Article
Cell & Tissue Engineering
Cagla Defterali, Mireia Moreno-Estelles, Carlos Crespo, Eva Diaz-Guerra, Maria Diaz-Moreno, Eva Vergano-Vera, Vanesa Nieto-Estevez, Anahi Hurtado-Chong, Antonella Consiglio, Helena Mira, Carlos Vicario
Summary: In this study, injected EGFP-labeled retroviral particles in the adult olfactory bulb core of mice revealed that NSCs could generate multipotent neurons and glial cells. These newly generated neurons were able to establish synaptic contacts and be integrated into the olfactory bulb circuits.
Article
Neurosciences
Ruilong Hu, Janam Shankar, Grant Z. Z. Dong, Pablo S. S. Villar, Ricardo C. C. Araneda
Summary: In the olfactory bulb (OB), noradrenaline (NA) modulates the hyperpolarization-activated currents (I-h) in adult-born granule cells (abGCs) through alpha(2)-adrenergic receptors (ARs), enhancing lateral inhibition onto mitral and tufted cells (MCs). This modulation also affects the subthreshold resonance in GCs, potentially impacting the temporal integration of abGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Carlotta Martelli, Douglas Anthony Storace
Summary: It remains an open question how the olfactory system adapts to different stimulus conditions and how this adaptation affects olfactory representations and perception. Although adaptation could allow the olfactory system to adjust sensory representations to the current stimulus conditions, surprisingly little is known about how adaptation changes olfactory representations and affects perception.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell & Tissue Engineering
Xin Su, Yury Kovalchuk, Nima Mojtahedi, Farzin Kamari, Manfred Claassen, Olga Garaschuk
Summary: Adult-born cells in the rodent olfactory bulb either integrate into the neural circuitry or get eliminated. Morphological and functional properties between these two populations are still unclear. This study used longitudinal in vivo two-photon imaging to investigate the dendritic morphogenesis, odor-evoked responsiveness, ongoing Ca2+ signaling, and survival/death of adult-born juxtaglomerular neurons (abJGNs). The results showed that maturation of abJGNs is accompanied by a reduction in dendritic complexity, and eliminated cells exhibit odor responsiveness similar to surviving cells but exhibit higher ongoing Ca2+ signals before death. Machine learning analysis revealed a relationship between abJGNs' activity and survival probability.
Article
Neurosciences
Stephen B. McHugh, Vitor Lopes-dos-Santos, Giuseppe P. Gava, Katja Hartwich, Shu K. E. Tam, David M. Bannerman, David Dupret
Summary: The study reveals the crucial role of adult-born granule cells (abDGCs) in controlling the information processing in the hippocampus by promoting sparser population firing and enhancing responses to novel stimuli.
NATURE NEUROSCIENCE
(2022)
Article
Biology
Didier De Saint Jan
Summary: This study investigated the role of basal forebrain (BF) inputs in modulating activity of different subtypes of periglomerular (PG) interneurons in the olfactory bulb (OB). The results showed that GABAergic BF inputs effectively inhibited PG cell firing, while cholinergic inputs excited a previously overlooked PG cell subtype. These findings highlight the importance of external inputs in synaptic inhibition in the OB.
Article
Chemistry, Multidisciplinary
Bingwei Wang, Miao Zhao, Zhijie Su, Baohua Jin, Xiaoning Yang, Chenyu Zhang, Bingbing Guo, Jiebo Li, Weili Hong, Jiarui Liu, Yun Zhao, Yujia Hou, Futing Lai, Wei Zhang, Lihua Qin, Weiguang Zhang, Jianyuan Luo, Ruimao Zheng
Summary: The RII beta subunit of cAMP-dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. RII beta-knockout mice show leanness and increased UCP1 in brown adipose tissue. RII beta reexpression in hypothalamic GABAergic neurons rescues the leanness. The authors investigate the role of RII beta-PKA in white adipose tissue (WAT) browning and find that RII beta-KO mice exhibit robust WAT browning. They also demonstrate that RII beta-PKA in dorsal median hypothalamic GABAergic neurons regulates WAT browning and affects body weight. Targeting RII beta-PKA in DMH GABAergic neurons may have therapeutic potential for obesity and metabolic disorders.
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Article
Cell Biology
Yiwen Zhu, John N. Armstrong, Anis Contractor
Summary: This study demonstrates the expression of KAR glutamate receptors in adult-born dentate granule cells and their impact on the functional properties of young cells during development through interaction with GABAergic signaling mechanisms. Disruption of KARs in a cohort of young adult-born neurons in mice affected their performance in a spatial discrimination task but not in a hippocampal-dependent fear conditioning task, highlighting the importance of KARs in the proper functional development of young cells.
Article
Cell Biology
Hyun-Jin Kim, Byungjae Hwang, Maria Reva, Jieun Lee, Byeong Eun Lee, Youngeun Lee, Eun Jeong Cho, Minseok Jeong, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Jung-Hoon Park, Jae-Ick Kim
Summary: Dopamine synapses are important for volitional movement and reward-related behaviors, with dysfunction leading to psychiatric and neurological disorders. Research reveals that dopamine transmission is strongly correlated with GABA co-transmission, and dopamine synapses have similar structure and function to GABAergic synapses with regional heterogeneity.
Article
Biochemistry & Molecular Biology
Kaizhen Li, Katherine Figarella, Xin Su, Yury Kovalchuk, Jessika Gorzolka, Jonas J. Neher, Nima Mojtahedi, Nicolas Casadei, Ulrike B. S. Hedrich, Olga Garaschuk
Summary: The development and survival of adult-born neurons are dependent on sensory signaling. Through in vivo analyses, it was found that impairments in migration, morphogenesis, survival, and functional integration were observed in adult-born juxtaglomerular cells with reduced excitability. Overexpression of Kv1.2 or Kir2.1 K+ channels led to downregulation of genes involved in neuronal migration and differentiation, and upregulation of apoptosis-related genes. Surprisingly, cells deprived of sensory-driven activity developed normally.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Joseph D. Zak, Nathan E. Schoppa
Summary: The GABAergic periglomerular (PG) cells in the olfactory bulb are proposed to act as a high-pass filter by selectively blocking weak stimulus signals within a single glomerulus. Despite being more easily activated, PG cells are not significantly more responsive to weak stimuli compared to external tufted cells (eTCs). The excitation/inhibition balance within the glomeruli can support a high-pass filter by various factors, ultimately enhancing stimulus contrast independently of cell-intrinsic properties.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Neurosciences
Joost X. Maier, Zihao Zhang
Summary: During early development, the brain undergoes significant structural changes at different levels, while still performing adaptive functions. The rodent olfactory system, which is essential for newborn survival, provides an ideal model to investigate how structurally immature brains process information and maintain stable function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Joseph D. Zak, Nathan E. Schoppa
Summary: The study reveals the presence of various cell types within the olfactory bulb, which play crucial roles in processing and modulating olfactory information through different chemical synaptic connections, highlighting the importance of local circuits in shaping olfactory function.
Article
Behavioral Sciences
Hanaa Malloul, Sara Bonzano, Mohammed Bennis, Silvia De Marchis, Saadia Ba-M'hamed
Summary: Exposure to volatile solvents can affect olfactory functioning and behavior in mice, but alterations in adult olfactory neurogenesis do not seem to be associated with impaired olfactory performances in chronically exposed animals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Francine Deprez, Fabia Vogt, Amalia Floriou-Servou, Carlos Lafourcade, Uwe Rudolph, Shiva K. Tyagarajan, Jean-Marc Fritschy
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Simon Frueh, Jennifer Romanos, Patrizia Panzanelli, Daniela Buergisser, Shiva K. Tyagarajan, Kevin P. Campbell, Mirko Santello, Jean-Marc Fritschy
JOURNAL OF NEUROSCIENCE
(2016)
Editorial Material
Neurosciences
Jean-Marc Fritschy, Martin Sarter
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Christoph Bode, Franziska Richter, Christine Sproete, Tanja Brigadski, Anne Bauer, Simone Fietz, Jean-Marc Fritschy, Angelika Richter
EXPERIMENTAL NEUROLOGY
(2017)
Editorial Material
Neurosciences
Jean-Marc Fritschy, Shiva K. Tyagarajan
Article
Neurosciences
Tilo Gschwind, Carlos Lafourcade, Tim Gfeller, Mariana Zaichuk, Lukas Rambousek, Irene Knuesel, Jean-Marc Fritschy
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Simon Fruh, Shiva K. Tyagarajan, Benjamin Campbell, Giovanna Bosshard, Jean-Marc Fritschy
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
Gioele W. Albisetti, Martina Pagani, Evgenia Platonova, Ladina Hoesli, Helge C. Johannssen, Jean-Marc Fritschy, Hendrik Wildner, Hannus Ulrich Zeilhofer
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Ida Luisa Boccalaro, Leonardo Cristia-Lara, Cornelia Schwerdel, Jean-Marc Fritschy, Lena Rubi
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Multidisciplinary Sciences
Lukas Rambousek, Tilo Gschwind, Carlos Lafourcade, Jean-Charles Paterna, Linda Dib, Jean-Marc Fritschy, Adriano Fontana
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Lena Rubi, Jean-Marc Fritschy
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Neurosciences
Ida Luisa Boccalaro, Cornelia Schwerdel, Leonardo Cristia-Lara, Jean-Marc Fritschy, Lena Rubi
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Kasifa Khalid, Julia Frei, Mostafa A. Aboouf, Christina Koester-Hegmann, Max Gassmann, Jean-Marc Fritschy, Edith M. Schneider Gasser
Summary: EPO stimulates postnatal maturation of GABAergic transmission in the hippocampus of mice, increasing neuronal survival, modulating critical plasticity periods, and enhancing synaptic transmission. EPORs are expressed on pyramidal cells, suggesting indirect impact of EPO on GABAergic maturation.
Article
Anatomy & Morphology
Patrizia Panzanelli, Simon Fruh, Jean-Marc Fritschy
BRAIN STRUCTURE & FUNCTION
(2017)