Article
Neurosciences
Abdalla M. Albeely, Caitlin J. Nolan, Duncan J. Rasmussen, Craig D. C. Bailey, Melissa L. Perreault
Summary: This study evaluated the impact of prefrontal cortical dopamine D5 receptor (D5R) knockdown on learning and memory in rats, and also assessed the role of D5R in the regulation of neuronal oscillatory activity and glycogen synthase kinase-3 beta (GSK-3 beta). The results showed that knockdown of D5R led to deficits in learning and memory, accompanied by increased theta oscillations in the prefrontal cortex, orbitofrontal cortex, and hippocampus, increased coherence between prefrontal cortex and orbitofrontal cortex, and decreased coherence between prefrontal cortex and thalamus.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Julia Greenfield, Veronique Delcroix, Wafae Ettaki, Romain Derollepot, Laurence Paire-Ficout, Maud Ranchet
Summary: This study analyzed the relationship between cortical activity and walking speed in elderly adults. The results showed that individuals with a slower preferred walking speed required a higher increase in cortical activity. Individuals in the fast cluster presented greater changes in cortical activation in the right hemisphere. This study demonstrates the importance of cortical activity in relation to walking speed and suggests that age may not be the most relevant factor.
Article
Neurosciences
Nathan Cross, Casey Paquola, Florence B. Pomares, Aurore A. Perrault, Aude Jegou, Alex Nguyen, Umit Aydin, Boris C. Bernhardt, Christophe Grova, Thien Thanh Dang-Vu
Summary: This study investigated the effects of sleep deprivation on brain function and cognitive performance, revealing gradients in cortical activity across different states and highlighting the predictive value of gradient axes features on the degree of decline in task performance.
Article
Neurosciences
Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B. Laprairie, Changiz Taghibiglou
Summary: Both type 1 and type 2 cannabinoid receptors were found in non-raft compartments in cortical tissue, contradicting previous findings in cultured cell lines. Further investigation is warranted to study the compartmental distribution of CB1 and CB2 receptors in various brain regions and cell types.
Article
Biochemistry & Molecular Biology
Candela Gonzalez-Arias, Andrea Sanchez-Ruiz, Julio Esparza, Cristina Sanchez-Puelles, Lucia Arancibia, Jorge Ramirez-Franco, Davide Gobbo, Frank Kirchhoff, Gertrudis Perea
Summary: This study reveals the altered astrocytic Ca2+ signaling in Major Depressive Disorder (MDD) and its impact on brain circuits and behavior. Boosting the astrocyte Ca2+ signaling can restore mood and cognitive abilities in MDD mice.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Lorenzo Pasquini, Susanna L. Fryer, Stuart J. Eisendrath, Zindel Segal, Alex J. Lee, Jesse A. Brown, Manish Saggar, Daniel H. Mathalon
Summary: Our study found that TRD patients have a reduced cortical gradient dispersion. This reduction is associated with increased network degree assessed through graph theory-based measures of network topology. Lower dispersion among default mode, control, and limbic network nodes relates to baseline levels of trait anxiety, depression, and mindfulness. Patients' baseline limbic network dispersion predicts trait anxiety scores 24 weeks after the intervention.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Cell Biology
Dakota F. Brockway, Keith R. Griffith, Chloe M. Aloimonos, Thomas T. Clarity, J. Brody Moyer, Grace C. Smith, Nigel C. Dao, Md Shakhawat Hossain, Patrick J. Drew, Joshua A. Gordon, David A. Kupferschmidt, Nicole A. Crowley
Summary: This study aimed to investigate the unique role of somatostatin (SST) in the prelimbic (PL) cortex of mice. The researchers conducted slice electrophysiology and fiber photometry to characterize the pharmacological mechanism and activity profile of SST neurons. The findings reveal that SST signaling can modulate microcircuits in the prefrontal cortex and affect exploratory behaviors.
Article
Cell Biology
Claudia Miguel-Quesada, Marta Zaforas, Salvador Herrera-Perez, Justin Lines, Elena Fernandez-Lopez, Elena Alonso-Calvino, Maria Ardaya, Federico N. Soria, Alfonso Araque, Juan Aguilar, Juliana M. Rosa
Summary: In this study, the researchers observed and manipulated the activity of astrocytes to investigate their role in sensory information processing at both circuit and behavioral levels. They found that astrocytes are able to control the dynamic range of cortical network activity, optimizing its responsiveness to sensory inputs. This astrocytic modulation of sensory processing helps to set the detection threshold for tactile and thermal behavior responses. The researchers also discovered that astrocytes achieve this control by modulating inhibitory transmission to adjust the gain and sensitivity of responding networks.
Article
Chemistry, Medicinal
Md Afjalus Siraj, Md Sariful Islam Howlader, Md Sohanur Rahaman, Jamil A. Shilpi, Veronique Seidel
Summary: The ethanol extract of Vernonia patula aerial parts demonstrated significant antinociceptive and sedative effects in animal tests, likely due to the presence of five phenolic compounds. Computational analysis revealed that vanillic acid and caffeic acid have high binding affinities towards the CB1 receptor.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Hye Ji J. Kim, Ayat Zagzoog, Anna Maria Smolyakova, Udoka C. Ezeaka, Michael J. Benko, Teagan Holt, Robert B. Laprairie
Summary: The endocannabinoid and orexin neuromodulatory systems play key roles in regulating sleep, appetite, pain processing, and emotional behaviors related to reward. They co-localize in the brain regions and physically interact as heterodimers, particularly in the ventral striatum. Male mice show greater effects following combined treatment with cannabinoid receptor agonist and orexin receptor antagonist.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Danilo Benette Marques, Rafael Naime Ruggiero, Lezio Soares Bueno-Junior, Matheus Teixeira Rossignoli, Joao Pereira Leite
Summary: The perception of control over a stressful experience may determine its impacts and generate resistance against future stressors. The study on male rats suggests that hippocampal-prefrontal network theta activity supports cognitive mechanisms of stress coping and is associated with escape performance and vulnerability to stress-related disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzi, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano
Summary: Corticosteroid-mediated stress responses involve complex brain circuits and mitochondrial activity, and the endocannabinoid system plays a role in regulating these processes. The study shows that corticosterone impairs novel object recognition (NOR) task performance in mice through the activation of mitochondrial CB1 receptors and the regulation of neuronal mitochondrial calcium levels. Different brain circuits are modulated by this mechanism to mediate the effects of corticosterone during specific phases of the task.
Article
Pharmacology & Pharmacy
Ayat Zagzoog, Ashley Cabecinha, Hanan Abramovici, Robert B. Laprairie
Summary: Cannabis sativa contains numerous cannabinoids and terpene compounds, and their pharmacological effects, interactions, and impact on physiological outcomes need further investigation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Cristina Izquierdo-Luengo, Marc Ten-Blanco, Maria Ponce-Renilla, Ramiro Perezzan, Inmaculada Pereda-Perez, Fernando Berrendero
Summary: The consumption of synthetic cannabinoids during adolescence is associated with an increased risk of psychiatric disorders in adulthood. This study examined the effects of exposure to JWH-018, a primary psychoactive component in Spice/K2, on anxiety-like behavior, fear extinction, and sensorimotor gating in male and female mice. The results showed that anxiety levels varied depending on the timing of treatment and analysis, and no changes were observed in fear extinction. Male mice exhibited a decrease in startle reflex inhibition, along with reduced perineuronal nets in the prefrontal cortex. Adolescent exposure to JWH-018 also led to activation of microglia and astrocytes in the prefrontal cortex of male mice, as well as a transient decrease in the expression of GAD67 and CB2 cannabinoid receptors. These findings suggest that JWH-018 exposure during adolescence can induce long-lasting neurobiological changes associated with psychotic-like symptoms, with sex-dependent effects.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Justin E. LaVigne, Ryan Hecksel, Attila Keresztes, John M. Streicher
Summary: Limited evidence suggests that terpenes found in Cannabis sativa may have cannabimimetic activity and can enhance cannabinoid activity. These multifunctional cannabimimetic ligands provide support for the entourage effect hypothesis, potentially enhancing the therapeutic properties of cannabinoids.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mark R. Bower, Michal T. Kucewicz, Erik K. St. Louis, Fredric B. Meyer, W. Richard Marsh, Matt Stead, Gregory A. Worrell
Article
Clinical Neurology
Charmaine Demanuele, Ullrich Bartsch, Bengi Baran, Sheraz Khan, Mark G. Vangel, Roy Cox, Matti Hamalainen, Matthew W. Jones, Robert Stickgold, Dara S. Manoach
Article
Clinical Neurology
Charmaine Demanuele, Ullrich Bartsch, Bengi Baran, Sheraz Khan, Mark G. Vangel, Roy Cox, Matti Hamalainen, Matthew W. Jones, Robert Stickgold, Dara S. Manoach
Article
Biochemical Research Methods
Anna C. Sales, Karl J. Friston, Matthew W. Jones, Anthony E. Pickering, Rosalyn J. Moran
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Psychology, Clinical
H. A. Moulding, U. Bartsch, J. Hall, M. W. Jones, D. E. Linden, M. J. Owen, M. B. M. van den Bree
PSYCHOLOGICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Cezar M. Tigaret, Tzu-Ching E. Lin, Edward R. Morrell, Lucy Sykes, Anna L. Moon, Michael C. O'Donovan, Michael J. Owen, Lawrence S. Wilkinson, Matthew W. Jones, Kerrie L. Thomas, Jeremy Hall
Summary: Genetic variations in the CACNA1C gene are strongly associated with psychiatric disorders such as schizophrenia and bipolar disorder. Studying the impact of mutations in Cacna1c on rat cognitive and synaptic functions revealed impairments in learning and synaptic plasticity, with dys-coordinated network oscillations and disrupted Ca2+ signaling pathways. Activation of the ERK pathway through small-molecule agonists rescued behavioral abnormalities in rats with Cacna1c mutations, suggesting targeted neurotrophin signaling pathways as a potential therapeutic approach for psychiatric disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Ullrich Bartsch, Laura J. Corbin, Charlotte Hellmich, Michelle Taylor, Kayleigh E. Easey, Claire Durant, Hugh M. Marston, Nicholas J. Timpson, Matthew W. Jones
Summary: The rs1344706 polymorphism in ZNF804A is associated with changes in neural network activity during sleep in a healthy population, impacting offline information processing. These findings underscore the utility of sleep neurophysiology in mapping the effects of common genetic variants associated with schizophrenia on neural circuit oscillations and function.
Article
Neurosciences
Flavie Kersante, Ross J. Purple, Matthew W. Jones
Summary: Benzodiazepines and 'Z-drugs' are commonly prescribed as hypnotics, but their effects on network and cellular activity during sleep and memory consolidation are not well understood. This study investigated the effects of zolpidem and other drugs on neural population activity and found that zolpidem enhanced coordinated activity between the hippocampus and neocortex during non-REM sleep. These findings suggest that zolpidem may have the potential to modulate offline memory processing.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Cagdas Topcu, Victoria S. Marks, Krishnakant V. Saboo, Michal Lech, Petr Nejedly, Vaclav Kremen, Gregory A. Worrell, Michal T. Kucewicz
Summary: This study investigates the critical brain regions and neural activities involved in human memory encoding by conducting intracranial electrophysiological recordings in epilepsy patients. The findings reveal significant differences in low theta frequency neural activities in the prefrontal cortex between subsequently recalled and forgotten words, with a more pronounced memory effect in the anterior cortical regions. The study identifies a focal hotspot in the prefrontal cortex as a potential target for modulating cognitive functions in patients.
Article
Biology
Nicholas A. Donnelly, Ullrich Bartsch, Hayley A. Moulding, Christopher Eaton, Hugh Marston, Jessica H. Hall, Jeremy Hall, Michael J. Owen, Marianne B. M. van den Bree, Matt W. Jones, Ole Jensen
Summary: This study provides a detailed description of sleep neurophysiology in individuals with 22q11.2 Deletion Syndrome (22q11.2DS), highlighting EEG signature alterations that are associated with neurodevelopmental conditions and psychiatric symptoms. Sleep EEG features may serve as biomarkers for understanding the neurobiology of 22q11.2DS and neuropsychiatric disorders.
Editorial Material
Neurosciences
Paul Anastasiades, Abhishek Banerjee, Matt Jones
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Psychiatry
Ullrich Bartsch, Andrew J. Simpkin, Charmaine Demanuele, Erin Wamsley, Hugh M. Marston, Matthew W. Jones
Article
Neurosciences
Michal T. Kucewicz, Krishnakant Saboo, Brent M. Berry, Vaclav Kremen, Laura R. Miller, Fatemeh Khadjevand, Cory S. Inman, Paul Wanda, Michael R. Sperling, Richard Gorniak, Kathryn A. Davis, Barbara C. Jobst, Bradley Lega, Sameer A. Sheth, Daniel S. Rizzuto, Ravishankar K. Lyer, Michael J. Kahana, Gregory A. Worrell
Article
Neurosciences
Michal T. Kucewicz, Brent M. Berry, Vaclav Kremen, Laura R. Miller, Fatemeh Khadjevand, Youssef Ezzyat, Joel M. Stein, Paul Wanda, Michael R. Sperling, Richard Gorniak, Kathryn A. Davis, Barbara C. Jobst, Robert E. Gross, Bradley Lega, S. Matt Stead, Daniel S. Rizzuto, Michael J. Kahana, Gregory A. Worrell
Article
Biochemistry & Molecular Biology
Youssef Ezzyat, James E. Kragel, John F. Burke, Deborah F. Levy, Anastasia Lyalenko, Paul Wanda, Logan O'Sullivan, Katherine B. Hurley, Stanislav Busygin, Isaac Pedisich, Michael R. Sperling, Gregory A. Worrell, Michal T. Kucewicz, Kathryn A. Davis, Timothy H. Lucas, Cory S. Inman, Bradley C. Lega, Barbara C. Jobst, Sameer A. Sheth, Kareem Zaghloul, Michael J. Jutras, Joel M. Stein, Sandhitsu R. Das, Richard Gorniak, Daniel S. Rizzuto, Michael J. Kahana