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Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
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Neurosciences
Nastaran Golitabari, Forouzan Mohammadian, Ali-Akbar Salari, Mohammad Amani
Summary: This study found that early life exposure to PCP can negatively affect the synaptic function of CA1 neurons in the hippocampus of adult rats, including inhibiting long-term potentiation and depression, and causing significant changes in complex response profiles.
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Cell Biology
Sylvie Perez, Yihui Cui, Gaetan Vignoud, Elodie Perrin, Alexandre Mendes, Zhiwei Zheng, Jonathan Touboul, Laurent Venance
Summary: This study reveals the presence of symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in the striatum, with opposite plasticity dominance and different roles in different stages and types of learning.
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Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
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Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
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Biology
David L. Haggerty, Braulio Munoz, Taylor Pennington, Gonzalo Viana Di Prisco, Gregory G. Grecco, Brady K. Atwood
Summary: Binge drinking alcohol leads to glutamatergic synaptic adaptations between the anterior insular cortex (AIC) and dorsolateral striatum (DLS), which maintain the behavioral sequences of binge consumption. These changes may serve as a circuit-based biomarker for the development of alcohol use disorder.
Editorial Material
Biology
Leigh C. Walker, Paulo Pinares-Garcia, Andrew J. Lawrence
Summary: A neural pathway related to goal-oriented behaviors is dysregulated in binge drinking and alcohol use disorder.
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Cell Biology
Jonas Cornelius, Stefan Haak, Martin Rothkegel, Martin Korte, Kristin Michaelsen-Preusse
Summary: The study reveals that phosphorylated profilin2a in glutamate uncaging agents regulates actin dynamics and structural plasticity in neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
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Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
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Clinical Neurology
Mahima Sharma, Forouzan Farahani, Marom Bikson, Lucas C. Parra
Summary: The study shows that applying DCS during repeated theta burst stimulation enhances LTP. Strong TBS protocols and electric fields saturate quickly, while weaker TBS and electric fields result in stronger relative efficacies.
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Behavioral Sciences
Sachie Sasaki-Hamada, Ayumu Fujiwara, Show Satoh, Takashi Iwai, Jun-Ichiro Oka
Summary: The study demonstrated that GLP-2 has the potential to restore cognitive impairments in childhood-onset diabetes rats, including deficits in spatial working memory and hippocampal long-term depression (LTD), and that the MEK1/2 inhibitor, U0126, can inhibit this recovery.
BEHAVIOURAL BRAIN RESEARCH
(2021)
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Psychiatry
Lukas Frase, Lydia Mertens, Arno Krahl, Kriti Bhatia, Bernd Feige, Sven P. Heinrich, Stefan Vestring, Christoph Nissen, Katharina Domschke, Michael Bach, Claus Normann
Summary: The study found that transcranial direct current stimulation (tDCS) can directly induce LTP-like plasticity in the human cortex, suggesting a mechanism of action for tDCS involving the restoration of dysregulated synaptic plasticity in psychiatric disorders such as depression and schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2021)
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Computer Science, Artificial Intelligence
Sergio Verduzco-Flores, William Dorrell, Erik De Schutter
Summary: This paper explores a neural control architecture that is both biologically plausible and capable of autonomous learning. It uses feedback controllers that learn to achieve a desired state by selecting the errors that drive them, employing a family of differential Hebbian learning rules. The architecture can control systems with monotonically or non-monotonically changing error responses through reinforcement learning. The use of feedback control simplifies the learning problem and allows for learning of more complex actions.
Article
Multidisciplinary Sciences
Malika Sammari, Yanis Inglebert, Norbert Ankri, Michael Russier, Salvatore Incontro, Dominique Debanne
Summary: This study reveals that brain oscillations at specific frequencies can induce both synaptic and intrinsic potentiation in O-LM interneurons, contrary to the typical response seen in glutamatergic neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Jennifer L. Sanderson, Ronald K. Freund, Jessica A. Gorski, Mark L. Dell'Acqua
Summary: Regulated insertion and removal of postsynaptic AMPA glutamate receptors mediate synaptic plasticity underlying learning and memory, with disrupted signaling balance and CP-AMPARs playing a crucial role in normal and aberrant plasticity, particularly in Alzheimer's disease where A beta oligomers impact AMPAR trafficking and LTP/LTD balance.
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Neurosciences
Jeff A. Beeler, Rudolf P. Faust, Susie Turkson, Honggang Ye, Xiaoxi Zhuang
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Neurosciences
Jessica L. Koranda, Anne C. Krok, Jian Xu, Anis Contractor, Daniel S. McGehee, Jeff A. Beeler, Xiaoxi Zhuang
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(2016)
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Neurosciences
Jianxun Xia, Allison M. Meyers, Jeff A. Beeler
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(2017)
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Multidisciplinary Sciences
Allison M. Meyers, Devry Mourra, Jeff A. Beeler
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Neurosciences
Jeff A. Beeler, Cristianne R. M. Frazier, Xiaoxi Zhuang
EUROPEAN JOURNAL OF NEUROSCIENCE
(2012)
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Neurosciences
Jeff A. Beeler, James E. McCutcheon, Zhen F. H. Cao, Mari Murakami, Erin Alexander, Mitchell F. Roitman, Xiaoxi Zhuang
EUROPEAN JOURNAL OF NEUROSCIENCE
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Neurosciences
Jessica L. Koranda, Jackson J. Cone, Daniel S. McGehee, Mitchell F. Roitman, Jeff A. Beeler, Xiaoxi Zhuang
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Review
Clinical Neurology
Giselle M. Petzinger, Beth E. Fisher, Sarah McEwen, Jeff A. Beeler, John P. Walsh, Michael W. Jakowec
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Neurosciences
James E. McCutcheon, Jeff A. Beeler, Mitchell F. Roitman
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Cell Biology
Jeff A. Beeler, Michael J. Frank, John McDaid, Erin Alexander, Susie Turkson, Maria Sol Bernandez, Daniel S. McGehee, Xiaoxi Zhuang
Correction
Cell Biology
Jeff A. Beeler, Michael J. Frank, John McDaid, Erin Alexander, Susie Turkson, Maria Sol Bernardez Sarria, Daniel S. McGehee, Xiaoxi Zhuang
Editorial Material
Neurosciences
Jeff A. Beeler, Roshan Cools, Monica Luciana, Sean B. Ostlund, Giselle Petzinger
FRONTIERS IN NEUROSCIENCE
(2014)
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Clinical Neurology
Jeff A. Beeler, Giselle Petzinger, Michael W. Jakowec
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Michael W. Jakowec, Zhou Wang, Daniel Holschneider, Jeff Beeler, Giselle M. Petzinger
JOURNAL OF HUMAN KINETICS
(2016)