期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 45, 页码 17691-17709出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3429-13.2013
关键词
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资金
- National Institutes of Health [R00NS069799, 1R01NS083702]
- Thomas B. McCabe and Jeanette E. Laws McCabe Pilot Award
- Basil O'Connor Starter Scholar Research Award
- University of Pennsylvania
- National Institutes of Health
- Shriners Hospitals for the Children
The long-standing doctrine regarding the functional organization of the direct dorsal column (DDC) pathway is the somatotopic map model, which suggests that somatosensory afferents are primarily organized by receptive field instead of modality. Using modality-specific genetic tracing, here we show that ascending mechanosensory and proprioceptive axons, two main types of the DDC afferents, are largely segregated into a medial-lateral pattern in the mouse dorsal column and medulla. In addition, we found that this modality-based organization is likely to be conserved in other mammalian species, including human. Furthermore, we identified key morphological differences between these two types of afferents, which explains how modality segregation is formed and why a rough somatotopic map was previously detected. Collectively, our results establish a new functional organization model for the mammalian direct dorsal column pathway and provide insight into how somatotopic and modality-based organization coexist in the central somatosensory pathway.
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