Article
Neurosciences
Kanghoon Jung, Minhyeok Chang, Andre Steinecke, Benjamin Burke, Youngjin Choi, Yasuhiro Oisi, David Fitzpatrick, Hiroki Taniguchi, Hyung-Bae Kwon
Summary: Chandelier cells (ChCs), a type of inhibitory interneurons, establish cortical microcircuits to organize neural coding through selective synaptic plasticity. They contribute to organized motor control by enhancing population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant activity. ChCs mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and redistributing inhibitory weights during learning, allowing for efficient cortical computation.
NATURE NEUROSCIENCE
(2023)
Article
Mathematics, Applied
Pradyumna Kumar Sahoo, Shyamal Chatterjee
Summary: This paper investigates the control of galloping oscillations of elastic structures under steady and unsteady wind using high-frequency excitation. The results show that high-frequency excitation, both direct and parametric, can effectively control galloping oscillations, with direct excitation completely eliminating the oscillations and parametric excitation limiting the amplitude.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Engineering, Civil
Nagesh Ramaswamy, Bhagirath Joshi, Jiaji Wang, Xiaoliang Li, F. Y. Menq, Xiaonan Shan, Kalyana Babu Nakshatrala, K. H. Stokoe, Y. L. Mo
Summary: Seismic isolation systems aim to protect structures and uncouple their motion from incoming waves by reducing the kinetic energy transferred. This research focuses on a non-invasive vibration isolation system using periodic barriers and conducts field tests to evaluate their performance. The tests compare the effectiveness of different barrier lengths and the number of unit cells, and analyze the responses of soil to various excitation inputs.
ENGINEERING STRUCTURES
(2023)
Article
Acoustics
Pradyumna Kumar Sahoo, S. Chatterjee
Summary: This study investigates the effects of high-frequency parametric excitation on the principal parametric resonance of a nonlinear beam through theoretical and experimental analysis. It is found that the high frequency excitation significantly modifies the effective damping and stiffness of the system, causing the parametric resonance curve to shift towards higher frequencies. Furthermore, it is discovered that the principal parametric resonance can be effectively controlled and suppressed by high frequency excitation.
JOURNAL OF SOUND AND VIBRATION
(2021)
Article
Multidisciplinary Sciences
Barbara Juarez, Mi-Seon Kong, Yong S. Jo, Jordan E. Elum, Joshua X. Yee, Scott Ng-Evans, Marcella Cline, Avery C. Hunker, Meagan A. Quinlan, Madison A. Baird, Abigail J. Elerding, Mia Johnson, Derek Ban, Adriana Mendez, Nastacia L. Goodwin, Marta E. Soden, Larry S. Zweifel
Summary: This study found that two ion channels, Kv4.3 and BKCa1.1, regulate the firing pattern and dopamine release of dopamine neurons, affecting different stages of reinforced behavior in mice. Inactivation of Kv4.3 increases dopamine neuron excitability and firing rate before lever pressing in a learned instrumental paradigm. Loss of Kv4.3 enhances performance of the learned response and facilitates extinction, while loss of BKCa1.1 increases burst firing and phasic dopamine release, enhancing learning and extinction behaviors. These findings demonstrate the differential effects of intrinsic regulators on dopamine dynamics during reinforcement and extinction learning.
Article
Mathematics, Applied
Pradyumna Kumar Sahoo, S. Chatterjee
Summary: This paper investigates the vibrational resonance and control of a nonlinear tilted cantilever beam under combined multi-harmonic low and non-resonant, high-frequency excitation. The research explores the non-trivial effects of high-frequency excitation on parametric amplification, vibrational resonance, and chaos, which have not been previously reported. The results demonstrate that high-frequency excitation can effectively control parametric amplification by shifting the resonance curve and increasing the effective damping.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Multidisciplinary Sciences
Alexander Hodapp, Martin E. Kaiser, Christian Thome, Lingjun Ding, Andrei Rozov, Matthias Klumpp, Nikolas Stevens, Moritz Stingl, Tina Sackmann, Nadja Lehmann, Andreas Draguhn, Andrea Burgalossi, Maren Engelhardt, Martin Both
Summary: Information processing in neuronal networks involves the recruitment of selected neurons into coordinated activity patterns. This recruitment is achieved through specific synaptic excitation and widespread synaptic inhibition.
Article
Medicine, General & Internal
Xiang Zou, Zilu Zhu, Yu Guo, Hongmiao Zhang, Yuchen Liu, Zhengyu Cui, Zunji Ke, Shize Jiang, Yusheng Tong, Zehan Wu, Ying Mao, Liang Chen, Deheng Wang
Summary: This study demonstrates that inadequate control of seizures by VPA monotherapy may be associated with neural excitatory rebounds, which can be predicted by intraoperative electrocorticogram (ECoG) analysis. Animal experiments and computational modeling further support this finding.
Article
Biochemical Research Methods
Yuanhong Tang, Lingling An, Quan Wang, Jian K. Liu
Summary: The research suggests that feedback inhibition is crucial for generating neural oscillations in the granular layer of the cerebellum. The cooperation of different types of Golgi cell inhibition plays an essential role in regulating synchronous oscillations of the granule cell population, potentially enhancing the computational capability of downstream neurons.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Cell Biology
Pedro Royero, Anne Quatraccioni, Rieke Fruengel, Mariella Hurtado Silva, Arco Bast, Thomas Ulas, Marc Beyer, Thoralf Opitz, Joachim L. Schultze, Mark E. Graham, Marcel Oberlaender, Albert Becker, Susanne Schoch, Heinz Beck
Summary: Maintaining a balance between excitation and inhibition is crucial for neuronal information processing. A study has shown that Ste20-like kinase (SLK) mediates the cell-autonomous regulation of this balance in the thalamocortical feedforward circuit, promoting stable excitatory-inhibitory ratios and ensuring robust and sparse coding in cortical pyramidal cells.
Article
Multidisciplinary Sciences
Panagiotis Fotiadis, Matthew Cieslak, Xiaosong He, Lorenzo Caciagli, Mathieu Ouellet, Theodore D. Satterthwaite, Russell T. Shinohara, Dani S. Bassett
Summary: Recent work has found that the relationship between structural and functional connectivity in the human brain varies across different regions, with reduced connectivity observed in the sensory-association cortical hierarchy. This study suggests that intracortical myelination and excitation-inhibition balance play a role in mediating the heterogeneous expression and temporal variance of structure-function coupling.
NATURE COMMUNICATIONS
(2023)
Article
Optics
Jinpeng Yuan, Hao Liu, Lirong Wang, Liantuan Xiao, Suotang Jia
Summary: A stable and continuously tunable 420 nm coherent blue light was generated in Rb vapor through cavity-enhanced four-wave mixing process, with high output power and stability. The generated laser has good beam qualities and potential applications in photon-atom interactions.
Article
Neurosciences
Jonathan Harnie, Johannie Audet, Alexander N. Klishko, Adam Doelman, Boris I. Prilutsky, Alain Frigon
Summary: The study found that sensorimotor circuits within the spinal cord generate backward locomotion but require additional excitability compared with forward locomotion. Spinal cats showed similar strategies for speed modulation and muscle activations during forward and backward locomotion, indicating a shared spinal locomotor network.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Mechanical
Mohammed F. Daqaq, Ali H. Alhadidi, Shadi Khazaaleh
Summary: This manuscript presents an alternative method to suppress galloping oscillations by subjecting the structure to high-frequency base excitation, resulting in a shift in the galloping speed. Experimental implementation on a galloping structure confirms the effectiveness of the proposed methodology.
NONLINEAR DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Raki Sudan, Elizabeth A. Luke, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Stephane Schurmans, Benedict J. Chambers, John D. Chisholm, William G. Kerr
Summary: By comparing different types of SHIP inhibitors, it was found that only pan-SHIP1/2 inhibitors can prevent obesity caused by excessive caloric intake. The study also discovered that the mechanism of action of pan-SHIPi is through the immune system, and it can also reduce hyperglycemia.
Article
Neurosciences
Nicola Jean Porter, Wen-Chang Li
BRAIN RESEARCH BULLETIN
(2018)
Article
Mathematical & Computational Biology
Andrea Ferrario, Robert Merrison-Hort, Stephen R. Soffe, Wen-Chang Li, Roman Borisyuk
JOURNAL OF MATHEMATICAL NEUROSCIENCE
(2018)
Article
Neurosciences
Stella Koutsikou, Robert Merrison-Hort, Edgar Buhl, Andrea Ferrario, Wen-Chang Li, Roman Borisyuk, Stephen R. Soffe, Alan Roberts
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Neurosciences
Wen-Chang Li, Stephen R. Soffe
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Valentina Saccomanno, Heather Love, Amy Sylvester, Wen-Chang Li
Summary: The study showed that the lateral line system plays a crucial role in Xenopus tadpole motor responses to suction stimulation, initiating swimming reliably. Additionally, the afferent and efferent activities of the tadpole anterior lateral line nerve were analyzed, with sensory interneurons located using calcium imaging techniques.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biochemical Research Methods
Andrea Ferrario, Andrey Palyanov, Stella Koutsikou, Wenchang Li, Steve Soffe, Alan Roberts, Roman Borisyuk
Summary: This study investigates how the brain processes sensory stimuli and decides whether to initiate locomotor behavior using two computer models of a tadpole. One model focuses on studying how sensory signals from the skin initiate and stop swimming, while the other model evaluates if the motor nerve outputs from the central nervous system model can produce swimming-like movements. The combination of these two models opens up new perspectives for experimental research.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Neurosciences
Andrea Ferrario, Valentina Saccomanno, Hong-Yan Zhang, Roman Borisyuk, Wen-Chang Li
Summary: The firing reliability of inhibitory interneurons in the developing spinal cord of hatchling frog tadpoles is negatively correlated with their membrane resistance. Neurons with higher resistances have outward rectifying properties, lower firing thresholds, and minimal delay in firing. The input synaptic currents received by these neurons are scaled with their membrane resistances, while their own synaptic outputs are correlated with the membrane resistances of their postsynaptic partners.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Physiology
Emma Jean Ritson, Wen-Chang Li
CURRENT OPINION IN PHYSIOLOGY
(2019)
Article
Biochemical Research Methods
Ugo Bussy, Yu-Wen Chung-Davidson, Tyler Buchinger, Ke Li, Scott A. Smith, A. Daniel Jones, Weiming Li
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Ugo Bussy, Yu-Wen Chung-Davidson, Tyler Buchinger, Ke Li, Scott A. Smith, A. Daniel Jones, Weiming Li
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)