期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 30, 页码 10078-10084出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1085-14.2014
关键词
Fourier; Lucifer; intracellular injections; pyramidal cells; spatial distribution
资金
- Ministerio de Economia y Competitividad (Instituto Cajal)
- Ministerio de Economia y Competitividad [GEN2003-20651-C06-06, BFU2006-13395, SAF2009-09394]
- Ministerio de Economia y Competitividad (Cajal Blue Brain Project)
- Spanish Ministry of Science and Innovation [TIN2010-21289, TIN2010-20900-C04-04]
- Spanish Ministry of Science and Innovation (Cajal Blue Brain Project, Spanish partner of the Blue Brain Project initiative from Ecole polytechnique federale de Lausanne)
- European Union [604102]
- National Institute of Neurological Disorders and Stroke [R21NS081393]
- National Institute of Mental Health [R21MH100646, R01MH100561]
- U.S. Army Research Laboratory
- U.S. Army Research Office [W911NF-12-1-0594]
Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell's dendrites along helical paths, perhaps maximizing the probability to contact different axons. To test whether spine helixes also occur in neocortex, we reconstructed >500 dendritic segments from adult human cortex obtained from autopsies. With Fourier analysis and spatial statistics, we analyzed spine position along apical and basal dendrites of layer 3 pyramidal neurons from frontal, temporal, and cingulate cortex. Although we occasionally detected helical positioning, for the great majority of dendrites we could not reject the null hypothesis of spatial randomness in spine locations, either in apical or basal dendrites, in neurons of different cortical areas or among spines of different volumes and lengths. We conclude that in adult human neocortex spine positions are mostly random. We discuss the relevance of these results for spine formation and plasticity and their functional impact for cortical circuits.
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