Article
Clinical Neurology
Domenique M. J. Muller, Pierre A. Robe, Hilko Ardon, Frederik Barkhof, Lorenzo Bello, Mitchel S. Berger, Wim Bouwknegt, Wimar A. Van den Brink, Marco Conti Nibali, Roelant S. Eijgelaar, Julia Furtner, Seunggu J. Han, Shawn L. Hervey-Jumper, Albert J. S. Idema, Barbara Kiesel, Alfred Kloet, Emmanuel Mandonnet, Jan C. De Munck, Marco Rossi, Tommaso Sciortino, W. Peter Vandertop, Martin Visser, Michiel Wagemakers, Georg Widhalm, Marnix G. Witte, Aeilko H. Zwinderman, Philip C. De Witt Hamer
Summary: This study used probability maps to quantify and compare surgical decision-making for glioblastoma patients by 12 neurosurgical teams. The study found treatment variations and identified differences in patient functional outcome and survival based on biopsy and resection decisions.
JOURNAL OF NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Karine Yu. Sarkisova, Alexandra V. V. Gabova, Ekaterina A. A. Fedosova, Alla B. B. Shatskova, Victor B. B. Narkevich, Vladimir S. S. Kudrin
Summary: This study found that L-methionine can alleviate depression and anxiety symptoms comorbid with epilepsy and suppress epileptic seizures, in contrast to conventional antidepressant imipramine. This suggests that L-methionine could be a promising new antidepressant drug with anxiolytic properties for the treatment of depression comorbid with epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Ayse Karson, Tijen Utkan, Tugce Demirtas Sahin, Fuat Balci, Sertan Arkan, Nurbay Ates
Summary: Pro-inflammatory cytokines may mediate the onset and comorbid symptoms of absence epilepsy in WAG/Rij rats, while treatment with etanercept (a tumor necrosis factor inhibitor) can improve cognitive deficits and depression-like behavior, as well as reduce the frequency of spike-wave discharges.
EPILEPSY & BEHAVIOR
(2021)
Article
Neurosciences
Martina Tallarico, Antonio Leo, Lorenza Guarnieri, Maria Caterina Zito, Carmen De Caro, Ferdinando Nicoletti, Emilio Russo, Andrew Constanti, Giovambattista De Sarro, Rita Citraro
Summary: The study found that N-acetylcysteine (NAC) can aggravate the number and duration of absence seizures in an animal model of absence epilepsy, while improving neuropsychiatric comorbidities. The mechanism of action of NAC may be related to an increase in brain mGlu2 receptor expression.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Forestry
Forrest Fleischman, Cory Struthers, Gwen Arnold, Michael J. Dockry, Tyler Scott
Summary: In this article, the authors respond to critiques of their previous work on the planning processes of the USDA Forest Service. They appreciate the introduction of new data by the critics and acknowledge the potential of data integration for a deeper understanding of agency activities. The authors' analysis largely aligns with their original claims, with the main difference being in their conceptualization of the planning process's relationship to agency goals. While the critics see the planning processes as barriers, the authors argue that they are tools used by the agency to achieve its land management goals.
JOURNAL OF FORESTRY
(2022)
Article
Clinical Neurology
Rita Citraro, Francesca Lembo, Carmen De Caro, Martina Tallarico, Lorena Coretti, Luigi Francesco Iannone, Antonio Leo, Domenico Palumbo, Mariella Cuomo, Elisabetta Buommino, Valentina Nesci, Nadia Marascio, Michelangelo Iannone, Angela Quirino, Roberto Russo, Antonio Calignano, Andrew Constanti, Emilio Russo, Giovambattista De Sarro
Summary: The study demonstrates the significant role of gut microbiota in absence epilepsy in a genetic animal model, showing that manipulation of microbiota through FMT can effectively reduce seizure occurrence.
Article
Neurosciences
Erika Lucente, Bo Soederpalm, Mia Ericson, Louise Adermark
Summary: This study aimed to investigate the acute and sustained effects of nicotine on the female rat brain, focusing on changes in dopamine neurotransmission and synaptic plasticity. The findings showed that nicotine can decrease excitatory neurotransmission, enhance synaptic long-term depression, and induce behavioral sensitization and increased neurophysiological responsiveness. These effects may contribute to the establishment of persistent nicotine taking habits.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Hatice Aygun, Ali Tugrul Akin, Nildem Kizilaslan, Orhan Sumbul, Derya Karabulut
Summary: This study investigated the effects of probiotic supplementation on absence epilepsy and anxiety- and depression-like behavior. The results showed that VSL#3 supplement reduced the duration and number of seizures and had anxiolytic and anti-depressive effects. Additionally, VSL#3 supplementation increased the immunoreactivity of neurotrophic factors and decreased the levels of proinflammatory cytokines.
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Gul Ilbay, Aymen Balikci, Sibel Kokturk, Melda Yardimoglu Yilmaz, Nurbay Ates, Canan Baydemir, Sibel Balci
Summary: The study aimed to investigate the impact of neonatal tactile stimulations on brain structures related to genetic absence epilepsy. Results showed that early tactile stimulations had long-term effects on dendritic spines in pyramidal neurons, suggesting its potential role in regulating epilepsy in the brain.
Article
Endocrinology & Metabolism
Alberto Arboit, Karla Krautwald, Frank Angenstein
Summary: We investigated the effects of neuronal afterdischarges on fMRI signals in the hippocampus under the influence of isoflurane and medetomidine. We found that neuronal afterdischarges can elicit different hemodynamic changes in the presence of these two drugs.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Orhan Sumbul, Reyhan Koroglu, Hatice Aygun
Summary: The aim of this study was to evaluate the effects of antiepileptic drug lacosamide on spontaneous absence seizures and anxiety in genetic absence-epilepsy WAG/Rij rats.
ARCHIVES OF EPILEPSY
(2022)
Article
Neurosciences
Ryota Tokunaga, Thierry Paquette, Tomokazu Tsurugizawa, Hugues Leblond, Mathieu Piche
Summary: This study compared neurovascular coupling under medetomidine and isoflurane anesthesia during noxious stimulation, showing that medetomidine significantly increased CBF/LFP ratio compared to isoflurane, but this effect was abolished by fasting. Fasting can reduce medetomidine-induced hyperglycemia and improve neurovascular coupling.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Muhammad H. Khan, Sandeep Kumar Mishra, A. B. M. Zakaria, Jelena M. Mihailovic, Daniel Coman, Fahmeed Hyder
Summary: This study investigates the effects of different ligand designs of lanthanide complexes on sodium-23 (Na-23) signals. The results show that gadolinium and thulium agents are mainly influenced by bulk magnetic susceptibility (BMS) and hyperfine effects. The shiftability and broadening of Na-23 signals are most sensitive to the concentration of lanthanide complexes. In brain tumor models, TmDOTP5- can separate Na+ in intracellular, blood, and interstitial pools, while GdDOTP5- can distinguish Na+ within intracellular and extracellular pools.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Jelena M. Mihailovic, Yuegao Huang, John J. Walsh, Muhammad H. Khan, Sandeep K. Mishra, Sara Samuels, Fahmeed Hyder, Daniel Coman
Summary: The study explores high-resolution pH imaging in vivo by combining CEST and BIRDS imaging techniques, investigating the impact of temperature on imaging results. Results show that the temperature calibration performed by BIRDS allows for more accurate pH measurement, enabling high-resolution pH imaging.
NMR IN BIOMEDICINE
(2022)
Article
Oncology
Fahmeed Hyder, Muhammad H. Khan
Summary: Acidity and salinity of the extracellular fluid play important roles in regulating cellular functions, especially in cancer. Pioneering imaging of extracellular acidity and salinity holds promise for early cancer diagnosis and tracking therapies.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
J. Jean Chen, Biranavan Uthayakumar, Fahmeed Hyder
Summary: Recent studies have shown that gas-free calibrated fMRI can effectively measure the cerebral metabolic rate of oxygen consumption (CMRO2) and have potential clinical applications. This review highlights the technological advances in gas-free calibrated fMRI experiments and their impact on neurological and neurodegenerative disease research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Basavaraju G. Sanganahalli, Garth J. Thompson, Maxime Parent, Justus V. Verhagen, Hal Blumenfeld, Peter Herman, Fahmeed Hyder
Summary: This study used high field fMRI to examine the activity patterns in the rat thalamus in response to different sensory stimuli. The results showed that tactile stimuli activated multiple regions in the thalamus, while non-tactile stimuli only activated specific thalamic nuclei.
Article
Clinical Neurology
Patrick D. Lyden, Francesca Bosetti, Marcio A. Diniz, Andre Rogatko, James Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S. B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh
Summary: Cerebral ischemia and reperfusion lead to neurological disabilities, and developing successful stroke treatments has been challenging. The Stroke Preclinical Assessment Network (SPAN) aims to reduce bias in treatment selection for clinical studies by rigorously assessing candidate treatments across multiple research laboratories. The first stage of SPAN successfully implemented standardized procedures, randomization, and blinded assessment. Subsequent stages will evaluate candidate treatments using aged animals and animals with comorbid conditions.
Article
Medicine, General & Internal
Miao Zhang, Qikai Qin, Shuning Zhang, Wei Liu, Hongping Meng, Mengyang Xu, Xinyun Huang, Xiaozhu Lin, Mu Lin, Peter Herman, Fahmeed Hyder, Raymond C. Stevens, Zheng Wang, Biao Li, Garth J. Thompson
Summary: For patients with temporal lobe epilepsy, OGI imaging during inter-ictal period shows higher values on the same side as the epileptic focus compared to the opposite side. OGI results agree with invasive electrophysiology, providing promising insights into metabolic changes in epilepsy.
Article
Neurosciences
Yuguo Yu, Adil Akif, Peter Herman, Miao Cao, Douglas L. Rothman, Richard E. Carson, Divyansh Agarwal, Alan C. Evans, Fahmeed Hyder
Summary: This study establishes a digital 3D atlas of cortical energy based on the energetic costs of different cortical regions. The atlas is validated using glucose oxidation measurements and reveals heterogeneous activity rates across cortical regions. The distribution of synaptic connections plays a crucial role in cortical energetics. Additionally, some cortical areas act as hubs with higher metabolic rates and synaptic density. The open-source BrainEnergyAtlas provides a granular framework for exploring design principles in energy-constrained human cortical circuits.
Article
Neurosciences
D. O'Connor, F. Mandino, X. Shen, C. Horien, X. Ge, P. Herman, F. Hyder, M. Crair, X. Papademetris, E. M. R. Lake, R. T. Constable
Summary: To improve the translation from the laboratory to the clinic, it is essential to have bidirectional knowledge flow between animal models and humans. This study presents a new pipeline for the preprocessing of wide-field optical fluorescence imaging data, along with functional connectivity and graph theory analyses inspired by recent work in human neuroimaging. The results demonstrate the usefulness of these approaches in quantifying differences between wakefulness states and cell populations, aiding translational neuroscience efforts.
Article
Multidisciplinary Sciences
Karen Perez de Arce, Adema Ribic, Dhrubajyoti Chowdhury, Katherine Watters, Garth J. J. Thompson, Basavaraju G. G. Sanganahalli, Elizabeth T. C. Lippard, Astrid Rohlmann, Stephen M. M. Strittmatter, Markus Missler, Fahmeed Hyder, Thomas Biederer
Summary: LRRTM1 is a post synaptic adhesion protein that promotes synaptic transmission. The authors found that LRRTM1 and SynCAM 1 work together to organize synapses in the prefrontal cortex, affecting cognitive function in mice. The study highlights the roles of LRRTM1 and SynCAM 1 in synaptic, network, and behavioral domains.
NATURE COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Line S. Reitlo, Jelena M. Mihailovic, Dorthe Stensvold, Ulrik Wisloff, Fahmeed Hyder, Asta Kristine Haberg
Summary: The study aimed to investigate the differences in hippocampal metabolites for neuronal viability and cell membrane density between older adults performing supervised exercise and those following national physical activity guidelines. The results showed that supervised exercise led to lower NAA/Cr levels in the hippocampal body compared to following guidelines. Higher training intensity was associated with lower Cho/Cr levels in the hippocampal body. Lower NAA/Cr levels were associated with poorer psychological health and slightly higher cognitive scores. Following national guidelines and not training at the highest intensity level resulted in the best neurochemical profile in the hippocampus at 3 years.
Article
Biochemistry & Molecular Biology
Mauro DiNuzzo, Gerald A. Dienel, Kevin L. Behar, Ognen A. Petroff, Helene Benveniste, Fahmeed Hyder, Federico Giove, Shalom Michaeli, Silvia Mangia, Suzana Herculano-Houzel, Douglas L. Rothman
Summary: During brain activation, cerebral blood flow increases more than cerebral metabolic rate of oxygen consumption, resulting in blood hyperoxygenation. The high neurovascular coupling constant in the brain is maintained to support mitochondrial ATP production and maintain homeostasis of pH, pCO2, and pO2. The optimal values of the neurovascular coupling constant and oxygen extraction fraction (OEF) are remarkably similar to their experimental values.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Patrick D. Lyden, Marcio A. Diniz, Francesca Bosetti, Jessica Lamb, Karisma A. Nagarkatti, Andre Rogatko, Sungjin Kim, Ryan P. Cabeen, James I. Koenig, Kazi Akhter, Ali S. Arbab, Brooklyn D. Avery, Hannah E. Beatty, Adnan Bibic, Suyi Cao, Ligia Simoes Braga Boisserand, Angel Chamorro, Anjali Chauhan, Sebastian Diaz-Perez, Krishnan Dhandapani, Nirav Dhanesha, Andrew Goh, Alison L. Herman, Fahmeed Hyder, Takahiko Imai, Conor W. Johnson, Mohammad B. Khan, Pradip Kamat, Senthilkumar S. Karuppagounder, Mariia Kumskova, Jelena M. Mihailovic, Joseph B. Mandeville, Andreia Morais, Rakesh B. Patel, Basavaraju G. Sanganahalli, Cameron Smith, Yanrong Shi, Brijesh Sutariya, Daniel Thedens, Tao Qin, Sofia E. Velazquez, Jaroslaw Aronowski, Cenk Ayata, Anil K. Chauhan, Enrique C. Leira, David C. Hess, Raymond C. Koehler, Louise D. Mccullough, Lauren H. Sansing
Summary: Human diseases can be modeled in animals for preclinical assessment of new clinical interventions, but recent failures in clinical trials have raised concerns about the value of preclinical assessment. To address this issue, we established the Stroke Preclinical Assessment Network (SPAN) and conducted a rigorous, multi-laboratory trial to evaluate candidate stroke treatments. By following a common protocol, six independent research laboratories enrolled 2615 animals and achieved full data completion and comprehensive animal tracking.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Ryan P. Cabeen, Joseph Mandeville, Fahmeed Hyder, Basavaraju G. Sanganahalli, Daniel R. Thedens, Ali S. Arbab, Shuning Huang, Adnan Bibic, Erendiz Tarakci, Jelena Mihailovic, Andreia Morais, Jessica Lamb, Karisma Nagarkatti, Arthur W. Toga, Patrick Lyden, Cenk Ayata
Summary: This study developed a pipeline for image-based stroke outcome quantification to improve the assessment quality and scalability of potential therapeutic interventions in rodent models. By analyzing multi-parameter MRI data, including measures of lesion extent and longitudinal changes, the study revealed the overall effects and long-term variations of stroke injury. The validated method may serve as a promising resource for future preclinical studies.
2023 IEEE 20TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI
(2023)
Article
Chemistry, Multidisciplinary
Sandeep K. Mishra, Peter Herman, Michael Crair, R. Todd Constable, John J. Walsh, Adil Akif, Justus V. Verhagen, Fahmeed Hyder
Summary: In this study, magnetic protein nanoparticles (MPNPs) with fluorescent dye (f-MPNPs) were successfully synthesized for optical cerebrovascular imaging without losing the properties of positive magnetic resonance imaging (MRI) contrast. In vivo experiments on mice showed that f-MPNPs provided detailed microvascular contrast enhancement with fast clearance and no toxic effects.