Article
Neurosciences
Sophia Bakola, Kathleen J. Burman, Sylwia Bednarek, Jonathan M. Chan, Natalia Jermakow, Katrina H. Worthy, Piotr Majka, Marcello G. P. Rosa
Summary: The study investigated cortical projections to the caudomedial frontal cortex in marmosets, revealing differences in labeled neurons distribution within different areas of 6M, suggesting homologues of SMA and pre-SMA. This indicates that marmosets can be valuable models for studying movement planning and control due to conservation of cortical motor control circuit in simian primates.
Article
Neurosciences
Salim Al-Wasity, Stefan Vogt, Aleksandra Vuckovic, Frank E. Pollick
Summary: The study used fMRI NF to train healthy participants to self-regulate brain signals, showing a gradual increase in SMA-related activity only in the NF group and shorter reaction times in a Go/No-go task after the NF training. These results suggest that NF can help participants develop greater control over a specifically targeted motor region, with implications for motor skill learning and rehabilitation.
Article
Neurosciences
Allan Lohse, Annemette Lokkegaard, Hartwig R. Siebner, David Meder
Summary: Impulsivity refers to acting prematurely or without forethought, and it is a major issue in many neuropsychiatric disorders. The pre-supplementary motor area (pre-SMA) may play a role in inhibitory control and impulsivity. In this study, low-frequency rTMS of the pre-SMA was found to modulate task-related engagement and influence risky choice behavior during sequential gambling, providing evidence for a causal link between pre-SMA activity and impulsive risk-taking behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Christin M. Sadler, Aline Tiemi Kami, Julie Nantel, Anthony N. Carlsen
Summary: This study examined the effects of tDCS on bradykinesia symptoms in PD patients, finding that anodal tDCS over SMA improved upper limb movement dynamics. The results suggest that anodal tDCS could be a useful therapy in mitigating bradykinesia associated with PD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyun Joo Cho, Rebecca Waugh, Tianxia Wu, Pattamon Panyakaew, Karin Mente, Demelio Urbano, Mark Hallett, Silvina. G. G. Horovitz
Summary: Sensory trick plays a crucial role in cervical dystonia, and the supplementary motor area (SMA) interacts with other brain regions during sensory trick performance and imagination. The left intraparietal sulcus (IPS) and the SMA-right cerebellum connectivity showed different patterns in CD patients compared to healthy controls.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Ya-Wen Xu, Peng Lin, Pei-Sen Yao, Shu-Fa Zheng, De-Zhi Kang
Summary: This study evaluated the structure and function of corticospinal projection originating from SMA using DTI and TMS, finding that contralesional ACST fibers were more abundant than ipsilesional ACST fibers in patients with SMA tumors. Most patients with SMA tumor experienced temporary akinesia postoperatively, and in a patient with M1 glioma, 741 fibers of ipsilateral ACST and no fibers of ipsilateral CST were detected.
Article
Neurosciences
Jasmine L. Mirdamadi, Courtney R. Seigel, Stephen D. Husch, Hannah J. Block
Summary: When there is a mismatch between visual and proprioceptive estimates of hand position, the brain realigns them to reduce the discrepancy. This realignment affects not only the representation of the finger itself, but also extends to other parts of the limb.
Article
Health Care Sciences & Services
Yoshihiro Noda, Mera S. Barr, Reza Zomorrodi, Robin F. H. Cash, Pantelis Lioumis, Robert Chen, Zafiris J. Daskalakis, Daniel M. Blumberger
Summary: This study utilized TMS-EEG to investigate cortical responses to brain stimulation in different populations, revealing changes in TEP amplitudes and latencies in older participants and patients with schizophrenia. These findings are important for understanding the neurophysiological changes in the brains of older individuals and schizophrenia patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Neurosciences
Isaac Moran, Javier Perez-Orive, Jonathan Melchor, Tonatiuh Figueroa, Luis Lemus
Summary: The study found that the supplementary motor area (SMA) in the brain is responsible for decision-related computation when transitioning from auditory to movement representations. The neural population in SMA is organized orthogonally during auditory and movement periods, indicating different computations are performed in each phase. These findings suggest that SMA integrates acoustic information to drive behavior through categorical signals.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Behavioral Sciences
Aviv Emanuel, Jasmine Herszage, Haggai Sharon, Nira Liberman, Nitzan Censor
Summary: This study reveals that the supplementary motor area (SMA) may play a role in coding effort value moment-to-moment during tasks, leading to a more equal distribution of effort over the course of the task. This phenomenon, known as the "stuck-in-the-middle" pattern (STIM), suggests that SMA activity influences how individuals allocate effort during tasks.
Article
Neurosciences
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double
Summary: Research has found that increased thickness of the substantia nigra in healthy older adults may be associated with changes in excitability of motor cortical circuitry. This finding has important implications for understanding brain changes in healthy older adults at risk of Parkinson's disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Elias P. Casula, Giorgio Leodori, Jaime Ibanez, Alberto Benussi, Vishal Rawji, Sara Tremblay, Anna Latorre, John C. Rothwell, Lorenzo Rocchi
Summary: Studies have shown that the direction and intensity of the applied current in transcranial magnetic stimulation (TMS) is important for stimulating different neural populations. The presupplementary motor area (pre-SMA) has recently gained attention in the study of motor inhibition. The lack of direct electrophysiological outcomes can be overcome by combining TMS with electroencephalography (TMS-EEG).
Article
Clinical Neurology
James Saravanamuttu, Natasha Radhu, Kaviraja Udupa, Julianne Baarbe, Carolyn Gunraj, Robert Chen
Summary: The study revealed that SICF is increased and the facilitatory effect of SICI on SICF is absent in Parkinson's disease patients, but can be restored with dopaminergic medication. This suggests that impaired interaction between M1 circuits is a pathophysiological feature of PD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Anke Ninija Karabanov, Keiichiro Shindo, Yuko Shindo, Estelle Raffin, Hartwig Roman Siebner
Summary: The study investigated the individual variability in the functional aftereffects of transcranial direct current stimulation (TDCS) targeting the primary motor hand area (M1-HAND). The results showed that real TDCS did not have consistent effects on mean MEP amplitude, task-related activity, or motor performance. However, individual changes in MEP amplitude were positively correlated with changes in task-related activity in the supplementary motor area.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Brian Mathias, Andrea Waibel, Gesa Hartwigsen, Leona Sureth, Manuela Macedonia, Katja M. Mayer, Katharina von Kriegstein
Summary: The study found that sensorimotor-enriched training can change the representations of L2 words in the motor cortex, thereby facilitating the translation of L2 words. Different training methods have different effects on the translation speed of L2 words.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E. Lang, Kathryn S. Hayward, Keith R. Lohse, Julia M. Juliano, Francesca Assogna, Lee A. Baugh, Anup K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Adriana B. Conforto, R. Cameron Craddock, Michael A. Dimyan, Adrienne N. Dula, Elsa Ermer, Mark R. Etherton, Kelene A. Fercho, Chris M. Gregory, Shahram Hadidchi, Jess A. Holguin, Darryl H. Hwang, Simon Jung, Steven A. Kautz, Mohamed Salah Khlif, Nima Khoshab, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Fabrizio Piras, Ander Ramos-Murguialday, Genevieve Richard, Pamela Roberts, Andrew D. Robertson, Jane M. Rondina, Natalia S. Rost, Nerses Sanossian, Nicolas Schweighofer, Na Jin Seo, Mark S. Shiroishi, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong W. Tang, Gregory T. Thielman, Daniela Vecchio, Arno Villringer, Nick S. Ward, Emilio Werden, Lars T. Westlye, Carolee Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson
Summary: The ENIGMA Stroke Recovery working group aims to understand the relationship between brain and behavior using meta- and mega-analytic approaches. They have developed neuroinformatics protocols and methods to manage large-scale data from over 2,100 stroke patients. The challenges and recommendations for data harmonization in stroke research are discussed.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Y. Yap, Bino A. Varghese, Steven Y. Cen, Darryl H. Hwang, Xiaomeng Lei, Bhushan Desai, Christopher Lau, Lindsay L. Yang, Austin J. Fullenkamp, Simin Hajian, Marielena Rivas, Megha Nayyar Gupta, Brian D. Quinn, Manju Aron, Mihir M. Desai, Monish Aron, Assad A. Oberai, Inderbir S. Gill, Vinay A. Duddalwar
Summary: This study utilized a radiomics framework to analyze tumor shape and texture features, revealing that shape metrics alone can achieve high prediction performance and should be used in conjunction with texture metrics.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bino A. Varghese, Darryl Hwang, Steven Y. Cen, Xiaomeng Lei, Joshua Levy, Bhushan Desai, David J. Goodenough, Vinay A. Duddalwar
Summary: The study evaluated the robustness and reproducibility of CTTA metrics extracted from CT images, showing that some features demonstrated excellent robustness and reproducibility. Different imaging variables affected the texture metrics, with changes in slice thickness having a more intense impact compared to other variables.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Urology & Nephrology
Saum Ghodoussipour, Sharath S. Reddy, Runzhuo Ma, Darryl Huang, Jessica Nguyen, Andrew J. Hung
Summary: Automated performance metrics provide a new approach for assessing surgical performance, especially in robotic assisted partial nephrectomy. The study showed significant differences in performance metrics between expert and trainee surgeons in different steps of the surgery. Automated performance metrics during key steps are correlated with objective measures of tumor complexity and may predict clinical outcomes.
JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brandon K. K. Fields, Natalie L. Demirjian, Darryl H. Hwang, Bino A. Varghese, Steven Y. Cen, Xiaomeng Lei, Bhushan Desai, Vinay Duddalwar, George R. Matcuk
Summary: The study successfully differentiated between benign and malignant soft tissue tumors using MRI radiomics metrics and machine learning. Adaboost and Random Forest machine learning approaches performed similarly well in distinguishing between benign and malignant lesions. Even when restricted to T2FS and STIR sequences, the machine learning models maintained comparable performance, showing promise in clinical application scenarios.
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Amy Seagroves, Heather M. Ross, Alaina P. Vidmar, Mitchell E. Geffner, William S. Kim, Darryl Hwang, Claudia Borzutzky, Nicole R. Fraga, Mimi S. Kim
Summary: Youth with classical CAH due to 21-hydroxylase deficiency have a higher prevalence of obesity and increased abdominal adiposity. Topiramate therapy has been shown to effectively reduce BMI and VAT in unaffected adolescents with exogenous obesity, but its efficacy in patients with classical CAH is not well known. This case report demonstrates that topiramate therapy led to reductions in BMI, as well as abdominal VAT and SAT, in an adolescent with classical CAH and severe obesity. Further studies are needed to investigate the potential benefits of topiramate therapy in obese youth with classical CAH and increased central adiposity.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Nima Nassiri, Marissa Maas, Giovanni Cacciamani, Bino Varghese, Darryl Hwang, Xiaomeng Lei, Monish Aron, Mihir Desai, Assad A. Oberai, Steven Y. Cen, Inderbir S. Gill, Vinay A. Duddalwar
Summary: The study found that radiomic-based machine learning platforms can distinguish benign from malignant renal masses, and can to a certain extent substitute for the accuracy of clinical diagnosis. This method has the potential to improve patient selection before surgery and increase the utilization of active surveillance protocols.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Natalie L. Demirjian, Bino A. Varghese, Steven Y. Cen, Darryl H. Hwang, Manju Aron, Imran Siddiqui, Brandon K. K. Fields, Xiaomeng Lei, Felix Y. Yap, Marielena Rivas, Sharath S. Reddy, Haris Zahoor, Derek H. Liu, Mihir Desai, Suhn K. Rhie, Inderbir S. Gill, Vinay Duddalwar
Summary: This study evaluated the utility of CT-based radiomics signatures in discriminating low-grade and high-grade, as well as low-stage and high-stage clear cell renal cell carcinomas (ccRCC). The results suggest that CT-based radiomics signatures have the potential to be valuable in distinguishing between different grades and stages of ccRCC.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemical Research Methods
Natalie J. McLain, Moheb S. Yani, Jason J. Kutch
Summary: The study investigates the stability of resting-state peak alpha frequency (PAF) in populations with pain using different analytic pipelines. The results demonstrate that PAF is a relatively stable marker in pain research and is correlated with interindividual differences in thalamic and salience network function.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Orthopedics
Moheb S. Yani, Sandrah P. Eckel, Daniel J. Kirages, Larissa Rodriguez, Daniel M. Corcos, Jason J. Kutch
Summary: This study found that men with CP/CPPS have changes in neural drive that impair their ability to relax pelvic floor muscles. The impaired ability to relax was strongest in men who reported ejaculation-related pain.
Article
Computer Science, Interdisciplinary Applications
Ragheb Raad, Dhruv Patel, Chiao-Chih Hsu, Vijay Kothapalli, Deep Ray, Bino Varghese, Darryl Hwang, Inderbir Gill, Vinay Duddalwar, Assad A. Oberai
Summary: In this manuscript, a novel probabilistic deep-learning algorithm is proposed to impute missing images in a sequence of medical images. The method trains a generative adversarial network (GAN) to learn the underlying probabilistic relation between the images, and uses Bayesian inference to infer the probability distribution of the missing image. A unique style loss for contrast-enhanced computed tomography (CECT) imaging is also proposed to improve the texture of the generated images.
ENGINEERING WITH COMPUTERS
(2022)
Review
Critical Care Medicine
Joseph T. Patterson, Jacob A. Becerra, Andrew Duong, Haley Nakata, Luke Lovro, Darryl H. Hwang, Nathanael Heckmann
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Clinical Neurology
Ben A. Strickland, Michelle Wedemeyer, Jacob Ruzevick, Alexander Micko, Shane Shahrestani, Siamak Daneshmand, Mark S. Shiroishi, Darryl H. Hwang, Frank Attenello, Thomas Chen, Gabriel Zada
Summary: This study describes the surgical experience and patient outcomes of 5-ALA-enhanced fluorescence-guided resection of high-grade glioma using endoscopic blue light visualization. The authors found that the blue light endoscope is a feasible and ergonomically favorable platform for optimizing tumor fluorescence detection during HGG resection.
JOURNAL OF NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bino Varghese, Steven Cen, Haris Zahoor, Imran Siddiqui, Manju Aron, Akash Sali, Suhn Rhie, Xiaomeng Lei, Marielena Rivas, Derek Liu, Darryl Hwang, David Quinn, Mihir Desai, Ulka Vaishampayan, Inderbir Gill, Vinay Duddalwar
Summary: CT radiomic signatures can accurately identify tumors with high CD8-T cell infiltration and positive PD-L1 expression in patients with ccRCC.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2022)
Correction
Endocrinology & Metabolism
Anny H. Xiang, Mayra P. Martinez, Enrique Trigo, Kristina M. Utzschneider, Melanie Cree-Green, Silva A. Arslanian, David A. Ehrmann, Sonia Caprio, Passant H. I. H. Mohamed, Darryl H. Hwang, Elizabeth Beale, Namir Katkhouda, Krishna S. Nayak, Thomas A. Buchanan