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Biochemistry & Molecular Biology
Geun Heo, Song-Hee Lee, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Dongjie Zhou, Jing Guo, Xiang-Shun Cui
Summary: This study investigated the function of GRP78 in porcine embryonic development and found that it affects the release of G proteins, subsequently downregulating the cAMP/PKA pathway and influencing CDK1, cyclin B, and mitochondrial function. The results suggest that inhibiting GRP78 function with HA15 treatment may have negative effects on porcine embryo quality and development.
Article
Neurosciences
Maria Jesus Valero-Aracama, Antonio Reboreda, Alberto Arboit, Magdalena Sauvage, Motoharu Yoshida
Summary: Persistent firing is considered a cellular correlate of working memory, where it is shown to be supported by cholinergic receptor activation in hippocampal CA1 pyramidal cells and suppressed by noradrenaline (NA). The inhibitory effect of NA on persistent firing is mediated through the cAMP-PKA pathway and activation of beta 1 and/or beta 3 adrenergic receptors, with high levels of NA and cAMP implicated in working memory decline under conditions such as high stress, aging, and schizophrenia.
Article
Pharmacology & Pharmacy
Fangfang Guo, Jianan Du, Lingling Liu, Yawei Gou, Mingming Zhang, Wei Sun, Hongmei Yu, Xueqi Fu
Summary: This study revealed that lncRNA OR3A4 promotes the proliferation and metastasis of ovarian cancer through the KLF6 pathway, and may also be involved in the resistance of ovarian cancer to therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yunmei Zhang, Yuan Zhang, Zizhang Wang, Yufang Sun, Xinghong Jiang, Man Xue, Yafeng Yu, Jin Tao
Summary: This study reveals that gentamicin decreases the I-DR in VG neurons through JNK and PKA-mediated signaling pathways, leading to neuronal hyperexcitability. Blocking JNK signaling and I-DR can attenuate this effect.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Article
Biochemistry & Molecular Biology
Sidong Cai, Junlei Chang, Mengqi Su, Yinxia Wei, Haoran Sun, Cong Chen, Kai-Hang Yiu
Summary: miR-455-5p plays a significant role in pathological cardiac remodeling by inactivating the PRMT1-mediated Notch signaling pathway. The miR-455-5p/PRMT1/Notch1 signaling axis may serve as potential therapeutic targets for pathological cardiac remodeling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Driever
Summary: Wnt/β-catenin signaling plays a crucial role in the development of dopaminergic neurons in zebrafish, specifically in the formation of the Otp-dependent dopaminergic neuron group. The activity of Wnt/β-catenin signaling promotes dopaminergic development during the proliferative stage of dopaminergic progenitor cells.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yi-Ting Cheng, Junsung Woo, Estefania Luna-Figueroa, Ehson Maleki, Akdes Serin Harmanci, Benjamin Deneen
Summary: Social experience plays a crucial role in the development and maintenance of higher-order brain function. By studying astrocyte function, this research shows that social isolation leads to increased Ca2+ activity and global changes in gene expression in hippocampal astrocytes of juvenile mice. The upregulation of the Ca2+ channel TRPA1 in astrocytes after social deprivation is found to be responsible for the physiological and cognitive deficits associated with social deprivation. Moreover, the inhibition of hippocampal circuits by TRPA1 is mediated by the release of the inhibitory neurotransmitter GABA by astrocytes after social deprivation.
Article
Immunology
Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang, Shu Yan Yu
Summary: Agomelatine exerts antidepressant effects by regulating neuroinflammation, autophagy disorder, and apoptosis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Desiree R. Seib, Delane F. Espinueva, Oren Princz-Lebel, Erin Chahley, Jordann Stevenson, Timothy P. O'Leary, Stan B. Floresco, Jason S. Snyder
Summary: Adult hippocampal neurogenesis plays a crucial role in decision making regarding future rewards, with inhibition of neurogenesis leading to aversion towards delayed rewards and preference for immediately available rewards. This suggests a specific role for newborn neurons in regulating choices involving future-oriented cognition.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Sadiq Nasrah, Aline Radi, Johanna K. Daberkow, Helmut Hummler, Stefanie Weber, Elie Seaayfan, Martin Koemhoff
Summary: Melanoma-associated antigen D2 (MAGED2) activates the cAMP/PKA pathway under hypoxic conditions, stimulating renal salt reabsorption and explaining the transient variant of Bartter's syndrome. MAGED2 depletion leads to upregulation of autophagy-related genes and accumulation of autophagosome marker LC3II, indicating an inhibitory role of MAGED2 in autophagy under stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Manman Ji, Zhengrong Zhang, Feng Gao, Shaojie Yang, Juan Wang, Xuncui Wang, Guoqi Zhu
Summary: This study found that CUR can prevent behavioral changes and synaptic deficits induced by PTSD through activating the cAMP-PKA signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Sang-Hyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heon-Su Kim, Gyu-Ho Choi, Eunhye Kim, Tae-Jin Kim
Summary: This study demonstrates that the ethanol extract from Rhynchosia volubilis can protect cells against apoptosis by activating the cAMP-PKA/ERK-CREB pathway.
Article
Biochemistry & Molecular Biology
Ran Zhong, Renling Miao, Jiao Meng, Rimao Wu, Yong Zhang, Dahai Zhu
Summary: Acetoacetate promotes muscle cell proliferation by upregulating muscle-specific miR-133b, which is transcriptionally mediated by MEF2 via the Mek-Erk1/2 signaling pathway, suggesting a new signaling role for AA in regulating cellular activities.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Immunology
Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin
Summary: TPM1 plays a crucial role in regulating pro-inflammatory phenotype of microglia, mediating LPS-induced inflammation through the PKA/CREB signaling pathway. TPM1 also regulates inflammation downstream of TREM2 and in a microglia-dependent manner.
JOURNAL OF NEUROINFLAMMATION
(2022)