Article
Biochemistry & Molecular Biology
Arnaud L. Lalive, Mauro Congiu, Christopher Lewis, Dominik Groos, Joseph A. Clerke, Anna Tchenio, Yuan Ge, Fritjof Helmchen, Manuel Mameli
Summary: Through experiments with mice, it was found that the activity of lateral habenula neurons decreases with the decrease of reward-related stimuli, and this phenomenon can guide reward-driven behavior through synaptic inhibition.
Article
Biochemistry & Molecular Biology
Cheng-Yung Lin, Hsiang-Chien Tseng, Yu-Rong Chu, Chia-Lun Wu, Po-Hsiang Zhang, Huai-Jen Tsai
Summary: Pgk1 promotes the survival of dopamine-producing cells and improves locomotion, and its effects are time- and dose-dependent, independent of the energy-supplying function of intracellular Pgk1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Neurosciences
Neha Upmanyu, Jialin Jin, Henrik von der Emde, Marcelo Ganzella, Leon Boesche, Viveka Nand Malviya, Evi Zhuleku, Antonio Zaccaria Politi, Momchil Ninov, Ivan Silbern, Marcel Leutenegger, Henning Urlaub, Dietmar Riedel, Julia Preobraschenski, Ira Milosevic, Stefan W. Hell, Reinhard Jahn, Sivakumar Sambandan
Summary: Vesicular transporters determine the type of neurotransmitter stored and released by synaptic vesicles. Most vesicles contain only one type of transporter, while a small percentage have dual transporters. The colocalization of transporters influences the content and release of vesicles.
Article
Biochemistry & Molecular Biology
Jason R. Borgus, Ying Wang, Dana J. DiScenza, B. Jill Venton
Summary: The study found that most dopamine transients in mice were coincident with adenosine, indicating a simultaneous release pattern. Adenosine receptors were identified as potential targets for modulating simultaneous release of adenosine and dopamine. Regulating adenosine and dopamine cotransmission could be crucial for developing treatments for dopamine-related diseases like Parkinson's or addiction.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Developmental Biology
Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L. He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A. Barker, Alessandro Fiorenzano, Malin Parmar
Summary: This study used single-cell RNA sequencing to analyze the transcriptional profile of human fetal VM during the generation and differentiation of dopamine neurons, revealing that 3D culture conditions are superior to monolayer conditions. These findings can guide stem cell-based therapies and disease modeling in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Chenhao Li, Yang Li, Wenwen Zhang, Zhenjie Ma, Shaobo Xiao, Wei Xie, Shuai Miao, Bozhi Li, Guangshuang Lu, Yingyuan Liu, Wenhao Bai, Shengyuan Yu
Summary: Clinical imaging studies have shown that the hypothalamus is activated in migraine patients before and during headache, and has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system in the hypothalamus, particularly the A11 nucleus, may play a crucial role in the pathogenesis of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Abhilash Sawant, Briana N. Ebbinghaus, Adam Bleckert, Clare Gamlin, Wan-Qing Yu, David Berson, Uwe Rudolph, Raunak Sinha, Mrinalini Hoon
Summary: This study used a combination of techniques to determine the composition and organization of inhibitory synapses in a well-characterized RGC type in the mouse retina. The researchers found the presence of mixed GABA-glycine receptor synapses, as well as the sequence of postsynaptic assembly for these synapses. These findings reveal the characteristics of an additional motif of inhibition in the mammalian retina.
Article
Biology
Songhui Hu, Yurong Wang, Xu Han, Min Dai, Yongxing Zhang, Yuanyuan Ma, Shijun Weng, Lei Xiao
Summary: The study identified the expression of oxytocin receptors in the mouse retina, mainly in GABAergic amacrine cells, especially dopaminergic cells. Exogenous oxytocin application activated retinal dopaminergic neurons and decreased bipolar cell activity through oxytocin and dopamine receptors, suggesting a modulation of visual information processing by oxytocin signaling in the retina from the hypothalamus.
Article
Neurosciences
Michael Kalyn, Marc Ekker
Summary: In this study, cerebroventricular microinjections of MPTP in adult transgenic zebrafish resulted in reduced dopaminergic neurons, mitochondrial fragmentation, and activation of the pink1/parkin pathway. This led to transient locomotor and olfactory impairments in the animals, contributing to a better understanding of the impact of mitochondria on dopaminergic survivability.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Willian Goulart Salgueiro, Marcell Valandro Soares, Cassiano Fiad Martins, Favero Reisdorfer Paula, Rafaela Maria Rios-Anjos, Thiago Carrazoni, Marcelo A. Mori, Roman-Ulrich Mueller, Michael Aschner, Chariston Andre Dal Belo, Daiana Silva Avila
Summary: Quercetin has been found to restore neuronal function in disease models, especially in diseases related to impaired dopaminergic neurotransmission. This study suggests that quercetin may act as a dopaminergic modulator by interacting with the dopamine transporter, thus altering the behavior of the nematode.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wang
Summary: This study presents a topographical distribution map of dopamine, GABA, and glutamate neurons in the ventral tegmental area of mice. The majority of neurons expressed a single type of mRNA, while a subset of neurons co-expressed two or three molecular characteristics. These different neuronal populations were distributed differently across sub-nuclei in the ventral tegmental area, suggesting a complex organization of neuronal molecular characteristics and potentially diverse functions.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Xin-Yue Wang, Xiang Xu, Rui Chen, Wen-Bin Jia, Peng-Fei Xu, Xiao-Qing Liu, Ying Zhang, Xin-Feng Liu, Yan Zhang
Summary: Chronic stress and chronic pain are major factors leading to depression. This study reveals the role of an inhibitory circuit from the sensory thalamic reticular nucleus to the lateral habenula in the development and modulation of depression.
Article
Biochemistry & Molecular Biology
Pinghui Wei, Guoge Han, Meiqin He, Yan Wang
Summary: This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating myopic refractive state. The results showed that after forced occlusion for 4 weeks, dopamine (DA) and γ-aminobutyric acid (GABA) concentrations decreased, while glutamate (Glu), 3-methoxytyramine (3-MT), and glycine concentrations increased, accompanied by an increase in myopic refraction and axial length (AL). Treating with D2R antagonist sulpiride increased glycine and DA levels, while decreasing 3-MT and Glu levels, accompanied by a decrease in myopic refraction and AL. The ratio of Glu to GABA (RGG) represents the balance between excitatory and inhibitory neurotransmitters, and changes in RGG correlated with changes in AL.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Dipanwita Pati, Thomas L. Kash
Summary: The study examines the differential effects of TNF-alpha on GABA and dopamine neurons in the vIPAG of female mice, providing new insights into the modulation of pain pathways by TNF-alpha.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Francesca Manago, Diego Scheggia, Maria Pontillo, Maddalena Mereu, Rosa Mastrogiacomo, Gayatri Udayan, Paola Valentini, Maria Cristina Tata, Daniel R. Weinberger, Cynthia S. Weickert, Pier Paolo Pompa, Maria A. De Luca, Stefano Vicari, Francesco Papaleo
Summary: This study discovered a genetic interaction between the Comt and Dtnbp1 genes, which modulate dopaminergic signaling in the brain and lead to specific cognitive disturbances. The researchers also developed an easy and inexpensive genetic screening kit for clinical application.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)