Article
Biochemistry & Molecular Biology
Yuki Tomiga, Kazuya Sakai, Song-Gyu Ra, Masaki Kusano, Ai Ito, Yoshinari Uehara, Hirokazu Takahashi, Kentaro Kawanaka, Hidenobu Soejima, Yasuki Higaki
Summary: This study found that relatively short-term running exercise can reduce anxiety-like behaviors, increase brain-derived neurotrophic factor (BDNF), and decrease neuronal nitric oxide synthase (nNOS) levels through epigenetic modifications in the brain. These effects mainly occur in the ventral hippocampal region, suggesting a potential mechanism for mood regulation via alterations in epigenetic mechanisms after a brief period of exercise.
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Hector R. Mendez-Gomez, Miriam Esgleas, Maria Jose Roman, Josep M. Canals, Shubha Tole, Carlos Vicario
Summary: This study investigates the impact of misexpression of the Tbr1 transcription factor on mouse neural progenitor cells. The results suggest that Tbr1 misexpression delays or disrupts neuronal migration, specification, and dendrite development, potentially leading to brain malformations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
Summary: Through studying the TcMAC21 mouse model, we found that it exhibits similar brain developmental abnormalities as individuals with Down syndrome (DS), making it a valuable model for investigating the causes of intellectual disability in DS individuals.
Article
Biochemistry & Molecular Biology
Taro Chaya, Yamato Maeda, Ryo Sugimura, Daisuke Okuzaki, Satoshi Watanabe, Leah R. Varner, Daisuke Motooka, Daichi Gyoten, Haruka Yamamoto, Hidemasa Kato, Takahisa Furukawa
Summary: This study found that miR-124a plays an important role in neuronal maturation rather than neurogenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Andrea Maset, Luisa Galla, Simona Francia, Olga Cozzolino, Paola Capasso, Rosa Chiara Goisis, Gabriele Losi, Angelo Lombardo, Gian Michele Ratto, Claudia Lodovichi
Summary: The study revealed a strong impact of the OPHN1 gene on inhibitory interneurons migration in mice, with reduced speed and disturbed directionality. Disruption in chloride homeostasis and overactivation of the ROCK signaling pathway were identified as underlying mechanisms. Targeting these pathways could potentially lead to successful therapeutic approaches for cognitive deficits associated with OPHN1 mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ricardo Laranjeiro, Girish Harinath, Amelia K. Pollard, Christopher J. Gaffney, Colleen S. Deane, Siva A. Vanapalli, Timothy Etheridge, Nathaniel J. Szewczyk, Monica Driscoll
Summary: The study found that in spaceflight conditions, worm neurons exhibited hyper-branching and an accumulation of neuronal waste in surrounding tissues, indicating impaired transcellular degradation of neuronal debris. The results highlight the significant impact of spaceflight on adult neuronal morphology and trash clearance, emphasizing the importance of assessing risks and developing countermeasures for safe long-duration space exploration.
Article
Behavioral Sciences
Macarena Gonzalez-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodriguez de Fonseca, Maria Pascual, Marta Rodriguez-Arias
Summary: This study evaluated the effects of oleoylethanolamide (OEA) on the rewarding properties of cocaine and relapse-related gene expression in the striatum and hippocampus. The results showed that OEA did not affect cocaine-induced conditioned place preference acquisition, but it blocked drug-induced reinstatement and inhibited the expression of dopamine receptor gene D1, dopamine receptor gene D2, and cannabinoid receptor 1 in the striatum and hippocampus. These findings suggest that OEA may be a promising pharmacological agent in the treatment of cocaine use disorder.
BEHAVIORAL AND BRAIN FUNCTIONS
(2023)
Article
Environmental Sciences
Oladele A. Oluwayiose, Chelsea Marcho, Haotian Wu, Emily Houle, Stephen A. Krawetz, Alexander Suvorov, Jesse Mager, J. Richard Pilsner
Summary: Preconception exposure to DEHP in male mice resulted in differential DNA methylation in sperm, embryonic, and extra-embryonic tissues, with overlapping changes observed between F0 and F1 generations. The altered transcriptomes at E7.5 in F1 embryos included developmental gene families such as Hox, Gata, and Sox, suggesting DEHP exposure affects gene expression in developing embryos. Gene ontology analyses showed enrichment of developmental processes, highlighting the impact of DEHP exposure on sperm methylome and embryonic development.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Article
Biochemistry & Molecular Biology
Gubbi Govindaiah, Rong-Jian Liu, Yanyan Wang
Summary: This study found that D2L deficiency can cause abnormalities in cholinergic interneurons (ChIs). Specifically, quinpirole enhances the excitability of ChIs, loses influence on spike firing of medium spiny projection neurons (MSNs), and continues to have an inhibitory effect on spike firing of fast-spiking interneurons (FSIs). Additionally, reduced spontaneous GABA release and dendritic spine density in ChIs were observed in D2L knockout (KO) mice. These findings provide new molecular and cellular mechanisms for understanding Parkinson's disease and drug-induced dyskinesias.
Article
Biochemistry & Molecular Biology
Lucia Caffino, Francesca Mottarlini, Sabrine Bilel, Giorgia Targa, Micaela Tirri, Coralie Maggi, Matteo Marti, Fabio Fumagalli
Summary: The study reveals that the expression of neuroplastic markers in the brain can be altered by low doses of MDPV or alpha-PVP, suggesting the widespread impact of these cathinones on brain plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Darshan Sapkota, Mandy S. J. Kater, Kristina Sakers, Kayla R. Nygaard, Yating Liu, Sarah K. Koester, Stuart B. Fass, Allison M. Lake, Rohan Khazanchi, Rana R. Khankan, Mitchell C. Krawczyk, August B. Smit, Susan E. Maloney, Mark H. G. Verheijen, Ye Zhang, Joseph D. Dougherty
Summary: Neuronal activity can regulate transcriptional and translational responses in astrocytes, providing an additional mechanism for astrocytes to dynamically modulate nervous system functioning.
Article
Multidisciplinary Sciences
Melody Li, Mohamed Eltabbal, Hoang- Dai Tran, Bernd Kuhn
Summary: In this study, researchers generated a mouse model of Scn2a insufficiency and found that spontaneous Ca2+ transients in somatosensory cortical neurons, as well as their pairwise co-activities, were decreased in Scn2a ASO mice during spontaneous awake state and induced seizure state. This reduction may be a mechanism driving SCN2A PTV pathology.
Article
Biochemistry & Molecular Biology
Robert G. Mealer, Sarah E. Williams, Maxence Noel, Bo Yang, Alexandria K. D'Souza, Toru Nakata, Daniel B. Graham, Elizabeth A. Creasey, Murat Cetinbas, Ruslan I. Sadreyev, Edward M. Scolnick, Christina M. Woo, Jordan W. Smoller, Ramnik J. Xavier, Richard D. Cummings
Summary: The missense mutation A391T in SLC39A8 is strongly associated with schizophrenia, and this study reveals its impact on protein glycosylation in the brain. This finding provides a mechanistic link between the risk allele and reversible biochemical changes, offering a new understanding of the molecular pathophysiology of schizophrenia and a potential avenue for therapeutic development.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychology, Developmental
Joseph Biederman, Maura Fitzgerald, Thomas J. Spencer, Pradeep G. Bhide, Deirdre M. McCarthy, K. Yvonne Woodworth, Alexandra Saunders, Stephen V. Faraone
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Psychology, Clinical
Thomas J. Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V. Faraone, Maura Fitzgerald, Amy M. Yule, Mai Uchida, Andrea E. Spencer, Anna M. Hall, Ariana J. Koster, Leah Feinberg, Sarah Kassabian, Barbara Storch, Joseph Biederman
JOURNAL OF CLINICAL PSYCHIATRY
(2018)
Article
Neurosciences
Melissa M. Martin, Deirdre M. McCarthy, Chris Schatschneider, Mia X. Trupiano, Sara K. Jones, Aishani Kalluri, Pradeep G. Bhide
Review
Cell Biology
Ann Marie Centner, Pradeep G. Bhide, Gloria Salazar
Article
Neurosciences
Russell W. Brown, Pradeep G. Bhide, W. Drew Gill, Loren D. Peeters
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Deirdre M. McCarthy, Sarah E. Lowe, Thomas J. Morgan, Elisa N. Cannon, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Lin Zhang, Deirdre M. McCarthy, Karen L. Eskow Jaunarajs, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
Summary: The study indicates that the KOR antagonist norbinaltorphimine (norBNI) and methylphenidate can improve attention and working memory in the PNE mouse model by increasing dopamine and noradrenaline release.
Article
Neurosciences
Samantha Pavlock, Deirdre M. McCarthy, Anisha Kesarwani, Pascal Jean-Pierre, Pradeep G. Bhide
Summary: The combination of the chemotherapy drug cyclophosphamide (CP) and the anti-inflammatory drug naproxen can affect hippocampal inflammation. However, individually using CP, naproxen, or undergoing ovariectomy does not cause significant cognitive changes associated with chemo brain. Only the combination of CP and ovariectomy has a significant effect on depression-like behavior, which is a comorbidity of chemo brain.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Reproductive Biology
Deirdre M. McCarthy, Pradeep G. Bhide
Summary: Research has expanded our understanding of how genetic and environmental factors interact to shape behavioral phenotypes, including environment-induced epigenetic modifications and their potential association with heritable behavioral phenotypes. The molecular basis of phenotypes resulting from environment-induced epigenetic modifications is not well defined, but there is accumulating phenomenological evidence in support of it. Attention has turned to epigenetic modification of germ cells as a possible mechanism of heritability, particularly focusing on the heritable effects of environmental influences on male founders.
BIOLOGY OF REPRODUCTION
(2021)
Article
Critical Care Medicine
Lin Zhang, Cathy W. Levenson, Valentina Cea Salazar, Joseph Biederman, Ross Zafonte, Pradeep G. Bhide
Summary: Attention deficit hyperactivity disorder (ADHD) may increase the risk for repetitive mild traumatic brain injury (mTBI) and result in poor neurocognitive outcomes. This study using a mouse model found that ADHD and repetitive mTBI contribute to transient novelty-seeking and depression-like behavior.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Behavioral Sciences
Gloria S. Lee, Devon L. Graham, Brenda L. Noble, Taylor S. Trammell, Deirdre M. McCarthy, Lisa R. Anderson, Marcelo Rubinstein, Pradeep G. Bhide, Gregg D. Stanwood
Summary: The study explores the impact of the loss of D2R in specific cell types in the cerebral cortex on neurobehavioral and cellular development. The findings suggest distinct roles for D2R in excitatory and inhibitory neurons in regulating behavior and interneuron development. These findings have important implications for understanding the role of D2R in cortical circuit formation and brain disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Deirdre M. M. McCarthy, Lin Zhang, Bradley J. J. Wilkes, David E. E. Vaillancourt, Joseph Biederman, Pradeep G. G. Bhide
Summary: The use of tobacco products during pregnancy increases the risk of neurodevelopmental disorders in offspring. Preclinical models have provided insights into the effects of developmental nicotine exposure on the brain, showing lasting effects on brain structure, neurotransmitter signaling, and behavior. These models have also contributed to the discovery of potential treatments for attention deficit hyperactivity disorder and demonstrated the heritability of behavioral phenotypes from nicotine-exposed parents to multiple generations. Additionally, research using these models has shown synergistic interactions between developmental nicotine exposure and repetitive mild traumatic brain injury in individuals with attention deficit hyperactivity disorder.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. McCarthy, Cynthia Vied, Gregg D. Stanwood, Chris Schatschneider, Pradeep G. Bhide
Summary: This study reports the effects of aspartame on anxiety-like behavior, neurotransmitter signaling, and gene expression in the amygdala. Mice drinking water with aspartame exhibited anxiety-like behavior and had altered gene expression in the amygdala. The changes in behavior and gene expression were also observed in the offspring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. McCarthy, Cynthia Vied, Gregg D. Stanwood, Chris Schatschneider, Pradeep G. Bhide
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Developmental Biology
Lin Zhang, Cathy W. Levenson, Valentina Cea Salazar, Deirdre M. McCarthy, Joseph Biederman, Ross Zafonte, Pradeep G. Bhide
Summary: ADHD appears to increase the risk for transient depression following repeated mTBI, while repeated mTBI may be a risk factor for transient attention deficit.
DEVELOPMENTAL NEUROSCIENCE
(2021)