Article
Genetics & Heredity
Neha Goveas, Claudia Waskow, Kathrin Arndt, Julian A. Heuberger, Qinyu Zhang, Dimitra A. Alexopoulou, Andreas Dahl, Walter A. Birchmeier, Konstantinos Anastassiadis, A. Francis A. Stewart, Andrea Kranz
Summary: The research reveals the importance of MLL1 in maintaining intestinal stem cells, with loss of MLL1 leading to intestinal failure. Additionally, the location and expression of MLL1 in the intestine are closely related to its function in regulating intestinal stem cells.
Article
Biology
Jonas-Frederic Sauer, Marlene Bartos
Summary: This study reveals alterations in prefrontal circuit function in Disc1-mutant mice, including reduced firing rates of interneurons and decreased phase-coupling with gamma oscillations. Additionally, the study found decreased spike transmission efficacy in local pyramidal cell-interneuron connections, resulting in altered activation of assembly patterns.
Article
Plant Sciences
Christina Rabeler, Mingjie Chen, Nick Kaplinsky
Summary: Phospholipid biosynthesis is a crucial metabolic pathway that affects plant growth and development. Choline/ethanolamine kinases (CEKs) are enzymes responsible for the synthesis of polar head groups on plant phospholipids. Through the study of a CEK4 mutant called bst, new roles for CEK4 in plant development and response to the environment have been revealed.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Charlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille, Andrea Lelli, Baptiste Plion, Ghizlene Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel, Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit, Didier Dulon, Saaid Safieddine
Summary: This study found that SNAP-25 is essential for normal hearing function by ensuring exocytosis and maintenance of ribbon synapses in IHCs.
Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Article
Biology
Chad W. Sauvola, Yulia Akbergenova, Karen L. Cunningham, Nicole A. Aponte-Santiago, J. Troy Littleton
Summary: The study demonstrates the role of Tomosyn protein in regulating synaptic output and sustaining release of neurotransmitters in different types of neurons in fruit flies, providing insights into synaptic signaling and plasticity mechanisms in the brain.
Article
Multidisciplinary Sciences
Liu Yang, Haiyan Yang, Yunxiang Chu, Yunhao Song, Lidan Ding, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye, Yinyin Wang, Zhijie Chang
Summary: This study reveals the essential role of CREPT in maintaining murine intestinal stem cells, with its deficiency impairing cell proliferation and regeneration. The downregulation of Wnt signaling due to CREPT deletion is identified as a key mechanism affecting ISC function.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Szi-Chieh Yu, Jana F. Liewald, Jiajie Shao, Wagner Steuer Costa, Alexander Gottschalk
Summary: The release of neuropeptides is crucial for neuromodulation, and our study demonstrates that synapsin SNN-1 is necessary for cAMP-dependent neuropeptide release in Caenorhabditis elegans. Through capturing dense core vesicles (DCVs) at synapses, synapsin plays a key role in making them available for release. Mutations in synapsin result in altered neuropeptide release and behavior in the nematode, indicating the importance of synapsin in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Susann Michanski, Rohan Kapoor, Anna M. Steyer, Wiebke Moebius, Iris Frueholz, Frauke Ackermann, Mehmet Gueltas, Craig C. Garner, F. Kent Hamra, Jakob Neef, Nicola Strenzke, Tobias Moser, Carolin Wichmann
Summary: In this study, the role of piccolino in the structure and function of inner hair cell synapses was investigated using piccolo gene-trap mutant rats. The findings suggest that piccolino is essential for normal hearing and contributes to the organization of the active zone in inner hair cells.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Tao Li, Rong Luo, Rachael Schmidt, Nicholas D'Alessandro, Priya Kishore, Beika Zhu, Diankun Yu, Xianhua Piao
Summary: ADGRG1/GPR56 is crucial for brain development and wiring, with the GPR56 alternative splicing isoform 4 (S4) playing a key role in microglia-mediated synaptic pruning, while being dispensable for cortical development and CNS myelination.
Article
Neurosciences
Brenda Rocamonde, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Emmanuelle Huillard
Summary: Ependymal cells, derived from radial glia, are crucial for proper cerebrospinal fluid flow and neurogenesis modulation. The transcriptional regulator ID4 plays a significant role in the development and maturation of ependymal cells.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-Ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto
Summary: The study suggests that the function of XRN1 in the hypothalamus is critical for maintaining metabolic homeostasis, as Xrn1-cKO mice exhibited symptoms such as obesity, insulin resistance, and hyperglycemia.
Article
Biochemistry & Molecular Biology
Urte Neniskyte, Ugne Kuliesiute, Auguste Vadisiute, Kristina Jevdokimenko, Ludovico Coletta, Senthilkumar Deivasigamani, Daina Pamedytyte, Neringa Daugelaviciene, Daiva Dabkeviciene, Emerald Perlas, Aditya Bali, Bernadette Basilico, Alessandro Gozzi, Davide Ragozzino, Cornelius T. Gross
Summary: The mature mammalian brain connectome develops through the extension and pruning of neuronal connections. Glial cells, particularly phospholipid scramblase Xkr8, play a crucial role in the elimination of unnecessary neuronal synapses and projections. This study highlights the importance of phospholipid scrambling by Xkr8 in the pruning of developing neuronal projections, with implications for brain development and hyperconnectivity.
Article
Cell Biology
Michal Gur, Tamir Edri, Sally A. Moody, Abraham Fainsod
Summary: Retinoic acid (RA) is a crucial signal for regulating developmental processes in vertebrate embryos. Inhibiting RA biosynthesis causes various defects in gastrulation, including delayed progression and rostral migration, as well as altered morphogenetic movements and gene expression patterns. These effects are likely due to impaired fibronectin deposition, compromised blastocoel separation, and reduced non-canonical Wnt signaling activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Abram Akopian, Sandeep Kumar, Hariharasubramanian Ramakrishnan, Suresh Viswanathan, Stewart A. Bloomfield
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Ophthalmology
Yiqin Bao, Feng Liu, Xiaobin Liu, Mi Huang, Liumin He, Seeram Ramakrishna, Huanmin Luo, Huiling Hu, Hongying Li, Ying Xu
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Ophthalmology
Mengjuan Wu, Yimei Liu, He Zhang, Meiling Lian, Juan Chen, Haiyan Jiang, Ying Xu, Ge Shan, Shengzhou Wu
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Yankun Yu, Mengrong Zhang, Ren Chen, Feng Liu, Pengfei Zhou, Lei Bu, Ying Xu, Lei Zheng
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Article
Biology
Huirong Li, Lili Lian, Bo Liu, Yu Chen, Jinglei Yang, Shuhui Jian, Jiajia Zhou, Ying Xu, Xiaoyin Ma, Jia Qu, Ling Hou
Article
Ophthalmology
Benjamin R. Thomson, Marta Grannonico, Feng Liu, Mingna Liu, Parry Mendapara, Ying Xu, Xiaorong Liu, Susan E. Quaggin
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2020)
Article
Engineering, Biomedical
Liumin He, Zhongqing Sun, Jianshuang Li, Rong Zhu, Ben Niu, Ka Long Tam, Qiao Xiao, Jun Li, Wenjun Wang, Chi Ying Tsui, Vincent Wing Hong Lee, Kwok-Fai So, Ying Xu, Seeram Ramakrishna, Qinghua Zhou, Kin Chiu
Summary: Electrical stimulation enhances neural stem cell differentiation into mature neurons by promoting autophagy signaling, which can significantly improve the success rate of neuroregeneration therapy at injured central nervous system sites.
Article
Clinical Neurology
Ying Zhao, Bing Yang, An-Ding Xu, Yi-Wen Ruan, Ying Xu, Hui-Ling Hu, Ze-Feng Tan
Summary: This study aimed to assess the association between retinal microvasculature and subtypes of ischemic stroke, finding that retinal MVD0.5-1.0DD (>82.23 mu m) might be associated with the AT stroke subtype. However, large-scale prospective studies are needed to explore the underlying mechanism and causal explanation for this finding.
FRONTIERS IN NEUROLOGY
(2021)
Article
Toxicology
Zhaoxia Liao, Zeqi Huang, Junhua Li, Hui Li, Liping Miao, Yanhui Liu, Jing Zhang, Ying Xu, Yujuan Li
Summary: Sevoflurane activated Cdk5/CRMP2 and GSK-3 beta/CRMP2 pathways in the hippocampus of neonatal rats, leading to reduced dendritic length, branches, and the density of dendritic spine in pyramidal neurons. Sevoflurane also reduced the expressions of PSD-95, drebrin, and synaptophysin in the hippocampus, impaired memory ability of rats, and inhibited LTP in hippocampal slices. Pretreatment with inhibitor of Cdk5 or GSK-3 beta attenuated all the impairment effects caused by sevoflurane.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Feng Liu, Xiaobin Liu, Yamin Zhou, Yankun Yu, Ke Wang, Zhengqun Zhou, Hao Gao, Kwok-Fai So, Noga Vardi, Ying Xu
Summary: The study found that treatment with ZD improved visual behavior, delayed photoreceptor degeneration in the rd10 mouse model of RP, and enhanced light responses in photoreceptors, bipolar cells, and retinal ganglion cells. ZD primarily mediated its anti-inflammatory function through the signal transducer and activator of transcription 3, chemokine (C-C motif) ligand 2, and MAPK pathways, making it a potential clinical candidate for RP treatment.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Mengrong Zhang, Liting Zhong, Xiu Han, Guoyin Xiong, Di Xu, Sensen Zhang, Haiyang Cheng, Kin Chiu, Ying Xu
Summary: The timeline of degenerative processes in the retina and the brain in 5xFAD mice is similar, supporting the use of non-invasive methods to test retinal structure and function for early Alzheimer's disease diagnosis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Feng Liu, Mengrong Zhang, Guoyin Xiong, Xiu Han, Vincent Wing Hong Lee, Kwok-Fai So, Kin Chiu, Ying Xu
Summary: This study tested the protective effects of trans-sclera electrical stimulation (TsES) on the retina of RP mice. The results showed that moderate TsES can improve retinal function and reduce the firing rate of retinal ganglion cells.
Article
Cell Biology
Xiao-Bin Liu, Feng Liu, Yi-Yao Liang, Gang Yin, Hui-Jun Zhang, Xue-Song Mi, Zai-Jun Zhang, Kwok-Fai So, Ang Li, Ying Xu
Summary: Luteolin demonstrates neuroprotective effects on rod cells in rd10 mice, improving visual performance, increasing photoreceptor survival, and delaying degeneration by regulating retinal oxidation and inflammation through inhibition of the JNK pathway. Thus, luteolin may serve as a supplementary treatment for retinitis pigmentosa.
NEURAL REGENERATION RESEARCH
(2021)
Meeting Abstract
Ophthalmology
Ying Xu, Zongqin Xiang, Yiqin Bao, Jia Zhang, Jun Dong, Yibo Qu
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Ophthalmology
Feng Liu, Jia Zhang, Zongqin Xiang, Di Xu, Kwok-Fai So, Noga Vardi, Ying Xu
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)