期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 35, 页码 11980-11990出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0984-12.2012
关键词
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资金
- Canadian Institutes of Health Research
- 973 Program of the Ministry of Science and Technology of China [2012CB517903]
- National Natural Science Foundation of China [31040085, 30830106, 30972461]
- Chongqing International Science and Technology Cooperation Foundation [cstc201110003]
It is well known that novel environments can enhance learning and memory. However, the underlying mechanisms remain poorly understood. Here, we report that, in freely moving rats, novelty exploration facilitates the production of hippocampal CA1 long-term depression (LTD), a well characterized form of synaptic plasticity believed to be a cellular substrate of spatial learning, and thereby converts short-term memory (STM) into long-term memory (LTM) in an inhibitory avoidance learning procedure. Blocking the induction or the expression of CA1 LTD with two mechanistically and structurally distinct inhibitors prevents not only novelty acquisition but also the novelty exploration-promoted conversion of STM into LTM. Moreover, production of LTD with a strong electrical stimulation induction protocol or facilitation of hippocampal LTD by pharmacological inhibition of glutamate transporter activity mimics the behavioral effects of novelty exploration, sufficiently promoting the conversion of STM into LTM. Together, our findings suggest that induction of LTD may play an essential role not only in novelty acquisition but also in novelty-mediated memory enhancement.
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