Article
Biology
Jose Ernesto Canton-Josh, Joanna Qin, Joseph Salvo, Yevgenia Kozorovitskiy
Summary: This study reveals the expression of dopamine type 1 receptors in unipolar brush cells of the mouse cerebellum, showing that their activation can increase firing rate. Evidence supports the hypothesis of dopaminergic co-release from locus coeruleus axons. It is also found that Purkinje cells directly inhibit Drd1-positive UBCs, forming a dopamine-sensitive recurrent circuit in the vestibulo-cerebellar system.
Article
Biochemistry & Molecular Biology
Dan Liu, Jun Wang, Liuqing Zhou, E. Tian, Jingyu Chen, Weijia Kong, Yisheng Lu, Sulin Zhang
Summary: Unilateral vestibular injury leads to changes in marker gene expression of unipolar brush cells in the flocculus, suggesting their involvement in vestibular compensation. The modulatory role of the cerebellum, particularly the flocculonodular lobe, in vestibular compensation is important for understanding vestibular disorder therapy and CNS plasticity after injury.
Article
Multidisciplinary Sciences
Chong Guo, Vincent Huson, Evan Macosko, Wade G. Regehr
Summary: The authors demonstrate that graded molecular heterogeneity in cerebellar unipolar brush cells (UBCs) leads to a continuum of temporal responses, allowing for stable cell-autonomous basis for temporal integration and learning over multiple time scales.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Jianchen Fan, Xinyan Dong, Yejiao Tang, Xuehui Wang, Donghui Lin, Lifen Gong, Chen Chen, Jie Jiang, Weida Shen, Anyu Xu, Xiangnan Zhang, Yicheng Xie, Xin Huang, Linghui Zeng
Summary: The pathogenesis of temporal lobe epilepsy (TLE) is closely related to neural circuits in the brain, especially the synaptic excitation/inhibition balance. Through a TLE model, the study found an increase in excitatory synapses and a decrease in inhibitory synapses, as well as active synaptic phagocytosis by microglia after seizure formation. These findings provide new insights into the understanding of TLE and potential therapeutic targets for epilepsy treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Harsha Gurnani, R. Angus Silver
Summary: Inhibitory neurons, specifically cerebellar Golgi cells (GoCs), exhibit multidimensional activity patterns that could be utilized for inhibition-mediated adaptive gain control and spatiotemporal patterning. The activity of GoCs is organized into multiple modes during spontaneous behaviors, with a slow, network-wide modulation correlating with whisking and locomotion, and faster differential population activity encoding more precise information. Modeling these circuits demonstrated the importance of electrical coupling for maintaining these population activity patterns.
Review
Cell Biology
Adriana Caballero, Amanda Orozco, Kuei Y. Tseng
Summary: The prefrontal cortex (PFC) plays critical roles in cognitive and emotional functions, with its intrinsic function defined by the interaction of local neurons and long-range inputs. An increase in GABAergic transmission during adolescence modifies the excitatory-inhibitory ratio in adults, potentially changing the dynamics of PFC networks during the transition to adulthood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaojuan Yang, Herve Le Corronc, Pascal Legendre, Antoine Triller, Christian G. Specht
Summary: Super-resolution imaging has shown that GlyRs and GABA(A)Rs are dynamically organized within sub-synaptic domains at mixed inhibitory synapses, with each occupying different sub-synaptic spaces. Differential regulation of GABA(A)Rs and GlyRs, particularly in response to increased network activity, suggests that distinct signaling pathways control the clustering of these receptors at synapses.
Article
Anesthesiology
Lou Cathenaut, Benjamin Leonardon, Robin Kuster, Perrine Inquimbert, Remy Schlichter, Sylvain Hugel
Summary: The networks in the dorsal horn of the spinal cord play a crucial role in processing nociceptive information and shaping pain perception. Short-term plasticity of inhibitory connections, particularly in lamina II, can modulate the balance between excitation and inhibition, thus influencing pain transmission. This study showed that GABAergic interneurons in lamina II had target-specific and frequency-specific plasticity, with connections onto eGFP+ (putative excitatory) interneurons showing frequency-dependent depression and connections onto eGFP- (putative inhibitory) interneurons displaying limited frequency-dependent changes. These findings suggest that the modulation of inhibitory connections may be a potential target for pain relief strategies.
Article
Neurosciences
Juan Chen, Xiao-Lin Ma, Hui Zhao, Xiao-Yu Wang, Min-Xin Xu, Hua Wang, Tian-Qi Yang, Cheng Peng, Shuang-Shuang Liu, Man Huang, Yu-Dong Zhou, Yi Shen
Summary: Autism spectrum disorder (ASD) is characterized by impaired social communication and rigid behaviors, and abnormal synapse development and E/I imbalance may contribute to its pathogenesis. Astrocytes play a crucial role in synaptic formation and function, and targeting altered GABAergic neurotransmission represents a promising therapeutic strategy for ASD.
Article
Neurosciences
Stefano Scarano, Viviana Rota, Luigi Tesio, Laura Perucca, Antonio Robecchi Majnardi, Antonio Caronni
Summary: This study analyzed the balance ability of patients with Fahr's disease and found vestibular balance control impairment during standing. The characteristics of balance impairment outlined in this study are of great significance for neurologists and physiatrists in detecting, staging, and treating this rare condition.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Xiao-Bo Wu, Qian Zhu, Yong-Jing Gao
Summary: The study showed that neuropathic pain affects the intensity of excitatory and inhibitory synaptic inputs to MSNs in the NAc shell, which in turn influences related behavioral outputs.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Chuchu Qi, Andi Chen, Honghui Mao, Erling Hu, Junye Ge, Guaiguai Ma, Keke Ren, Qian Xue, Wenting Wang, Shengxi Wu
Summary: This study explored the role of environmental factors, specifically medication during pregnancy, in the development of autism spectrum disorder (ASD). The researchers found that exposure to valproic acid (VPA) during pregnancy led to changes in excitatory and inhibitory synaptic function and contributed to ASD-like behaviors. They also discovered that treatment with exogenous brain-derived neurotrophic factor (BDNF) rescued synaptic functions and improved social defects in the mouse model.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Matthias Garten, Lars D. Mosgaard, Thomas Bornschloegl, Stephane Dieudonne, Patricia Bassereau, Gilman E. S. Toombes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cell Biology
Guy Bouvier, David Higgins, Maria Spolidoro, Damien Carrel, Benjamin Mathieu, Clement Lena, Stephane Dieudonne, Boris Barbour, Nicolas Brunel, Mariano Casado
Article
Biology
Guillaume P. Dugue, Matthieu Tihy, Boris Gourevitch, Clement Lena
Article
Biology
Sara Matias, Eran Lottem, Guillaume P. Dugue, Zachary F. Mainen
Article
Multidisciplinary Sciences
S. Senova, C. Poupon, J. Dauguet, H. J. Stewart, G. P. Dugue, C. Jan, K. Hosomi, G. S. Ralph, L. Barnes, X. Drouot, C. Pouzat, J. F. Mangin, F. Pain, I. Doignon, R. Aron-Badin, E. Brouillet, E. S. Boyden, K. A. Mitrophanous, P. Hantraye, S. Palfi
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Yo Otsu, Salvatore Lecca, Katarzyna Pietrajtis, Charly Vincent Rousseau, Paikan Marcaggi, Guillaume Pierre Dugue, Caroline Mailhes-Hamon, Manuel Mameli, Marco Alberto Diana
Article
Multidisciplinary Sciences
Oscar Hernandez, Katarzyna Pietrajtis, Benjamin Mathieu, Stephane Dieudonne
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Andrea Tinterri, Fabien Menardy, Marco A. Diana, Ludmilla Lokmane, Maryama Keita, Fanny Coulpier, Sophie Lemoine, Caroline Mailhes, Benjamin Mathieu, Paloma Merchan-Sala, Kenneth Campbell, Ildiko Gyory, Rudolf Grosschedl, Daniela Popa, Sonia Garel
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Y. Otsu, E. Darcq, K. Pietrajtis, F. Matyas, E. Schwartz, T. Bessaih, S. Abi Gerges, C. V. Rousseau, T. Grand, S. Dieudonne, P. Paoletti, L. Acsady, C. Agulhon, B. L. Kieffer, M. A. Diana
Article
Biochemistry & Molecular Biology
Vincent Villette, Mariya Chavarha, Ivan K. Dimov, Jonathan Bradley, Lagnajeet Pradhan, Benjamin Mathieu, Stephen W. Evans, Simon Chamberland, Dongqing Shi, Renzhi Yang, Benjamin B. Kim, Annick Ayon, Abdelali Jalil, Francois St-Pierre, Mark J. Schnitzer, Guoqiang Bi, Katalin Toth, Jun Ding, Stephane Dieudonne, Michael Z. Lin
Article
Biology
Ines Gonzalez-Calvo, Keerthana Iyer, Melanie Carquin, Anouar Khayachi, Fernando A. Giuliani, Severine M. Sigoillot, Jean Vincent, Martial Seveno, Maxime Veleanu, Sylvana Tahraoui, Melanie Albert, Oana Vigy, Celia Bosso-Lefevre, Yann Nadjar, Andrea Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi
Summary: The study revealed the importance of Susd4 gene in synaptic function and plasticity, with its constitutive loss affecting motor coordination adaptation and learning in mice. Additionally, SUSD4 was found to interact with proteins regulating AMPA receptor turnover, potentially playing a role in neurodevelopmental diseases.
Article
Chemistry, Analytical
Romain Fayat, Viviana Delgado Betancourt, Thibault Goyallon, Mathieu Petremann, Pauline Liaudet, Vincent Descossy, Lionel Reveret, Guillaume P. Dugue
Summary: Inertial sensors are increasingly being used in rodent research to estimate head orientation and tilt, with the potential for accurate tilt estimates during movement when combined with sensor calibration and appropriate filter and parameter choices. Additionally, these sensors can be applied in studying vestibular functions and behavioral analysis in rodents.
Article
Biochemistry & Molecular Biology
Diana Fernandez-Suarez, Favio A. Krapacher, Katarzyna Pietrajtis, Annika Andersson, Lilian Kisiswa, Alvaro Carrier-Ruiz, Marco A. Diana, Carlos F. Ibanez
Summary: The research on adult mice revealed that GFR alpha 1 plays a crucial role in maintaining and functioning of glutamatergic synapses. Loss of GFR alpha 1 leads to alterations in the stability and functionality of synapses, impacting anxiety and fear behaviors.
Article
Biology
Valeria Zampini, Jian K. Liu, Marco A. Diana, Paloma P. Maldonado, Nicolas Brunel, Stephane Dieudonne