Article
Biotechnology & Applied Microbiology
Yahong Li, Xingzhuo Yang, Zhangwu Zhao, Juan Du
Summary: Recent studies have found that alternative splicing plays a crucial role in regulating circadian rhythm, and clock neuron-specific alternative splicing is associated with circadian rhythm. Through genome-wide RNA sequencing, SRP54 was identified as one of the Clock-dependent alternative splicing factors, and its function is temperature-dependent.
Article
Cell Biology
Shyh-Chi Chen, Xin Tang, Tadahiro Goda, Yujiro Umezaki, Abigail C. Riley, Manabu Sekiguchi, Taishi Yoshii, Fumika N. Hamada
Summary: This study reveals the crucial roles of dorsal neurons 2 (DN2s) in temperature preference rhythm (TPR) regulation in Drosophila. DN2s control temperature preference by regulating contacts with posterior DN1 neurons (DN1ps). Additionally, anterior DN1 neurons (DN1as) are identified as important regulators of TPR.
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Riho Kobayashi, Shin Nakane, Jun Tomita, Hiromasa Funato, Masashi Yanagisawa, Kazuhiko Kume
Summary: Sleep behavior is observed across species from non-vertebrates to humans. A mutation in the Sik3 gene, known as Sik3-SA, has been found to increase sleep in mice and fruit flies. Further research revealed that overexpression of Sik3-SA in all neurons increased sleep, while overexpression only in PDF neurons affected the circadian rhythm and increased sleep during subjective daytime.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Physics, Fluids & Plasmas
Wenxin Zheng, Changgui Gu, Huijie Yang, Jos H. T. Rohling
Summary: This article theoretically analyzed the network of the two nuclei of the suprachiasmatic nucleus (SCN) in mammals and its relation to the function of the SCN. The authors found that the integration range is larger in the motifs containing a link between the ventrolateral (VL) parts across the nuclei, but it is smaller in the motifs that contain a link between the dorsomedial (DM) parts across the nuclei. The SCN can strengthen or weaken connections between the left and right nucleus to adapt to changes in external conditions.
Article
Multidisciplinary Sciences
Angelique Lamaze, Chenghao Chen, Solene Leleux, Min Xu, Rebekah George, Ralf Stanewsky
Summary: The authors investigated how fruit flies synchronize their behavioral activity in environments with changing light cycles. They discovered a newly evolved form of the TIMELESS protein that allows fruit flies to adapt to the natural conditions of Northern European summers. This functional gain is suggested to be driving the spread of this form of the protein in the northern regions.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Patricia Jarabo, Celia G. Barredo, Carmen de Pablo, Sergio Casas-Tinto, Francisco A. Martin
Summary: Neurodegeneration induced by glioblastoma disrupts circadian rhythms in Drosophila, and aligning these rhythms with the external period can lead to a longer lifespan, suggesting a potential therapeutic approach for human glioblastoma.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tatsuhiko Furukawa, Kentaro Mimami, Toshiyuki Nagata, Masatasu Yamamoto, Masami Sato, Akihide Tanimoto
Summary: The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have diverse functions in different cellular and tissue contexts. BHLHE41/DEC2 can act as both a cancer-suppressor and an oncogene during cancer development. Studies on the effects of BHLHE41/DEC2 on differentiation have been conducted using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, as well as through genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of clinical samples. We summarize these studies, discuss several issues, and highlight the need for further research to resolve contradictory findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Antoine Langeard, Amira Zouabi, Tristan Martin, Gaelle Quarck, Antoine Gauthier
Summary: The study aimed to investigate whether postural control in older adults followed a circadian rhythm and to examine the circadian variations in balance performances. The results showed that older adults presented a circadian rhythm of balance, especially in more challenging conditions, while vertical perception did not significantly follow a circadian rhythm.
Article
Chemistry, Medicinal
Zhen Qiao, Jiajie Luo, Yi-Quan Tang, Qiqi Zhou, Hang Qi, Zhengji Yin, Xiaowen Tang, Wei Zhu, Yanru Zhang, Ningning Wei, KeWei Wang
Summary: TRPA1 channel is implicated in sensing noxious stimuli and nociceptive signaling, while photoswitchable TRPA1 agonists can alleviate pain through channel desensitization, serving as potential pharmacological tools for study of pain signaling.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Samuel J. Belfer, Alexander G. Bashaw, Michael L. Perlis, Matthew S. Kayser
Summary: Insomnia is a common sleep disorder that can have impacts on individuals with psychiatric disorders. Cognitive behavioral therapy for insomnia involves restricting sleep opportunity to enhance sleep ability and opportunity matching.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Tadahiro Goda, Yujiro Umezaki, Fumika N. N. Hamada
Summary: Temperature influences animal physiology and behavior. Mammals set their body temperatures using metabolic and behavioral strategies, while small ectotherms such as Drosophila control their body temperatures by choosing appropriate environmental temperatures. The body temperature rhythm (BTR) and temperature preference rhythm (TPR) play important roles in regulating the daily fluctuation of body temperature. The regulatory mechanisms of TPR have been summarized, including the involvement of neuropeptides and their receptors. Understanding the mechanisms of TPR in Drosophila could provide insights into the regulation of mammalian BTR and the relationship between BTR and sleep regulation.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Neurosciences
Ceazar Nave, Logan Roberts, Patrick Hwu, Jerson D. Estrella, Thanh C. Vo, Thanh H. Nguyen, Tony Thai Bui, Daniel J. Rindner, Nicholas Pervolarakis, Paul J. Shaw, Tanya L. Leise, Todd C. Holmes
Summary: The study developed a method for imaging oscillations in fruit fly brain cells and found that weekend light shifts can disrupt neuronal synchrony and rhythmicity. Weekend light shifts were shown to cause desynchronization in circadian neuronal oscillators, leading to observed behavioral defects in sleep, learning, and memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Min Chen, Li Zhang, Mingting Shao, Jianhao Du, Yifei Xiao, Fugui Zhang, Tianpeng Zhang, Yifang Li, Qianqian Zhou, Kaisheng Liu, Zhigang Wang, Baojian Wu
Summary: This study investigates the role of circadian rhythms in the pathogenesis of delirium and identifies E4bp4 as a regulator of cognition in the crosstalk between circadian clock and delirium. The disrupted circadian rhythms and clock gene expression observed in mouse models and patients with delirium indicate a causal role of clock dysfunction in delirium development. E4bp4 restrains microglial activation and cognitive decline by inhibiting the ERK1/2 signaling pathway. Understanding these mechanisms is important for the prevention and treatment of delirium.
Article
Genetics & Heredity
Lydia Bergerson, Caleb Fitzmaurice, Tyler Knudtson, Halle McCormick, Alder M. Yu
Summary: Long-term shift work is believed to increase the risk of certain cancers, but the association with circadian rhythm disruption and DNA repair pathways is not well understood. An experiment on fruit flies suggests that circadian disruption does not significantly alter the usage of mutagenic DNA repair pathways.
Article
Cell Biology
Suman Rimal, Jiun Sang, Seeta Poudel, Dhananjay Thakur, Craig Montell, Youngseok Lee
Article
Biology
Jinfei D. Ni, Adishthi S. Gurav, Weiwei Liu, Tyler H. Ogunmowo, Hannah Hackbart, Ahmed Elsheikh, Andrew A. Verdegaal, Craig Montell
Article
Biology
Weiwei Liu, Anindya Ganguly, Jia Huang, Yijin Wang, Jinfei D. Ni, Adishthi S. Gurav, Morris A. Aguilar, Craig Montell
Article
Biochemistry & Molecular Biology
Nicole Y. Leung, Dhananjay P. Thakur, Adishthi S. Gurav, Sang Hoon Kim, Antonella Di Pizio, Masha Y. Niv, Craig Montell
Article
Biochemistry & Molecular Biology
Qiaoran Li, Nicolas A. DeBeaubien, Takaaki Sokabe, Craig Montell
Article
Genetics & Heredity
Jiaying Zhang, Junjie Luo, Jieyan Chen, Junbiao Dai, Craig Montell
Article
Genetics & Heredity
Zijing Chen, Craig Montell
Article
Neurosciences
Che-Hsiung Liu, Zijing Chen, Megan K. Oliva, Junjie Luo, Simon Collier, Craig Montell, Roger C. Hardie
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biology
Young-Cheon Kim, Daeun Choi, Ahra Cha, Yeong-Geun Lee, Nam-In Baek, Suman Rimal, Jiun Sang, Youngseok Lee, Sanghyeob Lee
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bhanu Shrestha, Youngseok Lee
Summary: DEET is a widely used insect repellent that suppresses feeding behavior and affects larval development in fruit flies.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sonali Puri, Youngseok Lee
Summary: Taste sensation and regulation are highly conserved between insects and mammals. The regulation of internal sodium concentrations is crucial for physiological processes in animals. Both mammals and flies respond differently to low and high salt concentrations based on their internal nutrient state.
Article
Biochemistry & Molecular Biology
Binod Aryal, Youngseok Lee
Summary: The study used fruit flies to dissect the molecular sensors required for histamine taste perception, finding that histamine activates bitter-sensing neurons and identifying GR22e and IR76b as essential receptors for histamine sensing.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiun Sang, Subash Dhakal, Youngseok Lee
Summary: Cucurbitacin B (cuc-B) is a bitter-tasting compound that can lower glucose levels and potentially be used to treat chronic metabolic diseases. Additionally, both cuc-B and metformin treatments improved sleep quality and memory consolidation in fruit flies.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Young Gi Hong, Bongsu Kang, Seongsoo Lee, Youngseok Lee, Bong-Gun Ju, Sangyun Jeong
MOLECULES AND CELLS
(2020)
Article
Biochemistry & Molecular Biology
Suman Rimal, Jiun Sang, Subash Dhakal, Youngseok Lee
MOLECULES AND CELLS
(2020)