Review
Cell Biology
Grzegorz Wiera, Jerzy W. Mozrzymas
Summary: Long-term synaptic plasticity is regulated by the controlled reorganization of the synaptic proteome, including the crucial role of extracellular matrix metalloproteinases (MMPs) such as MMP9 and MMP3 in excitatory synapses. These enzymes are also implicated in memory, learning deficits, and psychiatric disorders. Research into the role of extracellular proteolysis in inhibitory synapses is just beginning.
Article
Neurosciences
Maithe Loisy, Guillaume Bouisset, Sebastien Lopez, Maud Muller, Alena Spitsyn, Jeanne Duval, Rebecca Ann Piskorowski, Laure Verret, Vivien Chevaleyre
Summary: This study reveals a novel inhibitory plasticity mediated by cannabinoid type 1 receptor activation (CB1R-iLTD) in the CA2 region of the hippocampus, which plays a crucial role in social memory formation. The study also demonstrates that the previous induction of Delta-opioid receptor-mediated long-term depression (DOR-iLTDs) is necessary for the CB1R-iLTD to occur. The findings provide insights into the interplay between inhibitory plasticities and a new mechanism for social memory formation.
Article
Multidisciplinary Sciences
Sadra Sadeh, Claudia Clopath
Summary: The study shows that different types of neural network structures can influence the formation and dynamics of assemblies. Networks with dominant excitatory interactions enable fast assembly formation but may lead to some degree of non-specific induction, while networks with strong excitatory-inhibitory interactions ensure that assembly formation is constrained to perturbed neurons only, albeit at a slower pace. These two regimes offer different trade-offs between speed and specificity for computational and cognitive tasks.
Review
Neurosciences
Yue Kris Wu, Christoph Miehl, Julijana Gjorgjieva
Summary: This article explores the role of inhibitory neurons in the brain, influencing neuronal activity through modulating synaptic plasticity and forming memories as well as novelty detection. Experimental and modeling studies have revealed the crucial role of inhibitory plasticity in circuit dynamics and connectivity shaping.
TRENDS IN NEUROSCIENCES
(2022)
Article
Biochemical Research Methods
Christoph Miehl, Julijana Gjorgjieva
Summary: This article proposes a novel form of inhibitory synaptic plasticity to control the strength of excitatory synapses and achieve stable learning and memory. The research findings suggest that the dominance of inhibition and the nonlinear dependence of inhibitory plasticity on the firing rate of excitatory neurons are important factors in implementing this new form of plasticity.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Anesthesiology
Lou Cathenaut, Benjamin Leonardon, Robin Kuster, Perrine Inquimbert, Remy Schlichter, Sylvain Hugel
Summary: The networks in the dorsal horn of the spinal cord play a crucial role in processing nociceptive information and shaping pain perception. Short-term plasticity of inhibitory connections, particularly in lamina II, can modulate the balance between excitation and inhibition, thus influencing pain transmission. This study showed that GABAergic interneurons in lamina II had target-specific and frequency-specific plasticity, with connections onto eGFP+ (putative excitatory) interneurons showing frequency-dependent depression and connections onto eGFP- (putative inhibitory) interneurons displaying limited frequency-dependent changes. These findings suggest that the modulation of inhibitory connections may be a potential target for pain relief strategies.
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Mason S. Kleinjan, William C. Buchta, Roberto Ogelman, In-Wook Hwang, Masaaki Kuwajima, Dusten D. Hubbard, Dean J. Kareemo, Olga Prikhodko, Samantha L. Olah, Luis E. Gomez Wulschner, Wickliffe C. Abraham, Santos J. Franco, Kristen M. Harris, Won Chan Oh, Matthew J. Kennedy
Summary: Dendritic spines in the hippocampus can be directly connected to inhibitory and excitatory presynaptic terminals, resulting in close proximity of opposing synaptic functions at the nanometer scale. By using a combination of electron microscopy, live imaging, and synaptic activity manipulations, researchers have found that dual innervation occurs early in development, even when the excitatory input is silenced. The NMDA receptor currents are selectively reduced at dually innervated spines through GABAB receptor signaling, blocking the spine enlargement associated with long-term potentiation. Silencing somatostatin interneurons or blocking GABAB receptors restores NMDA receptor function and structural plasticity at dually innervated spines. Therefore, GABAergic signaling at the nanometer scale strongly regulates the function and plasticity of hippocampal dual innervated spines.
Article
Biology
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Monet, Thomas Chartrand, Nikolas L. Jorstad, Joseph T. Mahoney, Michael J. Taormina, Brian Long, Katherine Baker, Trygve E. Bakken, Luke Campagnola, Tamara Casper, Michael Clark, Nick Dee, Florence D'Orazi, Clare Gamlin, Brian E. Kalmbach, Sara Kebede, Brian R. Lee, Lindsay Ng, Jessica Trinh, Charles Cobbs, Ryder P. Gwinn, C. Dirk Keene, Andrew L. Ko, Jeffrey G. Ojemann, Daniel L. Silbergeld, Staci A. Sorensen, Jim Berg, Kimberly A. Smith, Philip R. Nicovich, Tim Jarsky, Hongkui Zeng, Jonathan T. Ting, Boaz P. Levi, Ed Lein
Summary: The study investigates synaptic properties between excitatory and inhibitory neurons in the human cortex, finding that the short-term plasticity of synaptic connections depends on the molecular identity of inhibitory neurons. This indicates the existence of target cell-specific synaptic properties and suggests evolutionary conservation of connectivity principles.
Article
Biology
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Monet, Thomas Chartrand, Nikolas L. Jorstad, Joseph T. Mahoney, Michael J. Taormina, Brian Long, Katherine Baker, Trygve E. Bakken, Luke Campagnola, Tamara Casper, Michael Clark, Nick Dee, Florence D'Orazi, Clare Gamlin, Brian E. Kalmbach, Sara Kebede, Brian R. Lee, Lindsay Ng, Jessica Trinh, Charles Cobbs, Ryder P. Gwinn, C. Dirk Keene, Andrew L. Ko, Jeffrey G. Ojemann, Daniel L. Silbergeld, Staci A. Sorensen, Jim Berg, Kimberly A. Smith, Philip R. Nicovich, Tim Jarsky, Hongkui Zeng, Jonathan T. Ting, Boaz P. Levi, Ed Lein
Summary: This study investigates the synaptic properties between excitatory pyramidal neurons and inhibitory PVALB- vs. SST-positive interneurons in the human cortex. The results show robust molecular differences in synapse-associated genes between these neuron types and heterogeneous synaptic dynamics in different postsynaptic cell types. The findings suggest the existence of target cell-specific synaptic properties in the human cortex, similar to rodents, indicating an evolutionary conservation of local circuit connectivity motifs from excitatory to inhibitory neurons and their synaptic dynamics.
Article
Medicine, General & Internal
Juan Guo, Mingzi Ran, Zilong Gao, Xinxin Zhang, Dan Wang, Huiming Li, Shiyi Zhao, Wenzhi Sun, Hailong Dong, Ji Hu
Summary: The study reveals that during anaesthetic-induced loss of consciousness, there is a general decrease in cortical GABA transmission and variations in glutamate transmission among different cell types, indicating a disrupted excitatory-inhibitory network leading to consciousness loss.
Article
Biology
Haleigh N. Mulholland, Bettina Hein, Matthias Kaschube, Gordon B. Smith
Summary: The study found that before visual experience, spontaneous activity in inhibitory neurons is already highly organized in distributed modular networks, in quantitative agreement with excitatory networks. Additionally, excitatory and inhibitory networks are strongly co-aligned at different scales.
Article
Biochemical Research Methods
Toviah Moldwin, Menachem Kalmenson, Idan Segev
Summary: This study explores the importance and application potential of synaptic clustering on neuronal dendrites in pattern recognition, proposing two models - single-branch clusteron and gradient clusteron - which utilize structural plasticity and functional plasticity to solve classification tasks. Experimental results demonstrate that the gradient clusteron achieves decent accuracy on the MNIST dataset tasks.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Leonidas M. A. Richter, Julijana Gjorgjieva
Summary: This study investigates the impact of deprivation-induced synaptic changes on excitatory and inhibitory firing rates. It reveals that a single interneuron subtype can only co-modulate the firing rates together, while independent modulation observed in experiments requires strong feedback from a second interneuron subtype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Mathematics, Applied
Lulu Lu, Zhuoheng Gao, Zhouchao Wei, Ming Yi
Summary: The study investigates the effects of excitatory-inhibitory balance and neural network structures on working memory tasks using a neuron-astrocyte network model. The results reveal that performance metrics are higher for scale-free networks compared to other structures, and the tasks can be successfully completed when the proportion of excitatory neurons exceeds 30%. An optimal region is identified for excitatory neuron proportion and synaptic weight, where memory performance metrics are higher. The study also highlights the overlap of spatial calcium patterns in the astrocyte network for different items in multi-item working memory tasks, suggesting similarities to cognitive memory formation in the brain. Additionally, cued recall in complex image tasks reduces systematic noise and maintains task stability.
Article
Neurosciences
Fikri Birey, Michelle Kloc, Manideep Chavali, Israa Hussein, Michael Wilson, Daniel J. Christoffel, Tony Chen, Michael A. Frohman, John K. Robinson, Scott J. Russo, Arianna Maffei, Adan Aguirre
Article
Neurosciences
Melissa S. Haley, Alfredo Fontanini, Arianna Maffei
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Arianna Maffei, Cecile Charrier, Maddalena Delma Caiati, Andrea Barberis, Vivek Mahadevan, Melanie A. Woodin, Shiva K. Tyagarajan
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Michelle Kloc, Arianna Maffei
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Trevor C. Griffen, Melissa S. Haley, Alfredo Fontanini, Arianna Maffei
Review
Neurosciences
Olivia K. Swanson, Arianna Maffei
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Review
Neurosciences
Marco Capogna, Pablo E. Castillo, Arianna Maffei
Summary: GABAergic interneurons are highly diverse and play a crucial role in regulating neural circuits for learning and memory. Inhibitory synaptic plasticity in the hippocampus and neocortex is essential for circuit dynamics, with different interneuron types supporting unique roles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Olivia K. Swanson, Rosa Semaan, Arianna Maffei
Summary: The study found that D1 and D2 receptor antagonism affects M1 pyramidal neurons in different ways. The effects of acute D1 antagonism were primarily driven by changes to intrinsic properties, while excitability shifts following D2 antagonism relied on synaptic transmission.
Review
Physics, Applied
B. A. W. Brinkman, H. Yan, A. Maffei, I. M. Park, A. Fontanini, J. Wang, G. La Camera
Summary: This article reviews neural metastable dynamics and explores its relevance to cognitive and behavioral functions. Through experimental evidence and theoretical research, it reveals how metastable states emerge in neural circuits and their impact on essential functions such as perception, memory, expectation, and decision making.
APPLIED PHYSICS REVIEWS
(2022)
Article
Multidisciplinary Sciences
Hillary C. Schiff, Joshua F. Kogan, Maria Isaac, Lindsey A. Czarnecki, Alfredo Fontanini, Arianna Maffei
Summary: Early experience with food influences taste preference in adulthood, but the mechanisms underlying this process are not well understood. In this study, we exposed weanling mice to a variety of taste solutions and found that the preference for sweet in adulthood was influenced by this early gustatory experience. We observed changes in sucrose palatability, neural responsiveness to sucrose, and inhibitory synaptic plasticity in the gustatory portion of the insular cortex. These findings highlight the importance of early life nutrition in shaping taste preferences and provide insights into the neural mechanisms underlying this process.
Article
Biology
Melissa S. Haley, Stephen Bruno, Alfredo Fontanini, Arianna Maffei
Article
Neurosciences
M. E. Stone, A. Fontanini, A. Maffei
Article
Neurosciences
Roberta Tatti, Olivia K. Swanson, Melinda S. E. Lee, Arianna Maffei
Review
Neurosciences
Arianna Maffei
CURRENT OPINION IN NEUROBIOLOGY
(2017)
Review
Neurosciences
Roberta Tatti, Melissa S. Haley, Olivia K. Swanson, Tenzin Tselha, Arianna Maffei
BIOLOGICAL PSYCHIATRY
(2017)