Article
Multidisciplinary Sciences
Susumu Takahashi, Takumi Hombe, Sakiko Matsumoto, Kaoru Ide, Ken Yoda
Summary: Animals demonstrate remarkable navigation abilities, possibly due to the presence of head direction cells that encode the animal's heading information. In the study of shearwater chicks, it was found that their head direction cells exhibited a preference for the north direction, indicating the existence of an internally generated magnetic compass in animals.
Article
Chemistry, Analytical
Yudi Chen, Zhi Xiong, Jianye Liu, Chuang Yang, Lijun Chao, Yang Peng
Summary: This paper proposes a brain-inspired positioning method based on multi-sensors' input, utilizing head-direction cell model and place cell model to encode information, decode direction and position, and output more accurate and stable navigation parameters.
Article
Multidisciplinary Sciences
Angelo Forli, Michael M. Yartsev
Summary: This article examines hippocampal activity in groups of bats engaged in collective spatial behavior and finds that many hippocampal neurons are tuned to key features of group dynamics. Social responses are anatomically distributed and robustly represented at the population level.
Article
Multidisciplinary Sciences
Jake Ormond, John O'Keefe
Summary: The hippocampus plays a crucial role in supporting flexible navigation by encoding location information in a vector-based model, allowing animals to select optimal paths to reach their goals.
Article
Multidisciplinary Sciences
William A. Liberti, Tobias A. Schmid, Angelo Forli, Madeleine Snyder, Michael M. Yartsev
Summary: Longitudinal monitoring of dorsal CA1 hippocampal neurons in freely flying bats reveals that the participation and spatial selectivity of most neurons remain stable over days and weeks, with apparent changes in tuning largely attributed to variations in bat flight behavior. The study also shows that bats navigating in the same environment under different lighting conditions exhibit substantial changes in flight behavior, but the stability of the hippocampal code persists when similar flight paths are compared across conditions.
Editorial Material
Biochemistry & Molecular Biology
Aylin Apostel, Jonas Rose
Summary: The study found head-direction cells, but not place cells, in the hippocampal formation of quails, shedding light on the poorly understood avian hippocampus.
Article
Chemistry, Multidisciplinary
Xiaoyang Long, Bin Deng, Calvin K. Young, Guo-Long Liu, Zeqi Zhong, Qian Chen, Hui Yang, Sheng-Qing Lv, Zhe Sage Chen, Sheng-jia Zhang
Summary: Head direction cells are an important component in the brain's spatial navigation system. FS HD cells in the somatosensory cortex display sharper head-directionality than RS HD cells and coexist with RS HD cells and AHV cells in a layer-specific manner. These findings challenge the concept that FS interneurons are weakly tuned to sensory stimuli and provide insights into the local circuit organization of HD signaling in the brain.
Article
Multidisciplinary Sciences
Lu Zhang, Stephanie M. Prince, Abigail L. Paulson, Annabelle C. Singer
Summary: This study investigates the role of nonplace cells in memory-guided navigation when spatial cues provide ambiguous information. It is found that nonplace cells differentiate between ambiguous spatial cues and show altered activity and modulation at task-relevant cues. This discrimination is absent in a mouse model of Alzheimer's disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Noah L. Pettit, Xintong C. Yuan, Christopher D. Harvey
Summary: The expression of spatial maps in the hippocampus can be modulated by the internal state of an animal, resulting in changes even without changes to the external world.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Yanbo Lian, Anthony N. Burkitt
Summary: This study demonstrates how theta phase precession in hippocampal place cells can emerge from medial entorhinal cortex (MEC) input, explaining the spatial and temporal properties of these cells. The MEC grid cells predominantly determine the temporal response properties of hippocampal place cells in this study.
Article
Biochemistry & Molecular Biology
Bruce Harland, Marco Contreras, Madeline Souder, Jean-Marc Fellous
Summary: In a large open environment, most dorsal CA1 place cells exhibit multiple place subfields of different sizes, suggesting a multi-scale representation of space within the dorsal hippocampus.
Article
Biochemistry & Molecular Biology
Eleonore Duvelle, Roddy M. Grieves, Anyi Liu, Selim Jedidi-Ayoub, Joanna Holeniewska, Adam Harris, Nils Nyberg, Francesco Donnarumma, Julie M. Lefort, Kate J. Jeffery, Christopher Summerfield, Giovanni Pezzulo, Hugo J. Spiers
Summary: The study found that the dorsal CA1 place cells of rats have limited ability to encode environmental connectivity, primarily coding location in a global reference frame with minimal response to doorways and other locations.
Article
Biochemistry & Molecular Biology
Yu Shikano, Yuji Ikegaya, Takuya Sasaki
Summary: The study found that hippocampal and striatal neurons are able to gradually change their firing rates and transiently increase firing rates at specific time points, representing successive time points on the order of minutes during the process of animals learning a time-reward relationship. These minute-encoding patterns progressively develop and undergo flexible scaling in parallel with timing behavior.
Article
Multidisciplinary Sciences
Nozomu H. H. Nakamura, Hidemasa Furue, Kenta Kobayashi, Yoshitaka Oku
Summary: The study reveals that temporal apnea induced by activating the PreBotzinger complex during memory formation can result in memory impairments. Respiration can coordinate hippocampal activity during offline brain states, but its role during online memory encoding remains unclear. When intermittent PreBotC-induced apnea occurred during object exploration time, novel object detection was impaired, and freezing behavior was not exhibited during fear-conditioned stimuli presentation.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Mi-Seon Kong, Eun Joo Kim, Sanggeon Park, Larry S. Zweifel, Yeowool Huh, Jeiwon Cho, Jeansok J. Kim
Summary: The study found dynamic interaction between fear signaling cells in the basal amygdala (BA) and spatial coding cells in the dorsal hippocampus (dHPC) as animals traverse safe and danger areas in their environment. Only when dHPC cells synchronized with predator-responsive BA cells did they significantly remap as risk locations escalated.
Article
Biochemical Research Methods
Daria Genzel, Michael M. Yartsev
Summary: By developing a fully automated bat flight room, researchers were able to study bat navigation behavior without human intervention, revealing the multiplexed characteristics of single neurons in the bat's retrosplenial cortex. The findings demonstrate efficient training of bats on complex visuospatial tasks and highlight the involvement of the bat RSC in aerial foraging behavior.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemistry & Molecular Biology
Elhanan Ben-Yishay, Ksenia Krivoruchko, Shaked Ron, Nachum Ulanovsky, Dori Derdikman, Yoram Gutfreund
Summary: This study used tetrodes to record hippocampal neurons in Japanese quails, finding that about 12% of the neurons were head-direction cells. The findings support the existence of an allocentric head-direction representation in the quail hippocampal formation.
Article
Multidisciplinary Sciences
Gily Ginosar, Johnatan Aljadeff, Yoram Burak, Haim Sompolinsky, Liora Las, Nachum Ulanovsky
Summary: Researchers discovered various types of spatial neurons in the brains of freely flying bats, including 3D border cells, 3D head-direction cells, and neurons with multiple 3D firing fields. The 3D grid cells exhibited only local order, unlike the global lattice arrangement seen in 2D grid cells, providing a locally ordered metric for space.
Article
Multidisciplinary Sciences
Tamir Eliav, Shir R. Maimon, Johnatan Aljadeff, Misha Tsodyks, Gily Ginosar, Liora Las, Nachum Ulanovsky
Summary: The study revealed a multiscale coding in hippocampal place cells, where individual cells exhibit multiple fields with significant differences in size, allowing for more precise representation of very large environments. This unique neural coding was observed in both wild-born and laboratory-born bats.
Article
Multidisciplinary Sciences
Nicholas M. Dotson, Michael M. Yartsev
Summary: The study finds that neural activity in the hippocampus of bats primarily encodes spatial information beyond the present moment, extending up to meters away from the bat's current position. This spatiotemporal representation extends both backward and forward in time, with emphasis on future locations, and is observed during both random exploration and goal-directed navigation.
Article
Multidisciplinary Sciences
Maimon C. Rose, Boaz Styr, Tobias A. Schmid, Julie E. Elie, Michael M. Yartsev
Summary: The neural activity of groups of Egyptian fruit bats engaged in vocal interactions distinguishes between self-produced and others' vocalizations, as well as between specific individuals. Coordinated neural activity among group members shows stable bidirectional interbrain correlation patterns specific to spontaneous communicative interactions. Furthermore, a relationship was found between social preferences and intra- and interbrain activity patterns within a group.
Article
Biology
Wujie Zhang, Maimon C. Rose, Michael M. Yartsev
Summary: The goal of this study is to understand the neural relationship between socially interacting individuals. By studying bats engaged in spontaneous social interactions, the researchers found fast fluctuations of activity difference across brains which parallel slow activity covariation across brains. A computational model suggests that positive and negative feedback could explain various experimental observations regarding inter-brain neural relationship.
Correction
Multidisciplinary Sciences
William A. Liberti, Tobias A. Schmid, Angelo Forli, Madeleine Snyder, Michael M. Yartsev
Article
Multidisciplinary Sciences
William A. Liberti, Tobias A. Schmid, Angelo Forli, Madeleine Snyder, Michael M. Yartsev
Summary: Longitudinal monitoring of dorsal CA1 hippocampal neurons in freely flying bats reveals that the participation and spatial selectivity of most neurons remain stable over days and weeks, with apparent changes in tuning largely attributed to variations in bat flight behavior. The study also shows that bats navigating in the same environment under different lighting conditions exhibit substantial changes in flight behavior, but the stability of the hippocampal code persists when similar flight paths are compared across conditions.
Article
Multidisciplinary Sciences
Ayelet Sarel, Shaked Palgi, Dan Blum, Johnatan Aljadeff, Liora Las, Nachum Ulanovsky
Summary: This study observes the switch between navigation and collision avoidance behaviors in bats and finds that hippocampal neurons can rapidly switch their core computation to represent relevant behavioral variables, supporting behavioral flexibility.
Article
Neurosciences
David B. Omer, Liora Las, Nachum Ulanovsky
Summary: This study identified two distinct populations of time cells in the bat hippocampal area CA1. One population encoded different temporal sequences based on the bat's location, thus encoding both spatial context and time. The other population encoded similar preferred times across different spatial contexts, purely encoding elapsed time. Additionally, time cells were found to encode temporal sequences aligned to another bat's landing in a social imitation task. These diverse time codes may support interval timing perception, episodic memory, and temporal coordination between self and others.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Arpit Agarwal, Ayelet Sarel, Dori Derdikman, Nachum Ulanovsky, Yoram Gutfreund
Summary: This study used a wireless electrophysiology system to record single neurons in freely flying barn owls. They found neurons in the hippocampus and other regions that encoded spatial information about the owl's position, direction of flight, and perching location. These findings suggest commonalities in spatial coding between mammals and birds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Bente Jacobsen, Heidi Kleven, Wairimu Gatome, Liora Las, Nachum Ulanovsky, Menno P. Witter
Summary: The hippocampal formation and entorhinal cortex are important for learning, memory, and spatial navigation in mammals. Bats, which have evolved flight, require spatial navigation in a 3D environment. The entorhinal-hippocampal projections in Egyptian fruit bats were investigated, and it was found that the terminal distributions are similar to other mammalian species such as rodents and primates, except for the entorhinal-DG projection.
Article
Neurosciences
Gily Ginosar, Johnatan Aljadeff, Liora Las, Dori Derdikman, Nachum Ulanovsky
Summary: The symmetric, lattice-like spatial pattern of grid-cell activity does not provide a neuronal global metric for space in more naturalistic settings due to distortions and disintegration. Grid cells may instead function as a local metric for proximal space, a metric for subjective action-relevant space, and distortions may indicate salient locations. Understanding these functions requires examining deviations from lattice symmetry.
Article
Multidisciplinary Sciences
Gily Ginosar, Ehud D. Karpas, Idan Weitzner, Nachum Ulanovsky
Summary: The perception of 3D space has been extensively studied, but there are conflicting reports on distortions. This study proposes that 3D perception consists of two processes: perception of traveled space and perception of surrounding space. By testing these two aspects on the same subjects, it was found that the perception of traveled space is experience-dependent, while the perception of surrounding space is not affected by experience. This suggests that these two aspects of 3D spatial perception emerge from distinct processes.
SCIENTIFIC REPORTS
(2023)