期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 5, 页码 1859-1866出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4812-11.2012
关键词
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资金
- Deutsche Forschungsgemeinschaft [FI-379-8/1, DFG-Exc-257]
- Bundesministerium fur Bildung und Forschung [FKZ0315673A, 01E00801]
- Else-Kroner Fresenius Stiftung [2009-141]
Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo (sham) controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.
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