Article
Multidisciplinary Sciences
Winston H. Cuddleston, Junhao Li, Xuanjia Fan, Alexey Kozenkov, Matthew Lalli, Shahrukh Khalique, Stella Dracheva, Eran A. Mukamel, Michael S. Breen
Summary: This study investigates RNA editing in different cell populations of the human prefrontal cortex and reveals selective and highly cell type-specific RNA editing in neurons. The findings provide insights into the functional roles of RNA editing in the brain and its implications for brain disorders.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Juan Qiao, Deyu Wu, Yuying Song, Wenliang Ji, Qingwei Yue, Lanqun Mao, Li Qi
Summary: A new fluorescent probe was designed to simultaneously measure intracellular temperature and norepinephrine (NE) variations, revealing an increase in cell temperature and decrease in NE reuptake during antidepressant drug inhibition. This study provides insight into the underlying mechanisms of neurotransmitter signaling pathways, which could aid in the treatment of depression.
ANALYTICAL CHEMISTRY
(2021)
Article
Ornithology
Yu-Chia Ku, Yu-Chi Chen, Chih-Ming Hung, Chen Siang Ng
Summary: This study investigated the genetic factors associated with the expansion of African Sacred Ibises in Taiwan and found that genetic variation in behavior-related genes may not have played a significant role in the successful invasion of these birds. Despite inbreeding effects, the behavior-related genes showed high levels of genetic variation.
Article
Neurosciences
Federica Campanelli, Gioia Marino, Noemi Barsotti, Giuseppina Natale, Valeria Calabrese, Antonella Cardinale, Veronica Ghiglieri, Giacomo Maddaloni, Alessandro Usiello, Paolo Calabresi, Massimo Pasqualetti, Barbara Picconi
Summary: The study reveals that sex-specific neural modulation may result in abnormalities in corticostriatal plasticity in mice. Furthermore, the interaction between dopaminergic and serotonergic systems plays a crucial role in controlling striatal synaptic plasticity.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L. Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B. -H. Tok, James C. Y. Dunn, Bianxiao Cui, Sergiu P. Pasca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Summary: Neurotransmitters play crucial roles in regulating neural circuit dynamics in the central and peripheral nervous systems, including the gastrointestinal tract. However, there is a lack of bioelectronic tools for real-time monitoring of neurotransmitter dynamics in vivo, especially in the enteric nervous system. In this study, the researchers developed a tissue-mimicking, stretchable neurochemical biological interface called NeuroString, which allows chronic in vivo real-time monitoring of monoamine levels in the brain and serotonin dynamics in the gut. This interface has the potential for studying the impact of neurotransmitters on gut microbes and brain-gut communication.
Editorial Material
Multidisciplinary Sciences
Anna E. Ingebretson, Julia C. Lemos
Summary: A new role has been discovered for the ubiquitous integrated stress response pathway in striatal-dependent learning and memory.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yurong Sun, Xinyi Wang, Shui Tian, Zhilu Chen, Huan Wang, Li Xue, Rui Yan, Zhijian Yao, Qing Lu
Summary: This study investigated the latent pathway of dopamine gene-hierarchical brain network-antidepressant treatment, revealing a close relationship between DRD1 genetic variants and SSRI treatment outcomes as well as brain network connection strength. DRD1 plays a significant role in antidepressant therapy, impacting both treatment response and brain network organization.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Avery McGuirt, Irena Pigulevskiy, David Sulzer
Summary: In this study, the enhanced pause expression of striatal cholinergic interneurons (ChI) in infantile mice is found to decrease as the excitatory input declines during development. The activation of noninactivating delayed rectifier Kv7.2/3 current in infantile ChIs promotes pause expression, which decreases over development, accompanied by an increase in I-h, demonstrating that the developmental changes in intrinsic and circuit mechanisms of ChI pause expression may underlie alterations in learning properties as the nervous system matures.
Article
Behavioral Sciences
Jasmin Obermanns, Hanna Meiser, Saskia Hoberg, Cynthia Segura Vesterager, Frank Schulz, Georg Juckel, Barbara Emons
Summary: This study found higher concentrations of AEA and decreased concentrations of 2-AG in patients with depression compared to healthy participants. Lower concentrations of 2-AG were correlated with higher levels of anxiety symptoms. Male patients had increased concentrations of 2-AG, while female patients had increased anxiety symptoms. Genotypic variations of 5-HT1A rs6295 and 5-HT2A rs6311 were associated with altered serotonergic activity and serotonin content in patients.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Zhuo Wang, Chen Li, Jiuyang Ding, Yanning Li, Zhihua Zhou, Yanjun Huang, Xiaohan Wang, Haoliang Fan, Jian Huang, Yitong He, Jianwei Li, Jun Chen, Pingming Qiu
Summary: This study investigated the serotonergic pathway involved in MA-induced emotional disorders using a chronic MA administration mouse model. The findings suggest that abnormal regulation of 5-HT2CR in the basolateral amygdala may contribute to the manifestation of emotional disorder-like symptoms induced by chronic MA use, making it a promising clinical target for treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Summary: Alcohol use disorder is a common yet poorly treated psychiatric condition, with reinforcement-based cognitive biases playing a key role in its development and treatment. Recent preclinical research offers new opportunities to understand the role of reinforcement sensitivity and RBCBs in various aspects of AUD.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lei Ma, Julian Day-Cooney, Omar Jaidar Benavides, Michael A. Muniak, Maozhen Qin, Jun B. Ding, Tianyi Mao, Haining Zhong
Summary: PKA activity is essential for normal locomotion in both direct and indirect pathway striatal spiny projection neurons. Dopamine activates PKA activity in direct pathway SPNs, while adenosine accumulation largely affects PKA activity in indirect pathway SPNs.
Review
Pharmacology & Pharmacy
Mydirah Littlepage-Saunders, Michael J. Hochstein, Doris S. Chang, Kari A. Johnson
Summary: Dopamine transmission in the striatum is regulated by various G protein-coupled receptors (GPCRs) that bind neuromodulators, including dopamine itself. These GPCRs can modulate dopamine release by acting on different components of the dopaminergic circuitry and can have distinct effects on behavior and psychoactive drug actions. This review discusses the mechanisms by which GPCRs regulate dopaminergic transmission and their relevance to the effects of psychoactive drugs on physiology and behavior.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
L. R. F. Faro, C. Costas-Ferreira, A. A. Pantoja, R. Duran
Summary: This study found that antioxidants can prevent excessive dopamine release induced by organophosphorus pesticides, reducing the risk of neuronal damage.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Neurosciences
Melissa M. Conti Mazza, Ashley Centner, David F. Werner, Christopher Bishop
Summary: L-DOPA is the standard treatment for Parkinson's disease, but chronic treatment leads to L-DOPA-induced dyskinesia. This study found that dopamine depletion and L-DOPA treatment alter the expression and function of dopamine and serotonin transporters, suggesting their potential as biomarkers and therapeutic targets for dyskinesia in Parkinson's disease patients.
Article
Neurosciences
Scott A. Langenecker, Mindy Westlund Schreiner, Leah R. Thomas, Katie L. Bessette, Sophia R. DelDonno, Lisanne M. Jenkins, Rebecca E. Easter, Jonathan P. Stange, Stephanie L. Pocius, Alina Dillahunt, Tiffany M. Love, K. Luan Phan, Vincent Koppelmans, Martin Paulus, Martin A. Lindquist, Brian Caffo, Brian J. Mickey, Robert C. Welsh
Summary: Resting-state graph-based network edges can be integrated with RDoC constructs for accurate identification of mood disorder-related markers. However, prior network models may lack sufficient diagnostic clarity, and parcel-based edges may be insufficiently sensitive for these purposes.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Biochemistry & Molecular Biology
Danielle S. Kroll, Katherine L. McPherson, Peter Manza, Melanie L. Schwandt, Pei-Hong Shen, David Goldman, Nancy Diazgranados, Gene-Jack Wang, Corinde E. Wiers, Nora D. Volkow
Summary: This study found that individuals with alcohol use disorder (AUD) had higher serum transferrin saturation compared to healthy controls. The genetic variation in HFE rs1799945 was associated with elevated transferrin saturation in both AUD and healthy controls. Serum transferrin saturation can predict alcohol withdrawal severity, suggesting its potential use as a predictor for treatment.
Article
Psychiatry
Brian J. Mickey, Yarden Ginsburg, Erica Jensen, Daniel F. Maixner
Summary: The study found that better acute ECT response may be associated with lower medication resistance, shorter index episodes, and the presence of psychotic features. Long-term depression outcomes were predicted by acute therapeutic response to ECT rather than ECT adverse effects. Marital status and baseline severity were related to long-term depression outcomes, independent of other factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Alan Prossin, Alisa Koch, Phillip Campbell, Geoffroy Laumet, Christian S. Stohler, Robert Dantzer, Jon-Kar Zubieta
Summary: Behavioral conditioning and positive expectation can influence disease pathology through placebo effects, involving modulation of inflammatory proteins. Neuroimaging studies reveal that placebo-induced reduction in IL-18 levels, correlated with endogenous opioid release, may play a key role in pain relief and mood regulation via neuroimmune interactions.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Haitao Zhang, Bridget F. Grant, Colin A. Hodgkinson, W. June Ruan, Bradley T. Kerridge, Boji Huang, Tulshi D. Saha, Amy Z. Fan, Veronica Wilson, Jeesun Jung, Abbas Parsian, David Goldman, S. Patricia Chou
Summary: The study indicates that substance use disorders (SUDs) are partially heritable and are cross-transmitted genetically. Using exome-focused genotyping, researchers identified susceptibility genes for SUDs that overlap significantly with genes previously implicated by GWAS studies. Polygenic scores revealed shared and unshared genetic contributions to the pathogenesis of SUDs, as well as differences in the inheritance patterns among different SUDs.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Javier Ballester, Anne K. Baker, Ilkka K. Martikainen, Vincent Koppelmans, Jon-Kar Zubieta, Tiffany M. Love
Summary: This study found that chronic pain patients at high risk for opioid misuse showed higher baseline MOR availability in the right amygdala, while patients at low risk for opioid misuse showed less pain-induced activation of MOR-mediated, endogenous opioid neurotransmission in the nucleus accumbens.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Microbiology
J. J. Barb, K. A. Maki, N. Kazmi, B. K. Meeks, M. Krumlauf, R. T. Tuason, A. T. Brooks, N. J. Ames, D. Goldman, G. R. Wallen
Summary: This study investigated the effects of alcohol cessation on the oral microbiome during inpatient treatment for alcohol use disorder (AUD). The results showed that alcohol preference was associated with changes in oral microbiome diversity, and alcohol cessation and attention to oral care improved dysbiosis and oral health.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Psychiatry
Caline S. Karam, Brenna L. Williams, Irina Morozova, Qiaoping Yuan, Rony Panarsky, Yuchao Zhang, Colin A. Hodgkinson, David Goldman, Sergey Kalachikov, Jonathan A. Javitch
Summary: Drug abuse, particularly of stimulants, is a significant public health issue with various complications. This study utilized the fruit fly model to investigate the transcriptional changes induced by amphetamines (AMPHs), identifying genes involved in mRNA translation control that were upregulated in response to AMPH. The findings contribute to our understanding of the molecular basis of drug addiction.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Jacob N. N. Hunter, Elizabeth K. K. Wood, Brandon L. L. Roberg, Leslie Neville, Melanie L. L. Schwandt, Lynn A. A. Fairbanks, Christina Barr, Stephen G. G. Lindell, David Goldman, Stephen J. J. Suomi, J. Dee Higley
Summary: This study examines the differences in rates of aggression exhibited by male and female rhesus monkeys in the presence of an unfamiliar stranger. The results suggest that males display higher rates of physical aggression towards the stranger, particularly when both the resident and stranger possess the s-allele of the 5-HTT genotype. Interestingly, resident females also exhibit higher rates of physical aggression, but towards familiar same-sex members of their social group.
HORMONES AND BEHAVIOR
(2022)
Correction
Gastroenterology & Hepatology
John B. Whitfield, Tae-Hwi Schwantes-An, Rebecca Darlay, Guruprasad P. Aithal, Stephen R. Atkinson, Ramon Bataller, Greg Botwin, Naga P. Chalasani, Heather J. Cordell, Ann K. Daly, Christopher P. Day, Florian Eyer, Tatiana Foroud, Dermot Gleeson, David Goldman, Paul S. Haber, Jean-Marc Jacquet, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y. Morgan, Sebastian Mueller, Beat Muellhaupt, Laura E. Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K. Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R. Thursz, Eric Trepo, Timothy R. Morgan, Devanshi Seth
JOURNAL OF HEPATOLOGY
(2022)
Article
Neurosciences
Tiffany Love, Andrey A. Shabalin, Rachel L. Kember, Anna R. Docherty, Hang Zhou, Vincent Koppelmans, Joel Gelernter, Anne K. Baker, Emily Hartwell, Jacob Dubroff, Jon-Kar Zubieta, Henry R. Kranzler
Summary: This study found a link between polygenic risk for major depressive disorder (MDD) and opioid use disorder (OUD) and opioid system activity, particularly under stress. The association was most significant among females and may help explain the high comorbidity between MDD and OUD. The results also suggest that opioid-modulating interventions may be useful in treating MDD and OUD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Jeesun Jung, Daniel L. McCartney, Josephin Wagner, Joyce Yoo, Andrew S. Bell, Lucas A. Mavromatis, Daniel B. Rosoff, Colin A. Hodgkinson, Hui Sun, Melanie Schwandt, Nancy Diazgranados, Alicia K. Smith, Vasiliki Michopoulos, Abigail Powers, Jennifer Stevens, Bekh Bradley, Negar Fani, Rosie M. Walker, Archie Campbell, David J. Porteous, Andrew M. McIntosh, Steve Horvath, Riccardo E. Marioni, Kathryn L. Evans, David Goldman, Falk W. Lohoff
Summary: The relationships between stress, alcohol use disorder (AUD), and premature aging are not well understood. A study found that using composite scores and DNA methylation markers to measure the impact of stress and alcohol consumption on aging can offer new insights into the pathophysiology of premature aging in AUD.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Zhifeng Zhou, Pamela Metten, Qiaoping Yuan, Hui Sun, Colin A. Hodgkinson, Pei-Hong Shen, Cheryl Marietta, John C. Crabbe, David Goldman
Summary: This study identified a polygenic network and neural signaling pathways contributing to ethanol withdrawal seizures and related phenotypes, which overlap with genes modulating epilepsy and neuronal excitability, through multi-omic analysis of mouse lines and human subjects.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychology, Biological
Jack W. Silcox, Brian Mickey, Brennan R. R. Payne
Summary: Readers use prior context to predict features of upcoming words, and accurate predictions increase comprehension efficiency. This study investigates the role of the left inferior frontal cortex (LIFC) in word predictability and memory. The findings demonstrate that the LIFC plays a causal role in prediction during silent reading and is associated with memory benefits for predictable words.