Article
Multidisciplinary Sciences
Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda
Summary: This study reveals that neuronal pentraxin 2 (NPTX2) upregulation in primary sensory neurons facilitates excitatory synaptic inputs onto gastrin-releasing peptide receptors (GRPR) expressing spinal neurons in chronic itch models.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Evdokia Menelaou, Sandeep Kishore, David L. McLean, Markus Meister
Summary: This study unravels the impact of mixed synapses within the spinal locomotor circuitry of larval zebrafish and finds that differences in mixed synapse density can contribute to excitability underestimations and connectivity overestimations, explaining the "violations" of the size principle.
Article
Neurosciences
Na Jin, Su-Yue Zhu, Xin-Yu Yang, Cheng Zhen, Yan Li, Huan-Huan Zhang, Ai-Ping Xu, Meng-Ya Wang, Chao Zheng
Summary: Orexin-A potentiates glycine currents in spinal cord ventral horn neurons by activating OX1R, likely through an IP3/Ca2+-dependent PKC signaling pathway.
BRAIN RESEARCH BULLETIN
(2021)
Article
Chemistry, Analytical
Zheng Ao, Hongwei Cai, Zhuhao Wu, Jonathan Krzesniak, Chunhui Tian, Yvonne Y. Lai, Ken Mackie, Feng Guo
Summary: The study introduces a human spinal organoid-on-a-chip device for modeling the biology and electrophysiology of human nociceptive neurons and dorsal horn interneurons. The device allows for testing nociceptive modulators and is cost-efficient, scalable, and easy to use. By integrating human sensory-spinal-cord organoids, the method shows promise for screening and validating novel therapeutics for human pain medicine discovery.
ANALYTICAL CHEMISTRY
(2022)
Review
Neurosciences
Stuart G. Cull-Candy, Mark Farrant
Summary: CP-AMPARs are important regulators of synaptic plasticity, with their functional characteristics being modulated by auxiliary subunits and involved in various forms of central synaptic plasticity. Maladaptive synaptic plasticity and neurological disorders often involve changes in CP-AMPAR expression, such as those induced by inflammatory pain, fear conditioning, and cocaine exposure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Yan Li, Xin-Yu Yang, Na Jin, Cheng Zhen, Su-Yue Zhu, Wan-Yu Chu, Huan-Huan Zhang, Ai-Ping Xu, Jie Wu, Meng-Ya Wang, Chao Zheng
Summary: This study aimed to investigate the effects of pilocarpine on glycine receptors in spinal cord neurons and the underlying mechanisms. The results showed that pilocarpine increased glycine currents through the activation of M3-AChRs and IP3/Ca2+/PKC pathways.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Kwan Yeop Lee, Dongchul Lee, Zachary B. Kagan, Dong Wang, Kerry Bradley
Summary: The study found that low-intensity 10 kHz SCS can inhibit pain-sensory processing in the spinal DH by activating inhibitory interneurons, resulting in paresthesia-free pain relief.
Article
Biochemistry & Molecular Biology
Miranda Mele, Pasqualino De Luca, Ana Rita Santos, Marta Vieira, Ivan L. Salazar, Paulo S. Pinheiro, Carlos B. Duarte
Summary: This study investigated the regulation of the synaptic protein GRASP1 by ubiquitin-dependent mechanisms, revealing an impact on the surface distribution and activity of AMPA receptors. Ubiquitination was found to decrease dendritic levels of GRASP1 and surface expression of GluA1 subunits, leading to a reduction in mEPSC amplitudes, effects that were partially reversed by cotransfection with GRASP1.
Article
Biochemistry & Molecular Biology
Miguel angel Velazquez-Flores, Gustavo Sanchez-Chavez, Sara L. Morales-Lazaro, Ruth Ruiz Esparza-Garrido, Alejandro Canizales-Ontiveros, Rocio Salceda
Summary: The expression of glycine receptors in the spinal cord is altered during diabetic neuropathy, suggesting their involvement in inflammatory and diabetic neuropathic pain.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Jennifer Burnsed, Weronika Matysik, Lu Yang, Huayu Sun, Suchitra Joshi, Jaideep Kapur
Summary: Postnatal maturation of the motor cortex is vital for developing motor learning capacity. During the first few weeks after birth, there are numerous neuronal and synaptic changes in the motor cortex, which vary by region and layer, likely due to different developmental functions and needs. Layer II/III of the motor cortex plays a crucial role in receiving and integrating inputs and generating attentional signals for motor learning and planning. By studying the changes in layer II/III pyramidal neurons of the mouse motor cortex from neonatal to young adult stages, we found several changes including increased dendritic branching, neuronal excitability, glutamatergic synapse number, and synaptic transmission. These changes are crucial for ongoing plasticity and motor learning capacity during development. Understanding these changes can help inform future studies on the impact of early-life injury and experiences on motor learning and development capacity.
Article
Multidisciplinary Sciences
Martin Hruska, Rachel E. Cain, Matthew B. Dalva
Summary: This study reveals the impact of nanoscale organization of glutamate receptors on synaptic features, with receptors containing specific subunits forming specific subsynaptic regions, which is crucial for events such as cell death and synaptic plasticity.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Maria Italia, Elena Ferrari, Monica Di Luca, Fabrizio Gardoni
Summary: AMPARs play a crucial role in excitatory synaptic transmission in the mammalian brain, with the GluA3 subunit being widely expressed and functionally relevant. Modulation of GluA3 through pharmacological means may offer a new approach for addressing altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Maria Italia, Elena Ferrari, Monica Diluca, Fabrizio Gardoni
Summary: A prominent feature of neurodegenerative diseases is synaptic dysfunction and spine loss. Misfolded proteins, such as tau and alpha-synuclein, play a critical role in driving synaptic toxicity at excitatory glutamatergic synapses. Understanding the role of these proteins in impairing the function of glutamate receptors can provide insights into the pathology of neurodegenerative diseases.
Article
Cell Biology
Jee-Yeon Hwang, Hannah R. Monday, Jingqi Yan, Andrea Gompers, Adina R. Buxbaum, Kirsty J. Sawicka, Robert H. Singer, Pablo E. Castillo, R. Suzanne Zukin
Summary: This study reveals that in a mouse model of Fragile X syndrome (FXS), the transcription of GluA2, a subunit of AMPA receptor, is upregulated, which is associated with intellectual disability and autism. The researchers also identify CPEB3 protein as a critical regulator of GluA2 mRNA expression. Increased GluA2 mRNA leads to an increase in GluA2 subunits at synapses, potentially contributing to an excitatory/inhibitory imbalance, a common theme in FXS and other autism spectrum disorders.
Article
Neurosciences
Jessica Troeger, Eric Seemann, Rainer Heintzmann, Michael M. Kessels, Britta Qualmann
Summary: Glycine receptor-mediated inhibitory neurotransmission is crucial for spinal cord function. This study reveals the mechanisms underlying the synaptic plasticity of glycine synapses, including the decoupling of GlyR beta from gephyrin scaffolds and the promotion of association between GlyR beta and syndapin I. Syndapin I plays an important role in organizing and altering the glycine receptor fields, and its deficiency leads to defects in receptor internalization.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Yasmine Cantaut-Belarif, Myriam Antri, Rocco Pizzarelli, Sabrina Colasse, Ilaria Vaccari, Sylvia Soares, Marianne Renner, Radhouane Dallel, Antoine Triller, Alain Bessis
JOURNAL OF CELL BIOLOGY
(2017)
Article
Clinical Neurology
Alexandre Androuin, Brigitte Potier, U. Valentin Naegerl, Daniel Cattaert, Lydia Danglot, Manon Thierry, Ihsen Youssef, Antoine Triller, Charles Duyckaerts, Khalid Hamid El Hachimi, Patrick Dutar, Benoit Delatour, Serge Marty
ACTA NEUROPATHOLOGICA
(2018)
Article
Nanoscience & Nanotechnology
Omri Bar-Elli, Dan Steinitz, Gaoling Yang, Ron Tenne, Anastasia Ludwig, Yung Kuo, Antoine Triller, Shimon Weiss, Dan Oron
Article
Biochemistry & Molecular Biology
Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes-Hamon, Audrey Coens, Luc Buee, Philippe Hantraye, Antoine Triller, Ronald Melki
Review
Neurosciences
Amulya Nidhi Shrivastava, Antoine Triller, Ronald Melki
Article
Engineering, Biomedical
Claire Leclech, Marianne Renner, Catherine Villard, Christine Metin
Article
Biophysics
Xianan Qin, Lei Liu, Sang Kwon Lee, Adolfo Alsina, Teng Liu, Chao Wu, Hojeong Park, Chenglong Yu, Hajin Kim, Jun Chu, Antoine Triller, Ben Zhong Tang, Changbong Hyeon, Chan Young Park, Hyokeun Park
BIOPHYSICAL JOURNAL
(2020)
Article
Neurosciences
Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cecile Charrier
Article
Multidisciplinary Sciences
Marianna Lamprou Kokolaki, Aurelien Fauquier, Marianne Renner
Article
Multidisciplinary Sciences
Ferran Gomez-Castro, Stefania Zappettini, Jessica C. Pressey, Carla G. Silva, Marion Russeau, Nicolas Gervasi, Marta Figueiredo, Claire Montmasson, Marianne Renner, Paula M. Canas, Francisco Q. Goncalves, Sofia Alcada-Morais, Eszter Szabo, Ricardo J. Rodrigues, Paula Agostinho, Angelo R. Tome, Ghislaine Caillol, Olivier Thoumine, Xavier Nicol, Christophe Leterrier, Rafael Lujan, Shiva K. Tyagarajan, Rodrigo A. Cunha, Monique Esclapez, Christophe Bernard, Sabine Levi
Summary: The research demonstrates that activation of adenosine A(2A) receptors is essential for stabilizing GABAergic synapses during neural circuit development. The synergistic action of GABAAR- and A(2A)R-dependent signaling pathways leads to the production of adenosine 3',5'-monophosphate. The stabilization of pre- and postsynaptic GABAergic elements involves the interaction between gephyrin and the synaptogenic membrane protein Slitrk3.
Article
Multidisciplinary Sciences
Fumihiro Niwa, Angela Patrizio, Antoine Triller, Christian G. Specht
Article
Neurosciences
Nora Gruenewald, Audric Jan, Charlotte Salvatico, Vanessa Kress, Marianne Renner, Antoine Triller, Christian G. Specht, Guenter Schwarz
Article
Neurosciences
Sereina Battaglia, Marianne Renner, Marion Russeau, Etienne Come, Shiva K. Tyagarajan, Sabine Levi