Article
Immunology
Linlin Zhang, Sangsu Bang, Qianru He, Megumi Matsuda, Xin Luo, Yong-Hui Jiang, Ru-Rong Ji
Summary: Excessive inflammation is linked to autism spectrum disorder (ASD), and mutations of the synaptic scaffolding protein SHANK3 are involved in ASD. In this study, it was found that Shank3 deficiency aggravates hypothermia, systemic inflammation, and sepsis mortality induced by lipopolysaccharide (LPS) in mice. Shank3 regulates body temperature, inflammation, and sepsis in vagal sensory neurons.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Ezidin G. Kaddumi, AbdulFattah S. Fararjeh, Manal Udwan
Summary: Although there is increasing evidence concerning urinary bladder innervation by vagal afferents, the functional aspects and conditions at which these afferents are recruited are still unclear. In this study, the neuronal responses of nodose ganglion were investigated following cystometry under different models of urinary bladder irritation. The results demonstrate the innervation of vagus afferents to the urinary bladder and suggest a possible role of the vagus nerve during urinary bladder pathology.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Simon Hoffman, Danielle Alvares, Khosrow Adeli
Summary: This study demonstrates that GLP-1 modulates intestinal lipid absorption and metabolism through the vagal gut-brain-liver axis, with its effects depending on intact afferent vagal signaling and changes in sympathetic tone. GLP-1R agonism in the nodose ganglia significantly reduces lipid levels, and loss of this pathway results in the loss of anti-lipemic effects of GLP-1.
MOLECULAR METABOLISM
(2022)
Article
Anatomy & Morphology
Safdar Jawaid, Amanda Herring, Paulina M. Getsy, Stephen J. Lewis, Michiko Watanabe, Hana Kolesova
Summary: Vagal afferents regulate various physiological functions and stimulation of nodose ganglia by infrared light may involve temperature-sensitive TRP ion channels. The spatial localization of six TRP channels, including TRPV1, TRPV4, TRPM3, TRPM8, TRPA1, and TRPC1, was detected in nodose ganglia, with different patterns of expression and subcellular localization. The presence of these TRP channels in nodose ganglia provides a basis for further studies on their roles in sensory transmission and responses to stimuli such as exposure to infrared light.
JOURNAL OF ANATOMY
(2022)
Article
Endocrinology & Metabolism
Esmira Mamedova, Oksana Dmytriyeva, Jens C. Rekling
Summary: Research has found that thyrotropin-releasing hormone (TRH) can activate a small group of neurons in the nodose ganglion, involving Gq signaling pathways, which may play a role in gut-brain signaling.
Article
Neuroimaging
Helena Alicart, Marcus Heldmann, Martin Goettlich, Martina A. Obst, Marc Tittgemeyer, Thomas F. Muente
Summary: This project investigates the modulation of food intake by non-invasive stimulation of the vagus nerve. Results show that electrical stimulation of the vagus nerve affects food image processing.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Anna Carolyna L. Gianlorenco, Paulo S. de Melo, Anna Marduy, Angela Yun Kim, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
Summary: Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive stimulation method that shows potential therapeutic benefits. This study conducted a systematic review on the effects of taVNS on EEG measures, finding that it increases activity in lower frequency bands and alters early components related to inhibitory tasks. Further research is needed to establish specific effects and metrics.
Review
Nutrition & Dietetics
Allison W. Rautmann, Claire B. de la Serre
Summary: The gut microbiota plays a key role in modulating host physiology and behavior, particularly in relation to feeding behavior, energy balance, and obesity. Changes in microbiome composition due to diet can lead to weight gain, adiposity, and alterations in ingestive behavior. Research is focused on understanding the role of the microbiome in the development of obesity and using microbiome manipulation to reduce food intake and promote weight loss.
Article
Chemistry, Multidisciplinary
Ji-hwan Kim, Dong-seok Lee, Soon-kak Kwon
Summary: This paper proposes a method to classify food types and estimate meal intake amounts using a deep learning object detection network. The food types and regions are detected through Mask R-CNN. The post-meal image is corrected to match the capturing environment of the pre-meal image. The 3D shape of the food is determined based on its type, and the meal intake amount is estimated by comparing the food volume in pre- and post-meal images. Simulation results show high accuracy in food classification and region detection, with accuracies up to 97.57% and 93.6%, respectively.
APPLIED SCIENCES-BASEL
(2023)
Article
Nutrition & Dietetics
Jayna M. Dave, Tzuan A. Chen, Maha Almohamad, Sonia Cotto-Moreno
Summary: This study evaluated the changes in children's dietary behaviors at childcare centers in Houston and San Antonio, Texas, after the implementation of the new CACFP meal pattern requirements. The results showed improvements in the consumption of several nutrients and food groups, particularly whole grains, milk, and juice.
Review
Pharmacology & Pharmacy
Diana L. Williams
Summary: GLP-1 receptors in the brain influence feeding behavior through various mechanisms, including suppressing appetite, inhibiting food reward motivation, inducing nausea, and reducing stress-induced hypophagia, but many questions about the organization of this system remain unanswered.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Fisheries
Jessica Calo, Marta Conde-Sieira, Sara Comesana, Jose L. Soengas, Ayelen M. Blanco
Summary: This study demonstrates the presence of a gut-brain axis in fish, as different types and lengths of fatty acids impact feed intake and appetite-regulatory centers in rainbow trout. The findings have important implications for aquaculture due to variations in fatty acid composition in aquafeeds.
Review
Psychology, Biological
Daniel Gero, Marco Bueter
Summary: This invited review presents the findings of two recent studies on changes in ingestive behavior following bariatric surgery (BS). The first study focuses on the long-term changes in daily calorie and fat intake in rodents undergoing Roux-en-Y gastric bypass (RYGB), while the second study examines postbariatric changes in meal size using longitudinal data from RYGB patients. The results highlight the role of ingestive adaptation and learning in achieving reduced calorie intake and weight loss after RYGB.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Nutrition & Dietetics
Laura M. Koenig, Julia E. Koller, Karoline Villinger, Deborah R. Wahl, Katrin Ziesemer, Harald T. Schupp, Britta Renner
Summary: This study found that the perception of meal colour variety was positively related to vegetable consumption across different meal types, while it was negatively associated with sweets consumption for breakfast, dinner, and snacks. These results suggest that choosing meals with a variety of colours may be a promising strategy to promote a healthier diet.
Article
Physiology
Edward A. Fox, Jessica E. Biddinger, Zachary C. Baquet, Kevin R. Jones, Jennifer McAdams
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2013)
Article
Neurosciences
E. A. Fox, J. E. Biddinger, K. R. Jones, J. McAdams, A. Worman
Article
Psychology, Biological
Jessica E. Biddinger, Edward A. Fox
PHYSIOLOGY & BEHAVIOR
(2010)
Article
Psychology, Biological
Edward A. Fox, Jessica E. Biddinger
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Biology
Jessica E. Biddinger, Roman M. Lazarenko, Michael M. Scott, Richard Simerly
Article
Multidisciplinary Sciences
Yu Yong, Isin Cakir, Pauline Lining Pan, Jessica E. Biddinger, Rebecca J. Bluett, Ken Mackie, Nathan Bingham, Sachin Patel, Masoud Ghamari-Langroudi
Summary: This passage discusses the importance of hypothalamic regulation of feeding and energy expenditure, as well as the roles of melanocortins and endogenous cannabinoids in these processes. The study shows that 2-AG regulates MC4R cell activity by inhibiting GABA input, impacting energy state, body weight, appetite, and energy expenditure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)