Article
Biology
Pascal Dominic Rem, Vita Sereikaite, Diego Fernandez-Fernandez, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salome Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Stromgaard, Bernhard Bettler
Summary: Amyloid-beta precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. A 17 amino acid peptide (APP17) derived from APP binds to the extracellular sushi domain 1 (SD1) of GABA(B) receptors (GBRs). However, APP17 does not influence GBR activity in heterologous cells, indicating that sAPP exerts its neuronal effects through receptors other than GBRs.
Article
Cell Biology
Sharon Negri, Francesca Scolari, Mauro Vismara, Valentina Brunetti, Pawan Faris, Giulia Terribile, Giulio Sancini, Roberto Berra-Romani, Francesco Moccia
Summary: This study reveals the molecular mechanisms by which GABA controls endothelial signaling at the neurovascular unit through activating GABA(A) and GABA(B) receptors, and involves multiple signaling pathways, which is of great significance for understanding the function of GABA in the neurovascular unit.
Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Article
Behavioral Sciences
Gabriele Floris, Gino Paolo Asuni, Giuseppe Talani, Francesca Biggio, Maria Giuseppina Pisu, Mary Tresa Zanda, Liliana Contu, Elisabetta Maciocco, Mariangela Serra, Paolo Follesa
Summary: This study investigates the role of the GABA(B)R receptor in alcohol consumption and preference in mice. The results show that mice lacking functional GABA(B)R drink more alcohol, prefer alcohol over water, and have higher blood alcohol concentrations compared to wild-type mice. Additionally, the study suggests that the GABA(B)R receptor modulates the activity of GABA(A) receptors in the hippocampus, potentially influencing alcohol preference in mice.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Neurosciences
Ayla Arslan
Summary: GABA(A) receptors play a key role in inhibiting the adult brain, with specific subtypes like the delta-subunit-GABA(A) receptors expressed in areas like the hippocampus. These receptors, containing the delta subunit, have integrative roles in network oscillations, adding complexity to the understanding of their functions.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Ilandarage Menu Neelaka Molagoda, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Yung Hyun Choi, You-Jin Jeon, Joung-Hyun Park, Bae-Jin Lee, Gi-Young Kim
Summary: Supplementation of exogenous GABA activates IGF-1 signaling pathway and promotes growth in zebrafish larvae by upregulating growth-stimulating genes. The stimulation of IGF-1 release by GABA is mediated through GABA(A) and GABA(B) receptors, leading to enhanced growth performance via IGF-1 receptor activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Fujun Luo, Alessandra Sclip, Sean Merrill, Thomas C. Sudhof
Summary: This study shows that neurexins are essential for the localization and function of presynaptic GABA(B)-receptor signaling complexes. Deletion of neurexins results in decreased sensitivity of neurotransmitter release to GABA(B)-receptor activation and loss of GABA(B)-receptors from the presynaptic active zone. Neurexins play a crucial role in regulating presynaptic GABA(B) receptors at multiple central nervous system synapses.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Faouzi Zarrouki, Sebastien Goutal, Ophelie Vacca, Luis Garcia, Nicolas Tournier, Aurelie Goyenvalle, Cyrille Vaillend
Summary: This study found that the loss of dystrophin in a mouse model of Duchenne muscular dystrophy (DMD) affects not only the stability of synaptic GABA(A) receptors, but also the composition and expression of subunits at both synaptic and extrasynaptic sites. These findings provide new measures to evaluate compensation for nervous system alterations in DMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Veronika Kovarikova, Alexandra Spirkova, Zuzana Sefcikova, Jozef Pisko, Laura Kalatova, Juraj Koppel, Dusan Fabian, Stefan Cikos
Summary: This study found that the activation of GABA receptors by certain substances can have negative effects on preimplantation embryos. The presence of various GABA receptor subunits was detected in mouse blastocysts and ovulated oocytes. Adding GABA or specific GABA receptor agonists to the culture medium significantly increased cell death in blastocysts, and this effect was prevented by GABA receptor antagonists.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Neurosciences
Yun Fei Feng, Yin Yong Zhou, Kai Ming Duan
Summary: Postpartum depression is a serious disease that has a high incidence and severe impact on pregnant women and infants. However, the mechanism of this condition is still unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. This review focuses on the function of GABA receptors, particularly extrasynaptic receptors, and their association with postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Ani Kaplanian, Michael Vinos, Irini Skaliora
Summary: Slow oscillations and their cellular counterpart, Up and Down states (UDSs), are considered as markers of cortical network organization. Inhibition mediated by GABA(B) and GABA(A) receptors plays a major role in regulating UDS activity. This study reveals for the first time age-dependent effects of GABA(B) and GABA(A) signaling on UDSs and highlights the differential subunit composition of postsynaptic GABA(A) receptors in young and adult animals. These findings provide insights into the mechanisms underlying the maturation of cortical network activity and contribute to our understanding of the development of neurodevelopmental disorders.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Immunology
Nathalia Rossoni Ronchi, Guilherme Diogo Silva
Summary: The main objective of this article is to enhance our understanding of the differences and similarities between anti-GABAaR and anti-GABAbR, two types of anti-gamma-aminobutyric acid receptor encephalitis. Through systematic data collection, the study found that both types of encephalitis are characterized by seizures, but show differences in patient age, the type of encephalitis, and associated tumors.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Hyung Won Ryu, Yung Hyun Choi, Jin-Woo Jeong, Sanghyuck Kang, Gi-Young Kim
Summary: The study demonstrates that GABA can significantly inhibit melanin synthesis by suppressing MITF and tyrosinase expression, reducing cAMP and CREB levels. GABA inhibits Ca2+ accumulation through GABA(A) and GABA(B) receptors, thereby reducing melanin production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Almudena Barbero-Castillo, Pedro Mateos-Aparicio, Leonardo Dalla Porta, Alessandra Camassa, Lorena Perez-Mendez, Maria V. Sanchez-Vives
Summary: This study explored the role of GABAergic inhibition in cortical complexity, finding that physiological levels of inhibition contribute to dynamical richness and spatiotemporal complexity, while decreased or increased inhibition leads to decreased cortical complexity. Using a computational model, the study demonstrated a link between excitatory/inhibitory balance and the complexity expressed by the cortical network.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Davide Bassetti
Summary: Gamma-aminobutyric acid (GABA) is the main neurotransmitter in the brain responsible for inhibiting neuronal activity. GABA(B) receptors play a crucial role in regulating proliferation, migration, and cell inhibition. They can shape neuronal activity and contribute to development by modulating the function of cells in response to varying levels of GABA concentration.
Review
Biochemistry & Molecular Biology
Julien Bacque-Cazenave, Rahul Bharatiya, Gregory Barriere, Jean-Paul Delbecque, Nouhaila Bouguiyoud, Giuseppe Di Giovanni, Daniel Cattaert, Philippe De Deurwaerdere
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cristiano Bombardi, Francis Delicata, Claudio Tagliavia, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Philippe De Deurwaerdere, Marta Ramos, Rahul Bharatiya, Emilie Puginier, Abdeslam Chagraoui, Julien Manem, Eleonora Cuboni, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovanni
Article
Biochemistry & Molecular Biology
Cristiano Bombardi, Francis Delicata, Claudio Tagliavia, Annamaria Grandis, Massimo Pierucci, Antonella Marino Gammazza, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
Summary: Serotonin is crucial in nicotine actions in the CNS, with the 5-HT2CR receptor identified as a potential drug target for smoking cessation. Acute and chronic nicotine exposure have differential effects on the central 5-HT2CR function, primarily in the LHb, which may have implications for nicotine addiction and its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Mary Gazea, Szabina Furdan, Peter Sere, Lukas Oesch, Benedek Molnar, Giuseppe Di Giovanni, Lief E. Fenno, Charu Ramakrishnan, Joanna Mattis, Karl Deisseroth, Susan M. Dymecki, Antoine R. Adamantidis, Magor L. Lorincz
Summary: The lateral hypothalamus selectively inhibits GABAergic neurons in the dorsal raphe nucleus, leading to increased firing of a substantial fraction of its neurons that ultimately promotes arousal. These wake active DRGABA neurons project to multiple brain areas involved in the control of arousal, including the LH, where their specific activation influences local network activity leading to arousal from sleep. Mutual inhibitory projections between the LH and the DR promote wakefulness and suggest a complex arousal control by intimate interactions between long-range connections and local circuit dynamics.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Paromita Sen, Alicia Molinero-Perez, Kenneth J. O'Riordan, Cian P. McCafferty, Ken D. O'Halloran, John F. Cryan
Summary: The article explores how the microbiota influences sleep directly and indirectly, as well as the alterations of the microbiota-gut-brain axis in various sleep disorders and pathologies. Manipulating the gut microbiota could potentially improve sleep quality.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Summary: The study reveals that the transcription factor ZEB1 plays a crucial role in the self-renewal of active RGL cells in the adult mammalian hippocampus, with its deletion leading to a shift towards symmetric cell division and an increase in newborn neurons while decreasing newly generated astrocytes. ZEB1 is identified as a positive regulator of the ets-domain transcription factor ETV5, which is essential for asymmetric division.
Article
Neurosciences
Maurizio Casarrubea, Giuseppe Di Giovanni, Giuseppe Crescimanno
Summary: The study using Hole-Board to test emotional behavior in rats found that Edge-Sniff and Head-Dip are among the most important behaviors for evaluating anxiety level, playing a significant role in T-pattern analysis.
Article
Neurosciences
Massimo Pierucci, Francis Delicata, Roberto Colangeli, Antonella Marino Gammazza, Alessandro Pitruzzella, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
Summary: This study found that nicotine-induced neuronal activity in the VTA is regulated by the LHb region, with acute and chronic nicotine having different effects on VTA DA neurons.
Article
Multidisciplinary Sciences
Bret Sanders, Daniel D'Andrea, Mark O. Collins, Elliott Rees, Tom G. J. Steward, Ying Zhu, Gareth Chapman, Sophie E. Legge, Antonio F. Pardinas, Adrian J. Harwood, William P. Gray, Michael C. O'Donovan, Michael J. Owen, Adam C. Errington, Derek J. Blake, Daniel J. Whitcomb, Andrew J. Pocklington, Eunju Shin
Summary: The coordinated programs of gene expression driving brain development have been studied in relation to neuropsychiatric disorders and cognition. This research combines human genetics with transcriptomic data and analyzes genetic variants and GWAS statistics to reveal the convergence on transcriptional programs regulating excitatory cortical neurogenesis.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Abdeslam Chagraoui, Giuseppe Di Giovanni, Philippe De Deurwaerdere
Summary: The discovery of the D3 receptor has sparked interest in the field of neurological diseases, particularly Parkinson's disease. This article discusses the role of D3 receptors in Parkinson's disease and their relationship with current treatments, highlighting the potential interactions between D1 and D3 receptors that may contribute to motor side effects.
Letter
Neurosciences
Daniel Cassar, Manuela Radic, Maurizio Casarrubea, Vincenzo Crunelli, Giuseppe Di Giovanni
Summary: In this study, GAERS and NEC rats were treated with the CB1/2 receptor agonist WIN 55,212-2 (2 mg/kg) and tested on the Elevated Plus-Maze.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Eluned Broom, Vivian Imbriotis, Frank Sengpiel, William M. Connelly, Adam Ranson
Summary: This study uses in vivo two-photon functional imaging to investigate the role of A24b/M2-V1(axons) in visual selective attention in mice. The results suggest that the activity of these axons is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the currently discriminated stimulus.
Article
Neurosciences
Maurizio Casarrubea, Manuela Radic, Tatiana Pinto Morais, Erika Mifsud, Eleonora Cuboni, Stefania Aiello, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovanni
Summary: The study compared Genetic Absence Epilepsy Rats from Strasbourg (GAERS), non-epileptic control (NEC), and Wistar rats bred under the same conditions, along with commercially available Wistar rats (Cm Wistar) as a control. The results showed that male GAERS rats lacked comorbid anxiety, and the study emphasized the importance of using Wistar rats from the same breeding conditions.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)