Review
Chemistry, Multidisciplinary
Harald Groeger, Fabrice Gallou, Bruce H. Lipshutz
Summary: Chemoenzymatic catalysis involves the merging of sequential reactions using both chemocatalysis and biocatalysis in a single reaction vessel. Running these reactions in water presents a challenge but offers many advantages, as most enzyme-catalyzed reactions occur in water, allowing for a wide synthetic diversity. This article presents creative approaches and solutions to combine chemo- and biocatalysis in water for synthetic purposes.
Article
Neurosciences
Aurina Arnatkeviciute, Ben D. Fulcher, Mark A. Bellgrove, Alex Fornito
Summary: The integration of modern neuroimaging methods with genetically informative designs and data sheds light on the molecular mechanisms underlying the structural and functional organization of the human connectome. Studies investigating the genetic basis of human brain network structure and function through quantifying phenotypic heritability, identifying specific DNA variants, and analyzing correlations between imaging phenotypes and gene expression profiles show that anatomical connectivity is under stronger genetic influence than functional connectivity, with certain regions and connections being more genetically controlled than others. This combination of imaging and genetics can help understand how genes drive brain dysfunction in different clinical disorders.
Review
Neurosciences
Yong-long Chen, Xiang-lan Feng, Chi-Wai Cheung, Jessica Aijia Liu
Summary: This article reviews the role of astrocytes in pain and discusses the molecular mechanisms that control their activity. Targeting detrimental astrocyte subtypes and activity is considered a promising strategy for pain management.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Computer Science, Hardware & Architecture
Ying-Chang Liang, Ruizhe Long, Qianqian Zhang, Dusit Niyato
Summary: This article introduces a novel paradigm for wireless communication called symbiotic communication (SC), where relevant radio systems form a symbiotic relationship through intelligent resource/service exchange. By leveraging the concept of ecosystems in biology, the SC paradigm provides a fresh perspective and guidelines for radio resource management and the design of future wireless communication systems.
IEEE WIRELESS COMMUNICATIONS
(2022)
Article
Biology
Laura Jones, Madeleine Verriotis, Robert J. Cooper, Maria Pureza Laudiano-Dray, Mohammed Rupawala, Judith Meek, Lorenzo Fabrizi, Maria Fitzgerald
Summary: Topographic cortical maps are crucial for spatial localization of sensory stimulation and generation of appropriate motor responses. In adult somatosensory (S1) cortex, somatosensation and nociception are finely mapped and aligned. However, in infancy, when pain behavior is disorganized and poorly directed, nociceptive maps may be less refined.
Article
Chemistry, Analytical
Antonio Delgado-Gonzalez, Rosario M. Sanchez-Martin
Summary: Mass cytometry is a highly multiparametric proteomic technology that utilizes metal-tagged probes for the measurement and quantification of cellular markers. Various types of mass-tag reagents, including polymer-based and nonpolymer-based materials, are used for cell barcoding and quantitation.
ANALYTICAL CHEMISTRY
(2021)
Review
Cell & Tissue Engineering
Nikolai Jaschke, Wolfgang Sipos, Lorenz C. Hofbauer, Tilman D. Rachner, Martina Rauner
Summary: This article explores how the skeleton regulates whole-body homeostasis by secreting hormones and discusses the origins and functions of two common skeletal mediators in physiology and their potential disease associations. It provides a theoretical framework to explain the evolutionary roles of these hormones in amniote physiology and addresses limitations and challenges in research. Additionally, unresolved questions and potential future studies in this growing field are summarized.
Review
Cell Biology
Giona Pedrioli, Paolo Paganetti
Summary: Extracellular vesicles are emerging as nanocarriers of biological information, transporting various biologically active macromolecules to induce phenotypic changes in recipient cells. However, the cellular mechanisms involved in the encounter of cargo proteins within extracellular vesicles with cytosolic targets are only partially understood at present.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Mariaenrica Tine, Matteo Daverio, Umberto Semenzato, Elisabetta Cocconcelli, Nicol Bernardinello, Marco Damin, Marina Saetta, Paolo Spagnolo, Elisabetta Balestro
Summary: Thoracic ultrasound plays a vital role in respiratory medicine, particularly in managing pleural diseases. This article describes the establishment and development of a pleural clinic in a large hospital, which has expanded its scope of practice and collaborated with other specialists to handle complex respiratory cases. The proposed organizational model can inspire similar clinics in other healthcare settings.
FRONTIERS IN MEDICINE
(2023)
Editorial Material
Cell Biology
Lucy Oldfield, Eithne Costello
Summary: The authors present a risk prediction model for pancreatic cancer based on circulating microbial and non-microbial metabolites, showing good performance in assessing 5-year risk.
CELL REPORTS MEDICINE
(2023)
Article
Computer Science, Information Systems
Peter Bellmann, Patrick Thiam, Hans A. Kestler, Friedhelm Schwenker
Summary: This article experimentally confirms the complexity of automated pain intensity recognition (PIR) task and compares it with the task of handwritten numerals distinction. The study shows that the PIR task exhibits chaotic nature, while the handwritten numerals distinction task is relatively simple.
Review
Biology
Christian Buechel
Summary: Chronic pain affects more than 10% of adults and is a major health problem. Pain can become persistent and lose its warning signal function. Psychological processes play an important role in the transition from acute to persistent pain, and interventions targeting these processes may prevent the development of persistent pain.
Review
Neurosciences
Yaara Yeshurun, Mai Nguyen, Uri Hasson
Summary: The default mode network integrates external and internal information over long timescales to represent shared meaning. It is a "sense-making" network that forms rich contextual models by integrating external and intrinsic information.
NATURE REVIEWS NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Mingfei Pan, Tao Shui, Ziqian Zhao, Mei Li, Hongbing Fan, Jianping Wu, Hongbo Zeng
Summary: Bioadhesives applied on human organs are promising soft implants for interventional diagnostics and therapeutics. A new strategy has been developed to overcome the bioadhesive-induced dysfunction on treated organs by engineering asymmetric surface functionalities on a tough yet biodegradable polysaccharide-peptide-derived hydrogel platform. The resulting hydrogel bioadhesive serves as a stamp with adhesive and defensive properties, enabling reliable wet tissue adhesion and reproducing the characteristics of original tissues.
CHEMISTRY OF MATERIALS
(2023)
Review
Medicine, General & Internal
Per-Johan Jakobsson, Luke Robertson, Janika Welzel, Mingshu Zhang, Yang Zhihua, Gao Kaixin, Huang Runyue, Wen Zehuai, Marina Korotkova, Ulf Goransson
Summary: Chinese medicine has a long tradition of use in the treatment and prevention of rheumatoid arthritis (RA). This article summarizes the background, mechanisms, and proposed clinical trial for using Chinese herbal medicine in the prevention of RA. RA is an autoimmune, inflammatory disease that primarily affects the joints and is associated with genetic variations and smoking.
JOURNAL OF INTERNAL MEDICINE
(2022)