Article
Psychology, Biological
Shosuke Suzuki, Victoria M. Lawlor, Jessica A. Cooper, Amanda R. Arulpragasam, Michael T. Treadway
Summary: The study identified functionally segregated regions within the ventral striatum that separately encoded effort activation, movement initiation, and effort discounting of rewards using functional magnetic resonance imaging with a naturalistic maze-navigation paradigm. The results suggest that different regions of the ventral striatum are involved in encoding effort and value, raising important questions about interpreting reward signals in the context of effort demands.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Neurosciences
Xiaoting Sun, Min Liu, Xinyu Xu, Chennan Shi, Liping Zhang, Zhimo Yao, Jiangfan Chen, Qin Wang
Summary: This study identifies the important role of A2AR in the nucleus accumbens in the control of effort-based decision making and suggests that pharmacological targeting of A2ARs could be an effective strategy for treating the aberrant effort-based decision making in neuropsychiatric disorders.
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Pierre Sauton, Jerome Jeanblanc, Farid Benzerouk, Fabien Gierski, Mickael Naassila
Summary: Binge drinking is a predictive factor for alcohol addiction and is harmful to health. Weak decision-making capacities may contribute to vulnerability to binge drinking, leading to impaired decision-making and perpetuating binge drinking. Longitudinal preclinical studies are lacking in understanding this complex relationship.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sharmili Edwin Thanarajah, Ruth Hanssen, Corina Melzer, Marc Tittgemeyer
Summary: The study explored the effect of FTO genetic variations on impulsivity and neuroplastic alterations. It found that FTO risk allele carriers exhibited higher impulsivity and increased structural connectivity between VTA/SN and NAc. These findings suggest that FTO variants may influence obesity-promoting behavioral traits through neuroplastic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychiatry
Rapheal G. Williams, Kevin H. Li, Paul E. M. Phillips
Summary: This study found that stress affects the interaction between CRF and dopamine in the core of the nucleus accumbens, which in turn affects performance in a reward-based decision-making task. Dopamine and CRF have different effects on different behavioral aspects.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Youssuf Saleh, Campbell Le Heron, Pierre Petitet, Michele Veldsman, Daniel Drew, Olivia Plant, Ursula Schulz, Arjune Sen, Peter M. Rothwell, Sanjay Manohar, Masud Husain
Summary: The study found a relationship between apathy in patients with small vessel cerebrovascular disease and disrupted decision making, as well as abnormalities in the white matter network. Apathetic patients accepted fewer offers on the decision-making task and showed reduced responsiveness to low rewards and aversion to investing in high effort. White matter integrity reductions were specifically associated with apathy, highlighting distinct mechanisms underlying apathy and depression.
Article
Neurosciences
Zahra Fatahi, Mohammad Fatahi, Mirmohammadali Mirramezani Alizamini, Ahmad Ghorbani, Mohammad Ismail Zibaii, Abbas Haghparast
Summary: Humans and animals make endeavor-based choices by assessing reinforcement value and response costs. The cortical-limbic-striatal pathway, especially the Nucleus Accumbens (NAc) and the Anterior Cingulate Cortex (ACC), mediates this behavior. Cannabinoid agonists impair decision-making processes. In this study, neural synchronization and functional connectivity between the NAc and ACC were evaluated during endeavor-related decision-making and reaching reward, and the effect of cannabinoids was assessed. The results showed functional connectivity in specific frequency bands during decision-making and reaching reward, but not when animals received cannabinoid agonists.
Article
Biology
Ioannis Zalachoras, Eva Ramos-Fernandez, Fiona Hollis, Laura Trovo, Joao Rodrigues, Alina Strasser, Olivia Zanoletti, Pascal Steiner, Nicolas Preitner, Lijing Xin, Simone Astori, Carmen Sandi
Summary: Emerging evidence suggests that mitochondrial function and metabolism in the nucleus accumbens are important for motivated performance. The level of the antioxidant glutathione (GSH) in the nucleus accumbens is closely associated with an individual's capacity to exert reward-incentivized effort over time. Increasing accumbal GSH levels may be a feasible approach to enhance motivation.
Article
Neurosciences
Simon Nougaret, Christelle Baunez, Sabrina Ravel
Summary: This study revealed the force and reward-modulated properties of subthalamic nucleus (STN) neurons through the recording of monkey behavior and STN neuron activity. Force-modulated neurons were active when a high effort was required, while reward-modulated neurons encoded the motivational value of the stimuli. These two populations of neurons played complementary roles in implementing action difficulty and enhancing or slowing execution based on subjective value.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Laura Colautti, Paola Iannello, Maria Caterina Silveri, Alessandro Antonietti
Summary: Through studies using the Iowa Gambling Task, it is found that patients with Parkinson's disease tend to prefer risky choices, possibly due to difficulties in anticipating negative consequences or insensitivity to punishment. Additionally, dopamine medications may have an impact on patients' decision-making under uncertain conditions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nobuhiro Hagura, Jamal Esmaily, Bahador Bahrami
Summary: This study examined the influence of action on decision making, particularly on decision confidence. The results showed that physical effort during the decision process does not affect subsequent decision processes and decision confidence.
Review
Biochemistry & Molecular Biology
Martyna Bayassi-Jakowicka, Grazyna Lietzau, Ewelina Czuba, Aleksandra Steliga, Monika Waskow, Przemyslaw Kowianski
Summary: The nucleus accumbens (NAc) plays a crucial role in both reward processes and central nervous system diseases. Understanding its diverse functions requires a combination of morphological and functional studies, as well as research on its connections, neuroplasticity, and neurotransmitter systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
John G. Howland, Rutsuko Ito, Christopher C. Lapish, Franz R. Villaruel
Summary: Emerging evidence suggests that the rodent medial prefrontal cortex (mPFC) plays a crucial role in adapting behavior to changing information. The mPFC subregions, such as the dorsal and ventral mPFC, have specific functions in regulating action control and translating affective signals. However, these subregions also interact and influence each other in the modulation of adaptive behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Han Yan, Nathan A. Shlobin, Youngkyung Jung, Kristina K. Zhang, Nebras Warsi, Abhaya Kulkarni, George M. Ibrahim
Summary: The nucleus accumbens (NAcc) is critically involved in goal- and reward-based behavior. This systematic review provides a synthesis of the literature on the known circuitry of the NAcc in healthy and diseased states, as well as the clinical outcomes following neuromodulation. The results suggest that NAcc neuromodulation may be an effective treatment for various psychiatric disorders.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Sara E. Morrison, Michael A. Bamkole, Saleem M. Nicola
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Neurosciences
Sara E. Morrison, Vincent B. McGinty, Johann du Hoffmann, Saleem M. Nicola
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Behavioral Sciences
Sara E. Morrison, C. Daniel Salzman
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR
(2011)
Review
Neurosciences
Sara E. Morrison, C. Daniel Salzman
CURRENT OPINION IN NEUROBIOLOGY
(2010)
Article
Neurosciences
Sara E. Morrison, C. Daniel Salzman
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Wujie Zhang, David M. Schneider, Marina A. Belova, Sara E. Morrison, Joseph J. Paton, C. Daniel Salzman
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Mattia Rigotti, Daniel Ben Dayan Rubin, Sara E. Morrison, C. Daniel Salzman, Stefano Fusi
Article
Neurosciences
Sara E. Morrison, Alexandre Saez, Brian Lau, C. Daniel Salzman
Article
Behavioral Sciences
Analise N. Rode, Bita Moghaddam, Sara E. Morrison
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Neurosciences
Zachary S. Gillis, Sara E. Morrison
Article
Neurosciences
Crista L. Barberini, Sara E. Morrison, Alex Saez, Brian Lau, C. Daniel Salzman
FRONTIERS IN NEUROSCIENCE
(2012)
Article
Neurosciences
Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel Salzman
Article
Multidisciplinary Sciences
JJ Paton, MA Belova, SE Morrison, CD Salzman