Article
Cell Biology
Meng-Shiun Wu, Ting-Wei Liao, Chun-Yuan Wu, Tzu-Han Hsieh, Ping-Chung Kuo, Yue-Chiun Li, Kuan-Chung Cheng, Hsueh-Cheng Chiang
Summary: Animals acquire surrounding information for appropriate behavior through social learning and self-learning. However, the regulatory mechanism of social learning, especially in transmitting aversive conditioning information, is still unknown. This study revealed species-dependent differences in how observer flies process aversive conditioning information acquired from demonstrator flies during social learning. Solitary flies, on the other hand, cannot learn this information through social learning, suggesting it is not an innate behavior.
Article
Neurosciences
Sanja Klein, Onno Kruse, Isabell Tapia Leon, Lukas Van Oudenhove, Sophie R. van 't Hof, Tim Klucken, Tor D. Wager, Rudolf Stark
Summary: Sharing and comparing imaging data across psychological tasks is becoming more feasible with the advancement of open science movement. This study validates the commonalities between aversive and appetitive classical conditioning through a multivariate approach, providing an empirical method to integrate fMRI findings across paradigms.
Article
Neurosciences
Yi-Ci Jhuang, Chun-hui Chang
Summary: The nucleus reuniens and the perirhinal cortex play important roles in the encoding of trace fear conditioning. Inactivation of either region partially impairs encoding, while inactivation of both regions completely abolishes encoding. Cholinergic modulation also plays a differential role in this process.
Article
Neurosciences
Daniela Calvigioni, Janos Fuzik, Pierre Le Merre, Marina Slashcheva, Felix Jung, Cantin Ortiz, Antonio Lentini, Veronika Csillag, Marta Graziano, Ifigeneia Nikolakopoulou, Moritz Weglage, Iakovos Lazaridis, Hoseok Kim, Irene Lenzi, Hyunsoo Park, Bjorn Reinius, Marie Carlen, Konstantinos Meletis
Summary: The authors use patch-sequencing to study the diversity of hypothalamic neurons projecting to the habenula. They identify an estrogen receptor-expressing neuron type that signals aversion and stress in female mice. The glutamatergic LHA-LHb neurons have unique electrophysiological properties, molecular profiles, and projection patterns, with Esr1(+) neurons inducing aversion and Npy(+) neurons controlling rearing behavior.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Raul Ramos, Chi-Hong Wu, Gina G. Turrigiano
Summary: Generalization is an adaptive mnemonic process that allows animals to use past learning experiences to navigate future scenarios. However, overgeneralization is a characteristic feature of anxiety disorders. This study demonstrates that strong conditioning results in a long-lasting generalized aversion that can persist for at least 2 weeks. The synaptic plasticity mechanisms that govern memory generalization and its persistence are explored, showing that strong conditioning leads to a long-lasting increase in synaptic strengths throughout different layers of the gustatory cortex. Repeated exposure to the generalized tastant causes a rapid attenuation of the generalized aversion and a reversal of the conditioning-induced increases in synaptic strength. These changes are more pronounced in the superficial layers. The data suggest that layer-specific synaptic plasticity mechanisms separately govern the persistence and generalization of memory for conditioned taste aversion.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Giuliana Fossati, Daniel Kiss-Bodolay, Julien Prados, Ronan Chereau, Elodie Husi, Christelle Cadilhac, Lucia Gomez, Bianca A. Silva, Alexandre Dayer, Anthony Holtmaat
Summary: The anterior cingulate cortex (ACC) is crucial for encoding, consolidating, and retrieving emotionally salient memories. The cortical layer 1 (L1) of the ACC, which is controlled by local inhibition, might be an important site for signal integration. L1 interneurons, many of which express the serotonin receptor 5HT3aR, play a role in fear memory processing. Understanding the dynamics of L1 interneurons in the ACC can provide insights into the microcircuit organization of fear learning and memory.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Behavioral Sciences
Indra R. Bishnoi, Caylen J. Cloutier, Cashmeira-Dove Tyson, Vangel M. Matic, Martin Kavaliers, Klaus -Peter Ossenkopp
Summary: This article reviews the effects of immune activation, primarily via LPS, on learning and memory, including the impact on fear and disgust responses and taste and place-related conditioned disgust memory. The central role of immune activation, particularly pro-inflammatory cytokine activity, in these effects is highlighted.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Biological
Jelena M. Wehrli, Yanfang Xia, Samuel Gerster, Dominik R. Bach
Summary: Trace fear conditioning is an important research paradigm for studying aversive learning, but the optimal measurement of memory retention is unclear. This study used psychophysiological measurements to investigate CS+ and CS- differentiation in a recall test, and found that fear-potentiated startle response was the most effective measure.
Article
Neurosciences
Eliza Bliss-Moreau, Anthony C. Santistevan, Jeffrey Bennett, Gilda Moadab, David G. Amaral
Summary: The study investigates the causal role of ACC in affective responding to threat in primates. Results suggest that the primate ACC is necessary for maintaining appropriate affective responses towards potentially harmful and/or novel stimuli, and that ACC lesions can lead to a reduced reactivity towards these stimuli, with implications for mood disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Ying Hao Yu, Arthur C. Tsai, Chen Yin Ou, Cai-N Cheng, Fang Chih Chang, Bai Chuang Shyu, Andrew Chih Wei Huang
Summary: This study found that optogenetic stimulation in the medial prefrontal cortex can modulate the valence of stimuli, including rewarding, aversive, and neutral states. This finding is important for the development of new treatments for drug addiction.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Li-Feng Yeh, Takaaki Ozawa, Joshua P. Johansen
Summary: The dorsolateral subregion of the PAG (dlPAG) plays a key role in memory formation in response to aversive events, while the ventrolateral PAG (vlPAG) does not have the same effect. In addition, specific populations of thalamus-projecting dlPAG neurons projecting to the anterior paraventricular thalamus (aPVT) can affect aversive learning, but do not impact previously learned defensive behaviors.
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yuqi You, Joshua Brown, Wen Li
Summary: Animal data suggest the sensory cortex plays a critical role in the long-term storage of aversive conditioning, post acquisition and consolidation in the amygdala. Through a human aversive conditioning study, it was found that M-biased conditioned stimuli led to stronger effects, especially in anxious individuals, across threat appraisal, physiological arousal, perceptual learning, and cortical plasticity. The long-term retention of conditioning in the basic sensory cortices supports the conserved role of the human sensory cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Eui-Ho Park, Nam-Soo Kim, Yeon-Kyung Lee, June-Seek Choi
Summary: Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a crucial role in the acquisition of fear memory during trace fear conditioning. Specifically, the prelimbic (PL) subregion within the mPFC is involved in short- and long-term trace fear memory formation. Furthermore, NMDA receptor-mediated neurotransmission in PL is required for the acquisition of trace fear memory.
Article
Anatomy & Morphology
Jose Francis-Oliveira, Owen Leitzel, Minae Niwa
Summary: This article discusses the nomenclature of the medial prefrontal cortex (mPFC) subdivisions, proposing a change in the naming of the rodent cingulate cortex to anterior cingulate cortex (aCg) and mid-cingulate cortex (mCg). Based on data, the authors show evidence of distinct cortico-cortical projections from aCg and mCg to the PrL, as well as a sex difference in the aCg with males having a higher proportion of layer V neurons projecting to the PrL.
FRONTIERS IN NEUROANATOMY
(2022)
Review
Clinical Neurology
Min Zhuo
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Anesthesiology
Yan Jin, Qian Meng, Lisheng Mei, Wenjie Zhou, Xia Zhu, Yu Mao, Wen Xie, Xulai Zhang, Min-Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Xiangyao Li, Zhi Zhang
Article
Neurosciences
Wen-Dong Zhang, Xiao-Ying Chen, Cheng Wu, Yan-Na Lian, Yong-Jie Wang, Jing-Hua Wang, Fan Yang, Chun-Hui Liu, Xiang-Yao Li
Review
Clinical Neurology
Xu-Hui Li, Qi-Yu Chen, Min Zhuo
Article
Multidisciplinary Sciences
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Long-term potentiation at hippocampal CA1 synapses can be achieved by increasing the number and/or single-channel conductance of AMPA receptors, with CaMKII and PKA working together to increase single-channel conductance.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Xin-Tai Wang, Lin Zhou, Xin-Yu Cai, Fang-Xiao Xu, Zhi-Heng Xu, Xiang-Yao Li, Ying Shen
Summary: Mutant mice with specific deletion of Mea6 in granule cells exhibit abnormal posture, balance, and motor learning, as well as disrupted migration of granule cell progenitors and damaged parallel fiber-Purkinje cell synapses, suggesting a role for Mea6 in cerebellar development and function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Qi-Yu Chen, Xu-Hui Li, Jing-Shan Lu, Yinglu Liu, Jung-Hyun Alex Lee, Yu-Xin Chen, Wantong Shi, Kexin Fan, Min Zhuo
Summary: This study found that GluN2C/2D subunits are expressed in the pyramidal cells of the ACC in adult mice. A selective antagonist of GluN2C/2D, UBP145, significantly reduced NMDAR-mediated currents without affecting synaptically evoked EPSCs. UBP145 also did not impact postsynaptic long-term potentiation (post-LTP), presynaptic LTP (pre-LTP), or LTD, but did decrease the frequency of miniature EPSCs (mEPSCs) without affecting their amplitude.
Review
Biochemistry & Molecular Biology
Jing-Hua Wang, Cheng Wu, Yan-Na Lian, Li Liu, Xiang-Yao Li
Summary: Injury or disease in the somatosensory nervous system can lead to neuropathic pain through changes in excitatory synaptic transmission. The regulation of synaptic strength and bidirectional changes play a role in neuropathic pain hypersensitivity, with long-term potentiation and long-term depression being key forms of synaptic plasticity. Understanding the molecular mechanisms of LTD may offer insights into the development of novel analgesic strategies for managing neuropathic pain.
Article
Neurosciences
Jung-Hyun Alex Lee, Zhuang Miao, Qi-Yu Chen, Xu-Hui Li, Min Zhuo
Summary: The anterior cingulate cortex (ACC) is crucial for processing pain-related information in the brain, with studies on synaptic connections within the ACC shedding light on basic cellular and molecular mechanisms underlying brain functions such as pain, emotion, and cognition. A new mapping technique combining single neuron whole-cell patch-clamp recording with multi-channel field potential recording was developed to investigate excitatory inputs into ACC neurons, revealing heterogeneous excitatory synaptic innervations from different ACC subregions. Pyramidal neurons in the ACC show faster conduction velocity with increasing stimulation distance, while different types of interneurons exhibit varying inactivation and activation properties in response to synaptic transmission modulation.
Review
Neurosciences
Qi-Yu Chen, Xu-Hui Li, Min Zhuo
Summary: The anterior cingulate cortex plays a critical role in pain modulation and pain-related emotional disorders. Long-term potentiation and long-term depression are key mechanisms underlying chronic pain and emotional disorders, with NMDARs playing important roles in these processes. Inhibiting NMDAR subtypes may offer potential drug targets for these conditions.
Article
Cell Biology
Wei Cao, Jia-hui Li, Shen Lin, Qiang-qiang Xia, Yong-lan Du, Qian Yang, Ying-zhi Ye, Ling-hui Zeng, Xiang-yao Li, Junyu Xu, Jian-hong Luo
Summary: This study shows that neuroligins are involved in autism spectrum disorder, and that dysfunction of NMDA receptors and PV+ interneurons in the medial prefrontal cortex contribute to social deficits in a mouse model of autism. The researchers found that restoring NMDA receptor function with a partial agonist improved the interneuron dysfunction and prevented social deficits. These findings suggest that targeting NMDA receptors and PV+ interneurons may be a potential therapeutic strategy for autism.
Review
Neurosciences
Jing-Shan Lu, Qi-Yu Chen, Xiang Chen, Xu-Hui Li, Zhaoxiang Zhou, Qin Liu, Yuwan Lin, Miaomiao Zhou, Ping-Yi Xu, Min Zhuo
Summary: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, often accompanied by chronic pain. Degeneration of dopaminergic neurons is the key mechanism of Parkinson's disease, leading to dysfunction in the nociceptive system.
Article
Neurosciences
Liu-kun Yang, Liang Lu, Ban Feng, Xin-shang Wang, Jiao Yue, Xu-bo Li, Min Zhuo, Shui-bing Liu
Article
Cell Biology
Yong-Jie Wang, Ming-Gang Liu, Jing-Hua Wang, Wei Cao, Cheng Wu, Zi-Yue Wang, Li Liu, Fan Yang, Zhi-Hui Feng, Li Sun, Fuxing Zhang, Yi Shen, Yu-Dong Zhou, Min Zhuo, Jian-Hong Luo, Tian-Le Xu, Xiang-Yao Li
Review
Neurosciences
Xiangyang Mei, Yixin Yang, Jinsong Zhao, Yongjie Wang, QiLiang Chen, Xiang Qian, Xiangyao Li, Zhiying Feng