Article
Multidisciplinary Sciences
Andre N. Herrera Charpentier, Doris I. Olekanma, Christian T. Valade, Christopher A. Reeves, Bo Ram Cho, Amy A. Arguello
Summary: The study found that the use of the protein synthesis inhibitor cycloheximide does not weaken the reconsolidation of cocaine-related memories and does not reduce relapse in adolescent or adult rats.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Deepika Kant, Sushil K. Jha
Summary: The dorsal hippocampus is primarily involved in the formation of contextual fear-conditioned memory, but such memory can also be formed in its absence. Additionally, the infralimbic cortex, a sub-region of the medial prefrontal cortex, plays an important role in the consolidation of contextual fear-conditioned memory, but its role in the development of compensatory memory is not yet known.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Fahd Yazin, Moumita Das, Arpan Banerjee, Dipanjan Roy
Summary: This study demonstrates that prediction errors in different naturalistic contexts can lead to changes in the temporal ordering of event structures in complex episodic memories. Newer sequences with prediction errors have a lower decision threshold and faster recall speed, suggesting a distinct and adaptive role for prediction errors in learning and reorganizing episodic temporal sequences.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Darryl C. Gidyk, Robert J. McDonald, Robert J. Sutherland
Summary: Results from experiments suggest that rats can maintain normal memory in adversarial learning and discrimination tasks even in the absence of the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Sean M. Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R. Seemiller, Molly A. Bogue, Stephen C. Grubb, Gary Peltz, Thomas J. Gould
Summary: The study found a significant relationship between acetylcholine activity in the dorsal hippocampus and learning capabilities, with levels of acetylcholinesterase varying among inbred mouse strains. There were differences in contextual and cued fear conditioning across different strains, and the dorsal hippocampus was found to be functionally distinct from the ventral hippocampus in relation to fear conditioning outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Wouter R. Cox, Leonidas Faliagkas, Amber Besseling, Rolinka J. van der Loo, Sabine Spijker, Merel Kindt, Priyanka Rao-Ruiz
Summary: This study aimed to investigate the neural mechanisms underlying post-reactivation changes in contextual fear memories in mice. However, results showed that neither propranolol nor anisomycin were effective in interfering with reactivated fear memories, indicating the elusive nature of reactivation-dependent changes in non-human fear memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Cassiano Ricardo Alves Faria Diniz, Leandro Antero da Silva, Gabriela Luiz Bertacchini, Antonio Furtado da Silva-Junior, Leonardo Barbosa Moraes Resstel
Summary: Re-exposure of rats to a previously fear-conditioned environment results in significant behavioral and cardiovascular changes. This study provides evidence for the involvement of the dorsal hippocampus (dHC) in contextual fear expression through cholinergic neurotransmission via muscarinic receptors (mAChRs) M1R and M3R. Activation of mAChRs in the dHC facilitates autonomic and behavioral responses associated with threats and dangers. These findings contribute to a better understanding of fear mechanisms in contextual conditioning.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Ji-Hye Lee, Woong Bin Kim, Eui Ho Park, Jun-Hyeong Cho
Summary: The consolidation process of remote contextual fear memories in mice involves the strengthening of excitatory connections between prefrontal cortical (PFC) engram neurons that were active during learning and reactivated during remote memory recall. The extinction of remote memories weakens these synapses. The synapse-specific plasticity is dependent on CREB and requires sustained hippocampal signals, which can be conveyed to PFC by the retrosplenial cortex. The strong connection between PFC engram neurons and other PFC neurons recruited during remote memory recall is also observed.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Kylie A. Huckleberry, Roberto Calitri, Anna J. Li, Mackenna Mejdell, Ashna Singh, Vasvi Bhutani, Mikaela A. Laine, Andrei S. Nastase, Maria Morena, Matthew N. Hill, Rebecca M. Shansky
Summary: Increasing evidence suggests that there may be differences in the neurobiological processes underlying learning and memory in males and females, but the specific mechanisms are not fully understood. This study explored the potential sex differences in the modulation of fear conditioning and extinction by endocannabinoids (eCBs). The results showed that females classified as "Darters" responded differently to the administration of eCB receptor drugs compared to those classified as "Non-darters". These findings suggest that there may be a sex-specific dependence on CB1Rs for context processing in females that is sensitive to disruption by TRPV1.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Lia P. Iglesias, Heliana B. Fernandes, Aline S. de Miranda, Malena M. Perez, Lucia H. Faccioli, Carlos A. Sorgi, Leandro J. Bertoglio, Daniele C. Aguiar, Carsten T. Wotjak, Fabricio A. Moreira
Summary: This study found that hippocampal TRPV1 channels play a role in the modulation of fear memories. Endocannabinoid signaling may mediate the effects of TRPV1 blockers. The intensity of the aversive stimulus affects the regulation of fear memories by TRPV1 channels. TRPV1 blockers also promote the transcription of specific genes, leading to a decrease in fear memory reinstatement.
Article
Neurosciences
Leandro Antero da Silva, Cassiano Ricardo Alves Faria Diniz, Daniela Lescano Uliana, Antonio Furtado Da Silva-Junior, Gabriela Luiz Bertacchini, Leonardo Barbosa Moraes Resstel
Summary: This study aimed to investigate the interaction between ACh and NO in modulating defensive responses, and found that the M1-M3/NO/cGMP/NMDA pathway in the dHC plays an important role in the retrieval of contextual fear responses.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Alexis C. Carpenter, Preston P. Thakral, Alison R. Preston, Daniel L. Schacter
Summary: Successful inference can alter representations of overlapping events and lead to false memories by integrating features associated with overlapping events in memory. This integration can result in misattribution of contextual details across related events.
Article
Behavioral Sciences
Gabrielle Araujo Pimentel, Ariela Maltarolo Crestani, Luiz Henrique Florindo
Summary: The study evaluated the function of the right and left CA3 in the dorsal hippocampus in processing recognition memory, spatial memory, working memory, and navigation strategy. Results showed that the dorsal CA3 may not be essential for learning and memory processing, but rats with right or bilateral lesions in the CA3 showed deficits in recognition memory.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xinhao Wang, Yize Zhao, Xiaorui Shi, Miao Gong, Ying Hao, Yaling Fu, Omar Israel Velez de-la-Paz, Xi Wang, Yuru Du, Xiangfei Guo, Li Song, Li Meng, Yuan Gao, Xi Yin, Sheng Wang, Yun Shi, Haishui Shi
Summary: This study found that the administration of exogenous SO2 derivatives has an effect on the formation of contextual fear memory, but no effect on reconsolidation and retention. This provides evidence for the development of new strategies for PTSD prevention and treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Shunya Yagi, Amanda Lee, Nadine Truter, Liisa A. M. Galea
Summary: From the results of the study, it can be seen that females showed significant sex differences compared to males in context discrimination. Although fear memory was similar between the two sexes, there were differences in activation patterns in different neural regions, with females showing more negative correlations and activation. These findings highlight the importance of studying sex differences in fear memory and the contribution of adult neurogenesis to the neuronal network.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Multidisciplinary Sciences
Weizhe Hong, Ann Kennedy, Xavier P. Burgos-Artizzu, Moriel Zelikowsky, Santiago G. Navonne, Pietro Perona, David J. Anderson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biology
Prabhat S. Kunwar, Moriel Zelikowsky, Ryan Remedios, Haijiang Cai, Melis Yilmaz, Markus Meister, David J. Anderson
Article
Multidisciplinary Sciences
Ryan Remedios, Ann Kennedy, Moriel Zelikowsky, Benjamin F. Grewe, Mark J. Schnitzer, David J. Anderson
Article
Biochemistry & Molecular Biology
Moriel Zelikowsky, May Hui, Tomomi Karigo, Andrea Choe, Bin Yang, Mario R. Blanco, Keith Beadle, Viviana Gradinaru, Benjamin E. Deverman, David J. Anderson
Article
Behavioral Sciences
Moriel Zelikowsky, Michael S. Fanselow
BEHAVIORAL NEUROSCIENCE
(2010)
Article
Neurosciences
Moriel Zelikowsky, Timothy A. Hast, Rebecca Z. Bennett, Michael Merjanian, Nathaniel A. Nocera, Ravikumar Ponnusamy, Michael S. Fanselow
BIOLOGICAL PSYCHIATRY
(2013)
Article
Neurosciences
Moriel Zelikowsky, Daniel L. Pham, Michael S. Fanselow
Article
Neurosciences
Moriel Zelikowsky, Sarah Hersman, Monica K. Chawla, Carol A. Barnes, Michael S. Fanselow
JOURNAL OF NEUROSCIENCE
(2014)
Article
Behavioral Sciences
Michael S. Fanselow, Moriel Zelikowsky, Jennifer Perusini, Vanessa Rodriguez Barrera, Sarah Hersman
NEUROBIOLOGY OF LEARNING AND MEMORY
(2014)
Article
Multidisciplinary Sciences
Moriel Zelikowsky, Stephanie Bissiere, Timothy A. Hast, Rebecca Z. Bennett, Andrea Abdipranoto, Bryce Vissel, Michael S. Fanselow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Stephanie Bissiere, Moriel Zelikowsky, Ravikumar Ponnusamy, Nathan S. Jacobs, Hugh T. Blair, Michael S. Fanselow
Article
Behavioral Sciences
Franklin B. Krasne, Michael S. Fanselow, Moriel Zelikowsky
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2011)
Article
Behavioral Sciences
Lindsay R. Halladay, Moriel Zelikowsky, Hugh T. Blair, Michael S. Fanselow
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2012)
Review
Psychology, Clinical
Michelle G. Craske, Katharina Kircanski, Moriel Zelikowsky, Jayson Mystkowski, Najwa Chowdhury, Aaron Baker
BEHAVIOUR RESEARCH AND THERAPY
(2008)