study demonstrated that 40-Hz LFMS treatment can promote differentiation of CG4 cells into oligodendrocytes through activation of non-canonical TGF-beta-Akt and TGF-beta-Erk1/2 pathways. The findings provide new evidence for the potential therapeutic mechanism of LFMS in demyelinating disorders.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Geriatrics & Gerontology
Colin J. Murray, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: Consumption of cannabis is increasing, especially among the elderly, but research on its impact on the aged brain is lacking. The aging process leads to changes in the brain's myelination process, which is associated with cognitive decline and neurological diseases. Animal studies suggest that cannabis can modulate the myelination process. However, research on the impact of cannabis on myelination in the aged brain is limited.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Oncology
Zhang Li, Ming Li, Pengcheng Xia, Lili Wang, Zhiming Lu
Summary: This study discovered that p53 exerts anti-oncogenic function on glioma development by suppressing IncRNA PVT1 and subsequently inactivating TGF-beta/Smad pathway.
CANCER BIOLOGY & THERAPY
(2022)
Article
Endocrinology & Metabolism
Pengfei Zhu, Zhijiao Song, Xingyu Bi, Yiliang Miao, Xueqing Wu
Summary: PRR11 plays an important role in early pregnancy loss by promoting cell proliferation, migration, and angiogenesis. It is correlated with EGR1 and the TGF-beta/Smad signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Neurosciences
Jun Zhang, Jian-guang Sun, Xiaowen Xing, Rong Wu, Lujun Zhou, Ying Zhang, Fang Yuan, Shukun Wang, Zengqiang Yuan
Summary: In both developmental myelination and remyelination in the central nervous system, the c-Abl kinase plays a crucial role in the proliferation of OL progenitor cells by directly phosphorylating the transcription factor Olig2. Lack of c-Abl results in insufficient OPC proliferation and reduced expression of myelin-related genes, leading to impaired myelination.
Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Review
Biochemistry & Molecular Biology
Shunqi Wang, Yingxing Wang, Suqi Zou
Summary: This article reviews the process of oligodendrocyte myelination and its regulatory factors, including proliferation, differentiation, and factors influencing myelination.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Neurosciences
Javier Palazuelos, Michael Klingener, Elaine W. Raines, Howard C. Crawford, Adan Aguirre
JOURNAL OF NEUROSCIENCE
(2015)
Review
Pharmacology & Pharmacy
Onintza Sagredo, Javier Palazuelos, Ana Gutierrez-Rodriguez, Valentina Satta, Ismael Galve-Roperh, Jose Martinez-Orgado
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Clinical Neurology
Alline C. Campos, Zaira Ortega, Javier Palazuelos, Manoela V. Fogaca, Daniele C. Aguiar, Javier Diaz-Alonso, Silvia Ortega-Gutierrez, Henar Vazquez-Villa, Fabricio A. Moreira, Manuel Guzman, Ismael Galve-Roperh, Francisco S. Guimaraes
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Javier Palazuelos, Zaira Ortega, Javier Diaz-Alonso, Manuel Guzman, Ismael Galve-Roperh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Neurosciences
Javier Palazuelos, Howard C. Crawford, Michael Klingener, Bingru Sun, Jason Karelis, Elaine W. Raines, Adan Aguirre
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Alba Huerga-Gomez, Tania Aguado, Anibal Sanchez-de la Torre, Ana Bernal-Chico, Carlos Matute, Susana Mato, Manuel Guzman, Ismael Galve-Roperh, Javier Palazuelos
Summary: This study demonstrates that acute THC administration in early postnatal mice enhances OL development and CNS myelination by promoting oligodendrocyte precursor cell cycle exit and differentiation, which is mediated by CB1 and CB2 cannabinoid receptors and relies on the activation of the mTORC1 signaling pathway.
Article
Pharmacology & Pharmacy
Tania Aguado, Alba Huerga-Gomez, Anibal Sanchez-de La Torre, Eva Resel, Juan Carlos Chara, Carlos Matute, Susana Mato, Ismael Galve-Roperh, Manuel Guzman, Javier Palazuelos
Summary: Research shows that administration of THC from the hemp plant can enhance oligodendrocyte regeneration, white matter remyelination, and motor function recovery. THC also promotes axonal remyelination by inducing oligodendrocyte precursor differentiation through CB1 cannabinoid receptor activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Anibal Sanchez-de la Torre, Tania Aguado, Alba Huerga-Gomez, Silvia Santamaria, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzman, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos
Summary: The study reveals that cannabinoids through CB1 receptors play a crucial role in modulating oligodendrocyte precursor cell differentiation and postnatal CNS myelination, possibly by regulating the RhoA/ROCK signaling pathway. Pharmacological activation of CB1 receptors promotes oligodendrocyte development and CNS myelination, while pharmacological inactivation of ROCK overcomes CB1 receptor deficiency-related defects.
CELL DEATH & DISEASE
(2022)
Article
Anatomy & Morphology
Andrea Manterola, Juan Carlos Chara, Tania Aguado, Javier Palazuelos, Carlos Matute, Susana Mato
Summary: CB1 receptors are present in a low proportion of adult oligodendrocyte progenitor cells (OPCs), which provides an anatomical basis for the remyelination effects of cannabinoids. This study opens a novel perspective on the roles of the endocannabinoid system in brain physiology through the modulation of NG2 glia.
FRONTIERS IN NEUROANATOMY
(2022)
Meeting Abstract
Neurosciences
T. Aguado, A. Huerga-Gomez, A. Sanchez-De la Torre, A. Martinez-Cortes, S. Mato, I. Galve-Roperh, M. Guzman, J. Palazuelos
Meeting Abstract
Neurosciences
J. Palazuelos, M. Klingener, A. Aguirre
Meeting Abstract
Clinical Neurology
J. Palazuelos, M. Klingener, A. Aguirre
MULTIPLE SCLEROSIS JOURNAL
(2014)
Meeting Abstract
Neurosciences
A. Aguirre, M. Klingener, J. Palazuelos
Meeting Abstract
Biochemistry & Molecular Biology
J. Palazuelos, M. Klingener, B. Sun, A. Aguirre
JOURNAL OF NEUROCHEMISTRY
(2013)
