Review
Clinical Neurology
Sara Katherine Pintwala, John Peever
Summary: This review discusses the symptoms, neuropathological basis, and laboratory animal models of narcolepsy. The relationship between narcolepsy and the loss of the orexin system, as well as the loss of muscle activity, is considered to be an important part of the pathogenesis of narcolepsy.
Article
Clinical Neurology
Craig W. Davis, Ulf Kallweit, Jean-Charles Schwartz, Lois E. Krahn, Ben Vaughn, Michael J. Thorpy
Summary: Pitolisant showed efficacy in reducing excessive daytime sleepiness and cataplexy in adult patients, especially those with severe narcolepsy symptoms burden.
Article
Clinical Neurology
Annika Triller, Fabio Pizza, Michel Lecendreux, Lea Lieberich, Rana Rezaei, Anna Pech de Laclause, Stefano Vandi, Giuseppe Plazzi, Ulf Kallweit
Summary: This study evaluated the effects and tolerability of pitolisant treatment in children and adolescents with narcolepsy. The results showed that pitolisant treatment effectively improved excessive daytime sleepiness and cataplexy, and it was well tolerated.
Article
Clinical Neurology
Richard K. Bogan, Michael J. Thorpy, Yves Dauvilliers, Markku Partinen, Rafael Del Rio Villegas, Nancy Foldvary-Schaefer, Roman Skowronski, Lihua Tang, Franck Skobieranda, Karel Sonka
Summary: The study evaluated the efficacy and safety of lower-sodium oxybate (LXB) compared to sodium oxybate (SXB) in adults with narcolepsy with cataplexy. Results showed that LXB demonstrated effectiveness in treating cataplexy and excessive daytime sleepiness, with a safety profile similar to SXB.
Article
Clinical Neurology
Benedicte Marie Finger, Annika Triller, Ashley M. Bourke, Gert Jan Lammers, Christian Veauthier, Merve Yildizli, Ulf Kallweit
Summary: This study investigated the frequency and characteristics of complementary and alternative medicine (CAM) use in German narcolepsy patients. 15% of patients were using CAM at the time of the survey, and an additional 18% reported past use. The most commonly used CAM treatments were vitamins/trace elements, homeopathy, and meditation. CAM users were more likely to experience side effects from medication and have low adherence to pharmacological treatment.
Review
Pediatrics
I-Hang Chung, Wei-Chih Chin, Yu-Shu Huang, Chih-Huan Wang
Summary: Pediatric narcolepsy is a common chronic sleep disorder in children, and early diagnosis and intervention are crucial for children's development. The comprehensive treatment approach includes medication, behavioral modification, and education/mental support.
Review
Medicine, General & Internal
Po-Yu Chien, Chan-Yen Kuo, Meng-Hsuan Lin, Yao-Jen Chang, Chin-Chuan Hung
Summary: Narcolepsy is a neurological disease characterized by excessive daytime sleepiness. A network meta-analysis found that solriamfetol showed superior efficacy in improving symptoms compared to other medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Shuntaro Uchida, Shingo Soya, Yuki C. Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Summary: This study identified a specific subpopulation of Gly(VMM) neurons in the ventromedial medulla that are involved in generating muscle atonia during REM sleep. Silencing this circuit resulted in REM sleep without muscle atonia and reduced time spent in cataplexy-like episodes. Additionally, Gly(VMM) neurons also play a crucial role in maintaining sleep and cataplexy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Charles J. Bae, Phyllis C. Zee, Eileen B. Leary, Douglas S. Fuller, Wayne Macfadden, Shawn Candler, Teresa L. Steininger, Aatif M. Husain
Summary: The TENOR study aimed to provide real-world insight into the experience of individuals with narcolepsy transitioning from sodium oxybate to low-sodium oxybate. The findings showed that the effectiveness and tolerability remained stable during the transition from sodium oxybate to low-sodium oxybate treatment.
Article
Clinical Neurology
Kiran Maski, Jennifer Worhach, Erin Steinhart, Madeline Boduch, Anne Marie Morse, Michael Strunc, Thomas Scammell, Judith Owens, Lindsay Jesteadt, Claire Crisp, David Williams, Georgios Sideridis
Summary: The study introduces a validated tool called the Pediatric Hypersomnolence Survey (PHS) that can accurately identify pediatric patients with narcolepsy and idiopathic hypersomnia. This tool has the potential to decrease diagnostic delays and time to treatment, ultimately reducing the burden of these debilitating conditions.
Article
Clinical Neurology
Alexander Kuts, Michael Poluektov, Alexander Zakharov, Vlada Govzman, Irina Ponomareva, Eduard Yakupov, Irina Zavalko, Olga Tikhomirova, Yurii Sviryaev, Alexey Yakovlev, Alexander Polyakov, Alexander Melnikov, Claudio L. A. Bassetti
Summary: This study aims to report the clinical and polysomnography/multiple sleep latency test (MSLT) results of narcolepsy in the Russian population and compare them with the data from the European Narcolepsy Network (EU-NN). The results of this first study of the Russian Narcolepsy Network suggest a similar profile to the recently reported EU-NN data, indicating a low awareness of narcolepsy in Russia.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Geoffroy Vellieux, Justine Frija-Masson, Anny Rouvel-Tallec, Xavier Drouot, Marie-Pia D'ortho
Summary: The case describes a male patient diagnosed with narcolepsy type 1 based on sleep and wake symptoms and various investigations. Despite receiving treatment with stimulants and anti-cataplectic drugs for several years without significant improvement, the patient experienced spontaneous remission of the disease after 15 years.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Lucie Barateau, Michel Lecendreux, Sofiene Chenini, Anna Laura Rassu, Regis Lopez, Carole Pesenti, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: The study validated the Narcolepsy Severity Scale (NSS) in adults with narcolepsy type 1 (NT1) and developed the Pediatric NSS (NSS-P). Through a survey of 209 children and adolescents, it was found that NSS-P has good psychometric properties and reliability in pediatric NT1 patients.
Article
Clinical Neurology
Claudio L. A. Bassetti, Ulf Kallweit, Luca Vignatelli, Giuseppe Plazzi, Michel Lecendreux, Elisa Baldin, Leja Dolenc-Groselj, Poul Jennum, Ramin Khatami, Mauro Manconi, Geert Mayer, Markku Partinen, Thomas Pollmaecher, Paul Reading, Joan Santamaria, Karel Sonka, Yves Dauvilliers, Gert J. Lammers
Summary: This paper provides evidence-based guidelines for the management of narcolepsy in adults and children, with main recommendations focusing on treatment options for excessive daytime sleepiness and cataplexy, tailored to each patient's individual circumstances.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Genetics & Heredity
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda
Summary: Idiopathic hypersomnia is a rare sleep disorder characterized by excessive daytime sleepiness. A study in a Japanese population identified a rare variant associated with this disorder, which results in decreased signaling through orexin receptors, similar to narcolepsy type 1.
NPJ GENOMIC MEDICINE
(2022)
Article
Biology
Yael Mandelblat-Cerf, Rohan N. Ramesh, Christian R. Burgess, Paola Patella, Zongfang Yang, Bradford B. Lowell, Mark L. Andermann
Article
Neurosciences
Alastair S. Garfield, Bhavik P. Shah, Christian R. Burgess, Monica M. Li, Chia Li, Jennifer S. Steger, Joseph C. Madara, John N. Campbell, Daniel Kroeger, Thomas E. Scammell, Bakhos A. Tannous, Martin G. Myers, Mark L. Andermann, Michael J. Krashes, Bradford B. Lowell
NATURE NEUROSCIENCE
(2016)
Article
Neurosciences
Christian R. Burgess, Rohan N. Ramesh, Arthur U. Sugden, Kirsten M. Levandowski, Margaret A. Minnig, Henning Fenselau, Bradford B. Lowell, Mark L. Andermann
Article
Multidisciplinary Sciences
Yoav Livneh, Rohan N. Ramesh, Christian R. Burgess, Kirsten M. Levandowski, Joseph C. Madara, Henning Fenselau, Glenn J. Goldey, Veronica E. Diaz, Nick Jikomes, Jon M. Resch, Bradford B. Lowell, Mark L. Andermann
Article
Neurosciences
Yael Mandelblat-Cerf, Angela Kim, Christian R. Burgess, Siva Subramanian, Bakhos A. Tannous, Bradford B. Lowell, Mark L. Andermann
Article
Neurosciences
Christian R. Burgess, Yoav Livneh, Rohan N. Ramesh, Mark L. Andermann
CURRENT OPINION IN NEUROBIOLOGY
(2018)
Article
Neurosciences
Rohan N. Ramesh, Christian R. Burgess, Arthur U. Sugden, Michael Gyetvan, Mark L. Andermann
Article
Neurosciences
Arthur U. Sugden, Jeffrey D. Zaremba, Lauren A. Sugden, Kelly L. McGuire, Andrew Lutas, Rohan N. Ramesh, Osama Alturkistani, Kristian K. Lensjo, Christian R. Burgess, Mark L. Andermann
NATURE NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
Alexa D. Faulkner, Christian R. Burgess
Summary: The study investigates the effects of metabolic demands on cortical coding and finds that food restriction has an impact on visual processing.
Article
Biochemistry & Molecular Biology
Kelly L. McGuire, Oren Amsalem, Arthur U. Sugden, Rohan N. Ramesh, Jesseba Fernando, Christian R. Burgess, Mark L. Andermann
Summary: This study investigates how neurons in the Postrhinal cortex (POR) of mice encode objects across different contexts. The researchers found two classes of neurons with distinct characteristics. One class showed minimal response to cues before learning but exhibited selective responses to specific cues in the context of reward and locomotion after learning. The other class of neurons showed transient cue responses that were unaffected by reward learning and adapted over time.
Editorial Material
Medicine, General & Internal
Christian R. Burgess, Thomas E. Scammell
Summary: A recent study reveals the significance of dopaminergic nerve terminals in modulating REM sleep and cataplexy, suggesting their potential role in emotional memory processing. This has implications for investigating REM sleep in individuals with post-traumatic stress disorder.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Neurosciences
Liam E. Potter, Christian R. Burgess
Summary: Given the impact of sleep disorders on health, researchers are exploring novel avenues of treatment, including targeting the melanin-concentrating hormone (MCH) system. This system has been implicated in sleep regulation and various physiological functions, but skepticism remains regarding the development of MCH-targeting drugs. Additional research is needed to fully understand the role of the MCH system in sleep regulation and address drug design challenges.
FRONTIERS IN NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Roberto De Luca, William D. Todd, Christian R. Burgess
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
B. G. Beekly, A. Rupp, C. R. Burgess, C. F. Elias
Summary: Hypothalamic melanin-concentrating hormone (MCH) neurons play important roles in neuroendocrine processes, and their effects may be influenced by co-released neurotransmitters. The debate on fast neurotransmitter co-release from MCH neurons has been controversial, with data supporting different possibilities. Instead of taking a stance in this debate, this review proposes an alternative explanation: the neurochemical identity of MCH neurons, including classical neurotransmitter content, can change. We suggest that MCH neurons may release GABA and/or glutamate at different points based on environmental and contextual factors. Through the perspective of the MCH system, we provide evidence that the field of neuroendocrinology would benefit from a more nuanced and dynamic interpretation of neurotransmitter identity.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Brandon A. Toth, Katie S. Chang, Sarah Fechtali, Christian R. Burgess
Summary: This study found that dopamine release in the striatum plays an important role in regulating cataplexy and REM sleep.
