Article
Behavioral Sciences
Nasya Thompson, Michael MacAskill, Maddie Pascoe, Tim Anderson, Campbell Le Heron
Summary: This study investigates the multidimensional pattern of apathy in individuals with Parkinson's disease (PD) using the Apathy Motivation Index (AMI), which explores behavioral, emotional, and social aspects of apathy. The results show that individuals with PD exhibit higher levels of behavioral and social apathy, but lower levels of emotional apathy. The study also demonstrates the connection between apathy and other non-motor comorbidities such as depression and anxiety. The findings highlight the importance of considering apathy as a multidimensional construct in clinical and research settings.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Lee-Anne Morris, Samuel J. Harrison, Tracy R. Melzer, John C. Dalrymple-Alford, Tim J. Anderson, Michael R. MacAskill, Campbell J. Le Heron
Summary: Morris et al. found that apathy in Parkinson's disease is associated with changes in functional connectivity and structural changes in the nucleus accumbens and anterior cingulate cortex, providing a potential causal pathway to loss of motivation. Their study demonstrates that disruption to key nodes within a network involved in motivated behavior may lead to the development of apathy. These findings suggest the possibility of identifying individuals at risk for apathy before the onset of motivational deficits.
Article
Health Care Sciences & Services
Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney
Summary: Apathy is often overlooked in Parkinson's Disease (PD) but can have a negative impact on quality of life and increase with disease severity. Early identification of apathy can aid in treatment and improve prognosis.
Article
Neurosciences
Linda Margraf, Daniel Krause, Matthias Weigelt
Summary: This study examines the changes in neural feedback processing during the practice of a motor task. Negative feedback elicits more negative responses in the feedback-related negativity, while late fronto-central positivity is associated with complex feedback. Positive feedback activates the P300 more strongly, indicating its significance in updating internal models. After practice, an increase in the P300 amplitude suggests an improved ability to update internal representations based on feedback information.
Article
Psychology, Multidisciplinary
Jennifer A. Foley, Lisa Cipolotti
Summary: Apathy in Parkinson's disease often coexists with depression and anxiety, with pure apathy being rare. Patients with mood disorders perform worse in non-verbal intellectual functioning, while those with apathy do not show additional cognitive losses. This suggests that apathy in PD may be primarily an epiphenomenon of mood disorder.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Victoria Tilton-Bolowsky, Sofia Vallila-Rohter, Yael Arbel
Summary: The study found that more participants adopted an optimal, multi-cue strategy following feedback-based training, suggesting the influence of feedback on learning approach. Additionally, participants using a single feature strategy showed a significant decrease in FRN amplitude, indicating potential differences in feedback utilization or prediction error. Overall, the findings suggest that training method affects learning and feedback processing can reflect changes in learning strategies.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Yifan Sun, Zixuan Huang, Xuezheng Gao, Limin Chen, Jun Wang, Zhenhe Zhou, Hongliang Zhou
Summary: In this study, the neural underpinnings of anhedonia in major depressive disorder (MDD) were explored through the examination of two event-related potential (ERP) components: feedback-related negativity (FRN) and stimulus-preceding negativity (SPN). The study found that MDD patients exhibited lower scores in anhedonia assessment and consistently reduced amplitudes of FRN and SPN compared to healthy controls. Limited correlations were observed between ERP metrics and clinical indicators, except for positive correlations between certain amplitudes and scores. The study suggests a shared impairment in reward feedback processing and anticipatory neural mechanisms in individuals with MDD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Clinical Neurology
Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P. Roiser
Summary: This study found that dopaminergic dysfunction in the midbrain is associated with motivational symptoms such as apathy and anhedonia in Parkinson's disease (PD), and this association becomes evident as the disease progresses. These findings can inform intervention strategies for improving the treatment of PD patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Neurosciences
Britta M. Hinneberg, Mathias Hegele
Summary: This article investigates the impact of reward feedback on reinforcement learning in decision-making tasks. The study finds that the performance and learning impairments due to feedback delay vary depending on the type of task, with implicit processing tasks being more affected. However, the feedback-related negativity, an event related potential in the electroencephalogram, is similarly affected by feedback delay regardless of task type. The article suggests a common explanatory approach for both behavioral and electrophysiological findings, envisioning implicit and explicit processing as opposite ends on a continuum determined by feedback delay.
Article
Geriatrics & Gerontology
Ruwei Ou, Yanbing Hou, Kuncheng Liu, Junyu Lin, Zheng Jiang, Qianqian Wei, Lingyu Zhang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
Summary: The frequency of fatigue in early Parkinson's disease patients slightly changed over a 3-year follow-up period, with patterns similar to anxiety. Fatigue was significantly associated with nocturnal sleep disorders, high Hamilton Anxiety Rating Scale score, and high Unified PD Rating Scale III score. High baseline UPDRS III score increased the risk of developing fatigue after 1 year, while high LEDD and HAMA score increased the risk after 3 years.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Meixue Jia, Aili Wang, Li Sui
Summary: The processing of feedback is crucial for learning, error detection, and correction, but the underlying mechanisms of its characteristics are not fully understood. This study investigated the effects of feedback reliability and responses on brain activity using event-related potentials. The findings suggest that different ERP components reflect distinct cognitive processes, with some associated with responses and others associated with feedback reliability and expectations.
Review
Neurosciences
Cristina del Toro Perez, Laura Amaya Pascasio, Antonio Arjona Padillo, Jesus Olivares Romero, Maria Victoria Mejias Olmedo, Javier Fernandez Perez, Manuel Payan Ortiz, Patricia Martinez-Sanchez
Summary: Literature research demonstrates that brainstem raphe hypoechogenicity is related to depression in both PD and non-PD patients, as well as overactive bladder. Substantia nigra hyperechogenicity is common in patients with visual hallucinations, and larger intracranial ventricles are correlated with dementia. The evaluation of the vagus nerve shows contradictory findings.
Review
Neurosciences
Segolene De Waele, Patrick Cras, David Crosiers
Summary: This article summarizes the research findings on apathy in Parkinson's disease, discusses the prevalence rates and screening tools, formulates patient-tailored treatment recommendations, and explores the clinical manifestations and prognosis of the Park apathy phenotype. It aims to provide a clinical and patient-oriented perspective on the vast theoretical knowledge available.
Article
Geriatrics & Gerontology
Jiang-ting Li, Yi Qu, Hong-ling Gao, Jing-yi Li, Qi-xiong Qin, Dan-lei Wang, Jing-wei Zhao, Zhi-juan Mao, Zhe Min, Yong-jie Xiong, Zheng Xue
Summary: Abnormal iron metabolism is associated with apathy in Parkinson's disease (PD), especially among men. A nomogram was constructed to predict apathetic patients with PD by incorporating age, sex, serum iron concentration, total iron binding capacity (TIBC), and Hamilton Depression Rating Scale (HAMD) scores. The nomogram showed good discrimination and calibration, providing an effective tool for predicting apathy in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Qiang Shen, Lian Zhu, Liang Meng, Wenwei Qiu, Qingguo Ma, Richard P. Ebstein, Jia Jin
Summary: Motivation is a key topic in research, with studies showing the interaction between intrinsic and extrinsic motivations in individual decision making. While the role of external social factors in intrinsic motivation remains unclear, this study uses electrophysiological measurements to demonstrate the importance of social information in shaping success-failure outcomes in motivated decision-making.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Saul Martinez-Horta, Clara Naima Marzal-Espi, Silvia Cuso-Garcia, Ignacio Aracil-Bolanos, Jaime Kulisevsky
Summary: A previously healthy woman presented with rapidly progressive neuropsychological deficits, characterized by reduplicative paramnesia and structured visual hallucinations. Initially misdiagnosed as vascular dementia, MRI revealed findings consistent with Heidenhain Variant of Creutzfeldt-Jakob disease.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Josep Gamez, Matilde Calopa, Esteban Munoz, Aileen Ferre, Oscar Huertas, Kevin McAllister, Nuria Reig, Catherine Scart-Gres, Raul Insa, Jaime Kulisevsky
Summary: The aim of this study was to investigate the efficacy and safety of SOM3355 as a repositioned treatment for reducing chorea in Huntington's disease. The results showed that SOM3355 reduced chorea in HD patients and was well-tolerated. Larger studies are needed to confirm its therapeutic utility as an antichoreic drug.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Frederic Sampedro, Arnau Puig-Davi, Saul Martinez-Horta, Javier Pagonabarraga, Andrea Horta-Barba, Ignacio Aracil-Bolan, Jaime Kulisevsky
Summary: Cognitive and neuropsychiatric symptoms in Parkinson's disease reflect cortical degeneration, and intracortical diffusivity can detect symptom-specific cortical microstructural damage.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Letter
Clinical Neurology
Saul Martinez-Horta, Ignacio Aracil-Bolanos, Jesus Perez-Perez, Laura Perez-Carasol, Julia Garcia-Cornet, Antonia Campolongo, Juan Angel Aibar-Duran, Rodrigo Rodriguez-Rodriguez, Berta Pascual-Sedano, Jaime Kulisevsky
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Pedro Renato de Paula Brandao, Danilo Assis Pereira, Talyta Cortez Grippe, Diogenes Diego de Carvalho Bispo, Fernando Bisinoto Maluf, Marcia Pereira Yunes, Gilberto Nunes Filho, Candida Helena Lopes Alves, Javier Pagonabarraga, Jaime Kulisevsky, Andressa Matos Luiz da Costa, Cristiano Franco do Val Serafim, Ana Carolina da Bouza Ferreira, Arthur de Melo Monteiro Bastos, Ana Clara Fernandes Belchior, Beatriz Luna Coutinho de Almeida, Brenda Macedo de Almeida e Castro, Matheus Sampaio Matos, Rodrigo Cardoso de Matos, Gabriel de Almeida Rios, Lorena Oliveira Carneiro, Bianca Christie Costa da Mota, Lucas Ernesto do Rego Castro, Vitoria Luisa Silveira Rocha, Maria Clotilde Henriques Tavares, Francisco Cardoso
Summary: This study investigated the reliability, validity, normative data, and accuracy of the PD-CRS for screening PD-MCI in Brazil. The PD-CRS showed good internal consistency and construct validity in the Brazilian context. Age and education level influenced PD-CRS scores, highlighting the importance of considering educational and cultural heterogeneity in cognitive testing.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Saul Martinez-Horta, Jesus Perez-Perez, Javier Oltra-Cucarella, Frederic Sampedro, Andrea Horta-Barba, Arnau Puig-Davi, Javier Pagonabarraga, Jaime Kulisevsky
Summary: There are different types of cognitive decline progression in patients with Huntington's disease, namely a slow progression group and an aggressive progression group. The aggressive group shows a more pronounced loss of functionality and a marked deterioration in motor and psychiatric symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Panceiras, Iago Garcia Diaz, Maria Cristina Iniguez Alvarado, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed the frequency of suicidal ideation and its related factors in Parkinson's Disease patients and compared them with a control group. The results showed no significant differences in suicidal ideation between the two groups. However, depression, poor quality of life, and comorbidity were associated with suicidal ideation.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Clinical Neurology
Wolfgang H. Jost, Jaime Kulisevsky, Peter A. LeWitt
Summary: Parkinson's disease (PD) is a neurodegenerative disorder that causes the degeneration of dopaminergic neurons, leading to a wide range of motor and non-motor symptoms. Oral levodopa remains the most effective treatment for symptomatic relief in PD, but over time, motor complications such as Off episodes can occur. Inhaled levodopa powder has been approved as an innovative on-demand therapy to treat Off episodes in PD patients receiving oral levodopa, providing a predictable and fast treatment effect. Clinical studies have shown significant improvement in motor symptoms with the use of inhaled levodopa powder.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Neurosciences
Andrea Horta-Barba, Saul Martinez-Horta, Frederic Sampedro, Jesus Perez-Perez, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study aimed to explore the performance and neural correlates of arithmetic deficits in individuals with pre-manifest and early symptomatic Huntington's disease (HD). The results revealed that lower arithmetic performance in HD participants was associated with reduced gray-matter volume and metabolic dysfunction, while in preHD individuals, it was associated with prefrontal alterations. These findings suggest that cognitive deficits in HD involve not only frontal-striatal dysfunctions but also fronto-temporal and parieto-occipital damage.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Jaime Kulisevsky, Saul Martinez-Horta, Antonia Campolongo, Berta Pascual-Sedano, Juan Marin-Lahoz, Helena Bejr-kasem, Jose L. Labandeira-Garcia, Jose L. Lanciego, Arnau Puig-Davi, Andrea Horta-Barba, Javier Pagonabarraga, Jon Rodriguez-Antiguedad
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Gonzalo Olmedo-Saura, Jesus Perez-Perez, Tomas Xucla-Ferrarons, Roger Collet, Ana Martinez-Viguera, Jaime Kulisevsky
Summary: This study reports three cases of cerebellar syndrome (CS) due to hypomagnesemia, with MRI findings of cerebellar vasogenic edema and symptomatic improvement after magnesium replacement. A literature review of 22 cases showed a subacute onset of symptoms, common encephalopathy and/or epileptic seizures, and MRI findings of vasogenic edema in the cerebellar hemispheres, vermis, or nodule. Early recognition and treatment of hypomagnesemia can avoid recurrences and permanent cerebellar impairment.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Jaime Kulisevsky, Cristian Falup-Pecurariu, Patrick Santens, Wolfgang H. H. Jost
Summary: Managing advanced Parkinson's disease requires education, support, and specialized outpatient care involving various healthcare professionals. Knowledge about existing therapies is important for general neurologists and professionals working with Parkinson's disease patients. Movement disorders specialists and PD nurses play a key role in coordinating a multidisciplinary approach. Access to these therapies remains a challenge, and education and support for stakeholders may improve quality of life.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Behavioral Sciences
Daniel Collerton, James Barnes, Nico J. Diederich, Rob Dudley, Dominic Ffytche, Karl Friston, Christopher G. Goetz, Jennifer G. Goldman, Renaud Jardri, Jaime Kulisevsky, Simon J. G. Lewis, Shigetoshi Naral, Claire O'Callaghan, Marco Onofrj, Javier Pagonabarraga, Thomas Parr, James M. Shine, Glenn Stebbins, John-Paul Taylor, Ichiro Tsuda, Rimona S. Weil
Summary: Despite years of research, it remains uncertain why people sometimes perceive things that aren't there. Eight models of complex visual hallucinations have been proposed since 2000, each based on different understandings of brain organization. To address this variability, researchers established an integrated Visual Hallucination Framework that aligns with current theories of veridical and hallucinatory vision, enabling a systematic investigation of the relationship between hallucination phenomenology and cognitive structures. The episodic nature of hallucinations suggests a complex relationship between state and trait markers, highlighting new avenues for research and potential approaches to treating distressing hallucinations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)