期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 41, 页码 14118-14124出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3340-12.2012
关键词
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资金
- National Institutes of Health [MH093412, MH070129, MH092576, MH47840, MH088985, MH58846, MH086947, MH083583]
- National Alliance for Research on Schizophrenia and Depression
- Medical Research Council Case Studentship
- Wellcome Trust
- State of California for Medical Research on Alcohol and Substance Abuse through the University of California at San Francisco
- Yerkes Base Grant [RR-00165]
- National Center for Research Resources [P51RR165]
- Office of Research Infrastructure Programs [OD P51OD11132]
Safety signals are learned cues that predict the nonoccurrence of an aversive event. As such, safety signals are potent inhibitors of fear and stress responses. Investigations of safety signal learning have increased over the last few years due in part to the finding that traumatized persons are unable to use safety cues to inhibit fear, making it a clinically relevant phenotype. The goal of this review is to present recent advances relating to the neural and behavioral mechanisms of safety learning, and expression in rodents, nonhuman primates, and humans.
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