Article
Clinical Neurology
Joachim Mazere, Bixente Dilharreguy, Gwenaelle Catheline, Marie Vidailhet, Marc Deffains, Delphine Vimont, Bastien Ribot, Elodie Barse, Laura Cif, Bernard Mazoyer, Nicolas Langbour, Antonio Pisani, Michele Allard, Frederic Lamare, Dominique Guehl, Philippe Fernandez, Pierre Burbaud
Summary: Early-onset torsion dystonia (DYT1) patients show disrupted cholinergic system in the putamen and cerebellar vermis, with changes occurring with age. Functional connectivity within the motor network and interregional correlation of cholinergic expression are altered in patients, indicating plasticity or compensatory mechanisms over time.
Article
Neurosciences
Kathryn M. Miller, Joseph R. Patterson, Joseph Kochmanski, Christopher J. Kemp, Anna C. Stoll, Christopher U. Onyekpe, Allyson Cole-Strauss, Kathy Steece-Collier, Jacob W. Howe, Kelvin C. Luk, Caryl E. Sortwell
Summary: Preclinical studies suggest a potential link between STN DBS and neuroprotection of nigrostriatal dopamine neurons through BDNF signaling, but the impact on alpha-synuclein aggregation and neuroinflammation remains unclear. The study in male rats using the PFF model showed that STN DBS did not affect PFF-induced accumulation of pSyn inclusions in the SNpc, but it did lead to increased BDNF protein in the striatum. These results indicate the potential of STN DBS in modifying the long-term consequences of synucleinopathy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ana Damianich, Carolina Lucia Facal, Javier Andres Muniz, Camilo Mininni, Mariano Soiza-Reilly, Magdalena Ponce De Leon, Leandro Urrutia, German Falasco, Juan Esteban Ferrario, Maria Elena Avale
Summary: Tauopathies are caused by abnormal metabolism of tau protein and an imbalance in 3R and 4R tau can lead to motor coordination impairments. Modulation of tau isoform content may be a potential disease-modifying therapy for primary tauopathies.
Article
Cell Biology
Gaurav Chhetri, Yuting Ke, Ping Wang, Muhammad Usman, Yan Li, Ellen Sapp, Jing Wang, Arabinda Ghosh, Md Ariful Islam, Xiaolong Wang, Adel Boudi, Marian DiFiglia, Xueyi Li
Summary: This study reveals that Rab11 dysfunction is involved in the regulation of striatal vulnerability in Huntington's disease through impairing XK transportation, which leads to insufficient manganese accumulation and ultimately results in striatal dysfunction.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Neurosciences
Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Katherine R. Brimblecombe
Summary: This study investigated the impact of human alpha-synuclein on DAT function in a transgenic mouse model of early PD. The results show that alpha-synuclein can promote striatal DAT function, which is regulated by extracellular cholesterol.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Engineering, Environmental
Zhipeng Qi, Shuang Wang, Jiashuo Li, Yi Wen, Rong Cui, Ke Zhang, Yanan Liu, Xinxin Yang, Lei Zhang, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng
Summary: Manganese exposure leads to abnormal dopaminergic neurons projection and reduced levels of FTO and ephrin-B2 through upregulation of Foxo3a. FTO can counteract manganese-induced down-regulation of axon guidance molecule ephrin-B2, ultimately affecting motor function.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Diones Bueno, Partha Narayan Dey, Teresa Schacht, Christina Wolf, Verena Wuellner, Elena Morpurgo, Liliana Rojas-Charry, Lena Sessinghaus, Petra Leukel, Clemens Sommer, Konstantin Radyushkin, Luise Florin, Jan Baumgart, Paul Stamm, Andreas Daiber, Guilherme Horta, Leonardo Nardi, Verica Vasic, Michael J. Schmeisser, Andrea Hellwig, Angela Oskamp, Andreas Bauer, Ruchika Anand, Andreas S. Reichert, Sandra Ritz, Gianluigi Nocera, Claire Jacob, Jonas Peper, Marion Silies, Katrin B. M. Frauenknecht, Michael K. E. Scha, Axel Methner
Summary: This study reveals the importance of NECAB2 in striatal function and mitochondrial homeostasis. Knockout of NECAB2 leads to mitochondrial dysfunction and loss of striatal synapses, suggesting its involvement in an endosomal pathway of mitochondrial stress response important for striatal function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Julia Steinhardt, Henrike Hanssen, Marcus Heldmann, Andreas Sprenger, Bjoern-Hergen Laabs, Aloysius Domingo, Charles Jourdan Reyes, Jannik Prasuhn, Max Brand, Raymond Rosales, Thomas F. Muente, Christine Klein, Ana Westenberger, Jean Q. Oropilla, Cid Diesta, Norbert Brueggemann
Summary: This study aimed to investigate whether motor or non-motor signs can serve as indicators of the prodromal phase of X-linked dystonia-parkinsonism (XDP). The study revealed balance and gait abnormalities in non-manifesting mutation carriers (NMCs) that preceded the onset of XDP, highlighting the predictive value of gait abnormalities for the estimated age at onset. These findings emphasize the importance of personalized treatment in monogenic neurodegenerative disorders.
MOVEMENT DISORDERS
(2022)
Article
Biology
Jonas-Frederic Sauer, Marlene Bartos
Summary: This study reveals alterations in prefrontal circuit function in Disc1-mutant mice, including reduced firing rates of interneurons and decreased phase-coupling with gamma oscillations. Additionally, the study found decreased spike transmission efficacy in local pyramidal cell-interneuron connections, resulting in altered activation of assembly patterns.
Article
Multidisciplinary Sciences
Olga Sergienko
Summary: Using theoretical, numerical and data analyses, this study finds that there are no general stability conditions for marine ice sheets if feedbacks caused by interactions of ice sheets with atmosphere, ocean and lithosphere are taken into account. Stability of individual configurations can be established only on a case-by-case basis.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Adam Goodworth, Duffy Felmlee, Faisal Karmali
Summary: This study examined intersubject variation in human balance, finding that these differences may arise from variances in central sensorimotor processing. Similar sensorimotor feedback mechanisms were found to be used for sagittal and frontal balance. Sensory weight and integral gain exhibited the highest correlations between planes of motion.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Zhongyun Chen, Jinghong Ma, Li Liu, Shuying Liu, Jing Zhang, Min Chu, Zhen Wang, Piu Chan, Liyong Wu
Summary: This study investigates the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient with prion protein gene (PRNP) mutation. The findings suggest that the alteration of frontal striatal loops may be involved in cognitive impairment in FTDP, while the development of parkinsonism in FTDP may primarily be due to the involvement of the presynaptic nigrostriatal loops in PRNP V180I mutation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Acoustics
Diana Deutsch, Miren Edelstein, Kevin Dooley, Trevor Henthorn
Summary: An experiment showed that short-term memory for pitch in absolute pitch possessors is more accurate than in nonpossessors, but can still be distorted or enhanced by illusory conjunctions of pitch and time. Both types of participants performed a memory task, with results suggesting a bidimensional system involving pitch height and pitch class.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Neurosciences
M. Thiele, K. S. L. Yuen, A. V. M. Gerlicher, R. Kalisch
Summary: Animal studies suggest that fear extinction learning involves prediction error signal encoded by dopamine neurons, similar to reward learning. However, the mechanisms in human fear extinction learning are still not fully understood, with previous findings indicating correlations with genetic variations related to dopamine.
Article
Biology
Amalia Papanikolaou, Fabio R. Rodrigues, Joanna Holeniewska, Keith G. Phillips, Aman B. Saleem, Samuel G. Solomon
Summary: Alzheimer's disease and other dementias impair neural plasticity. This study investigates the impact of tauopathy on visual cortical plasticity and visually evoked behaviors using a transgenic mouse model. The results reveal that both short- and long-term visual plasticity are disrupted in early stages of tauopathy and further reduced in older animals, and visually evoked behaviors are also affected.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Luis Carrillo-Reid, Rafael Yuste
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Review
Endocrinology & Metabolism
Yorgui Santiago-Andres, Matan Golan, Tatiana Fiordelisio
Summary: The pituitary gland, a master endocrine gland in vertebrates, has recently been found to consist of tightly wired large-scale networks of cells that communicate with each other in homo and heterotypic manners, optimizing hormone pulse generation in response to changing physiological demands. The development of 3D imaging methods and transgenic models has allowed for further research into functional pituitary networks across different vertebrate classes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
M. Golan, J. Boulanger-Weill, A. Pinot, P. Fontanaud, A. Faucherre, D. S. Gajbhiye, L. Hollander-Cohen, T. Fiordelisio-Coll, A. O. Martin, P. Mollard
Summary: Research in awake zebrafish larvae has shown that migrating GnRH neurons pause at the nasal-forebrain junction and form clusters that act as interhemisphere neuronal ensembles. Within these ensembles, GnRH neurons create an isolated, spontaneously active circuit that is internally wired through monosynaptic glutamatergic synapses, driving a phenotypic switch essential for proper migration toward their hypothalamic destination. This highlights the critical role of synaptic communication between migrating GnRH neurons in the reproductive process.
Review
Cell Biology
Luis Carrillo-Reid
Summary: A neuronal ensemble represents the collective activity of a specific group of neurons and can encompass various brain functions. Memory engram studies have traditionally focused on the location of memory storage, but disregarded the investigation of how neuronal activity patterns give rise to memories. Recent experiments have suggested that the association and reactivation of specific neuronal groups could be the main mechanism underlying memory. The neuronal ensemble framework can be useful in understanding memory processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Luis Carrillo-Reid, Shuting Han, Darik O'Neil, Ekaterina Taralova, Tony Jebara, Rafael Yuste
Summary: Neuronal ensembles play a crucial role in representing different states and guiding complex behaviors. The use of conditional random fields (CRFs) in identifying and manipulating pattern completion neurons that can activate entire ensembles shows potential in characterizing and selectively manipulating neural circuits.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Tatiana Fiordelisio, Ivette Buendia-Roldan, Mathieu Hautefeuille, Diana Del-Rio, Diana G. Rios-Lopez, Diego Zamarron-Hernandez, Samuel Amat-Shapiro, Andrea Campa-Higareda, Edgar Jimenez-Diaz, Erika Gonzalez-Villa, Janikua Nelson-Mora, Natllely Garcia-Carreno, Jehu Lopez-Aparicio, Eduardo Montes, Armando Santiago-Ruiz, Annie Pardo, Moises Selman
Summary: The study aimed to develop a fast and cost-effective detection method for diagnosing hypersensitivity pneumonitis using functionalized magnetic beads. The method was validated against traditional ELISA assays and showed comparable results.
Article
Biochemistry & Molecular Biology
Ana Patricia Juarez-Mercado, Rebeca Chavez-Genaro, Tatiana Fiordelisio, Adriana Gonzalez-Gallardo, Mauricio Diaz-Munoz, Francisco G. Vazquez-Cuevas
Summary: This study revealed the functional expression of purinergic P2Y2R in the ovarian surface epithelium, shedding light on the role of purines in ovarian physiology and opening up new research perspectives.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2021)
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Review
Endocrinology & Metabolism
Edgar Jimenez-Diaz, Diana Del-Rio, Tatiana Fiordelisio
Summary: Advances in cellular imaging and labeling techniques have greatly contributed to the understanding of the neuroendocrine system, from the initial characterizations to the high-resolution imaging of cellular activity. These techniques have facilitated the study of processes and dynamics at the cellular and tissue level, leading to paradigm shifts in neuroendocrinology. The development of these methods and equipment is the result of interdisciplinary integration and efforts to address significant scientific questions and health-related issues.
NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Aurelien Michau, Chrystel Lafont, Paula Bargi-Souza, Yasmine Kemkem, Anne Guillou, Magalie A. Ravier, Gyslaine Bertrand, Annie Varrault, Tatiana Fiordelisio, David J. Hodson, Patrice Mollard, Marie Schaeffer
Summary: Pancreatic islet vascular cells, particularly pericytes, play a crucial role in regulating insulin release and maintaining beta cell function. However, metabolic stress, such as obesity, can lead to pericyte hypertrophy and impaired vascular responses, which may contribute to beta cell failure in type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Luis Carrillo-Reid, Vladimir Calderon
Summary: This article proposes a conceptual framework for the identification and manipulation of neuronal ensembles using simultaneous calcium imaging and two-photon optogenetics in behaving mice. By transforming calcium transients into binary arrays and identifying neuronal ensembles as similar population vectors, the framework enables precise manipulation of neuronal ensembles.
Article
Medicine, Research & Experimental
Nicola Romano, Chrystel Lafont, Pauline Campos, Anne Guillou, Tatiana Fiordelisio, David J. Hodson, Patrice Mollard, Marie Schaeffer
Summary: Central integration of peripheral appetite-regulating signals is crucial for maintaining energy homeostasis. This study investigated the role of median eminence mural cells in modulating gut hormone effects on feeding behavior. The findings suggest that activation of these vascular cells can alter blood flow velocity, delaying the access of ghrelin to target neurons and thereby modulating food intake in response to peripheral ghrelin.
Article
Genetics & Heredity
Melissa D. Morales-Moreno, Erick G. Valdes-Galindo, Mariana M. Reza, Tatiana Fiordelisio, Jorge Peon, Armando Hernandez-Garcia
Summary: Using 2-3 gRNAs in parallel can enhance the sensitivity and speed of SARS-CoV-2 detection, accurately detecting positive and negative samples in a short time.
Article
Multidisciplinary Sciences
Miguel Zamora-Ursulo, Job Perez-Becerra, Luis Tellez, Nadia Saderi, Luis Carrillo-Reid
Summary: Motor deficits in Parkinson's disease are caused by the loss of dopaminergic neurons and dopamine depletion in different brain areas. The current therapy for this disorder involves the systemic intake of L-DOPA, making it difficult to determine the specific location where dopamine acts to alleviate motor control. In this study, the delivery of dopamine through optical stimulation in the striatum of dopamine-depleted mice produced contralateral turning behavior similar to systemic apomorphine injection. This response was dependent on the transient elevation of dopamine concentration and could be modulated by changing the light stimulation parameters. This optical delivery of dopamine recapitulated the motor effects of low concentration systemic L-DOPA, but with better temporal control of dopamine levels. Additionally, it reduced the pathological synchronization of striatal neuronal ensembles in dopamine-depleted mice. This study highlights the potential of using optical techniques to study the role of dopamine in different brain nuclei under normal and pathological conditions.
Article
Multidisciplinary Sciences
Masakazu Agetsuma, Issei Sato, Yasuhiro R. Tanaka, Luis Carrillo-Reid, Atsushi Kasai, Atsushi Noritake, Yoshiyuki Arai, Miki Yoshitomo, Takashi Inagaki, Hiroshi Yukawa, Hitoshi Hashimoto, Junichi Nabekura, Takeharu Nagai
Summary: The authors observe changes in neuronal ensembles during fear conditioning in the mouse prefrontal cortex using longitudinal imaging and computational approaches.
NATURE COMMUNICATIONS
(2023)