Article
Neurosciences
Rajtarun Madangopal, Leslie A. Ramsey, Sophia J. Weber, Megan B. Brenner, Veronica A. Lennon, Olivia R. Drake, Lauren E. Komer, Brendan J. Tunstall, Jennifer M. Bossert, Yavin Shaham, Bruce T. Hope
Summary: The study demonstrates that following discrimination training during abstinence, DS+ and DS- can independently control the expression and suppression of cocaine seeking. It is found that the infralimbic subregion of the medial prefrontal cortex plays a critical role in driving the relapse to cocaine seeking after prolonged abstinence.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Xin-Yue Wang, Wen-Bin Jia, Xiang Xu, Rui Chen, Liang-Biao Wang, Xiao-Jing Su, Peng-Fei Xu, Xiao-Qing Liu, Jie Wen, Xiao-Yuan Song, Yuan-Yuan Liu, Zhi Zhang, Xin-Feng Liu, Yan Zhang
Summary: This study reveals a pathway involving vesicular glutamate transporter 3 neurons and dopamine neurons that plays a crucial role in chronic pain and comorbid anhedonia-like behavior. Chronic neuropathic pain dampens the transmission of glutamate and the neural excitability in this pathway. Activation of this pathway can alleviate pain and comorbid anhedonia-like behavior, while inhibition of this pathway leads to pain-like reflexive hypersensitivity and anhedonia-like behavior.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Summary: In this study, researchers found that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behavior in mice.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Man-yi Jing, Xiao-yan Ding, Xiao Han, Tai-yun Zhao, Min-min Luo, Ning Wu, Jin Li, Rui Song
Summary: This study found that cue-induced reinstatement of reward seeking is partially mediated by activation of the dopaminergic pathway from the VTA to the NAcore. In a mouse model, activation of this pathway triggered reinstatement of drug-seeking behavior, while inhibition of this pathway suppressed reinstatement behavior.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Felix P. Mayer, Hideki Iwamoto, Maureen K. Hahn, Gregory J. Grumbar, Adele Stewart, Yulong Li, Randy D. Blakely
Summary: The study demonstrates that moving animals from a recording chamber back to a familiar or clean cage triggers dopamine release, showing a similar effect to cocaine injection in the recording chamber. This suggests that returning to a home-like environment can result in DA release, indicating a rewarding stimulus. The findings provide insights into the reward circuitry and offer potential for studying anhedonic states and developing new treatments for mood disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Cell Biology
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wang
Summary: Withdrawal from chronic opioid use leads to hypodopaminergic states and negative affect, promoting relapse. Activation of MORs in dMSNs in the striatal patch compartment suppresses striatopallidal transmission, and withdrawal potentiated this transmission. Fentanyl self-administration enhances striatonigral transmission and reduces dopaminergic activity, while activated striatal neurons mediate contextual memory retrieval. Inhibition of striatal MOR+ neurons rescues fentanyl withdrawal-induced physical symptoms and anxiety-like behaviors. These findings suggest that chronic opioid use induces GABAergic striatopallidal and striatonigral plasticity, leading to hypodopaminergic states and relapse.
Editorial Material
Biochemistry & Molecular Biology
Jingyi Chen, Michael Bruchas
Summary: The study demonstrates that dopamine signaling in the nucleus accumbens core encodes saliency during reinforcement learning in mice.
Article
Cell Biology
Ryota Imai, Keita Mizuno, Yuji Omiya, Kazushige Mizoguchi, Yuko Maejima, Kenju Shimomura
Summary: The study suggests that ninjin'yoeito (NYT) may modulate appetite and motivational behaviors by influencing the activity of dopaminergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc), as well as medium spiny neurons in the nucleus accumbens (NAc).
Review
Biochemistry & Molecular Biology
Yu Liu, Gavan P. McNally
Summary: Dopamine plays a crucial role in relapse to drug seeking, with different forms of relapse being driven by distinct dopamine mechanisms. Understanding the diverse dopamine pathways involved in relapse behaviors is essential for developing effective strategies to prevent relapse.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Rusty W. Nall, Jasper A. Heinsbroek, Todd B. Nentwig, Peter W. Kalivas, Ana-Clara Bobadilla
Summary: Studies on the neurobiological underpinnings of substance use disorder (SUD) have revealed specific brain regions necessary for behaviors driven by drugs versus natural rewards. While many brain regions are involved in behaviors motivated by all types of rewards, certain interconnected regions are selectively necessary for drug-seeking behaviors. Further research is needed to clarify the distinct roles of these brain regions in drug- versus natural reward-associated behaviors.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biology
Jessica N. Goedhoop, Bastijn J. G. van den Boom, Rhiannon Robke, Felice Veen, Lizz Fellinger, Wouter van Elzelingen, Tara Arbab, Ingo Willuhn
Summary: This study systematically investigates the role of dopamine in processing aversive stimuli and finds that NAC dopamine primarily tracks the prediction and duration of aversive events, rather than aversive prediction errors.
Article
Neurosciences
Vivian C. Chioma, Anna Kruyer, Ana-Clara Bobadilla, Ariana Angelis, Zachary Ellison, Ritchy Hodebourg, Michael D. Scofield, Peter W. Kalivas
Summary: This study found that heroin-associated cues transiently increased MMP-9 activity around D1-MSNs, while extinction training induced long-lasting increases in MMP-2 activity around D2-MSNs. Moreover, heroin cues also increased tissue inhibitor of metalloproteinases (TIMP-1,2) which temporarily inhibited MMP-2 activity around D2-MSNs during cue-induced heroin seeking. The differential regulation of heroin seeking and extinguished seeking by different MMP subtypes on distinct cell populations emphasizes the importance of MMP-2,9 activity in heroin-induced cell-specific synaptic plasticity.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Cajsa Aranaes, Christian E. Edvardsson, Olesya T. Shevchouk, Qian Zhang, Sarah Witley, Sebastian Blid Skoeldheden, Lindsay Zentveld, Daniel Valloef, Maximilian Tufvesson-Alm, Elisabet Jerlhag
Summary: This study found that glucagon-like peptide1 receptor (GLP-1R) agonists can reduce alcohol intake and prevent relapse in rodents. The results also showed that semaglutide has a suppressive effect on alcohol-induced behavior and its impact on the brain. These findings suggest that semaglutide may be effective in reducing alcohol consumption and body weight by reducing the rewarding effects of alcohol and its impact on neurons.
Article
Multidisciplinary Sciences
Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Taku Nagai, Kiyofumi Yamada, Hiroshi Arima
Summary: This study investigated the role of glucocorticoid receptor signaling in the reward system on the rewarding value of a high-fat diet under restricted caloric stress. Results showed that mice lacking functional GRs in dopaminergic neurons did not exhibit a preference for HFD, in contrast to corticostriatal neuron knockout mice and wild-type mice.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Johann du Hoffmann, Saleem M. Nicola
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Neurosciences
Sara E. Morrison, Vincent B. McGinty, Johann du Hoffmann, Saleem M. Nicola
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Biology
Hala Harony-Nicolas, Maya Kay, Johann du Hoffmann, Matthew E. Klein, Ozlem Bozdagi-Gunal, Mohammed Riad, Nikolaos P. Daskalakis, Sankalp Sonar, Pablo E. Castillo, Patrick R. Hof, Matthew L. Shapiro, Mark G. Baxter, Shlomo Wagner, Joseph D. Buxbaum
Review
Behavioral Sciences
Vincent B. McGinty, Benjamin Y. Hayden, Sarah R. Heilbronner, Eric C. Dumont, Steven M. Graves, Martine M. Mirrione, Johann du Hoffmann, Gregory C. Sartor, Rodrigo A. Espana, E. Zayra Millan, Alexandra G. DiFeliceantonio, Nathan J. Marchant, T. Celeste Napier, David H. Root, Stephanie L. Borgland, Michael T. Treadway, Stan B. Floresco, Jacqueline F. McGinty, Suzanne Haber
BEHAVIOURAL BRAIN RESEARCH
(2011)
Article
Neurosciences
Johann du Hoffmann, James J. Kim, Saleem M. Nicola
JOURNAL OF NEUROPHYSIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Risa Tona, Wenqian Chen, Yoko Nakano, Laura D. Reyes, Ronald S. Petralia, Ya-Xian Wang, Matthew F. Starost, Talah T. Wafa, Robert J. Morell, Kevin D. Cravedi, Johann du Hoffmann, Takushi Miyoshi, Jeeva P. Munasinghe, Tracy S. Fitzgerald, Yogita Chudasama, Koichi Omori, Carlo Pierpaoli, Botond Banfi, Lijin Dong, Inna A. Belyantseva, Thomas B. Friedman
HUMAN MOLECULAR GENETICS
(2019)
Article
Multidisciplinary Sciences
Tae-Un Han, Jessica Root, Laura D. Reyes, Elizabeth B. Huchinson, Johann du Hoffmann, Wang-Sik Lee, Terra D. Barnes, Dennis Drayna
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
F. Messanvi, A. Perkins, J. du Hoffmann, Y. Chudasama
PSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Jun Ma, Johann du Hoffmann, Morgan Kindel, B. Sofia Beas, Yogita Chudasama, Mario A. Penzo
Summary: The study found that in mice, the paraventricular thalamus (PVT) mediates the selection of defensive behaviors by interacting with the central nucleus of the amygdala (CeA) and the nucleus accumbens (NAc), driving passive or active defensive responses respectively. The PVT-CeA pathway drives conditioned freezing responses, while the PVT-NAc pathway signals active avoidance events. Optogenetic manipulations showed that activity in these pathways biases behavior towards passive or active defensive responses, demonstrating the PVT's role in flexible switching between different defensive behaviors.
NATURE NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Patrick Latuske, Moritz von Heimendahl, Serena Deiana, Carsten T. Wotjak, Johann du Hoffmann
Summary: Cognitive flexibility is crucial for healthy functioning and is often impaired in neuropsychiatric diseases. Probabilistic reversal learning (PRL), a commonly used method to measure cognitive flexibility, is often limited in rodents. A novel rat PRL task that occurs at longer intervals demonstrates increased sensitivity to drugs, offering potential for testing and developing novel treatments for cognitive impairment in human patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
J Larson, RE Jessen, D Kim, AKS Fine, J du Hoffmann
JOURNAL OF NEUROSCIENCE
(2005)