Article
Neurosciences
James A. Jones, Matthew H. Higgs, Erick Olivares, Jacob Pella, Charles J. Wilson
Summary: Autonomously firing GABAergic neurons in the external globus pallidus (GPe) form a local synaptic network. Silencing the firing of PV+ GPe neurons increases the firing rate and regularity of PV- neurons, while silencing Npas1+ GPe neurons has no significant effect on Npas1- neuron firing. Spontaneous GABAergic synaptic input blockade reproduces the effects of silencing PV+ neuron firing. Furthermore, as few as 5 unitary inputs can cause large increases in firing irregularity in GPe neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman
Summary: Integrated analysis of non-human primate data reveals that pauses in GPe firing are associated with pupil dilation, suggesting that GPe pauses may influence basal ganglia downstream structures and play a role in exploratory behavior.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mark D. Bevan
Summary: The basal ganglia play a crucial role in regulating behavior, with a new study revealing a feedback circuit that can strongly inhibit locomotion in mice.
Article
Neurosciences
Michael S. Patton, Samuel H. Sheats, Allison N. Siclair, Brian N. Mathur
Summary: Fast-spiking interneurons in the dorsal striatum can be modulated by ethanol, which may result in excessive activation of dopamine neurons and further promote compulsive ethanol consumption behavior.
Article
Neurosciences
Matthew H. Higgs, James A. Jones, C. Savio Chan, Charles J. Wilson
Summary: Neurons in the external globus pallidus (GPe) are autonomous pacemakers and receive periodic spontaneous inhibitory synaptic currents (IPSCs) from both parvalbumin (PV) and Npas1-expressing neurons. Optogenetic stimulation confirmed that the input arose from local neurons subject to striatal inhibition. PV neurons provided most of the active unitary inputs to both cell types, while the local network contributes to irregular firing in both PV and Npas1 neurons.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Jin-Jin Yu, Yan Xue, Ying Wang, Cui Liu, Lei Chen
Summary: Endocannabinoids play a key role in central motor control, particularly in the globus pallidus (GP) where cannabinoid receptors CB1R and CB2R are expressed. Cannabinoids exert diverse electrophysiological effects in the GP, primarily through CB1R, and produce complex behavioral responses.
Article
Clinical Neurology
Anna Gos, Johann Steiner, Kurt Truebner, Jonas Ungewickell, Christian Mawrin, Karol Karnecki, Michal Kaliszan, Tomasz Gos
Summary: Opioid addiction has worsened in the USA and Europe due to the COVID-19 pandemic. The globus pallidus (GP) is involved in regulating behavior and shows abnormalities in GABAergic function in heroin addicts. Our study using brain tissue samples from the Magdeburg Brain Bank found decreased fiber density in the external part of the GP and increased fiber density in the internal part in heroin addicts compared to healthy controls. These findings suggest dysregulation of GABAergic activity in the GP may contribute to the disturbed basal ganglia circuit function in opioid addiction.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Alexey Sedov, Prajakta Joshi, Ulia Semenova, Svetlana Usova, Svetlana Asriyants, Anna Gamaleya, Alexey Tomskiy, Hyder A. Jinnah, Aasef G. Shaikh
Summary: This study investigates the effects of neck vibration on the activity of neurons and local field potentials in the globus pallidum. The results show that neck vibration can increase the firing regularity of neurons and provide insight into the significance of burst neurons in dystonia.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Marc Deffains, Tho Hai Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Summary: The study recorded and examined the inhibition of pallidal neurons using DREADD technology in the NHP model, demonstrating its effectiveness in this context.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Nicholas Dietz, Ahmad Alhourani, Scott A. Wylie, Jessica L. McDonnell, Fenna T. Phibbs, Benoit M. Dawant, William J. Rodriguez, Elise B. Bradley, Joseph S. Neimat, Nelleke C. van Wouwe
Summary: Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Globus Pallidus (GPi) in Parkinson's disease (PD) patients have similar effects on inhibitory control processes.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Hongxia Liu, Yan Xue, Lei Chen
Summary: This study found that Ang II/AT1R alleviates parkinsonian motor deficits by activating globus pallidus neurons. This provides a theoretical basis for further research on the potential of Ang II in the treatment of motor disorders originating from the basal ganglia.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Alberto Averna, Sara Marceglia, Alberto Priori, Guglielmo Foffani
Summary: This study investigates the dynamics of spontaneous amplitude modulation (AM) and frequency modulation (FM) in Parkinson's disease patients. The results show a negative correlation between AM and FM, which changes after levodopa administration. AM and FM separately and jointly encode the dopaminergic state in patients, with FM being more informative than AM.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Rosa Mastrogiacomo, Gabriella Trigilio, Celine Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A. Rothmond, John L. Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S. Weickert, Francesca Manago, Francesco Papaleo
Summary: The abnormal activity of astrocytes is related to the dopaminergic abnormalities in schizophrenia. Dys1A isoform has a significant impact on basal ganglia-related behaviors and dopaminergic regulation in astrocytes, but has minimal effect on cortical functioning.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy, Jones G. Parker
Summary: Psychosis is associated with elevated dopamine transmission, and antipsychotic drugs are thought to rebalance the output by blocking D2 receptors. However, this study found that the efficacy of antipsychotic drugs is associated with the reversal of abnormal D1-SPN dynamics, not D2-SPN dynamics. The findings suggest that D1-SPN modulation plays an important role in the mechanism of antipsychotic drugs.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan, H. Bergman
Summary: This study reveals a strong coupling between beta oscillation frequency and dopamine tone in both monkeys and humans, indicating that beta frequency, rather than power, coherence, phase-locking, or PAC, is likely the key property of pathological oscillations in cortical and basal ganglia networks.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Hagar Lavian, Mara Almog, Ravit Madar, Yocheved Loewenstern, Izhar Bar-Gad, Eitan Okun, Alon Korngreen
JOURNAL OF NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Dorin Yael, Izhar Bar-Gad
Article
Anatomy & Morphology
Hagar Lavian, Yocheved Loewenstern, Ravit Madar, Mara Almog, Izhar Bar-Gad, Eitan Okun, Alon Korngreen
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Yael Oran, Izhar Bar-Gad
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Lilach Gorodetski, Reut Zeira, Hagar Lavian, Alon Korngreen
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Roy Amit, Dekel Abeles, Izhar Bar-Gad, Shlomit Yuval-Greenberg
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Dorin Yael, Orel Tahary, Boris Gurovich, Katya Belelovsky, Izhar Bar-Gad
JOURNAL OF NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Michal Israelashvili, Dorin Yael, Esther Vinner, Katya Belelovsky, Izhar Bar-Gad
Article
Multidisciplinary Sciences
Hagar Lavian, Alon Korngreen
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Esther Vinner Harduf, Ayala Matzner, Katya Belelovsky, Izhar Bar-Gad
Summary: The study demonstrates a reduction in tic expression during sleep in an animal model of chronic tic disorders and investigates the underlying neural mechanism. The findings point towards a possible mechanism for the modulation of tic expression in patients with TS during sleep and potentially during other behavioral states.
Article
Biophysics
Mara Almog, Nurit Degani-Katzav, Alon Korngreen
Summary: Ion channel kinetics are highly sensitive to temperature changes, but most investigations are conducted at room temperature. In this study, the kinetics of voltage-gated sodium channels were modeled using recordings of sodium currents from rat neocortical pyramidal neurons at different temperatures, revealing different temperature dependencies for activation and inactivation.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2022)
Article
Physiology
Sophia Kriegeskorte, Raya Bott, Martin Hampl, Alon Korngreen, Ralf Hausmann, Angelika Lampert
Summary: This study investigates the temperature sensitivity of different sodium channel subtypes and pain-associated mutations. The results show that increasing temperature enhances activation of sodium channels, while decreasing temperature strengthens persistent currents of specific sodium channels. These findings suggest that temperature plays a regulatory role in sodium channel function and has an impact on disease phenotypes.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Education, Scientific Disciplines
Alon Korngreen
ADVANCES IN PHYSIOLOGY EDUCATION
(2017)
Article
Neurosciences
Dorin Yael, Jacob J. Vecht, Izhar Bar-Gad