Article
Neurosciences
Sheng-Tao Yang, Min Wang, Veronica Galvin, Yang Yang, Amy F. T. Arnsten
Summary: The effects of mGluR5 antagonist MTEP on cognitive performance in aging rhesus monkeys with naturally occurring impairments were examined. It was found that MTEP had mixed effects on neuronal firing and cognitive performance, with low doses enhancing task-related firing but higher doses suppressing firing. Co-administration of mGluR5 PAM CDPPB blocked the beneficial effects of MTEP in some monkeys, indicating opposing actions at pre- vs. post-synaptic mGluR5 in dlPFC. Future clinical trials should consider low doses and potential subgroup responders.
PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Sihai Li, Christos Constantinidis, Xue-Lian Qi
Summary: The study investigated the roles of the dorsolateral prefrontal cortex and posterior parietal cortex in working memory, finding that neuronal activity can predict categorical judgments of information and deviations in firing rates reflect the contents of working memory.
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Youngsun T. Cho, Flora Moujaes, Charles H. Schleifer, Martina Starc, Jie Lisa Ji, Nicole Santamauro, Brendan Adkinson, Antonija Kolobaric, Morgan Flynn, John H. Krystal, John D. Murray, Grega Repovs, Alan Anticevic
Summary: This study investigated how reward and loss impact spatial working memory precision and neural circuits in human subjects. The results showed that both reward and loss improved spatial working memory precision, with specific regions like precentral sulcus and intraparietal sulcus having increased BOLD signal related to better working memory precision. Conversely, areas straddling executive networks displayed decreased BOLD signal during incentivized working memory.
Article
Neurosciences
Craig W. Berridge, David M. Devilbiss, Andrea J. Martin, Robert C. Spencer, Rick L. Jenison
Summary: Goal-directed behavior relies on neuronal activity in the prefrontal cortex (PFC) and extended frontostriatal circuitry. Stress impairs frontostriatal-dependent cognition, but the underlying neural mechanisms are not well understood. This study investigated the effects of acute noise-stress on neural activity and connectivity within cognition-related frontostriatal circuitry in rats. The results showed that stress suppressed neuronal responses and disrupted neural coding and functional connectivity during a spatial working memory task, providing insights into the cognitive impairing effects of stress.
Article
Multidisciplinary Sciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Chenjie Shen, Keith M. Skaggs, Yuanyuan Hou, Morgan Fleishman, Olivia Mosto, Alyssa Weninger, Guoping Feng
Summary: A specific region of the anterior thalamic nuclei plays a key role in spatial working memory tasks in aged mice, and targeting this region may be more beneficial for cognitive functions with fewer unintended effects compared to direct manipulation of the prefrontal cortex. Activation of neurons or circuits in this region can improve working memory, while direct activation of prefrontal cortex neurons may lead to increased anxiety levels in aged mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neuroimaging
Prerona Mukherjee, Tadeus Hartanto, Ana-Maria Iosif, J. Faye Dixon, Stephen P. Hinshaw, Murat Pakyurek, Wouter van den Bos, Amanda E. Guyer, Samuel M. McClure, Julie B. Schweitzer, Catherine Fassbender
Summary: Working memory deficits are important in ADHD, but they are not universal and may vary based on different components of working memory capacity. Complex working memory operations may be impaired in ADHD compared to simpler operations, and there are differences in neural activation between ADHD and neurotypical individuals under higher loads and greater complexity.
NEUROIMAGE-CLINICAL
(2021)
Article
Multidisciplinary Sciences
Clement M. Garin, Marie Garin, Leonardo Silenzi, Rye Jaffe, Christos Constantinidis
Summary: The size of the prefrontal cortex in humans is not disproportionately enlarged compared to other catarrhini species. However, humans have the most relatively enlarged frontal and parietal lobes in an infraorder exhibiting a disproportionate expansion of these areas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Charalampos Papadimitriou, Charles D. Holmes, Lawrence H. Snyder
Summary: The study finds that the dynamics of memory cells during spatial memory periods are more complex than previously thought. They suggest that memory may be supported by multiple attractor networks working in parallel, with each network having its own characteristic mean turn-off time that gradually frees up mnemonic resources over time.
Article
Neurosciences
Megan Roussy, Benjamin Corrigan, Rogelio Luna, Roberto A. Gulli, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujilio
Summary: The study found that LPFC neurons maintain robust and distinct neural codes for mnemonic and perceptual visuospatial representations during naturalistic vision, with animals using different behavioral strategies for working memory and perception tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Scott L. Brincat, Jacob A. Donoghue, Meredith K. Mahnke, Simon Kornblith, Mikael Lundqvist, Earl K. Miller
Summary: Research shows that visual working memory storage is largely independent between the left and right cerebral hemispheres, but memory integration involves transfer and convergence across hemispheres. During memory transfer, synchronization between the two hemispheres peaks at specific frequencies, facilitating the transfer of memory traces.
Article
Neurosciences
Xiaoyu Ma, Charles Zheng, Yenho Chen, Francisco Pereira, Zheng Li
Summary: The ability to perceive and locate spatial environments is crucial for animal survival. The medial prefrontal cortex (mPFC) has been implicated in spatially related behaviors, but its properties and how it is influenced by animal behavior are not well-defined. This study found that the population activity of mPFC neurons can predict animal locations, and this coding accuracy is higher in tasks involving working memory and reward-seeking.
Article
Geriatrics & Gerontology
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Summary: Age-related declines in cognition, especially in working memory and executive function, are mediated by the prefrontal cortex and the dopamine system within it. Administering the DA D1 R agonist PF-6294 to aged female rhesus monkeys improved memory span on the Delayed Recognition Span Task, particularly on repeated trials.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Noriki Yamaya, Kenji Tsuchiya, Ibuki Takizawa, Kaori Shimoda, Kazuki Kitazawa, Fusae Tozato
Summary: This study found that FAM can increase WMC and activate the bilateral DLPFC during the intervention, while the control group showed a decrease in WMC and no activation of the DLPFC. A correlation was found between the increase in WMC and the activation of the bilateral DLPFC among all participants.
BRAIN AND BEHAVIOR
(2021)
Article
Biology
Liping Yu, Jiawei Hu, Chenlin Shi, Li Zhou, Maozhi Tian, Jiping Zhang, Jinghong Xu
Summary: The study demonstrates the essential role of auditory cortex in information encoding and maintenance during an auditory working memory task, particularly in the early delay period.
Review
Neurosciences
Masaki Tanaka, Jun Kunimatsu, Tomoki W. Suzuki, Masashi Kameda, Shogo Ohmae, Akiko Uematsu, Ryuji Takeya
Summary: The cerebellum plays a crucial role in movement control and temporal prediction, exhibiting preparatory activity and time tracking mechanisms. It provides more accurate temporal information than the striatum and generates signals that regulate movement timing in the cerebral cortex.
Article
Multidisciplinary Sciences
Takeshi D. Itoh, Ryuji Takeya, Masaki Tanaka
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Ayano Matsushima, Ann M. Graybiel
Article
Neurosciences
Kei Matsuyama, Masaki Tanaka
Summary: Neurons in the central thalamus were found to exhibit different types of responses to repetitive stimuli, including sensory adaptation, increasing suppressive response, and switching activity. Switch-type neurons showed a correlation between their activity before stimulus omission and behavioral latency, suggesting a more advanced role in detecting stimulus omission. These findings imply that the central thalamus may play a crucial role in transmitting integrated signals for temporal information processing in predicting rhythmic event timing accurately.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Ann M. Graytie, Ayano Matsushima
Article
Neurosciences
Ryo Sawagashira, Masaki Tanaka
Summary: This study developed a novel behavioral paradigm to assess the impact of low-dose ketamine on various components of working memory in monkeys. It was found that memory capacity and utility rate were significantly reduced after ketamine administration, while memory decay remained largely unchanged. This suggests that the behavioral deficits observed during NMDA receptor blockade may be primarily attributed to decreased utilization of short-term memory.
Article
Multidisciplinary Sciences
Ryuji Takeya, Shuntaro Nakamura, Masaki Tanaka
Summary: By training monkeys to perform predictive saccades synchronized with visual stimuli, two types of motor segmentation were identified during synchronized movements: one related to the hierarchical organization of sequential movements and the other related to the spontaneous grouping of rhythmic events.
Article
Neurosciences
Tomoki W. Suzuki, Ken-Ichi Inoue, Masahiko Takada, Masaki Tanaka
Summary: The study shows that cortical feedback inputs play a role in modulating neuronal activity in the motor thalamus during goal-directed behavior, especially in primates. Optical stimulation influences thalamic neuron activity, with task-specific effects and non-task-specific changes observed.
Article
Neurosciences
Akiko Uematsu, Masaki Tanaka
Summary: The study investigates the role of the cerebellum in temporal information processing. Neurons in the cerebellar dentate nucleus exhibit periodic activity predicting stimulus timing. The relative contribution of signals from different sources to the periodic activity is assessed through pharmacological experiments. The results suggest that inputs from the cerebellar cortex contribute to the predictive neuronal activity in the dentate nucleus.
Correction
Cell Biology
Ayano Matsushima, Ann M. Graybiel
Article
Multidisciplinary Sciences
Ken-ichi Okada, Ryuji Takeya, Masaki Tanaka
Summary: This study investigated the response properties of cerebellar cells in macaques performing synchronized saccades and identified three groups of cerebellar neurons with distinct response profiles. One-third of the neurons were active regardless of saccade direction and showed greater activity for synchronized saccades. The activity of these neurons corresponded to the internal rhythmic structure rather than specific motor commands.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Ryo Sawagashira, Masaki Tanaka
Summary: The study examined the effects of AChR-related agents on working memory (WM) and eye movements during an oculomotor foraging task. Results showed that nicotine and mecamylamine significantly increased the utility of short-term memory, while the muscarinic AChR-related agents had no effect on any WM parameters. The findings suggest that nicotine improves visual search by enhancing the utility of short-term memory, with minimal changes in oculomotor parameters.
PSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriakitsa Galani, Julio Mantero, Geoffrey Tombaugh, Manolis Kellis, Myriam Heiman, Ann M. Graybiel
Summary: In human and mouse models of Huntington's disease, the two defining axes of striatal projection neurons are mixed and differentially affected. The indirect-pathway striatal projection neurons are the most depleted in human patients, while the transcriptomic distinctiveness of striosome-matrix neurons is diminished more in mouse models. The loss of striosome-matrix distinction is more prominent within the indirect-pathway neurons, suggesting the need for distinct therapeutic strategies based on the differential compromise of these two axes.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Masashi Kameda, Koichiro Niikawa, Akiko Uematsu, Masaki Tanaka
Summary: Both the cerebellum and basal ganglia play important roles in rhythm processing, but their specific functions are still unclear. Neurons in both areas exhibit periodic activity during rhythm perception, with the cerebellum involved in multiple stages from sensory prediction to motor control, and the basal ganglia consistently involved in motor preparation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Tomoki W. Suzuki, Masaki Tanaka
COMMUNICATIONS BIOLOGY
(2019)