期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 35, 页码 14184-14192出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1987-13.2013
关键词
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资金
- Sir Henry Wellcome Postdoctoral Fellowship
- UK Medical Research Council [MC_A060_5PR10]
- Medical Research Council [MC_U105579226] Funding Source: researchfish
- MRC [MC_U105579226] Funding Source: UKRI
A simple cue can be sufficient to elicit vivid recollection of a past episode. Theoretical models suggest that upon perceiving such a cue, disparate episodic elements held in neocortex are retrieved through hippocampal pattern completion. We tested this fundamental assumption by applying functional magnetic resonance imaging (fMRI) while objects or scenes were used to cue participants' recall of previously paired scenes or objects, respectively. We first demonstrate functional segregation within the medial temporal lobe (MTL), showing domain specificity in perirhinal and parahippocampal cortices (for object-processing vs scene-processing, respectively), but domain generality in the hippocampus (retrieval of both stimulus types). Critically, using fMRI latency analysis and dynamic causal modeling, we go on to demonstrate functional integration between these MTL regions during successful memory retrieval, with reversible signal flow from the cue region to the target region via the hippocampus. This supports the claim that the human hippocampus provides the vital associative link that integrates information held in different parts of cortex.
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