Article
Biology
Alexander Neil Young, Emerald Perlas, Nerea Ruiz-Blanes, Andreas Hierholzer, Nicola Pomella, Belen Martin-Martin, Alessandra Liverziani, Joanna W. Jachowicz, Thomas Giannakouros, Andrea Cerase
Summary: Using CRISPR/Cas-9 gene editing, researchers have created a mouse model with a 236bp N-terminal deletion in the Lbr gene, mimicking human PHA and showing minor defects in X chromosome inactivation. This model provides a valuable tool for pre-clinical studies and enhances understanding of PHA etiology and LBR functions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Margaret Driscoll, Steven N. Buchert, Victoria Coleman, Morgan McLaughlin, Amanda Nguyen, Divya Sitaraman
Summary: Sleep is an important behavioral state regulated by biogenic amines across species, but the precise neurocircuitry underlying how amines control sleep, arousal, and wakefulness remains unclear. Investigating the neural circuits in fruit flies provides insight into the balance of sleep, wakefulness, and arousal in organisms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sanchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Summary: Bromocriptine, an approved diabetes therapy, acts on brain dopamine D2 receptors and pancreas to regulate insulin and glucagon secretion, providing a new therapeutic mechanism for improving dysglycemia.
Article
Multidisciplinary Sciences
Hui Hong, Douglas Zeppenfeld, Laurence O. Trussell
Summary: Efferent neurons, specifically the lateral olivocochlear (LOC) neurons, play vital roles in maintaining auditory function. Through in vitro experiments, it was discovered that LOC neurons in juvenile and young adult mice exhibited extremely slow waves of activity driven by an intrinsic oscillator dependent on L-type Ca2+ channels. Additionally, optogenetic approaches helped identify both ascending and descending sources of synaptic excitation, as well as the synaptic receptors involved. These findings provide important insights into the mechanisms of diverse transmitter release by LOC fibers in the cochlea.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Songhui Hu, Yurong Wang, Xu Han, Min Dai, Yongxing Zhang, Yuanyuan Ma, Shijun Weng, Lei Xiao
Summary: The study identified the expression of oxytocin receptors in the mouse retina, mainly in GABAergic amacrine cells, especially dopaminergic cells. Exogenous oxytocin application activated retinal dopaminergic neurons and decreased bipolar cell activity through oxytocin and dopamine receptors, suggesting a modulation of visual information processing by oxytocin signaling in the retina from the hypothalamus.
Article
Cell Biology
Meng Chen, Zhaozhao Zhao, Lianqun Wu, Jiancheng Huang, Peng Yu, Jiang Qian, Ting Ni, Chen Zhao
Summary: This study discovered that the E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma, and CKS2 may serve as a potential therapeutic target for this disease.
CELL DEATH & DISEASE
(2022)
Article
Audiology & Speech-Language Pathology
Kiera E. Grierson, Tyler T. Hickman, M. Charles Liberman
Summary: Cochlear synaptopathy, characterized by the loss or damage of auditory-nerve fibers and inner hair cell connections, was investigated in this study. The degeneration of olivocochlear efferent innervation was examined, and it was found that noise exposure had only minor and temporary effects on the innervation density and spatial organization. Conversely, significant degeneration of efferent innervation and loss of cholinergic and dopaminergic terminals were observed in aged ears.
Article
Cell Biology
Jun Lv, Xiaolong Fu, Yige Li, Guodong Hong, Peipei Li, Jing Lin, Youfang Xun, Lucheng Fang, Weibin Weng, Rongyu Yue, Geng-Lin Li, Bing Guan, He Li, Yideng Huang, Renjie Chai
Summary: The Kcnj16 gene that encodes Kir5.1 is not essential for auditory function in mice, as the loss of Kcnj16 did not significantly affect hair cell development or auditory function, despite a decrease in the expression of some ion channel proteins. The number and distribution of ribbon synapses also showed no significant differences between Kcnj16(-/-) mice and wild-type littermates.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki
Summary: The study revealed that the 22q11.2 deletion causes various vulnerabilities in dopaminergic neurons, dependent on PERK dysfunction.
Article
Multidisciplinary Sciences
Annette J. J. Klomp, Ashley Plumb, Jacqueline B. B. Mehr, Deniz A. A. Madencioglu, Hsiang Wen, Aislinn J. J. Williams
Summary: Deletion of neuronal Ca(V)1.2 alters motor performance, acoustic startle reflex, and social behaviors in a sex-specific manner, while associative learning deficits generalize across sexes. Our data provide evidence for both sex-specific and sex-independent phenotypes related to neuronal expression of Ca(V)1.2.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen
Summary: This study established an Arrb2 knockout mouse model to investigate the biological function of Arrb2 in autistic-like behavior related to abnormalities in the dopaminergic system. The results demonstrated that Arrb2 regulates the dopaminergic system through the ERK signaling pathway and targeted deletion of Arrb2 impedes the development of autistic-like behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Analytical
Yanrong Wen, Ge Ge, Dan Xie, Zhen Liu
Summary: A comprehensive analytical platform is lacking for tracking and quantifying cell migration behaviors and molecular dynamics at the single-cell level. In this study, an integrated single living cell analysis platform was developed to address this limitation. It enables long-term observation of migration behavioral phenotypes in single cells and simultaneous analysis of signaling proteins and complexes, providing insights into the molecular mechanism and phenotypes in cell migration.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Driever
Summary: Wnt/β-catenin signaling plays a crucial role in the development of dopaminergic neurons in zebrafish, specifically in the formation of the Otp-dependent dopaminergic neuron group. The activity of Wnt/β-catenin signaling promotes dopaminergic development during the proliferative stage of dopaminergic progenitor cells.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Dongwook Kim, Hyeji Jung, Yoshinori Shirai, Hyeonho Kim, Jinhu Kim, Dongseok Lim, Takuma Mori, Hyojeong Lee, Dongseok Park, Hee Young Kim, Qi Guo, Bo Pang, Wen Qiu, Xueshan Cao, Emi Kouyama-Suzuki, Takeshi Uemura, Enas Kasem, Yu Fu, Seungjoon Kim, Akinori Tokunaga, Takahiro Yoshizawa, Tatsuo Suzuki, Hiroyuki Sakagami, Kea Joo Lee, Jaewon Ko, Katsuhiko Tabuchi, Ji Won Um
Summary: The study reveals the critical role of IQSEC3 in regulating synaptic inhibition in the hippocampal CA1 region for the formation of hippocampus-dependent fear memory. It mediates GABAergic synapse density and transmission and affects the maintenance of long-term potentiation. Additionally, abnormal activation of the S6K1 signaling pathway associated with IQSEC3 loss was also identified.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Stefanie C. Linden, Cameron J. Watson, Jacqueline Smith, Samuel J. R. A. Chawner, Thomas M. Lancaster, Ffion Evans, Nigel Williams, David Skuse, F. Lucy Raymond, Jeremy Hall, Michael J. Owen, David E. J. Linden, LeeAnne Green-Snyder, Wendy K. Chung, Anne M. Maillard, Sebastien Jacquemont, Marianne B. M. van den Bree
Summary: Copy number variants at the distal 1q21 locus are associated with high frequencies of psychopathology, with children showing predominantly neurodevelopmental disorders and adults demonstrating increased prevalence of mood and anxiety disorders. These findings suggest the importance of widening genetic testing in psychiatry, as carriers of neurodevelopmental CNVs with relevant psychopathology but no major cognitive impairment may not be receiving clinical genetic services routinely.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Xiao-Ping Liu, Julian R. A. Wooltorton, Sophie Gaboyard-Niay, Fu-Chia Yang, Anna Lysakowski, Ruth Anne Eatock
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Zoology
Ruth Anne Eatock
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2018)
Review
Neurosciences
Ruth Anne Eatock, Jocelyn E. Songer
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34
(2011)
Article
Neurosciences
Anping Xia, Julian R. A. Wooltorton, Donna J. Palmer, Philip Ng, Fred A. Pereira, Ruth Anne Eatock, John S. Oghalai
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2008)
Article
Neurosciences
Olga Schuth, Will J. McLean, Ruth Anne Eatock, Sonja J. Pyott
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2014)
Review
Biology
Ruth Anne Eatock, Jingbing Xue, Radha Kalluri
JOURNAL OF EXPERIMENTAL BIOLOGY
(2008)
Article
Neurosciences
Radha Kalluri, Jingbing Xue, Ruth Anne Eatock
JOURNAL OF NEUROPHYSIOLOGY
(2010)
Article
Neurosciences
Stephane F. Maison, Xiao-Ping Liu, Douglas E. Vetter, Ruth Anne Eatock, Neil M. Nathanson, Juergen Wess, M. Charles Liberman
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Anna Lysakowski, Sophie Gaboyard-Niay, Irina Calin-Jageman, Shilpa Chatlani, Steven D. Price, Ruth Anne Eatock
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Jocelyn E. Songer, Ruth Anne Eatock
JOURNAL OF NEUROSCIENCE
(2013)
Editorial Material
Multidisciplinary Sciences
Ruth Anne Eatock
Article
Neurosciences
Antonia Gonzalez-Garrido, Remy Pujol, Omar Lopez-Ramirez, Connor Finkbeiner, Ruth Anne Eatock, Jennifer S. Stone
Summary: Regenerated vestibular hair cells in adult mice show similarities to mature type II hair cells, but fail to fully recapture the properties of normal cells, displaying some characteristics of immature cells. Limitations in total cell number, cell type diversity, and extent of cellular differentiation suggest that interventions may be needed to promote full regeneration with potential for vestibular function recovery.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Aravind Chenrayan Govindaraju, Imran H. Quraishi, Anna Lysakowski, Ruth Anne Eatock, Robert M. Raphael
Summary: Vestibular hair cells transmit information through synapses to neurons, with some synapses forming enlarged terminals called calyces. These synapses support a form of electrical transmission called nonquantal transmission (NQT). A computational model is presented that supports the existence of an electrical potential in the synaptic cleft and demonstrates the impact of changes in cleft potential on transmission latency. The model also suggests that calyx morphology affects the magnitude and speed of NQT.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Julian R. A. Wooltorton, Sophie Gaboyard, Karen M. Hurley, Steven D. Price, Jasmine L. Garcia, Meng Zhong, Anna Lysakowski, Ruth Anne Eatock
JOURNAL OF NEUROPHYSIOLOGY
(2007)